{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:48:40Z","timestamp":1792547320792,"version":"4.5.0"},"reference-count":205,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tice.2026.103547","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:57:33Z","timestamp":1776873453000},"page":"103547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cell-free regenerative therapies for female infertility: The emerging role of mesenchymal stem cell secretome"],"prefix":"10.1016","volume":"102","author":[{"given":"Diba","family":"Ghasemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghahremani-Nasab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Barzegari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizeh Farshbaf","family":"Khalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizeh Rahmani","family":"Del Bakhshayesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103547_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin. Biochem"},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib2","first-page":"229","article-title":"Differentiation of human endometrial stem cells encapsulated in alginate hydrogel into oocyte-like cells","volume":"13","author":"Ghasemi","year":"2023","journal-title":"Bioimpacts"},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12905-024-03080-5","article-title":"Endometriosis in infertile women: an observational and comparative study of quality of life, anxiety, and depression","volume":"24","author":"Mori","year":"2024","journal-title":"BMC Women's. Health"},{"issue":"10","key":"10.1016\/j.tice.2026.103547_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102253","article-title":"Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility","volume":"9","author":"Esfandyari","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/jpm14020135","article-title":"Stem Cells and Infertility: A Review of Clinical Applications and Legal Frameworks","volume":"14","author":"Cucinella","year":"2024","journal-title":"J. Pers. Med"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12951-025-03267-4","article-title":"Infertility treatment using polysaccharides-based hydrogels: new strategies in tissue engineering and regenerative medicine","volume":"23","author":"Ghahremani-Nasab","year":"2025","journal-title":"J. Nanobiotechnology"},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib8","article-title":"Recent advances in nano-scaffolds for tissue engineering applications: toward natural therapeutics","volume":"15","author":"Rahmani Del Bakhshayesh","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnology"},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib9","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1002\/jcp.29376","article-title":"Premature ovarian failure and tissue engineering","volume":"235","author":"Ghahremani-Nasab","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tice.2026.103547_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/sci-2020-001","article-title":"Current state of stem cell-based therapies: an overview","volume":"7","author":"Aly","year":"2020","journal-title":"Stem Cell Invest."},{"issue":"11","key":"10.1016\/j.tice.2026.103547_bib11","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1002\/stem.1494","article-title":"Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy","volume":"31","author":"Naji","year":"2013","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical Trials With Mesenchymal Stem Cells: An Update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transpl."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tice.2026.103547_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/5584_2017_67","article-title":"Stem Cell Therapy for Fanconi Anemia","volume":"1083","author":"Zhang","year":"2018","journal-title":"Adv. Exp. Med Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1089\/hum.2017.224","article-title":"Stem-Cell Therapy Advances in China","volume":"29","author":"Hu","year":"2018","journal-title":"Hum. Gene Ther."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.biotechadv.2018.03.011","article-title":"Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review","volume":"36","author":"Bacakova","year":"2018","journal-title":"Biotechnol. Adv."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. the international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tice.2026.103547_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.626322","article-title":"Stem cell paracrine signaling for treatment of premature ovarian insufficiency","volume":"11","author":"Polonio","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/s13287-025-04623-9","article-title":"Mesenchymal stem cells: opening a new chapter in the treatment of gynecological diseases","volume":"16","author":"Hou","year":"2025","journal-title":"Stem Cell Res. & Ther."},{"key":"10.1016\/j.tice.2026.103547_bib20","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.2147\/CCID.S434439","article-title":"Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging","volume":"16","author":"Chou","year":"2023","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib21","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1080\/21691401.2019.1669619","article-title":"Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS)","volume":"47","author":"Zhao","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.tice.2026.103547_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen. Med"},{"issue":"18","key":"10.1016\/j.tice.2026.103547_bib23","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.7150\/thno.61690","article-title":"A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/REP-22-0485","article-title":"Mesenchymal stem cell secretome alters gene expression and upregulates motility of human endometrial stromal cells","volume":"166","author":"Zhao","year":"2023","journal-title":"Reproduction"},{"issue":"7","key":"10.1016\/j.tice.2026.103547_bib25","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/biom15070923","article-title":"Role of Granulosa Cell Dysfunction in Women Infertility Associated with Polycystic Ovary Syndrome and Obesity","volume":"15","author":"Chauvin","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.tice.2026.103547_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.601752","article-title":"Ovarian reserve markers in premature ovarian insufficiency: within different clinical stages and different etiologies","volume":"12","author":"Jiao","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042165","article-title":"Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy","volume":"22","author":"Esfandyari","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.970439","article-title":"Endocrine disorders and fertility and pregnancy: An update","volume":"13","author":"Bendarska-Czerwi\u0144ska","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1210\/clinem\/dgab766","article-title":"Approach to the patient with new-onset secondary amenorrhea: is this primary ovarian insufficiency?","volume":"107","author":"Stuenkel","year":"2022","journal-title":"J. Clin. Endocrinol. & Metab."},{"key":"10.1016\/j.tice.2026.103547_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9071720","article-title":"Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases","volume":"2019","author":"Zhao","year":"2019","journal-title":"Stem Cells Int"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/14737159.2023.2177536","article-title":"Updates in diagnosing polycystic ovary syndrome-related infertility","volume":"23","author":"Haddad-Filho","year":"2023","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib32","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/21524971251379699","article-title":"Clinical Application of Cell Therapy in the Treatment of Female Reproductive Diseases: A Systematic Review","volume":"27","author":"Saberi","year":"2025","journal-title":"Cell. Reprogramming"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/19396368.2025.2593345","article-title":"The biology and clinical aspects of female infertility","volume":"72","author":"Madjunkov","year":"2026","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.tice.2026.103547_bib34","article-title":"Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome","volume":"9","author":"Li","year":"2022","journal-title":"Front. Nutr."},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib35","first-page":"485","article-title":"Myo-inositol: from induction of ovulation to menopausal disorder management","volume":"67","author":"Gullo","year":"2015","journal-title":"Minerva Ginecol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib36","doi-asserted-by":"crossref","DOI":"10.1515\/med-2025-1293","article-title":"Supplement strategies for infertility in overweight women: Evidence and legal insights","volume":"20","author":"Gullo","year":"2025","journal-title":"Open Med."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib37","first-page":"1241","article-title":"Does Alpha-lipoic acid improve effects on polycystic ovary syndrome?","volume":"26","author":"LAGAN\u00c0","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib38","article-title":"D-chiro-inositol induces ovulation in non-polycystic ovary syndrome (PCOS), non-insulin-resistant young women, likely by modulating aromatase expression: a report of 2 cases","volume":"22","author":"Espinola","year":"2021","journal-title":"Am. J. case Rep."},{"issue":"01","key":"10.1016\/j.tice.2026.103547_bib39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.36129\/jog.2022.40","article-title":"Inositols administration: Further insights on their biological role","volume":"35","author":"Coldebella","year":"2023","journal-title":"Ital. J. Gynaecol. & Obstet."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib40","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.fertnstert.2016.07.1066","article-title":"How does closed system vitrification of human oocytes affect the clinical outcome? A prospective, observational, cohort, noninferiority trial in an oocyte donation program","volume":"106","author":"Papatheodorou","year":"2016","journal-title":"Fertil. Steril."},{"issue":"7","key":"10.1016\/j.tice.2026.103547_bib41","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3390\/medicina61071194","article-title":"Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology","volume":"61","author":"Sciorio","year":"2025","journal-title":"Medicina"},{"issue":"10","key":"10.1016\/j.tice.2026.103547_bib42","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1007\/s43032-023-01252-6","article-title":"Assisted reproductive techniques and risk of congenital heart diseases in children: a systematic review and meta-analysis","volume":"30","author":"Gullo","year":"2023","journal-title":"Reprod. Sci."},{"issue":"11","key":"10.1016\/j.tice.2026.103547_bib43","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s10815-017-1010-7","article-title":"GnRH antagonist administered twice the day before hCG trigger combined with a step-down protocol may prevent OHSS in IVF\/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes: a prospective randomized control trial","volume":"34","author":"Prapas","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib44","first-page":"1065","article-title":"Open vs. closed vitrification system: which one is safer?","volume":"26","author":"Gullo","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib45","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.rbmo.2011.10.011","article-title":"Cryptic sperm defects may be the cause for total fertilization failure in oocyte donor cycles","volume":"24","author":"Goudakou","year":"2012","journal-title":"Reprod. Biomed. Online"},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib46","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1331\/JAPhA.2012.12044","article-title":"Treatment of infertility in women","volume":"52","author":"Smith","year":"2012","journal-title":"J. Am. Pharm. Assoc."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0015-0282(16)48069-6","article-title":"Clomiphene citrate: mechanism(s) and site(s) of action--a hypothesis revisited","volume":"42","author":"Adashi","year":"1984","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1056\/NEJMoa1313517","article-title":"Letrozole versus clomiphene for infertility in the polycystic ovary syndrome","volume":"371","author":"Legro","year":"2014","journal-title":"N. Engl. J. Med"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejogrb.2012.12.016","article-title":"Prospective, randomized comparison between pulsatile GnRH therapy and combined gonadotropin (FSH+ LH) treatment for ovulation induction in women with hypothalamic amenorrhea and underlying polycystic ovary syndrome","volume":"168","author":"Dubourdieu","year":"2013","journal-title":"Eur. J. Obstet. & Gynecol. Reprod. Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib50","first-page":"556","article-title":"Successful use of pulsatile gonadotropin-releasing hormone (GnRH) for ovulation induction and pregnancy in a patient with GnRH receptor mutations","volume":"85","author":"Seminara","year":"2000","journal-title":"J. Clin. Endocrinol. & Metab."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib51","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.fertnstert.2018.09.020","article-title":"Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances","volume":"110","author":"Christianson","year":"2018","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib52","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/humrep\/dew075","article-title":"First line fertility treatment strategies regarding IUI and IVF require clinical evidence","volume":"31","author":"Bahadur","year":"2016","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jcma.2016.06.005","article-title":"Does intrauterine insemination timing matter for achieving pregnancy during ovulation induction using gonadotropins? A retrospective cohort study","volume":"80","author":"Yumusak","year":"2017","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.tice.2026.103547_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.humgen.2025.201384","article-title":"An investigation on genetic mutations affecting embryo, oocyte, and sperm quality: An IVF failure perspective","author":"Barati","year":"2025","journal-title":"Hum. Gene"},{"issue":"7","key":"10.1016\/j.tice.2026.103547_bib55","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.fertnstert.2018.10.003","article-title":"Ovarian endometriosis and infertility: in vitro fertilization (IVF) or surgery as the first approach?","volume":"110","author":"Lessey","year":"2018","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib56","first-page":"23","article-title":"Psychological impact of gynecological diseases: the importance of a multidisciplinary approach","volume":"30","author":"Rosa","year":"2018","journal-title":"Ital. J. Gynaecol. Obstet."},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib57","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.3390\/jcm14092923","article-title":"The role of the genital tract microbiome in human fertility: a literature review","volume":"14","author":"Gullo","year":"2025","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/jpm14020135","article-title":"Stem cells and infertility: A review of clinical applications and legal frameworks","volume":"14","author":"Cucinella","year":"2024","journal-title":"J. Pers. Med."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib59","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejogrb.2012.03.003","article-title":"Injection of embryo culture supernatant to the endometrial cavity does not affect outcomes in IVF\/ICSI or oocyte donation cycles: a randomized clinical trial","volume":"162","author":"Prapas","year":"2012","journal-title":"Eur. J. Obstet. & Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib60","article-title":"Using mesenchymal stem cells to treat female infertility: an update on female reproductive diseases","volume":"2019","author":"Zhao","year":"2019","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib61","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1080\/21691401.2019.1669619","article-title":"Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS)","volume":"47","author":"Zhao","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib62","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1095\/biolreprod.114.126771","article-title":"The endometrium as a source of mesenchymal stem cells for regenerative medicine","volume":"92","author":"Mutlu","year":"2015","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib63","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13287-018-1008-9","article-title":"The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure","volume":"9","author":"He","year":"2018","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib64","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","article-title":"Stem Cell Therapies in Clinical Trials: Progress and Challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib65","doi-asserted-by":"crossref","first-page":"709","DOI":"10.18502\/ijrm.v20i9.12061","article-title":"Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review","volume":"20","author":"Saeed","year":"2022","journal-title":"Int J. Reprod. Biomed."},{"key":"10.1016\/j.tice.2026.103547_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121658","article-title":"Therapeutic restoration of female reproductive and endocrine dysfunction using stem cells","volume":"322","author":"Liu","year":"2023","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib67","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/biom14020242","article-title":"Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency","volume":"14","author":"Kim","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.tice.2026.103547_bib68","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/690491","article-title":"The therapeutic potential of umbilical cord mesenchymal stem cells in mice premature ovarian failure","volume":"2013","author":"Wang","year":"2013","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.tice.2026.103547_bib69","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s11427-017-9272-2","article-title":"Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility","volume":"61","author":"Ding","year":"2018","journal-title":"Sci. China Life Sci."},{"issue":"18","key":"10.1016\/j.tice.2026.103547_bib70","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1016\/j.biomaterials.2014.02.046","article-title":"Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus","volume":"35","author":"Ding","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib71","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13287-021-02212-0","article-title":"Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities","volume":"12","author":"Fu","year":"2021","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib72","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13048-020-00671-2","article-title":"Recent trends in stem cell therapy for premature ovarian insufficiency and its therapeutic potential: a review","volume":"13","author":"Na","year":"2020","journal-title":"J. Ovarian Res"},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050467","article-title":"Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome","volume":"8","author":"Harrell","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib74","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/sctm.18-0038","article-title":"Concise Review: Therapeutic Potential of the Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Radiation-Induced Lung Injury: Progress and Hypotheses","volume":"8","author":"Xu","year":"2019","journal-title":"Stem Cells Transl. Med"},{"key":"10.1016\/j.tice.2026.103547_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1021581","article-title":"Mesenchymal stem cells-derived exosomes as a promising new approach for the treatment of infertility caused by polycystic ovary syndrome","volume":"13","author":"Izadi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103547_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.785649","article-title":"Potential of mesenchymal stem cell-derived exosomes as a novel treatment for female infertility caused by bacterial infections","volume":"12","author":"Zohrabi","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tice.2026.103547_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.665645","article-title":"Therapeutic role of mesenchymal stem cell-derived extracellular vesicles in female reproductive diseases","volume":"12","author":"Liao","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2026.103547_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103638","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ovarian granulosa cells inflammatory response through inhibition of NF-\u03baB signaling in polycystic ovary syndrome","volume":"152","author":"Zhao","year":"2022","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib79","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s43032-024-01720-7","article-title":"Mesenchymal stromal cell exosome-induced vascular regeneration in a PCOS mouse model","volume":"32","author":"Teng","year":"2025","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib80","doi-asserted-by":"crossref","first-page":"8321","DOI":"10.1038\/s41598-024-59093-5","article-title":"Umbilical cord mesenchymal stem cell-derived exosomes inhibits fibrosis in human endometrial stromal cells via miR-140-3p\/FOXP1\/Smad axis","volume":"14","author":"Song","year":"2024","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2023.06.008","article-title":"MicroRNA-122-5p alleviates endometrial fibrosis via inhibiting the TGF-\u03b2\/SMAD pathway in Asherman's syndrome","volume":"47","author":"Chen","year":"2023","journal-title":"Reprod. Biomed. Online"},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib82","doi-asserted-by":"crossref","first-page":"260","DOI":"10.15283\/ijsc21177","article-title":"Extracellular vesicles derived from mesenchymal stem cells as cell-free therapy for intrauterine adhesion","volume":"16","author":"Li","year":"2023","journal-title":"Int. J. stem Cells"},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib83","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/stem.3204","article-title":"Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7","volume":"38","author":"Ding","year":"2020","journal-title":"Stem Cells"},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib84","first-page":"706","article-title":"The role and application of exosomes and their cargos in reproductive diseases: A systematic review","volume":"9","author":"Chen","year":"2022","journal-title":"Vet. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118889","article-title":"Exosomes in assisted reproductive technologies: Discovery of new mechanisms and therapeutic possibilities","volume":"193","author":"Ebrahimi","year":"2025","journal-title":"Biomed. & Pharmacother."},{"issue":"7","key":"10.1016\/j.tice.2026.103547_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/cells12071018","article-title":"Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes","volume":"12","author":"Chen","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103547_bib87","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4150705","article-title":"MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair","volume":"2017","author":"Shao","year":"2017","journal-title":"Biomed. Res Int"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib88","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCRESAHA.117.311769","article-title":"Induced pluripotent stem cell (iPSC)\u2013derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs","volume":"122","author":"Adamiak","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.tice.2026.103547_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.949724","article-title":"Safety and biodistribution of exosomes derived from human induced pluripotent stem cells","volume":"10","author":"Gu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib90","doi-asserted-by":"crossref","first-page":"543","DOI":"10.34172\/apb.2024.059","article-title":"Novel Advances in Cell-Free Therapy for Premature Ovarian Failure (POF): A Comprehensive Review","volume":"14","author":"Yahyavi","year":"2024","journal-title":"Adv. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib91","doi-asserted-by":"crossref","first-page":"543","DOI":"10.34172\/apb.2024.059","article-title":"Novel advances in Cell-Free therapy for premature ovarian failure (POF): A comprehensive review","volume":"14","author":"Yahyavi","year":"2024","journal-title":"Adv. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13287-019-1508-2","article-title":"Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K\/AKT signaling pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res. & Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib93","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13287-018-0953-7","article-title":"Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD","volume":"9","author":"Huang","year":"2018","journal-title":"Stem Cell Res. & Ther."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib94","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/micmic\/ozad046","article-title":"Mesenchymal-Stem Cell-Derived Conditioned Media Versus Exosomes in the Treatment of Rat Model of Polycystic Ovary: An Attempt to Understand the Underlying Mechanisms (Biochemical and Histological Study)","volume":"29","author":"Abd-Elwahab","year":"2023","journal-title":"Microsc. Micro"},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/genes8120371","article-title":"Mesenchymal Stem Cell-Conditioned Medium Modulates Apoptotic and Stress-Related Gene Expression, Ameliorates Maturation and Allows for the Development of Immature Human Oocytes after Artificial Activation","volume":"8","author":"Akbari","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.tice.2026.103547_bib96","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.theriogenology.2018.10.012","article-title":"Conditioned medium of ovine Wharton's jelly-derived mesenchymal stem cells improves growth and reduces ROS generation of isolated secondary follicles after short-term in vitro culture","volume":"125","author":"Bezerra","year":"2019","journal-title":"Theriogenology"},{"issue":"11","key":"10.1016\/j.tice.2026.103547_bib97","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1590\/S0100-879X2008005000053","article-title":"Effect of conditioned medium of mesenchymal stem cells on the in vitro maturation and subsequent development of mouse oocyte","volume":"41","author":"Ling","year":"2008","journal-title":"Braz. J. Med Biol. Res"},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib98","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.ymthe.2020.02.003","article-title":"HucMSC-Derived Exosomes Mitigate the Age-Related Retardation of Fertility in Female Mice","volume":"28","author":"Yang","year":"2020","journal-title":"Mol. Ther."},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib99","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.fertnstert.2021.03.004","article-title":"vitro growth and maturation of primordial follicles and immature oocytes","volume":"115","author":"Telfer","year":"2021","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tice.2026.103547_bib100","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8849537","article-title":"Preventive Effects of Intrauterine Injection of Bone Marrow-Derived Mesenchymal Stromal Cell-Conditioned Media on Uterine Fibrosis Immediately after Endometrial Curettage in Rabbit","volume":"2020","author":"Bazoobandi","year":"2020","journal-title":"Stem Cells Int"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib101","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","article-title":"Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses","volume":"78","author":"Costa","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib102","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4252\/wjsc.v11.i6.347","article-title":"Similarities and differences between mesenchymal stem\/progenitor cells derived from various human tissues","volume":"11","author":"Kozlowska","year":"2019","journal-title":"World J. stem Cells"},{"key":"10.1016\/j.tice.2026.103547_bib103","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.reth.2025.03.019","article-title":"Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells","volume":"29","author":"Awano-Kim","year":"2025","journal-title":"Regen. Ther."},{"issue":"23-24","key":"10.1016\/j.tice.2026.103547_bib104","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/15473287251393282","article-title":"Decidual and Endometrial Multipotent Mesenchymal Stromal Cells: Emerging Therapeutic and Clinical Approaches for Intrauterine Adhesion Repair","volume":"34","author":"Yu","year":"2025","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.tice.2026.103547_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1268990","article-title":"Impaired receptivity of thin endometrium: therapeutic potential of mesenchymal stem cells","volume":"14","author":"Saad-Naguib","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2026.103547_bib106","article-title":"Endometrial ECM Modified Hemispherical Hydrogels Delivering MenSCs Promote the Regeneration of Thin Endometrium","author":"Chen","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib107","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/14712598.2025.2465826","article-title":"Steps towards the clinical application of endometrial and menstrual fluid mesenchymal stem cells for the treatment of gynecological disorders","volume":"25","author":"Sadiasa","year":"2025","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.tice.2026.103547_bib108","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1310149","article-title":"VitroGel-loaded human MenSCs promote endometrial regeneration and fertility restoration","volume":"11","author":"Wu","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"10","key":"10.1016\/j.tice.2026.103547_bib109","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/biom15101402","article-title":"Secretome from Uterine Cervical Mesenchymal Stem Cells as a Protector of Neuronal Cells Against Oxidative Stress and Inflammation","volume":"15","author":"Mateo","year":"2025","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib110","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.3390\/ijms18091852","article-title":"Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine","volume":"18","author":"Vizoso","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2024.12.007","article-title":"Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy","author":"Llorca","year":"2025","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tice.2026.103547_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2024.104193","article-title":"Immunological effects of human decidual mesenchymal stem cells in spontaneous and recurrent abortions","volume":"162","author":"B\u00fcy\u00fckbayrak","year":"2024","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib113","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/rmb2.12339","article-title":"Mesenchymal stem cells for restoring endometrial function: An infertility perspective","volume":"20","author":"Rungsiwiwut","year":"2021","journal-title":"Reprod. Med. Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib114","first-page":"813","article-title":"Effects of menstrual blood-derived stem cells on endometrial injury repair","volume":"19","author":"Hu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2026.103547_bib115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.actbio.2019.05.012","article-title":"A collagen scaffold loaded with human umbilical cord-derived mesenchymal stem cells facilitates endometrial regeneration and restores fertility","volume":"92","author":"Xin","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tice.2026.103547_bib116","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.actbio.2023.06.013","article-title":"Functionalized human umbilical cord mesenchymal stem cells and injectable HA\/Gel hydrogel synergy in endometrial repair and fertility recovery","volume":"167","author":"Zhang","year":"2023","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.tice.2026.103547_bib117","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s12015-025-10950-4","article-title":"A Comparative Study of Mesenchymal Stem Cells from Various Sources in Endometrial Repair: the Significant Advantages of Decidual Mesenchymal Stem Cells","volume":"21","author":"Yu","year":"2025","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.tice.2026.103547_bib118","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fcell.2020.00052","article-title":"Platelet-rich plasma therapy enhances the beneficial effect of bone marrow stem cell transplant on endometrial regeneration","volume":"8","author":"Zhou","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib119","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/1933719118799201","article-title":"Bone marrow mesenchymal stem cells (BMSCs) restore functional endometrium in the rat model for severe Asherman syndrome","volume":"26","author":"Gao","year":"2019","journal-title":"Reprod. Sci."},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib120","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1111\/jog.14888","article-title":"Effects of bone marrow mesenchymal stem cells on repair and receptivity of damaged endometrium in rats","volume":"47","author":"Wang","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib121","doi-asserted-by":"crossref","first-page":"322","DOI":"10.5653\/cerm.2021.04357","article-title":"Adipose tissue-derived mesenchymal stem cells reduce endometriosis cellular proliferation through their anti-inflammatory effects","volume":"48","author":"Meligy","year":"2021","journal-title":"Clin. Exp. Reprod. Med."},{"issue":"11","key":"10.1016\/j.tice.2026.103547_bib122","doi-asserted-by":"crossref","first-page":"9431","DOI":"10.3390\/ijms24119431","article-title":"The Therapeutic Potential of Multipotent Mesenchymal Stromal Cell\u2014Derived Extracellular Vesicles in Endometrial Regeneration","volume":"24","author":"Tabeeva","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib123","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00018-019-03268-1","article-title":"Placental mesenchymal stromal cells as an alternative tool for therapeutic angiogenesis","volume":"77","author":"Mathew","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tice.2026.103547_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1590393","article-title":"Advances in human amniotic placenta membrane-derived mesenchymal stromal cells (hAMSCs) for regenerative medicine: enhancing therapeutic potential with biomaterials and scaffolds","volume":"13","author":"de Laorden","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-022-02717-2","article-title":"Synergistic regenerative therapy of thin endometrium by human placenta-derived mesenchymal stem cells encapsulated within hyaluronic acid hydrogels","volume":"13","author":"Lin","year":"2022","journal-title":"Stem Cell Res. & Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00438-025-02241-x","article-title":"Placental mesenchymal stem cell\u2013derived exosomes treat endometrial injury in a rat model of intrauterine adhesions","volume":"300","author":"Liang","year":"2025","journal-title":"Mol. Genet. Genom."},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib127","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/term.362","article-title":"Placenta-derived MSCs are partially immunogenic and less immunomodulatory than bone marrow-derived MSCs","volume":"5","author":"Fazekasova","year":"2011","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.tice.2026.103547_bib128","article-title":"Oocyte quality is decreased in women with minimal or mild endometriosis","volume":"5","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib129","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5301\/je.5000271","article-title":"How to understand the complexity of endometriosis-related pain","volume":"9","author":"Chiantera","year":"2017","journal-title":"J. Endometr. Pelvic Pain. Disord."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib130","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/aogs.12941","article-title":"Oocyte competence in in vitro fertilization and intracytoplasmic sperm injection patients suffering from endometriosis and its possible association with subsequent treatment outcome: a matched case-control study","volume":"96","author":"Shebl","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"7","key":"10.1016\/j.tice.2026.103547_bib131","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/humrep\/dew085","article-title":"A prospective cohort study of endometriosis and subsequent risk of infertility","volume":"31","author":"Prescott","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tice.2026.103547_bib132","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x2022e11948","article-title":"vitro maturation medium supplementation: utilization of repaglinide, L-carnitine, and mesenchymal stem cell-conditioned medium to improve developmental competence of oocytes derived from endometriosis mouse models","volume":"55","author":"Kalehoei","year":"2022","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib133","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/jog.15569","article-title":"Therapeutic effects of L-arginine, L-carnitine, and mesenchymal stem cell-conditioned medium on endometriosis-induced oocyte poor quality in an experimental mouse model","volume":"49","author":"Kalehoei","year":"2023","journal-title":"J. Obstet. Gynaecol. Res"},{"key":"10.1016\/j.tice.2026.103547_bib134","article-title":"Extracellular vesicles inhibit proliferation and invasion of ovarian endometrial stromal cells and their expression of SF-1, ER\u03b2, and aromatase","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib135","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3892\/mmr.2020.11137","article-title":"Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells","volume":"22","author":"Feng","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib136","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1038\/s41598-021-84216-7","article-title":"Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib137","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s43032-023-01389-4","article-title":"Conservative Hypomethylation of Mesenchymal Stem Cells and Their Secretome Restored the Follicular Development in Cisplatin-Induced Premature Ovarian Failure Mice","volume":"31","author":"Nabil Salama","year":"2024","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib138","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720923575","article-title":"Extracellular Vesicles Derived from Mesenchymal Stem Cells Recover Fertility of Premature Ovarian Insufficiency Mice and the Effects on their Offspring","volume":"29","author":"Liu","year":"2020","journal-title":"Cell Transpl."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib139","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1007\/s43032-021-00499-1","article-title":"Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism","volume":"28","author":"Deng","year":"2021","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib140","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13287-019-1327-5","article-title":"Therapeutic effects of human umbilical cord mesenchymal stem cell-derived microvesicles on premature ovarian insufficiency in mice","volume":"10","author":"Yang","year":"2019","journal-title":"Stem Cell Res. & Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib141","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13287-018-0953-7","article-title":"Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD","volume":"9","author":"Huang","year":"2018","journal-title":"Stem Cell Res Ther."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib142","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1007\/s12015-023-10564-8","article-title":"EIF4A3-induced exosomal circLRRC8A alleviates granulosa cells senescence via the miR-125a-3p\/NFE2L1 axis","volume":"19","author":"Xing","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.tice.2026.103547_bib143","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.omtn.2020.05.013","article-title":"Exosomal miRNA-320a Is Released from hAMSCs and Regulates SIRT4 to Prevent Reactive Oxygen Species Generation in POI","volume":"21","author":"Ding","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.tice.2026.103547_bib144","article-title":"Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy","volume":"6","author":"Xiao","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib145","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41374-019-0321-y","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN","volume":"100","author":"Yang","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.tice.2026.103547_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2022.114015","article-title":"HucMSCs-exosomes containing miR-21 promoted estrogen production in ovarian granulosa cells via LATS1-mediated phosphorylation of LOXL2 and YAP","volume":"321-322","author":"Cai","year":"2022","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.tice.2026.103547_bib147","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9240569","article-title":"Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature","volume":"2022","author":"Xu","year":"2022","journal-title":"J. Health Eng."},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib148","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jcyt.2018.09.005","article-title":"Improvement of the folliculogenesis by transplantation of bone marrow mesenchymal stromal cells in mice with induced polycystic ovary syndrome","volume":"20","author":"Kalhori","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tice.2026.103547_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103638","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ovarian granulosa cells inflammatory response through inhibition of NF-\u03baB signaling in polycystic ovary syndrome","volume":"152","author":"Zhao","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.tice.2026.103547_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121739","article-title":"Adipose mesenchymal stem cell\u2013derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances","volume":"288","author":"Cao","year":"2022","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib151","doi-asserted-by":"crossref","first-page":"10365","DOI":"10.1002\/jcb.27380","article-title":"Improvement of oocyte in vitro maturation from mice with polycystic ovary syndrome by human mesenchymal stromal cell\u2013conditioned media","volume":"119","author":"Jafarzadeh","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tice.2026.103547_bib152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02472-w","article-title":"Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10","volume":"12","author":"Chugh","year":"2021","journal-title":"Stem Cell Res. & Ther."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib153","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3390\/biomedicines10020476","article-title":"Extracorporeal shock wave therapy combined with platelet-rich plasma during preventive and therapeutic stages of intrauterine adhesion in a rat model","volume":"10","author":"Cheng","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.tice.2026.103547_bib154","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fphys.2020.00105","article-title":"Intrauterine infusion of human platelet-rich plasma improves endometrial regeneration and pregnancy outcomes in a murine model of Asherman\u2019s syndrome","volume":"11","author":"Kim","year":"2020","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib155","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/aogs.13598","article-title":"Cellular therapies for the endometrium: An update","volume":"98","author":"Queckb\u00f6rner","year":"2019","journal-title":"Acta Obstet. Et. Gynecol. Scand."},{"key":"10.1016\/j.tice.2026.103547_bib156","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bpobgyn.2018.12.009","article-title":"Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review","volume":"59","author":"Guo","year":"2019","journal-title":"Best. Pract. & Res. Clin. Obstet. & Gynaecol."},{"key":"10.1016\/j.tice.2026.103547_bib157","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.679643","article-title":"ADSC exosomes mediate lncRNA-MIAT alleviation of endometrial fibrosis by regulating miR-150-5p","volume":"12","author":"Shao","year":"2021","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib158","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-cellbio-011723-021442","article-title":"Mechanisms of regeneration and fibrosis in the endometrium","volume":"39","author":"Ang","year":"2023","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.tice.2026.103547_bib159","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.3390\/ijerph19106162","article-title":"Endometriosis and infertility: a long-life approach to preserve reproductive integrity","volume":"19","author":"Coccia","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib160","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/AOG.0000000000005309","article-title":"Etiology, risk factors, and management of Asherman syndrome","volume":"142","author":"Khan","year":"2023","journal-title":"Obstet. & Gynecol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib161","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1477-7827-11-118","article-title":"The management of Asherman syndrome: a review of literature","volume":"11","author":"Conforti","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib162","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.fertnstert.2015.08.032","article-title":"Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome","volume":"104","author":"Cervell\u00f3","year":"2015","journal-title":"Fertil. Steril."},{"issue":"14","key":"10.1016\/j.tice.2026.103547_bib163","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900411","article-title":"Hyaluronic acid hydrogel integrated with mesenchymal stem cell-secretome to treat endometrial injury in a rat model of Asherman's syndrome","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2019.151465","article-title":"Effects of uterus derived mesenchymal stem cells and their exosomes on asherman's syndrome","volume":"122","author":"Saribas","year":"2020","journal-title":"Acta Histochem"},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib165","article-title":"Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia\/Reperfusion Injury","volume":"29","author":"Su","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"10","key":"10.1016\/j.tice.2026.103547_bib166","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jcyt.2022.05.011","article-title":"Macrophage bioassay standardization to assess the anti-inflammatory activity of mesenchymal stromal cell-derived small extracellular vesicles","volume":"24","author":"Malvicini","year":"2022","journal-title":"Cytotherapy"},{"issue":"16","key":"10.1016\/j.tice.2026.103547_bib167","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.3390\/ijms23169414","article-title":"Novel potency assay for MSC secretome-based treatment of idiopathic male infertility employed Leydig cells and revealed vascular endothelial growth factor as a promising potency marker","volume":"23","author":"Monakova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib168","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.reth.2025.04.005","article-title":"Method standardization of secretome production, collection, and characterization: New insights and challenges","volume":"29","author":"Singh","year":"2025","journal-title":"Regen. Ther."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib169","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/polym14061218","article-title":"Polymeric hydrogels as mesenchymal stem cell secretome delivery system in biomedical applications","volume":"14","author":"Arifka","year":"2022","journal-title":"Polymers"},{"issue":"5","key":"10.1016\/j.tice.2026.103547_bib170","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/acsabm.1c01312","article-title":"Delivery of stem cell secretome for therapeutic applications","volume":"5","author":"Li","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.tice.2026.103547_bib171","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221133345","article-title":"Intrauterine injection of umbilical cord mesenchymal stem cell exosome gel significantly improves the pregnancy rate in thin endometrium rats","volume":"31","author":"Zhang","year":"2022","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib172","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12958-024-01299-3","article-title":"Intraovarian injection of 3D-MSC-EVs-ECM gel significantly improved rat ovarian function after chemotherapy","volume":"22","author":"Zhang","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib173","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13287-024-03704-5","article-title":"The remodeling of ovarian function: targeted delivery strategies for mesenchymal stem cells and their derived extracellular vesicles","volume":"15","author":"Song","year":"2024","journal-title":"Stem Cell Res. & Ther."},{"issue":"8","key":"10.1016\/j.tice.2026.103547_bib174","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.3390\/pharmaceutics14081718","article-title":"Emerging Bioactive Agent Delivery-Based Regenerative Therapies for Lower Genitourinary Tissues","volume":"14","author":"Da","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.tice.2026.103547_bib175","doi-asserted-by":"crossref","first-page":"9667","DOI":"10.2147\/IJN.S527637","article-title":"Unveiling the pathological landscape of intrauterine adhesion: mechanistic insights and Exosome-Biomaterial therapeutic innovations","author":"Qin","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.tice.2026.103547_bib176","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1039\/D2BM01586B","article-title":"An injectable hydrogel scaffold with IL-1\u03b2-activated MSC-derived exosomes for the treatment of endometritis","volume":"11","author":"Zhao","year":"2023","journal-title":"Biomater. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib177","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.123298","article-title":"Integrative bioengineering strategies for endometrial regeneration: From biomaterials and stem cells to organoids and organ-on-a-chip technologies","volume":"16","author":"Kim","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.tice.2026.103547_bib178","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.actbio.2020.06.029","article-title":"A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation","volume":"113","author":"Xin","year":"2020","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib179","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13287-019-1524-2","article-title":"Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products","volume":"11","author":"Laggner","year":"2020","journal-title":"Stem Cell Res. & Ther."},{"issue":"8","key":"10.1016\/j.tice.2026.103547_bib180","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3390\/pharmaceutics17080990","article-title":"Navigating the global regulatory landscape for exosome-based therapeutics: challenges, strategies, and future directions","volume":"17","author":"Verma","year":"2025","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.tice.2026.103547_bib181","doi-asserted-by":"crossref","DOI":"10.1111\/cts.13904","article-title":"Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes","volume":"17","author":"Wang","year":"2024","journal-title":"Clin. Transl. Sci."},{"issue":"9","key":"10.1016\/j.tice.2026.103547_bib182","article-title":"Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles","volume":"11","author":"Visan","year":"2022","journal-title":"J. Extra Vesicles"},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib183","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jcyt.2022.08.009","article-title":"Proteomics profile of mesenchymal stromal cells and extracellular vesicles in normoxic and hypoxic conditions","volume":"24","author":"Braga","year":"2022","journal-title":"Cytotherapy"},{"issue":"8","key":"10.1016\/j.tice.2026.103547_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13081129","article-title":"Freeze-Dried Mesenchymal Stem Cell-Secretome Pharmaceuticalization: Optimization of Formulation and Manufacturing Process Robustness","volume":"13","author":"Mocchi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.tice.2026.103547_bib185","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13287-015-0209-8","article-title":"Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes","volume":"6","author":"Kalinina","year":"2015","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib186","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13287-025-04315-4","article-title":"Fine-tuning licensing strategies to boost MSC-based immunomodulatory secretome","volume":"16","author":"Rossello-Gelabert","year":"2025","journal-title":"Stem Cell Res. & Ther."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib187","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/biomedicines13030586","article-title":"Mesenchymal Stem Cell Secretome: Potential Applications in Human Infertility Caused by Hormonal Imbalance, External Damage, or Immune Factors","volume":"13","author":"Kavaldzhieva","year":"2025","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib188","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. vesicles"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib189","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. vesicles"},{"issue":"16","key":"10.1016\/j.tice.2026.103547_bib190","doi-asserted-by":"crossref","first-page":"12594","DOI":"10.3390\/ijms241612594","article-title":"Towards the standardization of mesenchymal stem cell secretome-derived product manufacturing for tissue regeneration","volume":"24","author":"Chouaib","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib191","doi-asserted-by":"crossref","DOI":"10.1002\/jex2.70","article-title":"GMP-compliant manufacturing of biologically active cell-derived vesicles produced by extrusion technology","volume":"1","author":"Lau","year":"2022","journal-title":"J. Extracell. Biol."},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib192","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.ymthe.2018.09.015","article-title":"Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity","volume":"26","author":"Haraszti","year":"2018","journal-title":"Mol. Ther."},{"issue":"18","key":"10.1016\/j.tice.2026.103547_bib193","doi-asserted-by":"crossref","first-page":"10522","DOI":"10.3390\/ijms231810522","article-title":"Methods of the large-scale production of extracellular vesicles","volume":"23","author":"Syromiatnikova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103547_bib194","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/biology14030313","article-title":"Generation of Current Good Manufacturing Practices-Grade Mesenchymal Stromal Cell-Derived Extracellular Vesicles Using Automated Bioreactors","volume":"14","author":"Wiest","year":"2025","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4068\/cmj.2024.60.1.1","article-title":"Unveiling the complex world of extracellular vesicles: novel characterization techniques and manufacturing considerations","volume":"60","author":"Lai","year":"2024","journal-title":"Chonnam Med. J."},{"issue":"21","key":"10.1016\/j.tice.2026.103547_bib196","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3390\/cells14211660","article-title":"Safety Assessment of Stem Cell-Based Therapies: Current Standards and Advancing Frameworks","volume":"14","author":"Leonov","year":"2025","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib197","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.stem.2014.01.013","article-title":"MSC-based product characterization for clinical trials: an FDA perspective","volume":"14","author":"Mendicino","year":"2014","journal-title":"Cell stem Cell"},{"issue":"2","key":"10.1016\/j.tice.2026.103547_bib198","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jcyt.2015.11.008","article-title":"International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials","volume":"18","author":"Galipeau","year":"2016","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib199","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1609206","article-title":"Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications","volume":"8","author":"Witwer","year":"2019","journal-title":"J. Extracell. vesicles"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib200","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J. Extracell. vesicles"},{"key":"10.1016\/j.tice.2026.103547_bib201","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jconrel.2014.07.049","article-title":"Extracellular vesicles as drug delivery systems: lessons from the liposome field","volume":"195","author":"van der Meel","year":"2014","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.tice.2026.103547_bib202","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials\u2013an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. vesicles"},{"issue":"12","key":"10.1016\/j.tice.2026.103547_bib203","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.3390\/ijms25126533","article-title":"Extracellular vesicles as next-generation diagnostics and advanced therapy medicinal products","volume":"25","author":"Stawarska","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103547_bib204","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.734720","article-title":"Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities","volume":"9","author":"Claridge","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.tice.2026.103547_bib205","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.3390\/ijms18061190","article-title":"Manufacturing of human extracellular vesicle-based therapeutics for clinical use","volume":"18","author":"Gimona","year":"2017","journal-title":"Int. J. Mol. Sci."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:16:18Z","timestamp":1784067378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626002405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":205,"alternative-id":["S0040816626002405"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103547","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-free regenerative therapies for female infertility: The emerging role of mesenchymal stem cell secretome","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103547"}}