{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:04:59Z","timestamp":1784070299491,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006049","name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tice.2026.103583","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T05:44:46Z","timestamp":1778391886000},"page":"103583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["HPV18 oncogenes increase viability and nuclear architecture stability in HaCaT cells exposed to UVB radiation"],"prefix":"10.1016","volume":"102","author":[{"given":"Magdalena","family":"Mill\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Parietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Yocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"P\u00e9rez-Zerpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Arocena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0875-2333","authenticated-orcid":false,"given":"Jimena","family":"Hochmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103583_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2024.102831","article-title":"Making the cut: multiscale simulation of membrane remodeling","volume":"87","author":"Beiter","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.tice.2026.103583_bib2","article-title":"The use of ultraviolet LED illumination for composite resin removal: An in vitro study","volume":"58","author":"Bush","year":"2010","journal-title":"Gen. Dent."},{"key":"10.1016\/j.tice.2026.103583_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/php.12368","article-title":"Oxidatively generated damage to cellular DNA by UVB and UVA radiation","author":"Cadet","year":"2015","journal-title":"Photochem. Photobio."},{"key":"10.1016\/j.tice.2026.103583_bib4","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMra1715715","article-title":"Head and Neck Cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tice.2026.103583_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102161","article-title":"Increased lamin b1 levels promote cell migration by altering perinuclear actin organization","volume":"9","author":"Fracchia","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103583_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/geronj\/31.4.396","article-title":"Nuclear inclusions: a study of aging in Drosophila","volume":"31","author":"Gartner","year":"1976","journal-title":"J. Gerontol."},{"key":"10.1016\/j.tice.2026.103583_bib7","article-title":"Pharyngeal and cervical cancer incidences significantly correlate with personal UV doses among whites in the United States","volume":"34","author":"Godar","year":"2014","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tice.2026.103583_bib8","article-title":"Ultraviolet radiation (UV) induces reorganization of actin cytoskeleton in CHOAA8 cells","volume":"53","author":"Grzanka","year":"2006","journal-title":"Neoplasma"},{"key":"10.1016\/j.tice.2026.103583_bib9","doi-asserted-by":"crossref","DOI":"10.4161\/cc.4.2.1486","article-title":"Histone H2AX phosphorylation after cell irradiation with UV-B: Relationship to cell cycle phase and induction of apoptosis","volume":"4","author":"Halicka","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.tice.2026.103583_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44880-3","article-title":"Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes","volume":"13","author":"Hochmann","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103583_bib11","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760190405","article-title":"Human papillomavirus type 18 e5 oncoprotein cooperates with e6 and e7 in promoting cell viability and invasion and in modulating the cellular redox state","volume":"115","author":"Hochmann","year":"2020","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.tice.2026.103583_bib12","doi-asserted-by":"crossref","DOI":"10.1101\/gad.182100","article-title":"Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins","volume":"14","author":"Jackson","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.tice.2026.103583_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2020.03.001","article-title":"The role of the cell nucleus in mechanotransduction","author":"Janota","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.tice.2026.103583_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/BF00275981","article-title":"Static equilibrium configurations of a model red blood cell","volume":"4","author":"Jenkins","year":"1977","journal-title":"J. Math. Biol."},{"key":"10.1016\/j.tice.2026.103583_bib15","doi-asserted-by":"crossref","unstructured":"Kanno, Y., 2011. Nonsmooth mechanics and convex optimization, Nonsmooth Mechanics and Convex Optimization. https:\/\/doi.org\/10.1201\/b10839.","DOI":"10.1201\/b10839"},{"key":"10.1016\/j.tice.2026.103583_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/S0020-7683(03)00215-4","article-title":"Minimum principle of complementary energy of cable networks by using second-order cone programming","volume":"40","author":"Kanno","year":"2003","journal-title":"Int. J. Solids Struct."},{"key":"10.1016\/j.tice.2026.103583_bib17","article-title":"Study of the Mechanical Behavior of Subcellular Organelles Using a 3D Finite Element Model of the Tensegrity Structure","volume":"11","author":"Khunsaraki","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.tice.2026.103583_bib18","doi-asserted-by":"crossref","DOI":"10.1007\/s40495-015-0027-9","article-title":"An overview of ultraviolet b radiation-induced skin cancer chemoprevention by silibinin","author":"Kumar","year":"2015","journal-title":"Curr. Pharmacol. Rep."},{"key":"10.1016\/j.tice.2026.103583_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-006-0004-1","article-title":"Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria","volume":"12","author":"Leverrier","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.tice.2026.103583_bib20","doi-asserted-by":"crossref","unstructured":"Lewis, W.J., 2003. Tension Structures: Form and Behaviour. https:\/\/doi.org\/10.1680\/tsfab.32361.","DOI":"10.1680\/tsfab.32361"},{"key":"10.1016\/j.tice.2026.103583_bib21","doi-asserted-by":"crossref","DOI":"10.1117\/1.2992139","article-title":"Model-based spectroscopic analysis of the oral cavity: impact of anatomy","volume":"13","author":"McGee","year":"2008","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.tice.2026.103583_bib22","doi-asserted-by":"crossref","DOI":"10.1007\/s00418-024-02350-5","article-title":"Differential cell architecture and microenvironmental responses of pretumoral and tumoral cellular models exposed to coverslip-induced hypoxia","volume":"163","author":"Mill\u00e1n","year":"2025","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.tice.2026.103583_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.03.054","article-title":"Mechanical profile of human keratinocytes expressing HPV-18 oncogenes","volume":"657","author":"Mill\u00e1n","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2026.103583_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00398-20","article-title":"Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins","volume":"5","author":"Minoni","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.tice.2026.103583_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.03.052","article-title":"Heterochromatin-driven nuclear softening protects the genome against mechanical stress-induced damage","volume":"181","author":"Nava","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.tice.2026.103583_bib26","doi-asserted-by":"crossref","DOI":"10.1007\/s12013-021-00966-1","article-title":"UV Radiation-induced Impairment of Cellular Morphology and Motility is Enhanced by DUSP3\/VHR Loss and FAK Activation","volume":"79","author":"Pereira","year":"2021","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.tice.2026.103583_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/v17040512","article-title":"E5 Oncoprotein: A Key Player in Human Papillomavirus-Positive Head and Neck Cancer Pathogenesis and Therapy Resistance","volume":"17","author":"Pereira Santos","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.tice.2026.103583_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf852","article-title":"Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation","volume":"53","author":"Roy","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.tice.2026.103583_bib29","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001540","article-title":"The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation","volume":"102","author":"Scarth","year":"2021","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.tice.2026.103583_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53","volume":"63","author":"Scheffner","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.tice.2026.103583_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2016.09.038","article-title":"The effect of delphinidin on the mechanical properties of keratinocytes exposed to UVB radiation","volume":"164","author":"Sobiepanek","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.tice.2026.103583_bib32","doi-asserted-by":"crossref","DOI":"10.2307\/3575342","article-title":"Radiation-induced invagination of the nuclear envelope","volume":"83","author":"Szekely","year":"1980","journal-title":"Radiat. Res."},{"key":"10.1016\/j.tice.2026.103583_bib33","doi-asserted-by":"crossref","DOI":"10.1136\/jim-2018-000968","article-title":"Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: An experience from the Egyptian National Cancer Institute","volume":"67","author":"Tealab","year":"2019","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.tice.2026.103583_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.03263-13","article-title":"The Human Papillomavirus E7 Proteins Associate with p190RhoGAP and Alter Its Function","volume":"88","author":"Todorovic","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.tice.2026.103583_bib35","doi-asserted-by":"crossref","DOI":"10.1080\/713846267","article-title":"Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus","author":"Tripodis","year":"2001","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.tice.2026.103583_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19850","article-title":"Calcium-mediated actin reset (CaAR) mediates acute cell adaptations","volume":"5","author":"Wales","year":"2016","journal-title":"ELife"},{"key":"10.1016\/j.tice.2026.103583_bib37","doi-asserted-by":"crossref","DOI":"10.3892\/mco.2013.145","article-title":"Narrow-band UVB radiation promotes dendrite formation by activating Rac1 in B16 melanoma cells","volume":"1","author":"Wang","year":"2013","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.tice.2026.103583_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.compstruc.2011.07.008","article-title":"An efficient computational method for mechanical analysis of bimodular structures based on parametric variational principle","volume":"89","author":"Zhang","year":"2011","journal-title":"Comput. Struct."},{"key":"10.1016\/j.tice.2026.103583_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-015-0361-x","article-title":"The role of the PI3K\/Akt\/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses","author":"Zhang","year":"2015","journal-title":"Mol. Cancer"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626002764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:13:56Z","timestamp":1784067236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626002764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0040816626002764"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103583","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HPV18 oncogenes increase viability and nuclear architecture stability in HaCaT cells exposed to UVB radiation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103583"}}