{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:07:01Z","timestamp":1784070421695,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2025KY1870"],"award-info":[{"award-number":["2025KY1870"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tice.2026.103603","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:21:40Z","timestamp":1778552500000},"page":"103603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Phenethylamine modulates intestinal inflammation and barrier integrity in diarrhea-predominant irritable bowel syndrome through the TAAR1-PKC signaling pathway"],"prefix":"10.1016","volume":"102","author":[{"given":"Li","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103603_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103445","article-title":"Spasmolytic effects of aphanizomenon flos aquae (AFA) extract on the human colon contractility","volume":"13","author":"Amato","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103603_bib2","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.3390\/cells12242846","article-title":"Epithelial barrier dysfunction in diarrhea-predominant irritable bowel syndrome (IBS-D) via downregulation of claudin-1","volume":"12","author":"Awad","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103603_bib3","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1172\/JCI140528","article-title":"Claudin-2 pore causes leak that breaches the dam in intestinal inflammation","volume":"130","author":"Barrett","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tice.2026.103603_bib4","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.1073\/pnas.0906522106","article-title":"The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system","volume":"106","author":"Bradaia","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tice.2026.103603_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10571-019-00772-7","article-title":"Actions of trace amines in the brain-gut-microbiome axis via trace amine-associated receptor-1 (TAAR1)","volume":"40","author":"Bugda Gwilt","year":"2020","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.tice.2026.103603_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153527","article-title":"Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: combined effects of synephrine, paeoniflorin and naringin","volume":"86","author":"Cai","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2026.103603_bib7","article-title":"Neurotransmitter and intestinal interactions: focus on the microbiota-gut-brain axis in irritable bowel syndrome","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tice.2026.103603_bib8","article-title":"Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders","volume":"13","author":"Chen","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103603_bib9","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3389\/fphar.2018.00680","article-title":"Trace amine-associated receptors as novel therapeutic targets for immunomodulatory disorders","volume":"9","author":"Christian","year":"2018","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.tice.2026.103603_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.117.015305","article-title":"Trace amines and their receptors","volume":"70","author":"Gainetdinov","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tice.2026.103603_bib11","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.4049\/jimmunol.1901059","article-title":"Molecular drivers of lymphocyte organization in vertebrate mucosal surfaces: revisiting the TNF superfamily hypothesis","volume":"204","author":"Heimroth","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.tice.2026.103603_bib12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3748\/wjg.v28.i4.412","article-title":"Gut bless you: the microbiota-gut-brain axis in irritable bowel syndrome","volume":"28","author":"Hillestad","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tice.2026.103603_bib13","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3748\/wjg.v29.i26.4120","article-title":"Irritable bowel syndrome: epidemiology, overlap disorders, pathophysiology and treatment","volume":"29","author":"Huang","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tice.2026.103603_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3164\/jcbn.16-92","article-title":"Claudin-2 expression is upregulated in the ileum of diarrhea predominant irritable bowel syndrome patients","volume":"60","author":"Ishimoto","year":"2017","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.tice.2026.103603_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01533-24","article-title":"Butyrate promotes visceral hypersensitivity in IBS model via mast cell-derived DRG neuron lincRNA-01028-PKC-TRPV1 pathway","volume":"15","author":"Li","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.tice.2026.103603_bib16","doi-asserted-by":"crossref","DOI":"10.4161\/21688370.2014.977176","article-title":"Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation","volume":"3","author":"Luettig","year":"2015","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.tice.2026.103603_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910440","article-title":"Molecular insights into SARS-CoV2-induced alterations of the gut\/brain axis","volume":"22","author":"Nataf","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103603_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12929-020-00688-1","article-title":"The trace aminergic system: a gender-sensitive therapeutic target for IBS?","volume":"27","author":"Pretorius","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tice.2026.103603_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu15071647","article-title":"Constipation-predominant irritable bowel syndrome (IBS-C): effects of different nutritional patterns on intestinal dysbiosis and symptoms","volume":"15","author":"Di Rosa","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103603_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12072558","article-title":"Irritable bowel syndrome and the gut microbiome: a comprehensive review","volume":"12","author":"Shaikh","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tice.2026.103603_bib21","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1016\/j.cell.2023.10.014","article-title":"Structural and signaling mechanisms of TAAR1 enabled preferential agonist design","volume":"186","author":"Shang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.tice.2026.103603_bib22","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2128605","article-title":"Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production","volume":"14","author":"Sugiyama","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.tice.2026.103603_bib23","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.3390\/ijms252313216","article-title":"Functional analysis of TAAR1 expression in the intestine wall and the effect of its gene knockout on the gut microbiota in mice","volume":"25","author":"Vaganova","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103603_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chom.2022.11.006","article-title":"Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis","volume":"31","author":"Zhai","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tice.2026.103603_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chom.2022.11.006","article-title":"Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis","volume":"31","author":"Zhai","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tice.2026.103603_bib26","article-title":"Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis","author":"Zhai","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.tice.2026.103603_bib27","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1038\/s41467-023-40552-y","article-title":"Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome","volume":"14","author":"Zhai","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2026.103603_bib28","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1038\/s41467-023-40552-y","article-title":"Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome","volume":"14","author":"Zhai","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2026.103603_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biom14121643","article-title":"The role of gut microbiome in irritable bowel syndrome: implications for clinical therapeutics","volume":"14","author":"Zhao","year":"2024","journal-title":"Biomolecules"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662600296X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662600296X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:25:59Z","timestamp":1784067959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081662600296X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S004081662600296X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103603","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenethylamine modulates intestinal inflammation and barrier integrity in diarrhea-predominant irritable bowel syndrome through the TAAR1-PKC signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103603","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103603"}}