{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:05:56Z","timestamp":1784070356742,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2024\\u201300409554"],"award-info":[{"award-number":["RS-2024\\u201300409554"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2022-NR071955"],"award-info":[{"award-number":["RS-2022-NR071955"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tice.2026.103626","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:53:27Z","timestamp":1779432807000},"page":"103626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Real-time profiling of brazilin-induced cytotoxic responses in HepG2 cells and exosome-associated metabolic signaling under lipid accumulation"],"prefix":"10.1016","volume":"102","author":[{"given":"Seongje","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Jin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Su","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Woo","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dokyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-7791","authenticated-orcid":false,"given":"Kyung Oh","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103626_bib1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3390\/nu12061757","article-title":"Antiproliferative and apoptotic effects of cardamonin against hepatocellular carcinoma HepG2 cells","volume":"12","author":"Badroon","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103626_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41419-022-04591-5","article-title":"Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes","volume":"13","author":"Beillevaire","year":"2022","journal-title":"Cell Death & Dis."},{"key":"10.1016\/j.tice.2026.103626_bib3","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.tice.2026.103626_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12929-024-01055-0","article-title":"Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials","volume":"31","author":"Chen","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tice.2026.103626_bib5","article-title":"Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: current status and therapeutic targets","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2026.103626_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102121","article-title":"A comprehensive review on recent advances in exosome isolation and characterization: toward clinical applications","volume":"50","author":"Dilsiz","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.tice.2026.103626_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.895703","article-title":"Cytoplasmic beta and gamma actin isoforms reorganization and regulation in tumor cells in culture and tissue","volume":"13","author":"Dugina","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103626_bib8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.tice.2026.103626_bib9","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/ajcn\/79.5.774","article-title":"Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment","volume":"79","author":"Gross","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tice.2026.103626_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2015.03.033","article-title":"Exosomes as drug delivery vehicles for Parkinson's disease therapy","volume":"207","author":"Haney","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.tice.2026.103626_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fenrg.2022.860627","article-title":"Brazilin from Caesalpinia sappan L. Induced Apoptosis via mTOR and HO-1 pathway in SW480 human colon cancer cells","volume":"10","author":"Hong","year":"2022","journal-title":"Front. Energy Res."},{"key":"10.1016\/j.tice.2026.103626_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2147\/JHC.S447578","article-title":"Advances in targeted drug resistance associated with dysregulation of lipid metabolism in hepatocellular carcinoma","author":"Huang","year":"2024","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.tice.2026.103626_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70688","article-title":"Brazilin inhibits the proliferation of non-small cell lung cancer by regulating the STING\/TBK1\/IRF3 pathway","volume":"29","author":"Kang","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tice.2026.103626_bib14","article-title":"Hepatocellular carcinoma","volume":"2","author":"Llovet","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.tice.2026.103626_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2025.101571","article-title":"Hepatocellular carcinoma: epidemiology, diagnosis and treatment","author":"Mauro","year":"2025","journal-title":"JHEP Rep."},{"key":"10.1016\/j.tice.2026.103626_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrgastro.2013.183","article-title":"NAFLD, NASH and liver cancer","volume":"10","author":"Michelotti","year":"2013","journal-title":"Nat. Rev. Gastroenterol. & Hepatol."},{"key":"10.1016\/j.tice.2026.103626_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1158\/1055-9965.EPI-13-0785","article-title":"Molecular biomarkers of cancer stem\/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers","volume":"23","author":"Mimeault","year":"2014","journal-title":"Cancer Epidemiol. Biomark. & Prev."},{"key":"10.1016\/j.tice.2026.103626_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106023","article-title":"Brazilin: biological activities and therapeutic potential in chronic degenerative diseases and cancer","volume":"175","author":"Nava-Tapia","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tice.2026.103626_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.apjtm.2015.05.014","article-title":"Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: a review","volume":"8","author":"Nirmal","year":"2015","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.tice.2026.103626_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature20791","article-title":"Targeting metastasis-initiating cells through the fatty acid receptor CD36","volume":"541","author":"Pascual","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103626_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1355533","article-title":"Article review: Brazilin as potential anticancer agent","volume":"15","author":"Raptania","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103626_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41420-021-00504-1","article-title":"Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis","volume":"7","author":"Ren","year":"2021","journal-title":"Cell death Discov."},{"key":"10.1016\/j.tice.2026.103626_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nature11706","article-title":"How cancer metabolism is tuned for proliferation and vulnerable to disruption","volume":"491","author":"Schulze","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103626_bib24","doi-asserted-by":"crossref","first-page":"13234","DOI":"10.1021\/acsami.3c18102","article-title":"Screening of CPT1A-targeting lipid metabolism modulators using mitochondrial membrane chromatography","volume":"16","author":"Su","year":"2024","journal-title":"ACS Appl. Mater. & Interfaces"},{"key":"10.1016\/j.tice.2026.103626_bib25","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1007\/s00210-024-02980-5","article-title":"Diffractaic acid exerts anti-cancer effects on hepatocellular carcinoma HepG2 cells by inducing apoptosis and suppressing migration through targeting thioredoxin reductase 1","volume":"397","author":"Suluko\u011flu","year":"2024","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.tice.2026.103626_bib26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41419-022-04730-y","article-title":"CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma","volume":"13","author":"Tang","year":"2022","journal-title":"Cell Death & Dis."},{"key":"10.1016\/j.tice.2026.103626_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/JHC.S450423","article-title":"Lipid metabolism as a potential target of liver cancer","author":"Wu","year":"2024","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.tice.2026.103626_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12964-024-01521-0","article-title":"Exosomes derived from programmed cell death: mefchanism and biological significance","volume":"22","author":"Xiong","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.tice.2026.103626_bib29","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1248\/bpb.b22-00637","article-title":"Brazilin inhibits the invasion and metastasis of breast cancer","volume":"46","author":"Yang","year":"2023","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tice.2026.103626_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. & Hepatol."},{"key":"10.1016\/j.tice.2026.103626_bib31","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1038\/s41598-021-84577-z","article-title":"The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017","volume":"11","author":"Zhai","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:17:09Z","timestamp":1784067429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"alternative-id":["S0040816626003198"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103626","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Real-time profiling of brazilin-induced cytotoxic responses in HepG2 cells and exosome-associated metabolic signaling under lipid accumulation","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103626"}}