{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:34:36Z","timestamp":1792704876688,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103642","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:51:34Z","timestamp":1780069894000},"page":"103642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Protective effects of human umbilical cord-derived exosomes on testicular ischemia-reperfusion injury: Comparison of local versus systemic administration"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1640-5673","authenticated-orcid":false,"given":"Funda","family":"Elumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4173-7548","authenticated-orcid":false,"given":"Elif","family":"\u00dcnl\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-0352","authenticated-orcid":false,"given":"Kamuran","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-1082","authenticated-orcid":false,"given":"\u00d6zlem","family":"\u00d6zmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-5004","authenticated-orcid":false,"given":"\u0130brahim Halil","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-4714","authenticated-orcid":false,"given":"Ali","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103642_bib1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.juro.2012.10.056","article-title":"Development and initial validation of a scoring system to diagnose testicular torsion in children","volume":"189","author":"Barbosa","year":"2013","journal-title":"J. Urol."},{"key":"10.1016\/j.tice.2026.103642_bib2","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.932722","article-title":"D-chiro-inositol induces ovulation in non-polycystic ovary syndrome (PCOS), non-insulin-resistant young women, likely by modulating aromatase expression: a report of 2 cases","volume":"22","author":"Bezerra Espinola","year":"2021","journal-title":"Am. J. Case Rep."},{"key":"10.1016\/j.tice.2026.103642_bib3","doi-asserted-by":"crossref","DOI":"10.52225\/narra.v5i1.1785","article-title":"Association of MPV, NLR, PLR and CRP on testicular salvage in testicular torsion: a systematic review and meta-analysis","volume":"5","author":"Brodjonegoro","year":"2025","journal-title":"Narra J."},{"key":"10.1016\/j.tice.2026.103642_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/pharmaceutics17020147","article-title":"Exosome source matters: a comprehensive review from the perspective of diverse cellular origins","volume":"17","author":"Chen","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.tice.2026.103642_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/toxsci\/kft207","article-title":"SOT symposium highlight: translatable indicators of testicular toxicity: inhibin B, microRNAs, and sperm signatures","volume":"136","author":"Dere","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tice.2026.103642_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2025.2532195","article-title":"Effect of local versus systemic exosomes administration on both testes in rat model of testicular ischemic reperfusion injury: shedding light on blood testis barrier","volume":"14","author":"Gaber Ibrahim","year":"2026","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.tice.2026.103642_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/19396368.2022.2074325","article-title":"The effects and molecular mechanism of heat stress on spermatogenesis and the mitigation measures","volume":"68","author":"Gao","year":"2022","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.tice.2026.103642_bib8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.rbmo.2011.10.011","article-title":"Cryptic sperm defects may be the cause for total fertilization failure in oocyte donor cycles","volume":"24","author":"Goudakou","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.tice.2026.103642_bib9","first-page":"1065","article-title":"Open vs. closed vitrification system: which one is safer?","volume":"26","author":"Gullo","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tice.2026.103642_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000506803","article-title":"Closed vs. open oocyte vitrification methods are equally effective for blastocyst embryo transfers: prospective study from a sibling oocyte donation program","volume":"85","author":"Gullo","year":"2020","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.tice.2026.103642_bib11","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/medicina58091218","article-title":"Neonatal outcomes and long-term follow-up of children born from frozen embryo, a narrative review of latest research findings","volume":"58","author":"Gullo","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.tice.2026.103642_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/jcm11051351","article-title":"Congenital Zika syndrome: genetic avenues for diagnosis and therapy, possible management and long-term outcomes","volume":"11","author":"Gullo","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tice.2026.103642_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113961","article-title":"Dosing extracellular vesicles","volume":"178","author":"Gupta","year":"2021","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.tice.2026.103642_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/RD9.0000000000000103","article-title":"Immediate intratesticular injection of circulating blood serum-derived exosomes may alleviate orchitis caused by cisplatin","volume":"9","author":"Hemmatabadi","year":"2025","journal-title":"Reprod. Dev. Med."},{"key":"10.1016\/j.tice.2026.103642_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13036-024-00431-6","article-title":"Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues","volume":"18","author":"Huang","year":"2024","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.tice.2026.103642_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-physiol-021115-104929","article-title":"Exosomes: fundamental biology and roles in cardiovascular physiology","volume":"78","author":"Ibrahim","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tice.2026.103642_bib17","doi-asserted-by":"crossref","first-page":"7736","DOI":"10.1021\/acsnano.7b01087","article-title":"Exosomes mediate epithelium-mesenchyme crosstalk in organ development","volume":"11","author":"Jiang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.tice.2026.103642_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000178170","article-title":"Testicular biopsy score count\u2013a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.tice.2026.103642_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102459","article-title":"Proanthocyanidin alleviates testicular torsion\/detorsion-induced ischemia\/reperfusion injury in rats","volume":"89","author":"Kazak","year":"2024","journal-title":"Tissue Cell."},{"key":"10.1016\/j.tice.2026.103642_bib20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ame2.12232","article-title":"Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion","volume":"5","author":"Keivan","year":"2022","journal-title":"Anim. Models Exp. Med."},{"key":"10.1016\/j.tice.2026.103642_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PloS. Biol."},{"key":"10.1016\/j.tice.2026.103642_bib22","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1080\/21655979.2021.1928441","article-title":"Human umbilical cord\u2013derived mesenchymal stem cells improve chronic pancreatitis in rats via the AKT-mTOR-S6K1 signaling pathway","volume":"12","author":"Kong","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.tice.2026.103642_bib23","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.3390\/ijms25147794","article-title":"Clinical applications of exosomes: a critical review","volume":"25","author":"Lee","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103642_bib24","doi-asserted-by":"crossref","first-page":"W444","DOI":"10.2214\/AJR.12.10036","article-title":"Retrospective review of diagnosis and treatment in children presenting to the pediatric department with acute scrotum","volume":"200","author":"Liang","year":"2013","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.tice.2026.103642_bib25","article-title":"Adipose mesenchymal stromal cell-derived exosomes prevent testicular torsion injury via activating PI3K\/AKT and MAPK\/ERK1\/2 pathways","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103642_bib26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/biomedicines12010098","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes rescue testicular aging","volume":"12","author":"Luo","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.tice.2026.103642_bib27","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/andr.13418","article-title":"Testicular torsion in vivo models: mechanisms and treatments","volume":"11","author":"Minas","year":"2023","journal-title":"Andrology"},{"key":"10.1016\/j.tice.2026.103642_bib28","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s00018-019-03125-1","article-title":"Biological functions of mesenchymal stem cells and clinical implications","volume":"76","author":"Naji","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tice.2026.103642_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pestbp.2011.12.003","article-title":"Apoptosis in adult rabbit testes during subacute endosulfan toxicity","volume":"102","author":"Ozmen","year":"2012","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.tice.2026.103642_bib30","first-page":"151","article-title":"Evaluation of the effectiveness of human breast milk exosomes in experimental testicular torsion-detorsion injury model","volume":"93","author":"\u00d6zt\u00fcrk","year":"2025","journal-title":"Cirugia y. cirujanos"},{"key":"10.1016\/j.tice.2026.103642_bib31","doi-asserted-by":"crossref","first-page":"a008672","DOI":"10.1101\/cshperspect.a008672","article-title":"Cellular mechanisms controlling caspase activation and function","volume":"5","author":"Parrish","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tice.2026.103642_bib32","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tice.2026.103642_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejogrb.2012.03.003","article-title":"Injection of embryo culture supernatant to the endometrial cavity does not affect outcomes in IVF\/ICSI or oocyte donation cycles: a randomized clinical trial","volume":"162","author":"Prapas","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.tice.2026.103642_bib34","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s10815-017-1010-7","article-title":"GnRH antagonist administered twice the day before hCG trigger combined with a step-down protocol may prevent OHSS in IVF\/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes: a prospective randomized control trial","volume":"34","author":"Prapas","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.tice.2026.103642_bib35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jcyt.2021.05.002","article-title":"Human umbilical cord tissue-derived mesenchymal stromal cells as adjuvant therapy for myocardial infarction: a review of current evidence focusing on pre-clinical large animal models and early human trials","volume":"23","author":"Raposo","year":"2021","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tice.2026.103642_bib36","first-page":"23","article-title":"Psychological impact of gynecological diseases: the importance of a multidisciplinary approach","volume":"30","author":"Rosa","year":"2018","journal-title":"Ital. J. Gynaecol. Obstet."},{"key":"10.1016\/j.tice.2026.103642_bib37","first-page":"165","article-title":"Epidemiology and etiology of malpractice lawsuits involving children in US emergency departments and urgent care centers","volume":"21","author":"Selbst","year":"2005","journal-title":"Pediatr. Emerg. Care"},{"key":"10.1016\/j.tice.2026.103642_bib38","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/cdd.2014.216","article-title":"Old, new and emerging functions of caspases","volume":"22","author":"Shalini","year":"2015","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.tice.2026.103642_bib39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00383-023-05487-x","article-title":"Exosomes obtained from adipose mesenchymal stem cells prevent ischemia\u2013reperfusion injury after torsion\u2013detorsion in rat testes","volume":"39","author":"\u015eim\u015fek","year":"2023","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.tice.2026.103642_bib40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jcyt.2015.11.018","article-title":"Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell","volume":"18","author":"Sun","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tice.2026.103642_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","article-title":"Clinical applications of stem cell-derived exosomes","volume":"9","author":"Tan","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.tice.2026.103642_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2164\/jandrol.05134","article-title":"Testicular torsion alters the presence of specific proteins in the mouse testis as well as the phosphorylation status of specific proteins","volume":"27","author":"Turner","year":"2006","journal-title":"J. Androl."},{"key":"10.1016\/j.tice.2026.103642_bib43","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcyt.2012.11.007","article-title":"Effect of umbilical cord mesenchymal stem cells on treatment of severe acute pancreatitis in rats","volume":"15","author":"Yang","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tice.2026.103642_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102405","article-title":"Phoenixin-14 may ameliorate testicular damage caused by torsion-detorsion by reducing oxidative stress and inflammation in prepubertal rats","volume":"88","author":"Yilmaz","year":"2024","journal-title":"Tissue Cell."},{"key":"10.1016\/j.tice.2026.103642_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s13287-020-01918-x","article-title":"Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon","volume":"11","author":"Zhang","year":"2020","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.tice.2026.103642_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176724","article-title":"Mangiferin alleviated poststroke cognitive impairment by modulating lipid metabolism in cerebral ischemia\/reperfusion rats","volume":"977","author":"Zhang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tice.2026.103642_bib47","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.juro.2011.07.024","article-title":"Pediatric testicular torsion epidemiology using a national database: incidence, risk of orchiectomy and possible measures toward improving the quality of care","volume":"186","author":"Zhao","year":"2011","journal-title":"J. Urol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:16:02Z","timestamp":1789244162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0040816626003356"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103642","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of human umbilical cord-derived exosomes on testicular ischemia-reperfusion injury: Comparison of local versus systemic administration","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103642"}}