{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:06:10Z","timestamp":1789247170498,"version":"build-2803163510"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["EMR\/2017\/001382"],"award-info":[{"award-number":["EMR\/2017\/001382"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/FST\/LSI\\u2212560\/2013"],"award-info":[{"award-number":["SR\/FST\/LSI\\u2212560\/2013"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["37(1735)\/19\/EMR-II"],"award-info":[{"award-number":["37(1735)\/19\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012623","name":"Presidency University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/INF\/22\/SP45088\/2022"],"award-info":[{"award-number":["BT\/INF\/22\/SP45088\/2022"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103654","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:55:41Z","timestamp":1780300541000},"page":"103654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tbx20 and Sirt1 synergize to ameliorate cardiac aging through enhanced autophagy"],"prefix":"10.1016","volume":"103","author":[{"given":"Riffat","family":"Khanam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pabitra","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Khamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parna","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devrani","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103654_bib1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/CIRCRESAHA.118.312208","article-title":"Autophagy in cardiovascular aging","volume":"123","author":"Abdellatif","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.tice.2026.103654_bib2","unstructured":"Anone. n.d. rapamycin-transiently-induces-mitochondrial-remodeling-to-reprog-2016."},{"key":"10.1016\/j.tice.2026.103654_bib3","unstructured":"Anone. n.d. The Role of Tbx20 in Cardiovascular Development and Function."},{"key":"10.1016\/j.tice.2026.103654_bib4","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/nar\/gky092","article-title":"UniProt: the universal protein knowledgebase","volume":"46","author":"Apweiler","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2026.103654_bib5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/cpr.12024","article-title":"Identification and biological characterization of chicken embryonic cardiac progenitor cells","volume":"46","author":"Bai","year":"2013","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.tice.2026.103654_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yjmcc.2013.05.018","article-title":"Tbx20 promotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts","volume":"62","author":"Chakraborty","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.tice.2026.103654_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yjmcc.2013.05.018","article-title":"Journal of molecular and cellular cardiology Tbx20 promotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts","volume":"62","author":"Chakraborty","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.tice.2026.103654_bib8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ydbio.2011.12.034","article-title":"Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo","volume":"363","author":"Chakraborty","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib9","first-page":"143","article-title":"MiR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5","volume":"43","author":"Chang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2026.103654_bib10","doi-asserted-by":"crossref","DOI":"10.20517\/jca.2021.13","article-title":"Ser9 phosphorylation of GSK-3\u03b2 promotes aging in the heart through suppression of autophagy","author":"Chen","year":"2021","journal-title":"J. Cardiovasc. Aging"},{"key":"10.1016\/j.tice.2026.103654_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111215","article-title":"SIRT1 and aging related signaling pathways","volume":"187","author":"Chen","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.tice.2026.103654_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ydbio.2012.11.007","article-title":"Evolutionary conservation of Nkx2.5 autoregulation in the second heart field","volume":"374","author":"Clark","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib13","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/ars.2017.7178","article-title":"SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection","volume":"28","author":"D\u2019Onofrio","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tice.2026.103654_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.103031","article-title":"ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival","volume":"299","author":"Das","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103654_bib15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/CIRCRESAHA.107.163428","article-title":"Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors","volume":"102","author":"Evans-Anderson","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.tice.2026.103654_bib16","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.molmed.2017.08.001","article-title":"NAD+ in aging: molecular mechanisms and translational implications","volume":"23","author":"Fang","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tice.2026.103654_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/1947601911410223","article-title":"The regulation of aging and longevity: a new and complex role of p53","volume":"2","author":"Feng","year":"2011","journal-title":"Genes. Cancer"},{"key":"10.1016\/j.tice.2026.103654_bib18","first-page":"195","article-title":"Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling","volume":"45","author":"Gao","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2026.103654_bib19","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2353\/ajpath.2009.080875","article-title":"Functional significance and morphological characterization of starvation-induced autophagy in the adult heart","volume":"174","author":"Kanamori","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tice.2026.103654_bib20","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2353\/ajpath.2009.080875","article-title":"Functional significance and morphological characterization of starvation-induced autophagy in the adult heart","volume":"174","author":"Kanamori","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tice.2026.103654_bib21","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1152\/ajpheart.01056.2010","article-title":"Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion","volume":"300","author":"Kanamori","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tice.2026.103654_bib22","series-title":"The role of autophagy emerging in postinfarction cardiac remodelling","first-page":"330","author":"Kanamori","year":"2018"},{"key":"10.1016\/j.tice.2026.103654_bib23","series-title":"The role of autophagy emerging in postinfarction cardiac remodelling","first-page":"330","author":"Kanamori","year":"2018"},{"key":"10.1016\/j.tice.2026.103654_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-13918-3","article-title":"Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries","volume":"12","author":"Khanam","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103654_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02503-9","article-title":"The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells","volume":"11","author":"Khing","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103654_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1086\/519530","article-title":"Mutations in crdiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy","volume":"81","author":"Kirk","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tice.2026.103654_bib27","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib28","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.3892\/mmr.2016.5660","article-title":"Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phase","volume":"14","author":"Liu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tice.2026.103654_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.797927","article-title":"Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts","volume":"9","author":"L\u00f3pez-Muneta","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib30","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2353\/ajpath.2008.080434","article-title":"Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer\u2019s disease","volume":"173","author":"Louneva","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tice.2026.103654_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbadis.2014.05.010","article-title":"The role of the autophagy in myocardial ischemia\/reperfusion injury","volume":"1852","author":"Ma","year":"2015","journal-title":"Biochim. Et. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.tice.2026.103654_bib32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jmb.2009.04.056","article-title":"Conformational Stability and DNA Binding Specificity of the Cardiac T-Box Transcription Factor Tbx20","volume":"389","author":"Macindoe","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/BST20170121","article-title":"The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders","volume":"46","author":"Maiese","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tice.2026.103654_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.733696","article-title":"Sirtuin 1 in endothelial dysfunction and cardiovascular aging","volume":"12","author":"Ministrini","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tice.2026.103654_bib35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","article-title":"Vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker","volume":"15","author":"Mizushima","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.tice.2026.103654_bib36","series-title":"Methods for Measuring Autophagy in Mice","first-page":"1","author":"Moulis","year":"2017"},{"key":"10.1016\/j.tice.2026.103654_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048176","article-title":"Vitro site selection of a consensus binding site for the Drosophila melanogaster Tbx20 Homolog Midline","volume":"7","author":"Najand","year":"2012","journal-title":"PLoS. One"},{"key":"10.1016\/j.tice.2026.103654_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048176","article-title":"Vitro site selection of a consensus binding site for the Drosophila melanogaster Tbx20 Homolog Midline","volume":"7","author":"Najand","year":"2012","journal-title":"PLoS. One"},{"key":"10.1016\/j.tice.2026.103654_bib39","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014A visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.tice.2026.103654_bib40","article-title":"Asporin reduces adult aortic valve interstitial cell mineralization induced by osteogenic media and Wnt Signaling Manipulation In Vitro","volume":"2020","author":"Polley","year":"2020"},{"key":"10.1016\/j.tice.2026.103654_bib41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jacc.2018.04.042","article-title":"Cardiovascular Diseases in India Compared With the United States","volume":"72","author":"Prabhakaran","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tice.2026.103654_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-62703-239-1_3","article-title":"Senescence regulation by the p53 protein family","volume":"965","author":"Qian","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib43","doi-asserted-by":"crossref","DOI":"10.20517\/jca.2021.24","article-title":"GSK-3\u03b2 mediates cardiac senescence through inhibition of ULK1 directed autophagy","author":"Rabinovich-Nikitin","year":"2021","journal-title":"J. Cardiovasc. Aging"},{"key":"10.1016\/j.tice.2026.103654_bib44","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.tice.2026.103654_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s12276-021-00570-6","article-title":"GSK3B induces autophagy by phosphorylating ULK1","volume":"53","author":"Ryu","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"D20","key":"10.1016\/j.tice.2026.103654_bib46","article-title":"Database resources of the National Center for Biotechnology Information","volume":"50","author":"Sayers","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2026.103654_bib47","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4161\/auto.6143","article-title":"The role of autophagy in neonatal tissues: Just a response to amino acid starvation?","volume":"4","author":"Schiaffino","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.tice.2026.103654_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121427","article-title":"The role of autophagy in the heart","volume":"80","author":"Sciarretta","year":"2018","journal-title":"Annu. Rev. Physiol. Is. Online"},{"key":"10.1016\/j.tice.2026.103654_bib49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10522-020-09864-0","article-title":"The crosstalk of NAD, ROS and autophagy in cellular health and ageing","volume":"21","author":"Sedlackova","year":"2020","journal-title":"Biogerontology"},{"key":"10.1016\/j.tice.2026.103654_bib50","first-page":"643","article-title":"Tbx20 promotes H9c2 cell survival against oxidative stress and hypoxia in vitro","volume":"57","author":"Sen","year":"2019","journal-title":"Indian. J. Exp. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12869-4","article-title":"Nkx2.5+ cardiomyoblasts contribute to cardiomyogenesis in the neonatal heart","volume":"7","author":"Serpooshan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103654_bib52","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1016\/j.ijcard.2013.06.018","article-title":"Tbx20 functions as an important regulator of estrogen-mediated cardiomyocyte protection during oxidative stress","volume":"168","author":"Shen","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tice.2026.103654_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0062134","article-title":"Age and Sex Pattern of Cardiovascular Mortality, Hospitalisation and Associated Cost in India","volume":"8","author":"Srivastava","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.tice.2026.103654_bib54","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0012-1606(03)00385-3","article-title":"Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart","volume":"262","author":"Stennard","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib55","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0012-1606(03)00385-3","article-title":"Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart","volume":"262","author":"Stennard","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib56","series-title":"Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation","first-page":"2451","author":"Stennard","year":"2010"},{"key":"10.1016\/j.tice.2026.103654_bib57","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jmb.2010.04.052","article-title":"Structural Basis of TBX5\u2013DNA Recognition: The T-Box Domain in Its DNA-Bound and -Unbound Form","volume":"400","author":"Stirnimann","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tice.2026.103654_bib58","article-title":"Nkx2-5 regulates the proliferation and migration of H9c2 Cells","volume":"26","author":"Wang","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.tice.2026.103654_bib59","doi-asserted-by":"crossref","unstructured":"Wang, X., Guo, Z., Ding, Z. & Mehta, J.L. In fl ammation, Autophagy, and Apoptosis After Myocardial Infarction. https:\/\/doi.org\/10.1161\/JAHA.117.008024 (2018) doi:10.1161\/JAHA.117.008024.","DOI":"10.1161\/JAHA.117.008024"},{"key":"10.1016\/j.tice.2026.103654_bib60","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2026.103654_bib61","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1093\/eurheartj\/ehv290","article-title":"Protective effects of sirtuins in cardiovascular diseases: From bench to bedside","volume":"36","author":"Winnik","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tice.2026.103654_bib62","first-page":"1","volume":"9","author":"Wu","year":"2014","journal-title":"Impair. Autophagy Contrib. Advers. Card. Remodel. Acute Myocard. Infarct."},{"key":"10.1016\/j.tice.2026.103654_bib63","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/CIRCULATIONAHA.115.019357","article-title":"Overexpression of Tbx20 in adult cardiomyocytes promotes proliferation and improves cardiac function after myocardial infarction","volume":"133","author":"Xiang","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.tice.2026.103654_bib64","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/cvr\/cvt116","article-title":"Macrophage migration inhibitory factor plays a permissive role in the maintenance of cardiac contractile function under starvation through regulation of autophagy","volume":"99","author":"Xu","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tice.2026.103654_bib65","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1253\/circj.CJ-18-1065","article-title":"Autophagy in the heart","volume":"83","author":"Yamaguchi","year":"2019","journal-title":"Circ. J."},{"key":"10.1016\/j.tice.2026.103654_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110444","article-title":"Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis","volume":"38","author":"Yamamoto-Imoto","year":"2022","journal-title":"Cell. Rep."},{"key":"10.1016\/j.tice.2026.103654_bib67","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1515\/cclm-2015-0328","article-title":"TBX20 loss-of-function mutation associated with familial dilated cardiomyopathy","volume":"54","author":"Zhao","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.tice.2026.103654_bib68","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/CIRCRESAHA.116.308544","article-title":"Loss of adult cardiac myocyte GSK-3 leads to mitotic catastrophe resulting in fatal dilated cardiomyopathy","volume":"118","author":"Zhou","year":"2016","journal-title":"Circ. Res."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:15:53Z","timestamp":1789244153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":68,"alternative-id":["S0040816626003472"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103654","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tbx20 and Sirt1 synergize to ameliorate cardiac aging through enhanced autophagy","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103654","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103654"}}