{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:07:03Z","timestamp":1789247223937,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020410","name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131","doi-asserted-by":"publisher","award":["38432"],"award-info":[{"award-number":["38432"]}],"id":[{"id":"10.13039\/100020410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103660","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:21:58Z","timestamp":1780356118000},"page":"103660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Determination of the relationship between thymoquinone and apelin in isoproterenol-induced myocardial infarction"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-364X","authenticated-orcid":false,"given":"Rifat","family":"\u00d6zmen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun","family":"\u00c7etin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Sayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necla","family":"De\u011fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"\u00d6nal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman Okan","family":"\u00d6zocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"Tufano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.tice.2026.103660_bib1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jsps.2019.09.008","article-title":"Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive\/anticancer agent: Chemistry and biological effects","volume":"27","author":"Ahmad","year":"2019","journal-title":"Saudi Pharm. J."},{"issue":"4","key":"10.1016\/j.tice.2026.103660_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/pr.118.017129","article-title":"Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure","volume":"71","author":"Arendse","year":"2019","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.tice.2026.103660_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.yexcr.2014.08.035","article-title":"Dynamics of apelin receptor\/G protein coupling in living cells","volume":"328","author":"Bai","year":"2014","journal-title":"Exp. Cell. Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103660_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11897-013-0178-0","article-title":"Angiotensin-converting enzyme 2 as a therapeutic target for heart failure","volume":"11","author":"Chamsi-Pasha","year":"2014","journal-title":"Curr. Heart Fail. Rep."},{"issue":"6","key":"10.1016\/j.tice.2026.103660_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1139\/bcb-2014-0072","article-title":"The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR","volume":"92","author":"Chapman","year":"2014","journal-title":"Biochem. Cell. Biol."},{"issue":"17","key":"10.1016\/j.tice.2026.103660_bib6","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1042\/CS20200479","article-title":"Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications","volume":"134","author":"Chatterjee","year":"2020","journal-title":"Clin. Sci. (Lond. )"},{"issue":"1-2","key":"10.1016\/j.tice.2026.103660_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1022808224917","article-title":"Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine","volume":"245","author":"Chattopadhyay","year":"2003","journal-title":"Mol. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.tice.2026.103660_bib8","doi-asserted-by":"crossref","first-page":"12149","DOI":"10.1002\/jcp.27942","article-title":"Apelin\/APJ system: a potential therapeutic target for endothelial dysfunction-related diseases","volume":"234","author":"Cheng","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.tice.2026.103660_bib9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.devcel.2013.11.002","article-title":"ELABELA: a hormone essential for heart development signals via the apelin receptor","volume":"27","author":"Chng","year":"2013","journal-title":"Dev. Cell."},{"issue":"23","key":"10.1016\/j.tice.2026.103660_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/foods12234351","article-title":"Grapevine shoot extract rich in trans-resveratrol and trans-\u03b5-viniferin: evaluation of their potential use for cardiac health","volume":"12","author":"Contreras","year":"2023","journal-title":"Foods"},{"issue":"4","key":"10.1016\/j.tice.2026.103660_bib11","doi-asserted-by":"crossref","first-page":"H1646","DOI":"10.1152\/ajpheart.00688.2020","article-title":"G\u03b1i-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats","volume":"320","author":"Coquerel","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tice.2026.103660_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2021.170697","article-title":"Apelin pathway in cardiovascular, kidney, and metabolic diseases: therapeutic role of apelin analogs and apelin receptor agonists","volume":"147","author":"de Oliveira","year":"2022","journal-title":"Peptides"},{"key":"10.1016\/j.tice.2026.103660_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110090","article-title":"Thymoquinone regulates nitric oxide synthase enzymes and receptor-interacting serine-threonine kinases in isoproterenol-induced myocardial infarcted rats","volume":"365","author":"Deger","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tice.2026.103660_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116534","article-title":"The isoproterenol-induced myocardial fibrosis: a biochemical and histological investigation","volume":"174","author":"Flori","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.tice.2026.103660_bib15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10741-015-9475-x","article-title":"Effects of apelin on the cardiovascular system","volume":"20","author":"Folino","year":"2015","journal-title":"Heart Fail. Rev."},{"issue":"5","key":"10.1016\/j.tice.2026.103660_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/CM9.0000000000000122","article-title":"Differences in symptoms and pre-hospital delay among acute myocardial infarction patients according to ST-segment elevation on electrocardiogram: an analysis of China Acute Myocardial Infarction (CAMI) registry","volume":"132","author":"Fu","year":"2019","journal-title":"Chin. Med. J."},{"issue":"4","key":"10.1016\/j.tice.2026.103660_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1753944714531638","article-title":"Exploration of pharmacological interventions to prevent isoproterenol-induced myocardial infarction in experimental models","volume":"8","author":"Garg","year":"2014","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"10.1016\/j.tice.2026.103660_bib18","doi-asserted-by":"crossref","unstructured":"Ghazouani, L., Khdhiri, E., Elmufti, A., Feriani, A., Tir, M., Baaziz, I., Mnafgui, K., 2019. Cardioprotective effects of (E)-4-hydroxy-N\u2032-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat modelCan. J. Physiol. Pharmacol.971098999810.1139\/cjpp-2019-0085.","DOI":"10.1139\/cjpp-2019-0085"},{"issue":"Pt B","key":"10.1016\/j.tice.2026.103660_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cca.2015.09.029","article-title":"Apelin\/APJ signaling in hypoxia-related diseases","volume":"451","author":"He","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.tice.2026.103660_bib20","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2020.11644","article-title":"Apelin\u201136 protects against lipopolysaccharide\u2011induced acute lung injury by inhibiting the ASK1\/MAPK signaling pathway","volume":"23","author":"He","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"1-3","key":"10.1016\/j.tice.2026.103660_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.regpep.2005.09.033","article-title":"Apelin protects myocardial injury induced by isoproterenol in rats","volume":"133","author":"Jia","year":"2006","journal-title":"Regul. Pept."},{"key":"10.1016\/j.tice.2026.103660_bib22","article-title":"The effects of apelin and elabela ligands on apelin receptor distinct signaling profiles","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103660_bib23","first-page":"184","article-title":"L-Carnitine ameliorates the liver by regulating alpha-SMA, iNOS, HSP90, HIF-1alpha, and RIP1 expressions of CCL4-toxic rats","volume":"24","author":"Karabulut","year":"2021","journal-title":"Iran. J. Basic. Med. Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103660_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.18565\/cardio.2015.6.54-62","article-title":"The action of Apelin-12 and its analog on hemodynamics and cardiac Contractile function of rats with isoproterenol-induced myocardial lesion","volume":"55","author":"Lakomkin","year":"2015","journal-title":"Kardiologiia"},{"issue":"12","key":"10.1016\/j.tice.2026.103660_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS. ONE"},{"issue":"5","key":"10.1016\/j.tice.2026.103660_bib26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.21037\/atm.2020.02.07","article-title":"Apelin\/Elabela-APJ: a novel therapeutic target in the cardiovascular system","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"5","key":"10.1016\/j.tice.2026.103660_bib27","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s10741-020-09957-5","article-title":"The Elabela-APJ axis: a promising therapeutic target for heart failure","volume":"26","author":"Ma","year":"2021","journal-title":"Heart Fail. Rev."},{"issue":"11","key":"10.1016\/j.tice.2026.103660_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/biom12111546","article-title":"Cardioprotective effect of taxifolin against isoproterenol-induced cardiac injury through decreasing oxidative stress, inflammation, and cell death, and activating Nrf2\/HO-1 in mice","volume":"12","author":"Obeidat","year":"2022","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.tice.2026.103660_bib29","article-title":"Effectiveness of beta-blockers in reducing mortality and recurrence after myocardial infarction: a systematic review of contemporary and foundational evidence","volume":"17","author":"Popraya","year":"2025","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.tice.2026.103660_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15051408","article-title":"APJ as promising therapeutic target of peptide analogues in myocardial infarction- and hypertension-induced heart failure","volume":"15","author":"Rossin","year":"2023","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.tice.2026.103660_bib31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/13813455.2018.1453521","article-title":"Interactive effects of apelin, renin-angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats","volume":"125","author":"Sabry","year":"2019","journal-title":"Arch. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.tice.2026.103660_bib32","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4149\/gpb_2021028","article-title":"Pyr1]apelin-13 relaxes the rat thoracic aorta via APJ, NO, AMPK, and potassium channels","volume":"40","author":"Sahinturk","year":"2021","journal-title":"Gen. Physiol. Biophys."},{"issue":"1","key":"10.1016\/j.tice.2026.103660_bib33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/Angiotensin-(1-7)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7)","volume":"98","author":"Santos","year":"2018","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.tice.2026.103660_bib34","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1172\/JCI69608","article-title":"Apelin is a positive regulator of ACE2 in failing hearts","volume":"123","author":"Sato","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.tice.2026.103660_bib35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/j.2040-4603.2018.tb00012.x","article-title":"Apelinergic system structure and function","volume":"8","author":"Shin","year":"2017","journal-title":"Compr. Physiol."},{"issue":"8","key":"10.1016\/j.tice.2026.103660_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071876","article-title":"Decreases in electrocardiographic R-wave amplitude and QT interval predict myocardial ischemic infarction in Rhesus monkeys with left anterior descending artery ligation","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS. ONE"},{"issue":"3","key":"10.1016\/j.tice.2026.103660_bib37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s12265-025-10597-z","article-title":"Apelin13 loaded nano-niosomes confer cardioprotection in a rat model of myocardial ischemia reperfusion by targeting the Nrf2\/HO-1 pathway","volume":"18","author":"Tekiyeh Maroof","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103660_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0165-6147(00)01994-5","article-title":"The angiotensin-converting enzyme gene family: genomics and pharmacology","volume":"23","author":"Turner","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"issue":"17","key":"10.1016\/j.tice.2026.103660_bib39","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103660_bib40","article-title":"Roosting ecology of amazonian bats: evidence for guild structure in hyperdiverse mammalian communities","volume":"000389724500001","author":"Voss","year":"2016","journal-title":"Am. Mus. Novit."},{"key":"10.1016\/j.tice.2026.103660_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2013.09.001","article-title":"Apelin and its receptor APJ in cardiovascular diseases","volume":"428","author":"Yu","year":"2014","journal-title":"Clin. Chim. Acta"},{"issue":"8","key":"10.1016\/j.tice.2026.103660_bib42","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.bbadis.2016.11.007","article-title":"Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases","volume":"1863","author":"Zhong","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:21:47Z","timestamp":1789244507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":42,"alternative-id":["S0040816626003538"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103660","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of the relationship between thymoquinone and apelin in isoproterenol-induced myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103660"}}