{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:07:18Z","timestamp":1789247238694,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J01532"],"award-info":[{"award-number":["2024J01532"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2023Y9064"],"award-info":[{"award-number":["2023Y9064"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103669","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:25:41Z","timestamp":1780759541000},"page":"103669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Suppression of GRK6 inhibits hepatocellular carcinoma progression by arresting the cell cycle"],"prefix":"10.1016","volume":"103","author":[{"given":"Jun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinluan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fude","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s42003-026-09568-0","article-title":"Cell-based and isoform-selective G protein-coupled receptor kinase assays for comprehensive inhibitor evaluation","volume":"9","author":"Blum","year":"2026","journal-title":"Commun. Biol."},{"issue":"7","key":"10.1016\/j.tice.2026.103669_bib2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/gutjnl-2016-312268","article-title":"Palbociclib (PD-0332991), a selective CDK4\/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma","volume":"66","author":"Bollard","year":"2017","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.tice.2026.103669_bib3","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1021\/acs.jmedchem.3c02198","article-title":"FGF19-Based Mini Probe Targeting FGFR4 for Diagnosis and Surgical Navigation of Hepatocellular Carcinoma","volume":"67","author":"Cai","year":"2024","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.tice.2026.103669_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113932","article-title":"Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization","volume":"21","author":"Chaudhary","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1182\/bloodadvances.2019000467","article-title":"GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets","volume":"4","author":"Chen","year":"2020","journal-title":"Blood Adv."},{"issue":"43","key":"10.1016\/j.tice.2026.103669_bib6","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1038\/sj.onc.1207945","article-title":"Cell cycle inhibitors in normal and tumor stem cells","volume":"23","author":"Cheng","year":"2004","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12951-024-02354-2","article-title":"Smart responsive Fe\/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation","volume":"22","author":"Du","year":"2024","journal-title":"J. Nanobiotechnology"},{"issue":"4","key":"10.1016\/j.tice.2026.103669_bib8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/sj.bjp.0705101","article-title":"G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells","volume":"138","author":"Ghadessy","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.tice.2026.103669_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac291","article-title":"Immune infiltration and clinical significance analyses of the coagulation-related genes in hepatocellular carcinoma","volume":"23","author":"He","year":"2022","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.tice.2026.103669_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.968591","article-title":"Clinical applications of circulating tumor cells in hepatocellular carcinoma","volume":"12","author":"Hua","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.diff.2009.04.001","article-title":"Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest","volume":"78","author":"Laughlin","year":"2009","journal-title":"Differentiation"},{"issue":"8","key":"10.1016\/j.tice.2026.103669_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081493","article-title":"Programmed Death 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma","volume":"16","author":"Lee","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tice.2026.103669_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2023.107233","article-title":"Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension","volume":"153","author":"Liu","year":"2023","journal-title":"Vasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s10020-023-00731-5","article-title":"Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma","volume":"29","author":"Liu","year":"2023","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12032-012-0379-5","article-title":"Clinical implications of deregulated CDK4 and Cyclin D1 expression in patients with human hepatocellular carcinoma","volume":"30","author":"Lu","year":"2013","journal-title":"Med. Oncol."},{"key":"10.1016\/j.tice.2026.103669_bib16","first-page":"7","article-title":"Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells.\"","author":"Mademtzoglou","year":"2018","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113275","article-title":"From cyclins to CDKIs: Cell cycle regulation of skeletal muscle stem cell quiescence and activation","volume":"420","author":"Mademtzoglou","year":"2022","journal-title":"Exp. Cell. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103669_bib18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.devcel.2020.07.005","article-title":"A dedicated evolutionarily conserved molecular network licenses differentiated cells to return to the cell cycle","volume":"55","author":"Miao","year":"2020","journal-title":"Dev. Cell."},{"key":"10.1016\/j.tice.2026.103669_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.pep.2021.105890","article-title":"Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma","volume":"185","author":"Olson","year":"2021","journal-title":"Protein Expr. Purif."},{"issue":"8","key":"10.1016\/j.tice.2026.103669_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41419-023-06077-4","article-title":"Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice","volume":"14","author":"Otto","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110987","article-title":"Regulation of the orphan G-protein-coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy","volume":"302","author":"Pont-Espinos","year":"2026","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103669_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1375864","article-title":"Prognostic value of CD8(+)T cells related genes and exhaustion regulation of Notch signaling pathway in hepatocellular carcinoma","volume":"15","author":"Pu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2026.103669_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molimm.2018.12.016","article-title":"Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and beta-arrestin 2 in inflammatory macrophages","volume":"106","author":"Serafin","year":"2019","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.tice.2026.103669_bib24","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/1871527322666230403130324","article-title":"G Protein-coupled Receptors (GPCRs) as Potential Therapeutics for Psychiatric Disorders","volume":"23","author":"Sharaf","year":"2024","journal-title":"CNS Neurol. Disord. Drug. Targets"},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1515\/hsz-2022-0162","article-title":"M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6","volume":"404","author":"Song","year":"2023","journal-title":"Biol. Chem."},{"issue":"22","key":"10.1016\/j.tice.2026.103669_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13225680","article-title":"Cyclin E1 in murine and human liver cancer: a promising target for therapeutic intervention during tumour progression","volume":"13","author":"Sonntag","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.tice.2026.103669_bib27","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ab57f7","article-title":"Label-free detection of biomarker alpha fetoprotein in serum by ssDNA aptamer functionalized magnetic nanoparticles","volume":"31","author":"Su","year":"2020","journal-title":"Nanotechnology"},{"issue":"4","key":"10.1016\/j.tice.2026.103669_bib28","first-page":"5879","article-title":"Overexpression of GRK6 associates with the progression and prognosis of colorectal carcinoma","volume":"15","author":"Tao","year":"2018","journal-title":"Oncol. Lett."},{"issue":"15","key":"10.1016\/j.tice.2026.103669_bib29","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1021\/acs.jmedchem.1c00506","article-title":"Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma","volume":"64","author":"Uehling","year":"2021","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.tice.2026.103669_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13058-024-01953-z","article-title":"GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the beta-Arrestin 2\/MAPKs\/NF-kappaB signaling axis","volume":"26","author":"Wang","year":"2024","journal-title":"Breast Cancer Res."},{"issue":"18","key":"10.1016\/j.tice.2026.103669_bib31","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1074\/jbc.M111217200","article-title":"Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells","volume":"277","author":"Willets","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103669_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1476-4598-12-18","article-title":"Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration","volume":"12","author":"Yuan","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tice.2026.103669_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916646381","article-title":"Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion","volume":"12","author":"Zhou","year":"2016","journal-title":"Mol. Pain."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:16:13Z","timestamp":1789244173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":33,"alternative-id":["S0040816626003630"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103669","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of GRK6 inhibits hepatocellular carcinoma progression by arresting the cell cycle","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103669"}}