{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:05:25Z","timestamp":1789247125052,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103675","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:25:24Z","timestamp":1780759524000},"page":"103675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dapansutrile alleviates sepsis-induced cardiac injury by modulating NF-\u043aB-induced inflammatory response and TXNIP\/NLRP3\/ GSDMD-mediated pyroptosis"],"prefix":"10.1016","volume":"103","author":[{"given":"Fahad","family":"Alahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany M.","family":"Abo-Haded","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani","family":"Saeedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra S.","family":"Andijani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaa F.","family":"Alsiyud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-7560","authenticated-orcid":false,"given":"Sabrin R.M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael M.","family":"Elsaed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina S.","family":"El-Agamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103675_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2015.01.008","article-title":"NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases","volume":"4","author":"Abderrazak","year":"2015","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103675_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12012-019-09539-4","article-title":"Suppression of LPS-Induced Hepato- and Cardiotoxic Effects by Pulicaria petiolaris via NF-\u03baB dependent mechanism","volume":"20","author":"Ahmed","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.tice.2026.103675_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118026","article-title":"Dapansutrile mitigates concanavalin A- induced autoimmune hepatitis: Involvement of NLRP3\/IL-1\u03b2 and JNK\/ p38 MAPK pathways","volume":"186","author":"Alenezi","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.tice.2026.103675_bib4","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3390\/molecules26123534","article-title":"Preservation of contractile reserve and diastolic function by inhibiting the NLRP3 inflammasome with OLT1177\u00ae (Dapansutrile) in a mouse model of severe ischemic cardiomyopathy due to non-reperfused anterior wall myocardial infarction","volume":"26","author":"Aliaga","year":"2021","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.tice.2026.103675_bib5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/pharmaceutics17081003","article-title":"Pristimerin dampens acetaminophen-induced hepatotoxicity; The role of NF-\u03baB\/iNOS\/COX-II\/Cytokines, PI3K\/AKT, and BAX\/BCL-2\/Caspase-3 signaling pathways","volume":"17","author":"Altowijri","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.tice.2026.103675_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113889","article-title":"Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury","volume":"347","author":"Amo-Aparicio","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.tice.2026.103675_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.990469","article-title":"Exploring the mechanism of action of dapansutrile in the treatment of gouty arthritis based on molecular docking and molecular dynamics","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Physiol."},{"issue":"19","key":"10.1016\/j.tice.2026.103675_bib8","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.3390\/cells11192992","article-title":"TMEM43 Protects against sepsis-induced cardiac injury via inhibiting ferroptosis in mice","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"issue":"Pt 2","key":"10.1016\/j.tice.2026.103675_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2022.10.080","article-title":"FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII\/NF\u03baB signaling","volume":"636","author":"Cui","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.tice.2026.103675_bib10","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1002\/ptr.7191","article-title":"Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation","volume":"35","author":"Dai","year":"2021","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103675_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/jpet.119.259069","article-title":"Indigo fruits ingredient, aucubin, protects against LPS-induced cardiac dysfunction in mice","volume":"371","author":"Duan","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tice.2026.103675_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111869","article-title":"The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage","volume":"131","author":"Fang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103675_bib13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/ptr.8093","article-title":"Astilbin protects from sepsis-induced cardiac injury through the NRF2\/HO-1 and TLR4\/NF-\u03baB pathway","volume":"38","author":"Fang","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.tice.2026.103675_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.570441","article-title":"Shikonin ameliorates LPS-induced cardiac dysfunction by SIRT1-dependent inhibition of NLRP3 inflammasome","volume":"11","author":"Guo","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tice.2026.103675_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177589","article-title":"Tomentosin mitigates the LPS induced cardiac injury by regulating Nrf-2\/Nf-\u03ba\u03b2 pathway in mice","volume":"996","author":"G\u00fcven\u00e7","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tice.2026.103675_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2018.02.013","article-title":"Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ROS-TXNIP-NLRP3 biological axis","volume":"16","author":"Han","year":"2018","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.tice.2026.103675_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.tice.2026.103675_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3306559","article-title":"Visfatin amplifies cardiac inflammation and aggravates cardiac injury via the NF-\u03baB p65 signaling pathway in LPS-treated mice","volume":"2022","author":"Hu","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.tice.2026.103675_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111333","article-title":"piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip\/NLRP3-mediated pyroptosis in db\/db mice","volume":"122","author":"Jiao","year":"2024","journal-title":"Cell. Signal."},{"issue":"13","key":"10.1016\/j.tice.2026.103675_bib20","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: An overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103675_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.903834","article-title":"The NLRP3 inflammasome inhibitor dapansutrile attenuates cyclophosphamide-induced interstitial cystitis","volume":"13","author":"Kiran","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.tice.2026.103675_bib22","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2665-9913(20)30065-5","article-title":"Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial","volume":"2","author":"Kl\u00fcck","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.tice.2026.103675_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101215","article-title":"STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3","volume":"24","author":"Li","year":"2019","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.103675_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s10020-023-00769-5","article-title":"ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS\/STING pathway","volume":"29","author":"Liu","year":"2023","journal-title":"Mol. Med."},{"issue":"6","key":"10.1016\/j.tice.2026.103675_bib25","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s10753-019-01081-3","article-title":"SS31 Ameliorates Sepsis-Induced Heart Injury by Inhibiting Oxidative Stress and Inflammation","volume":"42","author":"Liu","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.tice.2026.103675_bib26","first-page":"32145","article-title":"The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer\u2019s disease","volume":"117","author":"Lonnemann","year":"2020"},{"issue":"4","key":"10.1016\/j.tice.2026.103675_bib27","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1002\/jcp.29268","article-title":"Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases","volume":"235","author":"Lu","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.tice.2026.103675_bib28","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s10753-023-01954-8","article-title":"Nicorandil regulates ferroptosis and mitigates septic cardiomyopathy via TLR4\/SLC7A11 signaling pathway","volume":"47","author":"Lu","year":"2024","journal-title":"Inflammation"},{"issue":"12","key":"10.1016\/j.tice.2026.103675_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22939","article-title":"LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3\/AMPK\u03b1","volume":"9","author":"Luo","year":"2023","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.tice.2026.103675_bib30","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1002\/jcb.29556","article-title":"Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4\/NF-kB\/NLRP3 pathway","volume":"121","author":"Luo","year":"2020","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.tice.2026.103675_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76066-w","article-title":"Acute exposure to LPS induces cardiac dysfunction via the activation of the NLRP3 inflammasome","volume":"14","author":"Maluleke","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103675_bib32","first-page":"E1530","article-title":"CA. OLT1177, a \u03b2-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation","volume":"115","author":"Marchetti","year":"2018"},{"key":"10.1016\/j.tice.2026.103675_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tips.2019.01.001","article-title":"Intracellular lipopolysaccharide sensing as a potential therapeutic target for sepsis","volume":"40","author":"Pfalzgraff","year":"2019","journal-title":"Trends Pharm. Sci."},{"issue":"9","key":"10.1016\/j.tice.2026.103675_bib34","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1139\/cjpp-2020-0321","article-title":"Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3\/TLR4 pathway","volume":"99","author":"Ren","year":"2021","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.tice.2026.103675_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109772","article-title":"Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-\u03baB p65 and MAPK signaling pathways in septic AKI mice","volume":"122","author":"Ren","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.tice.2026.103675_bib36","first-page":"938","article-title":"Cepabiflas B and C as novel anti-inflammatory and anti-apoptotic agents against endotoxin-induced acute kidney and hepatic injury in mice: Impact on Bax\/Bcl2 and Nrf2\/NF-\u03baB signalling pathways","volume":"12","author":"Rizq","year":"2023","journal-title":"Biol. (Basel)"},{"key":"10.1016\/j.tice.2026.103675_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119123","article-title":"BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R\/NLRP3 and MyD88\/NF-\u03baB signaling in DSS-induced colitis in rats","volume":"270","author":"Saber","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103675_bib38","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.3389\/fimmu.2019.02578","article-title":"OLT1177 (Dapansutrile), a selective NLRP3 Inflammasome inhibitor, ameliorates experimental autoimmune encephalomyelitis pathogenesis","volume":"10","author":"Sanchez-Fernandez","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.tice.2026.103675_bib39","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.4081\/ejh.2023.3816","article-title":"Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway","volume":"67","author":"Shen","year":"2023","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.tice.2026.103675_bib40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2020.02.011","article-title":"Geniposide protects against sepsis-induced myocardial dysfunction through AMPK\u03b1-dependent pathway","volume":"152","author":"Song","year":"2020","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.tice.2026.103675_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111897","article-title":"Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy","volume":"131","author":"Su","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2026.103675_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/09603271221145401","article-title":"Dapansutrile ameliorated chondrocyte inflammation and osteoarthritis through suppression of MAPK signaling pathway","volume":"41","author":"Tang","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.tice.2026.103675_bib43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","article-title":"The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases","volume":"21","author":"Toldo","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.tice.2026.103675_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/FJC.0000000000000658","article-title":"The NLRP3 inflammasome inhibitor, OLT1177 (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse","volume":"73","author":"Toldo","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"8","key":"10.1016\/j.tice.2026.103675_bib45","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12012-022-09751-9","article-title":"Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride-induced cardiotoxicity in rats","volume":"22","author":"Var\u0131\u015fl\u0131","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.tice.2026.103675_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108545","article-title":"Disulfiram inhibits oxidative stress and NLRP3 inflammasome activation to prevent LPS-induced cardiac injury","volume":"105","author":"Wei","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.tice.2026.103675_bib47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/cimb47030148","article-title":"Dapansutrile regulates mitochondrial oxidative stress and reduces hepatic lipid accumulation in diabetic mice","volume":"47","author":"Wu","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103675_bib48","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1080\/21655979.2021.2001913","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction","volume":"12","author":"Xiao","year":"2021","journal-title":"Bioengineered"},{"issue":"189","key":"10.1016\/j.tice.2026.103675_bib49","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.24976\/Discov.Med.202436189.193","article-title":"Propofol ameliorates sepsis-induced myocardial dysfunction via anti-apoptotic, anti-oxidative properties, and mTOR signaling","volume":"36","author":"Xie","year":"2024","journal-title":"Discov. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103675_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.hlc.2023.09.017","article-title":"Dapansutrile ameliorates atrial inflammation and vulnerability to atrial fibrillation in HFpEF rats","volume":"33","author":"Yang","year":"2024","journal-title":"Heart Lung Circ."},{"issue":"1","key":"10.1016\/j.tice.2026.103675_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"Pt A","key":"10.1016\/j.tice.2026.103675_bib52","article-title":"Dapagliflozin attenuates the vulnerability to atrial fibrillation in rats with lipopolysaccharide-induced myocardial injury","volume":"125","author":"Zhao","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2026.103675_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.711939","article-title":"The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: A review","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.tice.2026.103675_bib54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tice.2026.103675_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113327","article-title":"Verbascoside protects from LPS-induced septic cardiomyopathy via alleviating cardiac inflammation, oxidative stress and regulating mitochondrial dynamics","volume":"233","author":"Zhu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:11:08Z","timestamp":1789243868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":55,"alternative-id":["S0040816626003691"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103675","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dapansutrile alleviates sepsis-induced cardiac injury by modulating NF-\u043aB-induced inflammatory response and TXNIP\/NLRP3\/ GSDMD-mediated pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103675"}}