{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:07:18Z","timestamp":1789247238609,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103680","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:25:34Z","timestamp":1781159134000},"page":"103680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Applications of hollow-fiber systems in bone, liver, and pancreatic tissue engineering"],"prefix":"10.1016","volume":"103","author":[{"given":"Leila","family":"Naserpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Fathbayati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2160-4730","authenticated-orcid":false,"given":"Alireza","family":"Rezapour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohadeseh","family":"Khoshandam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103680_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cocis.2025.101933","article-title":"Aqueous two-phase emulsion systems in 3D cell culture","volume":"78","author":"Dyab","year":"2025","journal-title":"Curr. Opin. Colloid & Interface Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.preme.2026.100057","article-title":"Artificial cells in disease therapy: Structural and functional biomimicry, challenges, and future perspectives","volume":"3","author":"Tan","year":"2026","journal-title":"Precis. Med. Eng."},{"key":"10.1016\/j.tice.2026.103680_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119536","article-title":"Progress in 3D bioprinting technology for tissue\/organ regenerative engineering","volume":"226","author":"Matai","year":"2020","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.tice.2026.103680_bib4","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/term.2932","article-title":"Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization","volume":"13","author":"Rademakers","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"11","key":"10.1016\/j.tice.2026.103680_bib5","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.3390\/molecules29112637","article-title":"A Comprehensive Review of Hollow-Fiber Membrane Fabrication Methods across Biomedical, Biotechnological, and Environmental Domains","volume":"29","author":"Wojciechowski","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103680_bib6","series-title":"Seminars in cell & developmental biology","article-title":"Stem cell-and scaffold-based tissue engineering approaches to osteochondral regenerative medicine","author":"Sundelacruz","year":"2009"},{"issue":"36","key":"10.1016\/j.tice.2026.103680_bib7","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1002\/adfm.201203880","article-title":"Hydrogels for two-photon polymerization: a toolbox for mimicking the extracellular matrix","volume":"23","author":"Torgersen","year":"2013","journal-title":"Adv. Funct. Mater."},{"issue":"111","key":"10.1016\/j.tice.2026.103680_bib8","article-title":"Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture","author":"Storm","year":"2016","journal-title":"J. Vis. Exp. JoVE"},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5301\/ijao.5000466","article-title":"Hollow Fiber Bioreactor Technology for Tissue Engineering Applications","volume":"39","author":"Eghbali","year":"2016","journal-title":"Int. J. Artif. Organs"},{"issue":"4","key":"10.1016\/j.tice.2026.103680_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.gendis.2017.10.002","article-title":"3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends","volume":"4","author":"Bishop","year":"2017","journal-title":"Genes. & Dis."},{"issue":"7","key":"10.1016\/j.tice.2026.103680_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202100003","article-title":"3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration","volume":"1","author":"Su","year":"2021","journal-title":"Small Sci."},{"issue":"5","key":"10.1016\/j.tice.2026.103680_bib12","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1039\/C5CS00777A","article-title":"Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment","volume":"45","author":"Peng","year":"2016","journal-title":"Chem. Soc. Rev."},{"issue":"4","key":"10.1016\/j.tice.2026.103680_bib13","first-page":"447","article-title":"Hollow Fiber and Nanofiber Membranes in Bioartificial Liver and Neuronal Tissue Engineering","volume":"211","author":"Morelli","year":"2022","journal-title":"Cells Tissues Organs"},{"issue":"55","key":"10.1016\/j.tice.2026.103680_bib14","doi-asserted-by":"crossref","first-page":"82632","DOI":"10.1007\/s11356-022-23066-w","article-title":"Structural design of the electrospun nanofibrous membrane for membrane distillation application: a review","volume":"29","author":"Kim","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.tice.2026.103680_bib15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/btpr.348","article-title":"Technological progresses in monoclonal antibody production systems","volume":"26","author":"Rodrigues","year":"2010","journal-title":"Biotechnol. Progress."},{"key":"10.1016\/j.tice.2026.103680_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8870530","article-title":"Evaluating the Toxicity and Histological Effects of Al(2)O(3) Nanoparticles on Bone Tissue in Animal Model: A Case-Control Study","volume":"2020","author":"Soltaninejad","year":"2020","journal-title":"J. Toxicol."},{"issue":"2","key":"10.1016\/j.tice.2026.103680_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s42242-018-0015-0","article-title":"Osteochondral tissue repair in osteoarthritic joints: clinical challenges and opportunities in tissue engineering","volume":"1","author":"Tamaddon","year":"2018","journal-title":"Biodes Manuf."},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/prd.12413","article-title":"Complications in bone-grafting procedures: Classification and management","volume":"88","author":"Sanz-S\u00e1nchez","year":"2022","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.tice.2026.103680_bib19","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.injury.2021.01.043","article-title":"Autologous bone graft: Is it still the gold standard?","volume":"52","author":"Schmidt","year":"2021","journal-title":"Injury"},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jdsr.2018.09.003","article-title":"Bone grafting materials in dentoalveolar reconstruction: A comprehensive review","volume":"55","author":"Titsinides","year":"2019","journal-title":"Jpn. Dent. Sci. Rev."},{"issue":"4","key":"10.1016\/j.tice.2026.103680_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsamd.2024.100806","article-title":"Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies","volume":"9","author":"Selim","year":"2024","journal-title":"Journal Science Advanced Materials Devices"},{"issue":"23-24","key":"10.1016\/j.tice.2026.103680_bib22","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1089\/ten.tea.2017.0026","article-title":"Extracellular matrices for bone regeneration: a literature review","volume":"23","author":"Mansour","year":"2017","journal-title":"Tissue Eng. Part. A"},{"issue":"10","key":"10.1016\/j.tice.2026.103680_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/jfb15100280","article-title":"Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions","volume":"15","author":"Todd","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.tice.2026.103680_bib24","first-page":"271","article-title":"Recent advances in biomaterials for 3D scaffolds: A review","volume":"4","author":"Nikolova","year":"2019","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.tice.2026.103680_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/978-3-319-08831-0_58","article-title":"Cell culture conditions: Cultivation of stem cells under dynamic conditions","author":"Clementi","year":"2020","journal-title":"Cell. Eng. Regen."},{"issue":"13","key":"10.1016\/j.tice.2026.103680_bib26","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1016\/j.ces.2007.02.054","article-title":"Multiscale simulation of nutrient transport in hollow fibre membrane bioreactor for growing bone tissue: Sub-cellular scale and beyond","volume":"62","author":"Das","year":"2007","journal-title":"Chem. Eng. Sci."},{"issue":"12","key":"10.1016\/j.tice.2026.103680_bib27","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/pr8121656","article-title":"Advanced 3D Cell Culture Techniques in Micro-Bioreactors, Part I: A Systematic Analysis of the Literature Published between 2000 and 2020","volume":"8","author":"Gr\u00fcn","year":"2020","journal-title":"Processes"},{"key":"10.1016\/j.tice.2026.103680_bib28","doi-asserted-by":"crossref","unstructured":"Suhaimi H. Glucose diffusivity in tissue engineering membranes and scaffolds: implications for hollow fibre membrane bioreactor: Loughborough University; 2015.","DOI":"10.1016\/j.ces.2014.12.029"},{"issue":"4","key":"10.1016\/j.tice.2026.103680_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/membranes11040257","article-title":"Effects of scaffold pore morphologies on glucose transport limitations in hollow fibre membrane bioreactor for bone tissue engineering: experiments and numerical modelling","volume":"11","author":"Wang","year":"2021","journal-title":"Membranes"},{"key":"10.1016\/j.tice.2026.103680_bib30","unstructured":"Piard C.M. Development of An Endothelial Cell\/Mesenchymal Stem Cell Coculture Strategy for The Vascularization of Engineered Bone Tissue: University of Maryland, College Park; 2019."},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/pr2010034","article-title":"Model-Based Optimization of Scaffold Geometry and Operating Conditions of Radial Flow Packed-Bed Bioreactors for Therapeutic Applications","volume":"2","author":"Donato","year":"2014","journal-title":"Processes"},{"key":"10.1016\/j.tice.2026.103680_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2018.00105","article-title":"Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects","volume":"6","author":"Perez","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s10047-012-0649-1","article-title":"Computational modeling of adherent cell growth in a hollow-fiber membrane bioreactor for large-scale 3-D bone tissue engineering","volume":"15","author":"Mohebbi-Kalhori","year":"2012","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.tice.2026.103680_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijbiomac.2022.01.096","article-title":"3D printed concentrated alginate\/GelMA hollow-fibers-packed scaffolds with nano apatite coatings for bone tissue engineering","volume":"202","author":"Luo","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"28","key":"10.1016\/j.tice.2026.103680_bib35","article-title":"Multifunctional Nanofibrous Hollow Microspheres for Enhanced Periodontal Bone Regeneration","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.tice.2026.103680_bib36","article-title":"Advances in In Vitro and In Vivo Bioreactor-Based Bone Generation for Craniofacial Tissue Engineering","volume":"4","author":"Watson","year":"2023","journal-title":"BME Front."},{"key":"10.1016\/j.tice.2026.103680_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbac033","article-title":"Three-dimensional-printed polycaprolactone scaffolds with interconnected hollow-pipe structures for enhanced bone regeneration","volume":"9","author":"Duan","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.tice.2026.103680_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.162444","article-title":"Hollow-whisker modified calcium phosphate loaded with deferoxamine to promote osteoporotic bone regeneration by acting HIF-1\u03b1 signaling pathway","volume":"512","author":"Tan","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.tice.2026.103680_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142578","article-title":"Alginate\/bacterial cellulose\/GelMA scaffolds with aligned nanopatterns and hollow channel networks for vascularized bone repair","volume":"308","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.tice.2026.103680_bib40","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.memsci.2019.02.065","article-title":"Porous morphology and mechanical properties of poly(lactide-co-glycolide) hollow fiber membranes governed by ternary-phase inversion","volume":"579","author":"Wang","year":"2019","journal-title":"J. Membr. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.msec.2006.05.024","article-title":"Fabrication of nanocrystalline hydroxyapatite doped degradable composite hollow fiber for guided and biomimetic bone tissue engineering","volume":"27","author":"Zhang","year":"2007","journal-title":"Materials Science Engineering C"},{"key":"10.1016\/j.tice.2026.103680_bib42","first-page":"640","article-title":"Hierarchical micro-\/nanostructured hydroxyapatite scaffolds promote osteoporotic bone regeneration via activation of hedgehog and HIF-1\u03b1 signaling","volume":"60","author":"Zhao","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.tice.2026.103680_bib43","unstructured":"Meneghello G. Development of a Novel PVA-PLGA Hollow Fibre Bioreactor for Tissue Engineering: University of Bath; 2010."},{"key":"10.1016\/j.tice.2026.103680_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1107055","article-title":"A novel approach for large-scale manufacturing of small extracellular vesicles from bone marrow-derived mesenchymal stromal cells using a hollow fiber bioreactor","volume":"11","author":"Jakl","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"49","key":"10.1016\/j.tice.2026.103680_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202408032","article-title":"3D Bioprinting for Engineered Tissue Constructs and Patient-Specific Models: Current Progress and Prospects in Clinical Applications","volume":"36","author":"Lee","year":"2024","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bjae.2020.11.006","article-title":"Management of acute liver failure in intensive care","volume":"21","author":"Aziz","year":"2021","journal-title":"BJA Educ."},{"issue":"4","key":"10.1016\/j.tice.2026.103680_bib47","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.hbpd.2020.06.015","article-title":"Small-for-size syndrome in liver transplantation: Definition, pathophysiology and management","volume":"19","author":"Masuda","year":"2020","journal-title":"Hepatobiliary & Pancreat. Dis. Int."},{"issue":"6","key":"10.1016\/j.tice.2026.103680_bib48","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.3892\/etm.2016.3887","article-title":"Clinical observation on the treatment of acute liver failure by combined non-biological artificial liver","volume":"12","author":"Li","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.tice.2026.103680_bib49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/hep4.1136","article-title":"Liver tissue engineering: From implantable tissue to whole organ engineering","volume":"2","author":"Mazza","year":"2018","journal-title":"Hepatol. Commun."},{"issue":"6","key":"10.1016\/j.tice.2026.103680_bib50","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1021\/acsabm.3c00032","article-title":"A Unification of Nanotopography and Extracellular Matrix in Electrospun Scaffolds for Bioengineered Hepatic Models","volume":"6","author":"Gao","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbe.2023.11.003","article-title":"Hollow fiber bioreactor with genetically modified hepatic cells as a model of biologically active function block of the bioartificial liver","volume":"44","author":"Jakubowska","year":"2024","journal-title":"Biocybern. Biomed. Eng."},{"issue":"5","key":"10.1016\/j.tice.2026.103680_bib52","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/ten.tec.2010.0580","article-title":"Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies","volume":"17","author":"Zeilinger","year":"2011","journal-title":"Tissue Eng. Part. C. Methods"},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib53","article-title":"Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions","volume":"5","author":"Freyer","year":"2018","journal-title":"Bioeng. (Basel)"},{"issue":"7","key":"10.1016\/j.tice.2026.103680_bib54","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3390\/biomimetics10070443","article-title":"Current Advances and Future Perspectives of Liver-on-a-Chip Platforms Incorporating Dynamic Fluid Flow","volume":"10","author":"Yun","year":"2025","journal-title":"Biomimetics"},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib55","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1038\/s41598-017-03424-2","article-title":"Functional Evaluation of a Bioartificial Liver Support System Using Immobilized Hepatocyte Spheroids in a Porcine Model of Acute Liver Failure","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.tice.2026.103680_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800430","article-title":"Bioengineering Organs for Blood Detoxification","volume":"7","author":"Legallais","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.tice.2026.103680_bib57","first-page":"117","article-title":"Transport advances in disposable bioreactors for liver tissue engineering","volume":"115","author":"Catapano","year":"2009","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70390","article-title":"Standard Protocols for Characterising Primary and In Vitro-Generated Human Hepatocytes","volume":"29","author":"Heydari","year":"2025","journal-title":"J. Cell. Mol. Med."},{"issue":"8","key":"10.1016\/j.tice.2026.103680_bib59","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1124\/dmd.31.8.1035","article-title":"Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties","volume":"31","author":"Wilkening","year":"2003","journal-title":"Drug. Metab. Dispos."},{"issue":"9","key":"10.1016\/j.tice.2026.103680_bib60","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000788","article-title":"Bioartificial liver: Where lies the path ahead-A review","volume":"9","author":"Jiang","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.tice.2026.103680_bib61","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-1-0716-0255-3_18","article-title":"Porcine Hepatocytes: Isolation and Liver Tissue Engineering for Xenotransplantation","volume":"2110","author":"Li","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"11","key":"10.1016\/j.tice.2026.103680_bib62","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3748\/wjg.v23.i11.1974","article-title":"Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells","volume":"23","author":"Sakiyama","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib63","doi-asserted-by":"crossref","first-page":"M463","DOI":"10.1097\/00002480-199207000-00077","article-title":"Immunoprotection of xenocytes in a hollow fiber bioartificial liver","volume":"38","author":"Nyberg","year":"1992","journal-title":"Asaio J."},{"key":"10.1016\/j.tice.2026.103680_bib64","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.msec.2017.04.003","article-title":"Islet encapsulated implantable composite hollow fiber membrane based device: A bioartificial pancreas","volume":"77","author":"Teotia","year":"2017","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"key":"10.1016\/j.tice.2026.103680_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.811942","article-title":"Optimization and Validation of a Custom-Designed Perfusion Bioreactor for Bone Tissue Engineering: Flow Assessment and Optimal Culture Environmental Conditions","volume":"10","author":"Yamada","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"7","key":"10.1016\/j.tice.2026.103680_bib66","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3390\/polym13071105","article-title":"A comparative review of natural and synthetic biopolymer composite scaffolds","volume":"13","author":"Reddy","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.tice.2026.103680_bib67","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.progpolymsci.2015.02.004","article-title":"Advancing biomaterials of human origin for tissue engineering","volume":"53","author":"Chen","year":"2016","journal-title":"Progress. Polym. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103680_bib68","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/01.sla.0000132986.75257.19","article-title":"Clinical application of bioartificial liver support systems","volume":"240","author":"van de Kerkhove","year":"2004","journal-title":"Ann. Surg."},{"issue":"10","key":"10.1016\/j.tice.2026.103680_bib69","first-page":"1027","article-title":"Functional study on two artificial liver bioreactors with collagen gel","volume":"30","author":"Bing","year":"2014","journal-title":"J. Clin. Hepatol."},{"key":"10.1016\/j.tice.2026.103680_bib70","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.addr.2014.02.011","article-title":"Bioreactor technologies to support liver function in vitro","volume":"69-70","author":"Ebrahimkhani","year":"2014","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.tice.2026.103680_bib71","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.colsurfb.2019.06.051","article-title":"Polyethersulfone-carbon nanotubes composite hollow fiber membranes with improved biocompatibility for bioartificial liver","volume":"181","author":"Verma","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"4","key":"10.1016\/j.tice.2026.103680_bib72","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1051\/ject\/201143195","article-title":"Extracorporeal bioartificial liver for treating acute liver diseases","volume":"43","author":"Kumar","year":"2011","journal-title":"J. Extra Corpor. Technol."},{"issue":"5","key":"10.1016\/j.tice.2026.103680_bib73","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/aor.14915","article-title":"Extracorporeal liver support systems in patients with acute-on-chronic liver failure: An updated systematic review and meta-analysis","volume":"49","author":"Liu","year":"2025","journal-title":"Artif. Organs"},{"issue":"6","key":"10.1016\/j.tice.2026.103680_bib74","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1021\/acsapm.3c00522","article-title":"Cellulose Acetate Hollow Fiber Membranes for Forward Osmosis Using the Green Solvent Agnique AMD 3 L","volume":"5","author":"G\u00f6tz","year":"2023","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.tice.2026.103680_bib75","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.colsurfb.2018.01.038","article-title":"Functionally coated polyethersulfone hollow fiber membranes: A substrate for enhanced HepG2\/C3A functions","volume":"164","author":"Verma","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.tice.2026.103680_bib76","first-page":"475","article-title":"Biofabrication methods for reconstructing extracellular matrix mimetics","volume":"31","author":"Aazmi","year":"2024","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.tice.2026.103680_bib77","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1039\/C7BM00963A","article-title":"Three-dimensional multiscale fiber matrices: development and characterization for increased HepG2 functional maintenance for bio-artificial liver application","volume":"6","author":"Verma","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.tice.2026.103680_bib78","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.colsurfb.2017.09.024","article-title":"Human liver microtissue spheroids in hollow fiber membrane bioreactor","volume":"160","author":"Ahmed","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.tice.2026.103680_bib79","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2015.08.107","article-title":"The bioartificial pancreas (BAP): Biological, chemical and engineering challenges","volume":"100","author":"Iacovacci","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"13","key":"10.1016\/j.tice.2026.103680_bib80","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1002\/adhm.201600058","article-title":"Hybrid Polycaprolactone\/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans","volume":"5","author":"Marchioli","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.tice.2026.103680_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2019.00134","article-title":"Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation","volume":"7","author":"Hu","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib82","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jbiotec.2008.12.004","article-title":"Development of a polysulfone hollow fiber vascular bio-artificial pancreas device for in vitro studies","volume":"139","author":"Silva","year":"2009","journal-title":"J. Biotechnol."},{"issue":"1","key":"10.1016\/j.tice.2026.103680_bib83","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5500\/wjt.v6.i1.69","article-title":"Survival of encapsulated islets: More than a membrane story","volume":"6","author":"Barkai","year":"2016","journal-title":"World J. Transplant."},{"issue":"3","key":"10.1016\/j.tice.2026.103680_bib84","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/jbm.a.32134","article-title":"Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function","volume":"90","author":"Weber","year":"2009","journal-title":"J. Biomed. Mater. Res. A"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626003745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:16:33Z","timestamp":1789244193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626003745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":84,"alternative-id":["S0040816626003745"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103680","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Applications of hollow-fiber systems in bone, liver, and pancreatic tissue engineering","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103680"}}