{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:06:27Z","timestamp":1789247187182,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011488","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103711","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:18:39Z","timestamp":1781911119000},"page":"103711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NEDD4L suppresses colorectal cancer metastasis and immune escape by inhibiting STAT3 signaling"],"prefix":"10.1016","volume":"103","author":[{"given":"Dong","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bensong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.tice.2026.103711_bib1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/gene.2011.43","article-title":"CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer","volume":"12","author":"\u00c5gesen","year":"2011","journal-title":"Genes. Immun."},{"issue":"11","key":"10.1016\/j.tice.2026.103711_bib2","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1136\/gutjnl-2011-301179","article-title":"ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis","volume":"61","author":"Agesen","year":"2012","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.tice.2026.103711_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103669","article-title":"Immunotherapy and immunoevasion of colorectal cancer","volume":"28","author":"Al Zein","year":"2023","journal-title":"Drug. Discov. Today"},{"issue":"9","key":"10.1016\/j.tice.2026.103711_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137171","article-title":"Discovery of a novel immune gene signature with profound prognostic value in colorectal cancer: a model of cooperativity disorientation created in the process from development to cancer","volume":"10","author":"An","year":"2015","journal-title":"PloS. One"},{"issue":"9927","key":"10.1016\/j.tice.2026.103711_bib5","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(13)61649-9","article-title":"Colorectal cancer","volume":"383","author":"Brenner","year":"2014","journal-title":"Lancet (Lond. Engl. )"},{"issue":"9","key":"10.1016\/j.tice.2026.103711_bib6","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/1878-0261.12347","article-title":"Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer","volume":"12","author":"Bruun","year":"2018","journal-title":"Mol. Oncol."},{"issue":"2","key":"10.1016\/j.tice.2026.103711_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/imm.13785","article-title":"A new strategy for immunotherapy of microsatellite-stable (MSS)-type advanced colorectal cancer: multi-pathway combination therapy with PD-1\/PD-L1 inhibitors","volume":"173","author":"Cai","year":"2024","journal-title":"Immunology"},{"key":"10.1016\/j.tice.2026.103711_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia (New. Y. NY)"},{"issue":"4","key":"10.1016\/j.tice.2026.103711_bib9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41401-023-01190-8","article-title":"E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the \u03b2-catenin\/HIF-1\u03b1 positive feedback loop in chronic rhinosinusitis with nasal polyps","volume":"45","author":"Chen","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"13","key":"10.1016\/j.tice.2026.103711_bib10","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2215132120","article-title":"circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1","volume":"120","author":"Chen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.tice.2026.103711_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11523-019-00690-0","article-title":"Immune checkpoint inhibition in colorectal cancer: microsatellite instability and beyond","volume":"15","author":"Cohen","year":"2020","journal-title":"Target. Oncol."},{"issue":"5","key":"10.1016\/j.tice.2026.103711_bib12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41580-021-00448-5","article-title":"Ubiquitin ligases: guardians of mammalian development","volume":"23","author":"Cruz Walma","year":"2022","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"W1","key":"10.1016\/j.tice.2026.103711_bib13","doi-asserted-by":"crossref","first-page":"W534","DOI":"10.1093\/nar\/gkaf388","article-title":"TIMER3: an enhanced resource for tumor immune analysis","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103711_bib14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41418-020-00648-0","article-title":"Ubiquitin signaling in cell cycle control and tumorigenesis","volume":"28","author":"Dang","year":"2021","journal-title":"Cell. death Differ."},{"issue":"9","key":"10.1016\/j.tice.2026.103711_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024419","article-title":"Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome","volume":"6","author":"Danielsen","year":"2011","journal-title":"PloS. One"},{"issue":"1","key":"10.1016\/j.tice.2026.103711_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-020-0107-0","article-title":"The role of ubiquitination in tumorigenesis and targeted drug discovery","volume":"5","author":"Deng","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.tice.2026.103711_bib17","article-title":"NEDD4L inhibits epithelial-mesenchymal transition in gastric cancer by mediating BICC1 ubiquitination","author":"Duan","year":"2024","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"14","key":"10.1016\/j.tice.2026.103711_bib18","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.7150\/ijbs.64077","article-title":"Immunotherapy in colorectal cancer: current achievements and future perspective","volume":"17","author":"Fan","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103711_bib19","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innov. (Camb. (Mass. ))"},{"issue":"6","key":"10.1016\/j.tice.2026.103711_bib20","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.7150\/ijbs.69411","article-title":"The role of ubiquitination and deubiquitination in tumor invasion and metastasis","volume":"18","author":"Han","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.tice.2026.103711_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177743","article-title":"Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1","volume":"1000","author":"He","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.tice.2026.103711_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33144","article-title":"The role of CD8(+) T-cells in colorectal cancer immunotherapy","volume":"10","author":"He","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.tice.2026.103711_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/gcc.22512","article-title":"Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery","volume":"57","author":"Hu","year":"2018","journal-title":"Genes. Chromosomes & Cancer"},{"issue":"3","key":"10.1016\/j.tice.2026.103711_bib24","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ymthe.2020.12.032","article-title":"Emerging role of ubiquitination in the regulation of PD-1\/PD-L1 in cancer immunotherapy","volume":"29","author":"Hu","year":"2021","journal-title":"Molecular therapy journal American Society Gene Therapy"},{"key":"10.1016\/j.tice.2026.103711_bib25","article-title":"Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt\/\u03b2-catenin signaling activation","volume":"11","author":"Liu","year":"2023","journal-title":"Gastroenterol. Rep. (Oxf. )"},{"issue":"8","key":"10.1016\/j.tice.2026.103711_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112870","article-title":"14-3-3\u03c3-NEDD4L axis promotes ubiquitination and degradation of HIF-1\u03b1 in colorectal cancer","volume":"42","author":"Liu","year":"2023","journal-title":"Cell. Rep."},{"issue":"Pt B","key":"10.1016\/j.tice.2026.103711_bib27","article-title":"Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK\/STAT3\/PDL1 pathway in gastric cancer","volume":"142","author":"Liu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103711_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s40537-023-00844-y","article-title":"BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors","volume":"10","author":"Liu","year":"2023","journal-title":"J. Big Data"},{"issue":"2","key":"10.1016\/j.tice.2026.103711_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188447","article-title":"Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: from bench to bedside","volume":"1874","author":"Lizardo","year":"2020","journal-title":"Biochim. Et. Biophys. Acta Rev. Cancer"},{"issue":"21","key":"10.1016\/j.tice.2026.103711_bib30","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"issue":"W1","key":"10.1016\/j.tice.2026.103711_bib31","doi-asserted-by":"crossref","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","article-title":"TIMER2.0 for analysis of tumor-infiltrating immune cells","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.tice.2026.103711_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"7-8","key":"10.1016\/j.tice.2026.103711_bib33","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1002\/jcp.29494","article-title":"PD-1\/PD-L1-dependent immune response in colorectal cancer","volume":"235","author":"Payandeh","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tice.2026.103711_bib34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/bs.mie.2019.05.056","article-title":"Deconvoluting tumor-infiltrating immune cells from RNA-seq data using quanTIseq","volume":"636","author":"Plattner","year":"2020","journal-title":"Methods Enzymol."},{"issue":"4","key":"10.1016\/j.tice.2026.103711_bib35","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1007\/s13277-015-4328-8","article-title":"miR-93 promotes TGF-\u03b2-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells","volume":"37","author":"Qu","year":"2016","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"issue":"4","key":"10.1016\/j.tice.2026.103711_bib36","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tips.2023.01.003","article-title":"Metastatic colorectal cancer: mechanisms and emerging therapeutics","volume":"44","author":"Shin","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.tice.2026.103711_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009722","article-title":"Immune checkpoint blockade: timing is everything","volume":"12","author":"Sinicrope","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"43","key":"10.1016\/j.tice.2026.103711_bib38","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.tice.2026.103711_bib39","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA a cancer journal clinicians"},{"issue":"3","key":"10.1016\/j.tice.2026.103711_bib40","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.immuni.2018.03.014","article-title":"Regulation and Function of the PD-L1 Checkpoint","volume":"48","author":"Sun","year":"2018","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.tice.2026.103711_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081514","article-title":"NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling","volume":"8","author":"Tanksley","year":"2013","journal-title":"PloS. One"},{"issue":"13","key":"10.1016\/j.tice.2026.103711_bib42","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.7150\/thno.41498","article-title":"ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma","volume":"10","author":"Tong","year":"2020","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.tice.2026.103711_bib43","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1158\/1078-0432.CCR-10-2884","article-title":"Clinical significance of osteoprotegerin expression in human colorectal cancer","volume":"17","author":"Tsukamoto","year":"2011","journal-title":"Clinical cancer research official journal American Association Cancer Research"},{"issue":"6220","key":"10.1016\/j.tice.2026.103711_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science (New York NY)"},{"issue":"8","key":"10.1016\/j.tice.2026.103711_bib45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41419-022-05172-2","article-title":"LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2","volume":"13","author":"Wang","year":"2022","journal-title":"Cell. death & Dis."},{"key":"10.1016\/j.tice.2026.103711_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113566","article-title":"CBLN2 overexpression inhibits colorectal cancer progression and improves immunotherapy responses","volume":"144","author":"Wang","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.tice.2026.103711_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/biom14050577","article-title":"NEDD4 and NEDD4L: ubiquitin ligases closely related to digestive diseases","volume":"14","author":"Xu","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.tice.2026.103711_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.582695","article-title":"STK35 is ubiquitinated by nedd4l and promotes glycolysis and inhibits apoptosis through regulating the AKT signaling pathway, influencing chemoresistance of colorectal cancer","volume":"8","author":"Yang","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"issue":"35","key":"10.1016\/j.tice.2026.103711_bib49","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1038\/s41388-021-01944-w","article-title":"Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway","volume":"40","author":"Zhang","year":"2021","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.tice.2026.103711_bib50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41419-024-06480-5","article-title":"TRPM8 inhibits substance P release from primary sensory neurons via PKA\/GSK-3beta to protect colonic epithelium in colitis","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell. death & Dis."},{"key":"10.1016\/j.tice.2026.103711_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1291773","article-title":"NEDD4L in human tumors: regulatory mechanisms and dual effects on anti-tumor and pro-tumor","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103711_bib52","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41420-021-00736-1","article-title":"The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell. death Discov."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626004052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626004052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:17:05Z","timestamp":1789244225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626004052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":52,"alternative-id":["S0040816626004052"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103711","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NEDD4L suppresses colorectal cancer metastasis and immune escape by inhibiting STAT3 signaling","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103711"}}