{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:06:20Z","timestamp":1789247180634,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tice.2026.103728","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:17:05Z","timestamp":1782199025000},"page":"103728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MAFF mediates transcriptional activation of CFLAR to reduce regulatory T cell apoptosis and inhibit diabetic retinopathy progression"],"prefix":"10.1016","volume":"103","author":[{"given":"Xinle","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103728_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109145","article-title":"Microglia-endothelial cross-talk regulates diabetes-induced retinal vascular dysfunction through remodeling inflammatory microenvironment","volume":"27","author":"Ben","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.tice.2026.103728_bib2","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41418-024-01349-8","article-title":"TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia","volume":"31","author":"Chen","year":"2024","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.tice.2026.103728_bib3","article-title":"ALKBH5-Mediated m(6)A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2026.103728_bib4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41419-023-06318-6","article-title":"Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide","volume":"14","author":"Cristaldi","year":"2023","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.tice.2026.103728_bib5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41467-017-00751-w","article-title":"Foxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis","volume":"8","author":"Deliyanti","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2026.103728_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2415517","article-title":"HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis","volume":"46","author":"Deng","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.tice.2026.103728_bib7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.omtn.2021.08.027","article-title":"miR-320a induces pancreatic beta cells dysfunction in diabetes by inhibiting MafF","volume":"26","author":"Du","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.tice.2026.103728_bib8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s40291-024-00718-w","article-title":"Beyond death: unmasking the intricacies of apoptosis escape","volume":"28","author":"Ergun","year":"2024","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.tice.2026.103728_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583687","article-title":"The role of inflammation in diabetic retinopathy","volume":"11","author":"Forrester","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2026.103728_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/genes14101883","article-title":"Exploring Large MAF transcription factors: functions, pathology, and mouse models with point mutations","volume":"14","author":"Fujino","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.tice.2026.103728_bib11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10456-024-09911-1","article-title":"Microglia in retinal angiogenesis and diabetic retinopathy","volume":"27","author":"Hu","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.tice.2026.103728_bib12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41419-021-03683-y","article-title":"Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells","volume":"12","author":"Huangfu","year":"2021","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.tice.2026.103728_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.gene.2016.03.058","article-title":"Small Maf proteins (MafF, MafG, MafK): history, structure and function","volume":"586","author":"Katsuoka","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.tice.2026.103728_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s11658-025-00721-x","article-title":"MAFF alleviates hepatic ischemia-reperfusion injury by regulating the CLCF1\/STAT3 signaling pathway","volume":"30","author":"Lei","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.tice.2026.103728_bib15","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1007\/s00125-022-05719-0","article-title":"ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes","volume":"65","author":"Lessieur","year":"2022","journal-title":"Diabetologia"},{"key":"10.1016\/j.tice.2026.103728_bib16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s12964-024-01838-w","article-title":"alpha-Klotho prevents diabetic retinopathy by reversing the senescence of macrophages","volume":"22","author":"Li","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.tice.2026.103728_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12964-024-01653-3","article-title":"Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion","volume":"22","author":"Li","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.tice.2026.103728_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117146","article-title":"HMGB1 upregulates NF-kB by inhibiting IKB-alpha and associates with diabetic retinopathy","volume":"241","author":"Liang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103728_bib19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12974-024-03323-0","article-title":"Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes","volume":"21","author":"Llorian-Salvador","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.tice.2026.103728_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biology14030275","article-title":"The role of Th17\/Treg axis in retinal pathology associated with diabetes and treatment options","volume":"14","author":"Mickael","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.tice.2026.103728_bib21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2337\/db22-0619","article-title":"Transcriptomic profiling reveals Chemokine CXCL1 as a mediator for neutrophil recruitment associated with blood-retinal barrier alteration in diabetic retinopathy","volume":"72","author":"Monickaraj","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.tice.2026.103728_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.celrep.2016.12.022","article-title":"c-FLIP expression in Foxp3-expressing cells is essential for survival of regulatory T cells and prevention of autoimmunity","volume":"18","author":"Plaza-Sirvent","year":"2017","journal-title":"Cell. Rep."},{"key":"10.1016\/j.tice.2026.103728_bib23","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1089\/hum.2021.024","article-title":"Regulatory T cells and diabetes mellitus","volume":"32","author":"Qin","year":"2021","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tice.2026.103728_bib24","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4239\/wjd.v14.i7.1013","article-title":"Tight junction disruption and the pathogenesis of the chronic complications of diabetes mellitus: a narrative review","volume":"14","author":"Robles-Osorio","year":"2023","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.tice.2026.103728_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.immuni.2024.01.009","article-title":"Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis","volume":"57","author":"Savage","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.tice.2026.103728_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/01.CIR.0000080735.93327.00","article-title":"Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy","volume":"108","author":"Sennlaub","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.tice.2026.103728_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cells14050376","article-title":"Diabetic retinopathy (DR): mechanisms, current therapies, and emerging strategies","volume":"14","author":"Seo","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103728_bib28","article-title":"Diabetic retinopathy: looking forward to 2030","volume":"13","author":"Tan","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tice.2026.103728_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149760","article-title":"Transcriptomics confirms IRF1 as a key regulator of pyroptosis in diabetic retinopathy","volume":"709","author":"Xian","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2026.103728_bib30","first-page":"789","article-title":"Sensitive blood-retinal barrier breakdown quantitation using Evans blue","volume":"42","author":"Xu","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tice.2026.103728_bib31","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/s41401-023-01081-y","article-title":"TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP\/PKA\/c-FLIP\/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis","volume":"44","author":"Yang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tice.2026.103728_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12974-024-03141-4","article-title":"cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma","volume":"21","author":"Yang","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.tice.2026.103728_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0366-6999.221263","article-title":"Protective effects of leukemia inhibitory factor on retinal vasculature and cells in Streptozotocin-induced diabetic mice","volume":"131","author":"Yang","year":"2018","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.tice.2026.103728_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2024.106862","article-title":"Berberine alleviates diabetic retinopathy by regulating the Th17\/Treg ratio","volume":"267","author":"Yang","year":"2024","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.tice.2026.103728_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1055087","article-title":"The role of inflammation in immune system of diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"13","author":"Yue","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tice.2026.103728_bib36","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.2147\/JIR.S519885","article-title":"Biological functions and clinical implications of CFLAR: from cell death mechanisms to therapeutic targeting in immune regulation","volume":"18","author":"Zhang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.tice.2026.103728_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.103229","article-title":"Early growth response 2 activates MAF bZIP transcription factor F to protect beta-cells from oxidative stress in type 1 diabetes","volume":"99","author":"Zhang","year":"2026","journal-title":"Tissue Cell."},{"key":"10.1016\/j.tice.2026.103728_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216373","article-title":"PGF(2alpha) facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR(+) CXC chemokine expression","volume":"15","author":"Zhao","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.tice.2026.103728_bib39","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1158\/2326-6066.CIR-23-0092","article-title":"Ncoa2 Promotes CD8+ T cell-mediated antitumor immunity by stimulating T-cell activation via upregulation of PGC-1alpha critical for mitochondrial function","volume":"11","author":"Zhong","year":"2023","journal-title":"Cancer Immunol. Res."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626004222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626004222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:19:18Z","timestamp":1789244358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626004222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"alternative-id":["S0040816626004222"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103728","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MAFF mediates transcriptional activation of CFLAR to reduce regulatory T cell apoptosis and inhibit diabetic retinopathy progression","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103728"}}