{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:21:45Z","timestamp":1787458905135,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260179"],"award-info":[{"award-number":["82260179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023GXNSFAA026040"],"award-info":[{"award-number":["2023GXNSFAA026040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103791","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:28:07Z","timestamp":1784244487000},"page":"103791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Reuterin drives osteogenic and suppresses adipogenic differentiation of bone marrow mesenchymal stem cells via BMP\/SMAD signaling to ameliorate osteoporosis"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0431-3472","authenticated-orcid":false,"given":"Jian","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103791_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4196\/kjpp.2021.25.3.197","article-title":"Carnosol induces the osteogenic differentiation of bone marrow-derived mesenchymal stem cells via activating BMP-signaling pathway","volume":"25","author":"Abdallah","year":"2021","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.tice.2026.103791_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12929-019-0544-7","article-title":"5'-hydroxy Auraptene stimulates osteoblast differentiation of bone marrow-derived mesenchymal stem cells via a BMP-dependent mechanism","volume":"26","author":"Abdallah","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tice.2026.103791_bib3","article-title":"Four Isosteroidal Alkaloids from Fritillaria Alleviate Lipopolysaccharide-Induced Inflammation in vitro and in vivo through MyD88- and TRIF-Dependent Signaling Pathways","author":"Aga","year":"2025","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.tice.2026.103791_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ccell.2021.12.001","article-title":"Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance","volume":"40","author":"Bell","year":"2022","journal-title":"Cancer Cell."},{"key":"10.1016\/j.tice.2026.103791_bib5","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","article-title":"Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model","volume":"229","author":"Britton","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tice.2026.103791_bib6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrrheum.2009.175","article-title":"Promising bone-related therapeutic targets for rheumatoid arthritis","volume":"5","author":"Choi","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.tice.2026.103791_bib7","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2256043","article-title":"Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling","volume":"15","author":"Danhof","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.tice.2026.103791_bib8","unstructured":"Drugs@FDA: FDA-Approved Drugs 2022 [August 2, 2022]. Available from: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm."},{"key":"10.1016\/j.tice.2026.103791_bib9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.stemcr.2022.01.016","article-title":"Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis","volume":"17","author":"Franco","year":"2022","journal-title":"Stem Cell. Rep."},{"key":"10.1016\/j.tice.2026.103791_bib10","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1002\/ptr.7780","article-title":"Peiminine regulates bone-fat balance by canonical Wnt\/beta-catenin pathway in an ovariectomized rat model","volume":"37","author":"Gu","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.tice.2026.103791_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262211203","article-title":"Peimine alleviates DSS-induced colitis by modulating gut microbiota and attenuating inflammation and oxidative stress","volume":"26","author":"Guan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103791_bib12","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/jre.13233","article-title":"Reuterin isolated from the probiotic Lactobacillus reuteri promotes periodontal tissue regeneration by inhibiting Cx43-mediated the intercellular transmission of endoplasmic reticulum stress","volume":"59","author":"Han","year":"2024","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.tice.2026.103791_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1369\/0022155418806865","article-title":"Histological effects of the combined administration of eldecalcitol and a parathyroid hormone in the metaphyseal trabeculae of ovariectomized rats","volume":"67","author":"Hasegawa","year":"2019","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.tice.2026.103791_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-02089-6","article-title":"Anti-osteoporotic potential of a probiotic mixture containing Limosilactobacillus reuteri and Weissella cibaria in ovariectomized rats","volume":"15","author":"Hossain","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103791_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41419-017-0126-0","article-title":"IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways","volume":"9","author":"Huang","year":"2018","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.tice.2026.103791_bib16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/ten.teb.2015.0357","article-title":"A review of the clinical side effects of bone morphogenetic protein-2","volume":"22","author":"James","year":"2016","journal-title":"Tissue Eng. Part. B Rev."},{"key":"10.1016\/j.tice.2026.103791_bib17","doi-asserted-by":"crossref","DOI":"10.29219\/fnr.v67.9064","article-title":"Lactobacillus plantarum LP45 inhibits the RANKL\/OPG signaling pathway and prevents glucocorticoid-induced osteoporosis","volume":"67","author":"Jiang","year":"2023","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.tice.2026.103791_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ecl.2022.10.009","article-title":"Osteoporosis: review of etiology, mechanisms, and approach to management in the aging population","volume":"52","author":"Khandelwal","year":"2023","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"key":"10.1016\/j.tice.2026.103791_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","article-title":"The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor. Rev."},{"key":"10.1016\/j.tice.2026.103791_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biocel.2013.11.018","article-title":"All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP\/Smad and Wnt\/beta-catenin signaling pathways","volume":"47","author":"Liu","year":"2014","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.tice.2026.103791_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156445","article-title":"3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury","volume":"139","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2026.103791_bib22","article-title":"Effect of gut hormones on bone metabolism and their possible mechanisms in the treatment of osteoporosis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103791_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072277","article-title":"At the crossroads of the adipocyte and osteoclast differentiation programs: future therapeutic perspectives","volume":"21","author":"Muruganandan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103791_bib24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/joim.12805","article-title":"Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial","volume":"284","author":"Nilsson","year":"2018","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.tice.2026.103791_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4067\/S0716-97602012000300009","article-title":"osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis","volume":"45","author":"Pino","year":"2012","journal-title":"Biol. Res."},{"key":"10.1016\/j.tice.2026.103791_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117208","article-title":"Resveratrol reversed rosiglitazone administration induced bone loss in rats with type 2 diabetes mellitus","volume":"178","author":"Qu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2026.103791_bib27","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1021\/acsptsci.3c00170","article-title":"Small-molecule probes as pharmacological tools for the bone morphogenetic protein signaling pathway","volume":"6","author":"Riege","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.tice.2026.103791_bib28","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3892\/ijmm.2015.2185","article-title":"Quercetin prevents adipogenesis by regulation of transcriptional factors and lipases in OP9 cells","volume":"35","author":"Seo","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2026.103791_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157203","article-title":"Jiawei yanghe decoction alleviates osteoporotic osteoarthritis by promoting MSC osteogenic differentiation and homing via ITGB6\/TGF-beta\/CXCR4 pathway","volume":"147","author":"Sheng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2026.103791_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bone.2013.10.005","article-title":"A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat","volume":"58","author":"Smith","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.tice.2026.103791_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00774-020-01152-8","article-title":"Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats","volume":"39","author":"Souza","year":"2021","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.tice.2026.103791_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13018-025-05665-8","article-title":"Therapeutic potential of total flavonoids of Rhizoma Drynariae: inhibiting adipogenesis and promoting osteogenesis via MAPK\/HIF-1alpha pathway in primary osteoporosis","volume":"20","author":"Su","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.tice.2026.103791_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157456","article-title":"Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy","volume":"148","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2026.103791_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115829","article-title":"Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt\/beta-catenin pathway","volume":"217","author":"Wang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tice.2026.103791_bib35","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.biopha.2017.11.141","article-title":"Teriparatide promotes healing of critical size femur defect through accelerating angiogenesis and degradation of beta-TCP in OVX osteoporotic rat model","volume":"96","author":"Xie","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2026.103791_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.01.039","article-title":"The fast degradation of beta-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide","volume":"112","author":"Xie","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2026.103791_bib37","doi-asserted-by":"crossref","first-page":"572","DOI":"10.7150\/ijbs.63505","article-title":"Myokine Irisin promotes osteogenesis by activating BMP\/SMAD signaling via alphaV integrin and regulates bone mass in mice","volume":"18","author":"Xue","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.tice.2026.103791_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1454408","article-title":"Glycerol-derived reuterin regulates human intestinal microbiota and metabolites","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tice.2026.103791_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103244","article-title":"Criteria for osteoporosis diagnosis: a systematic review and meta-analysis of osteoporosis diagnostic studies with DXA and QCT","volume":"83","author":"Yang","year":"2025","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.tice.2026.103791_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157277","article-title":"Taraxasterol alleviates osteoporosis by targeting PI3K\/AKT\/PPARgamma signaling axis to suppress necroptosis and reverse osteogenic-adipogenic differentiation imbalance in BMSCs","volume":"149","author":"Zeng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2026.103791_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117253","article-title":"Active components and mechanisms of total flavonoids from Rhizoma Drynariae in enhancing cranial bone regeneration: an investigation employing serum pharmacochemistry and network pharmacology approaches","volume":"319","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.tice.2026.103791_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152888","article-title":"Icariin regulates the Hippo\/TAZ signaling pathway to promote osteogenic differentiation and bone remodeling in osteoporosis","volume":"792","author":"Zhao","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2026.103791_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70552","article-title":"FKBP5 induces senescence in BMSCs and inhibits osteogenic differentiation through the canonical WNT\/beta-catenin signalling pathway in senile osteoporosis","volume":"29","author":"Zhu","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tice.2026.103791_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.736863","article-title":"Peiminine suppresses RANKL-induced osteoclastogenesis by inhibiting the NFATc1, ERK, and NF-kappaB signaling pathways","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626004854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626004854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:58:52Z","timestamp":1787457532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626004854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":44,"alternative-id":["S0040816626004854"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103791","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reuterin drives osteogenic and suppresses adipogenic differentiation of bone marrow mesenchymal stem cells via BMP\/SMAD signaling to ameliorate osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103791"}}