{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:21:41Z","timestamp":1787458901546,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2025GXNSFBA069542"],"award-info":[{"award-number":["2025GXNSFBA069542"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2024GXNSFAA010369"],"award-info":[{"award-number":["2024GXNSFAA010369"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103858","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T14:09:52Z","timestamp":1786889392000},"page":"103858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Effect of Notoginsenoside R1 on reparative dentin formation via regulating the function of human dental pulp stem cells"],"prefix":"10.1016","volume":"104","author":[{"given":"Xuan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103858_bib1","first-page":"2588393","article-title":"A cell culture method for the isolation and study of primary human dental pulp cells","author":"Arora","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tice.2026.103858_bib2","first-page":"3","article-title":"Direct pulp capping with mineral trioxide ag- gregate: an observational study","volume":"139","author":"Bogen","year":"2008","journal-title":"J. Am. Dent. Assoc. (1939)"},{"issue":"10","key":"10.1016\/j.tice.2026.103858_bib3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00403-013-1415-9","article-title":"Study of small proline-rich proteins (SPRRs) in health and disease: a review of the literature","volume":"305","author":"Carregaro","year":"2013","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103858_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13287-021-02141-y","article-title":"Resolvin E1 accelerates pulp repair by regulating inflammation and stimulating dentin regeneration in dental pulp stem cells","volume":"12","author":"Chen","year":"2021","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.tice.2026.103858_bib5","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2023-0444","article-title":"LncRNA XIST facilitates the odontogenic differentiation of dental pulp stem cells via the FUS\/ZBTB16","volume":"32","author":"Cheng","year":"2024","journal-title":"J. Appl. Oral. Sci."},{"issue":"4","key":"10.1016\/j.tice.2026.103858_bib6","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.joen.2014.01.019","article-title":"Scaffolds to Control Inflammation and Facilitate Dental Pulp Regeneration","volume":"40","author":"Colombo","year":"2014","journal-title":"J. Endod."},{"issue":"4_","key":"10.1016\/j.tice.2026.103858_bib7","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.joen.2014.01.011","article-title":"Pulp stem cells: implication in reparative dentin formation","volume":"40","author":"Dimitrova-Nakov","year":"2014","journal-title":"J. Endod."},{"issue":"5","key":"10.1016\/j.tice.2026.103858_bib8","first-page":"463","article-title":"Comparison of Coronal Tooth Discoloration Elicited by Various Endodontic Reparative Materials MTA Plus, Bio MTA+, and Biodentine: An Ex Vivo Study","volume":"13","author":"Disha","year":"2020","journal-title":"Int. J. Clin. Pediatr. Dent."},{"issue":"9","key":"10.1016\/j.tice.2026.103858_bib9","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1164\/rccm.201304-0803OC","article-title":"S100A8\/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis","volume":"188","author":"Gopal","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.tice.2026.103858_bib10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0022034509340867","article-title":"Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine","volume":"88","author":"Huang","year":"2009","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.tice.2026.103858_bib11","first-page":"5948","article-title":"Direct pulp capping procedures - Evidence and practice","author":"Islam","year":"2023","journal-title":"Jpn Dent. Sci. Rev."},{"issue":"9","key":"10.1016\/j.tice.2026.103858_bib12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1089\/jmf.2024.k.0014","article-title":"Panax Notoginseng Saponins Regulate Angiogenic Cytokines Through the PI3K\/AKT\/mTOR Signaling Pathway to Promote Fracture Healing in Ovariectomized Rats","volume":"27","author":"Jiang","year":"2024","journal-title":"J. Med. Food"},{"issue":"9","key":"10.1016\/j.tice.2026.103858_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cells8091002","article-title":"Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration","volume":"8","author":"Komichi","year":"2019","journal-title":"Cells"},{"issue":"24","key":"10.1016\/j.tice.2026.103858_bib14","doi-asserted-by":"crossref","first-page":"11278","DOI":"10.1111\/jcmm.17054","article-title":"Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway","volume":"25","author":"Li","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.tice.2026.103858_bib15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jep.2010.11.075","article-title":"Panax notoginseng saponins promotes proliferation and osteogenic differentiation of rat bone marrow stromal cells","volume":"134","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.tice.2026.103858_bib16","first-page":"1135","article-title":"Calcium-binding Protein S100A9 and Neurodegenerative Diseases","volume":"38","author":"Li","year":"2022","journal-title":"Chin. J. Immunol."},{"issue":"2","key":"10.1016\/j.tice.2026.103858_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3892\/ijmm.2016.2652","article-title":"Notoginsenoside R1 significantly promotes in vitro osteoblastogenesis","volume":"38","author":"Liu","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2026.103858_bib18","article-title":"Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK\/mTOR\/Nrf2 Signaling Pathway","volume":"12687394","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.tice.2026.103858_bib19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13770-026-00809-1","article-title":"Effect of hUCMSC-sEV-Loaded GelMA Microspheres on Pulp\/Dentin Repair and Regeneration","volume":"23","author":"Lu","year":"2026","journal-title":"Tissue Eng. Regen. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103858_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/iep.12494","article-title":"Notoginsenoside R1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERalpha\/GSK-3beta\/beta-catenin signalling pathway[J]","volume":"105","author":"Lu","year":"2024","journal-title":"Int. J. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.tice.2026.103858_bib21","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4103\/jispcd.JISPCD_249_19","article-title":"Comparison between iRoot BP Plus (EndoSequence Root Repair Material) and Mineral Trioxide Aggregate as Pulp-capping Agents: A Systematic Review","volume":"9","author":"Mahgoub","year":"2019","journal-title":"J. Int. Soc. Prev. Community Dent."},{"issue":"7","key":"10.1016\/j.tice.2026.103858_bib22","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.72.7.4102-4108.2004","article-title":"S100 and cytokine expression in caries","volume":"72","author":"McLachlan","year":"2004","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.tice.2026.103858_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1267\/ahc.18030","article-title":"Collapsin Response Mediator Protein 1, a Novel Marker Protein for Differentiated Odontoblasts","volume":"51","author":"Miyazaki","year":"2018","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.tice.2026.103858_bib24","article-title":"Expression profiling identifies key genes and biological functions associated with eosinophilic esophagitis in human patients","volume":"41239273","author":"Morrison","year":"2023","journal-title":"Front. Allergy"},{"issue":"194","key":"10.1016\/j.tice.2026.103858_bib25","article-title":"Notoginsenoside R1 Promotes Osteogenic Differentiation of Dental Pulp Stem Cells via MAPK Pathway","volume":"37","author":"Pan","year":"2025","journal-title":"Discov. Med."},{"issue":"3","key":"10.1016\/j.tice.2026.103858_bib26","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.joen.2009.09.009","article-title":"Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action","volume":"36","author":"Parirokh","year":"2010","journal-title":"J. Endod."},{"issue":"2","key":"10.1016\/j.tice.2026.103858_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/iej.12841","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part I: vital pulp therapy","volume":"51","author":"Parirokh","year":"2018","journal-title":"Int. Endod. J."},{"issue":"1","key":"10.1016\/j.tice.2026.103858_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 proteins","volume":"13","author":"R Donato","year":"2013","journal-title":"Curr. Mol. Med."},{"issue":"7","key":"10.1016\/j.tice.2026.103858_bib29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2591.2005.00963.x","article-title":"Physico\u2013 chemical properties of MTA and a novel experimental cement","author":"Santos","year":"2005","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.tice.2026.103858_bib30","article-title":"An injectable nano-hydroxyapatite-incorporated hydrogel with sustained release of Notoginsenoside R1 enhances bone regeneration by promoting angiogenesis through Notch1\/Akt signaling","author":"Tan","year":"2025","journal-title":"J. Adv. Res."},{"issue":"Pt 1","key":"10.1016\/j.tice.2026.103858_bib31","article-title":"Isolation, structural features, and bioactivities of polysaccharides from Panax notoginseng: A review","volume":"280","author":"Tao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.tice.2026.103858_bib32","first-page":"535","article-title":"Pulpal response to a resin-modified glass-ionomer material on nonexposed and exposed monkey pulps","volume":"29","author":"Tarim","year":"1998","journal-title":"Quintessence Int."},{"issue":"8","key":"10.1016\/j.tice.2026.103858_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011957","article-title":"Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing","volume":"5","author":"Vermeij","year":"2010","journal-title":"PLoS. One"},{"issue":"9","key":"10.1016\/j.tice.2026.103858_bib34","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.tice.2026.103858_bib35","first-page":"122160","article-title":"Notoginsenoside R1 functionalized gelatin hydrogels to promote reparative dentinogenesis","author":"Wang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tice.2026.103858_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115680","article-title":"Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy","volume":"300","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103858_bib37","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbrc.2015.09.014","article-title":"Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling","volume":"466","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.tice.2026.103858_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1186\/s12967-023-04550-4","article-title":"Clinical application of calcium silicate-based bioceramics in endodontics","volume":"21","author":"Wang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"04","key":"10.1016\/j.tice.2026.103858_bib39","first-page":"263","article-title":"Research progress on the odontogenic differentiation of dental pulp stem cells","volume":"14","author":"Wang Chenxu","year":"2023","journal-title":"Oral. Biomed."},{"issue":"3","key":"10.1016\/j.tice.2026.103858_bib40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/00220345221135766","article-title":"Novel Functional Peptide for Next-Generation Vital Pulp Therapy","volume":"102","author":"Watanabe","year":"2023","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103858_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3724\/SP.J.1009.2012.00043","article-title":"Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R\/PI3K\/AKT\/NF\u03baB signaling pathway","volume":"23","author":"Wu","year":"2025","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103858_bib42","article-title":"Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis","volume":"23","author":"Yang","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.tice.2026.103858_bib43","first-page":"1341","article-title":"Identification of certain Panax species to be potential substitutes for Panax notoginseng in hemostatic treatments","author":"Yang","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.tice.2026.103858_bib44","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/s41401-024-01250-7","article-title":"Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt\/\u03b2-Catenin signaling[J]","volume":"45","author":"Yu","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tice.2026.103858_bib45","first-page":"47118","article-title":"Notoginsenoside R1 suppresses wear particle-induced osteolysis and RANKL mediated osteoclastogenesis in vivo and in vitro","author":"Zhao","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2026.103858_bib46","article-title":"Notoginsenoside R1 activates the Ang2\/Tie2 pathway to promote angiogenesis","volume":"78153302","author":"Zhong","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tice.2026.103858_bib47","article-title":"Notoginsenoside R1 Improves Cerebral Ischemia\/Reperfusion Injury by Promoting Neurogenesis via the BDNF\/Akt\/CREB Pathway","volume":"12615998","author":"Zhu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103858_bib48","article-title":"Notoginsenoside R1 activates the NAMPT-NAD(+)-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling","volume":"140111693","author":"Zhu","year":"2021","journal-title":"Biomed. Pharmacother."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:51:52Z","timestamp":1787457112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626005525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":48,"alternative-id":["S0040816626005525"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103858","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Notoginsenoside R1 on reparative dentin formation via regulating the function of human dental pulp stem cells","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103858"}}