{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:06:30Z","timestamp":1789589190165,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF\\u22122026\\u20131080"],"award-info":[{"award-number":["ORF\\u22122026\\u20131080"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103875","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:05:11Z","timestamp":1787007911000},"page":"103875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Phosphocreatine mitigates pulmonary fibrosis in STZ-induced diabetic rats with bleomycin injury through TGF-\u03b2\/Smad and Wnt\/\u03b2-catenin pathways"],"prefix":"10.1016","volume":"104","author":[{"given":"Fu Han","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman Khaled","family":"Alwesabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-9341","authenticated-orcid":false,"given":"Eskandar","family":"Qaed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Aldahmash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mueataz A.","family":"Mahyoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"almoiliqy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103875_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tice.2026.103875_bib2","doi-asserted-by":"crossref","unstructured":"Anon, 2015. Erratum: An Official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. an update of the 2011 Clinical Practice Guideline. Am J Respir Crit Care Med 192, 644.","DOI":"10.1164\/rccm.1925erratum"},{"key":"10.1016\/j.tice.2026.103875_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101509","article-title":"Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis","volume":"33","author":"Bueno","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.tice.2026.103875_bib4","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1517\/13543784.2014.913569","article-title":"Emerging therapeutic interventions for idiopathic pulmonary fibrosis","volume":"23","author":"Chakraborty","year":"2014","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"10.1016\/j.tice.2026.103875_bib5","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/s41401-023-01202-7","article-title":"Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK\/FoxO3\/SIRT3 axis","volume":"45","author":"Fu","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tice.2026.103875_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells14131026","article-title":"The effects of different types of exercise on pulmonary inflammation and fibrosis in mice with type 2 diabetes mellitus","volume":"14","author":"Gao","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.tice.2026.103875_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s40265-021-01487-0","article-title":"Nintedanib: a review in fibrotic interstitial lung diseases","volume":"81","author":"Lamb","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.tice.2026.103875_bib8","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1038\/ki.2010.418","article-title":"Mechanistic connection between inflammation and fibrosis","author":"Lee","year":"2010","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.tice.2026.103875_bib9","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/annrheumdis-2016-209698","article-title":"The transcription factor GLI2 as a downstream mediator of transforming growth factor-\u03b2-induced fibroblast activation in SSc","volume":"76","author":"Liang","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.tice.2026.103875_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.26502\/aimr.0165","article-title":"Pulmonary fibrosis and diabetes mellitus: two coins with the same face","volume":"7","author":"Mari","year":"2024","journal-title":"Arch. Intern. Med. Res."},{"key":"10.1016\/j.tice.2026.103875_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12985-022-01814-1","article-title":"COVID-19 infection: an overview on cytokine storm and related interventions","volume":"19","author":"Montazersaheb","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.tice.2026.103875_bib12","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev-pathol-042320-030240","article-title":"Pathogenic mechanisms underlying idiopathic pulmonary fibrosis","volume":"17","author":"Moss","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.tice.2026.103875_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1431405","article-title":"Evaluating the impact of type 2 diabetes mellitus on pulmonary vascular function and the development of pulmonary fibrosis","volume":"15","author":"Mzimela","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2026.103875_bib14","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12964-024-01925-y","article-title":"The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19","volume":"22","author":"Niayesh-Mehr","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.tice.2026.103875_bib15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/intimm\/dxab040","article-title":"Macrophages in lung fibrosis","volume":"33","author":"Ogawa","year":"2021","journal-title":"Int. Immunol."},{"key":"10.1016\/j.tice.2026.103875_bib16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbadis.2009.06.004","article-title":"TGF-beta and fibrosis in different organs - molecular pathway imprints","volume":"1792","author":"Pohlers","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tice.2026.103875_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6521218","article-title":"Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2\/STAT3 signaling pathway in vivo and in vitro","volume":"2019","author":"Qaed","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103875_bib18","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of idiopathic pulmonary fibrosis. an official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tice.2026.103875_bib19","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","article-title":"An Official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. an update of the 2011 clinical practice guideline","volume":"192","author":"Raghu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tice.2026.103875_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12890-024-02840-1","article-title":"Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training","volume":"24","author":"Rajizadeh","year":"2024","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.tice.2026.103875_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s13287-022-03136-z","article-title":"Human pluripotent stem cell-derived macrophages and macrophage-derived exosomes: therapeutic potential in pulmonary fibrosis","volume":"13","author":"Rasaei","year":"2022","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.tice.2026.103875_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30449-y","article-title":"Diabetes induces fibrotic changes in the lung through the activation of TGF-\u03b2 signaling pathways","volume":"8","author":"Talakatta","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103875_bib23","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/annrheumdis-2014-206234","article-title":"Tribbles homologue 3 stimulates canonical TGF-\u03b2 signalling to regulate fibroblast activation and tissue fibrosis","volume":"75","author":"Tomcik","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.tice.2026.103875_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/14656566.2018.1425681","article-title":"Nintedanib for the treatment of idiopathic pulmonary fibrosis","volume":"19","author":"Varone","year":"2018","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.tice.2026.103875_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fpubh.2020.00196","article-title":"Diabetes mellitus contributes to idiopathic pulmonary fibrosis: a review from clinical appearance to possible pathogenesis","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Public. Health"},{"key":"10.1016\/j.tice.2026.103875_bib26","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00161-2019","article-title":"Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases","volume":"54","author":"Wollin","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.tice.2026.103875_bib27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/jcmm.13085","article-title":"Activation of Wnt\/\u03b2-catenin signalling is required for TGF-\u03b2\/Smad2\/3 signalling during myofibroblast proliferation","volume":"21","author":"Xu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tice.2026.103875_bib28","article-title":"Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tice.2026.103875_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14336\/AD.2016.0627","article-title":"Potential biochemical mechanisms of lung injury in diabetes","volume":"8","author":"Zheng","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.tice.2026.103875_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12931-024-02878-z","article-title":"Current state of signaling pathways associated with the pathogenesis of idiopathic pulmonary fibrosis","volume":"25","author":"Zhou","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.tice.2026.103875_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5188306","article-title":"Mitochondrial dysfunction in chronic respiratory diseases: implications for the pathogenesis and potential therapeutics","volume":"2021","author":"Zhou","year":"2021","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:43:36Z","timestamp":1789587816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626005707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":31,"alternative-id":["S0040816626005707"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103875","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphocreatine mitigates pulmonary fibrosis in STZ-induced diabetic rats with bleomycin injury through TGF-\u03b2\/Smad and Wnt\/\u03b2-catenin pathways","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103875"}}