{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:14:06Z","timestamp":1792444446774,"version":"4.5.0"},"reference-count":226,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103884","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:17:57Z","timestamp":1787325477000},"page":"103884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P2","title":["Melatonin: A versatile neuroprotective molecule in neurodegenerative diseases: A narrative review"],"prefix":"10.1016","volume":"104","author":[{"given":"Amirreza Ahmadi","family":"Jazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Babak","family":"Mojaveraghili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Amirkhanlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Yekani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Farzanegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mostafa","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yousef","family":"Memar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09291016.2024.2430563","article-title":"Exploring melatonin\u2019s therapeutic potential in neurological disorders: a review of current evidence","volume":"56","author":"Singh","year":"2025","journal-title":"Biol. Rhythm. Res."},{"key":"10.1016\/j.tice.2026.103884_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102480","article-title":"Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment","volume":"101","author":"Reiter","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.32794\/mr112500141","article-title":"Melatonin: An anticancer molecule in esophageal squamous cell carcinoma: A mechanistic review","volume":"6","author":"Heydari","year":"2023","journal-title":"Melatonin Res."},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib4","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s10787-025-01751-9","article-title":"Multifaceted roles of melatonin in oncology: an insight into its therapeutic potential in cancer management","volume":"33","author":"Maghsoudi","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.tice.2026.103884_bib5","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3389\/fphar.2023.1332567","article-title":"The potential influence of melatonin on mitochondrial quality control: a review","volume":"14","author":"Lei","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.32794\/mr112500165","article-title":"Nanocarriers for melatonin delivery","volume":"6","author":"Jazi","year":"2023","journal-title":"Melatonin Res."},{"key":"10.1016\/j.tice.2026.103884_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113548","article-title":"Molecular pathways and biological roles of melatonin and vitamin D; effects on immune system and oxidative stress","volume":"143","author":"Yousefi","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib8","article-title":"Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases","volume":"15","author":"Bao","year":"2026","journal-title":"Biol. (Basel)"},{"key":"10.1016\/j.tice.2026.103884_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biochi.2022.06.008","article-title":"Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy","volume":"202","author":"Targhazeh","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.tice.2026.103884_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116487","article-title":"Gut microbiota in neurological diseases: Melatonin plays an important regulatory role","volume":"174","author":"Ahmadi","year":"2024","journal-title":"Biomed. & Pharmacother."},{"issue":"13","key":"10.1016\/j.tice.2026.103884_bib11","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1039\/D4BM01609B","article-title":"Melatonin and the nervous system: nanomedicine perspectives","volume":"13","author":"Luo","year":"2025","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41380-024-02691-6","article-title":"Melatonin: A potential nighttime guardian against Alzheimer\u2019s","volume":"30","author":"Zhang","year":"2025","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/cxo.12824","article-title":"Ocular and systemic melatonin and the influence of light exposure","volume":"102","author":"Ostrin","year":"2019","journal-title":"Clin. Exp. Optom."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1521-690X(03)00016-2","article-title":"Melatonin: clinical relevance","volume":"17","author":"Reiter","year":"2003","journal-title":"Best. Pract. & Res. Clin. Endocrinol. & Metab."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23020272","article-title":"Evaluation of Melatonin Secretion and Metabolism Exponents in Patients with Ulcerative and Lymphocytic Colitis","volume":"23","author":"Chojnacki","year":"2018","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.tice.2026.103884_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082439","article-title":"Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3","volume":"19","author":"Reiter","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cells11101690","article-title":"Activation of MT1\/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1\/Nrf2 Signaling Pathway","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12952","article-title":"Melatonin receptor structure and signaling","volume":"76","author":"Okamoto","year":"2024","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/cbf.3672","article-title":"Melatonin: A smart molecule in the DNA repair system","volume":"40","author":"Mir","year":"2022","journal-title":"Cell. Biochem. Funct."},{"key":"10.1016\/j.tice.2026.103884_bib20","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.3390\/ijms140611208","article-title":"Melatonin receptor genes in vertebrates","volume":"14","author":"Li","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103884_bib21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejphar.2015.07.010","article-title":"Antinociceptive properties of selective MT2 melatonin receptor partial agonists","volume":"764","author":"L\u00f3pez-Canul","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tice.2026.103884_bib22","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/ijms17122124","article-title":"Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics","volume":"17","author":"Tan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1055\/a-2226-3971","article-title":"Revealing Melatonin's Mysteries: Receptors, Signaling Pathways, and Therapeutics Applications","volume":"56","author":"Kulsoom","year":"2024","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.tice.2026.103884_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5152\/eurasianjmed.2015.0267","article-title":"A review of melatonin, its receptors and drugs","volume":"48","author":"Emet","year":"2016","journal-title":"Eurasia J. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13024-024-00728-6","article-title":"Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration","volume":"19","author":"Yehia","year":"2024","journal-title":"Mol. Neurodegener."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10522-025-10254-7","article-title":"Unveiling mysteries of aging: the potential of melatonin in preventing neurodegenerative diseases in older adults","volume":"26","author":"Unal","year":"2025","journal-title":"Biogerontology"},{"issue":"11","key":"10.1016\/j.tice.2026.103884_bib27","doi-asserted-by":"crossref","first-page":"11139","DOI":"10.18632\/aging.103328","article-title":"Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.tice.2026.103884_bib28","doi-asserted-by":"crossref","DOI":"10.2174\/0109298673416300251023052701","article-title":"Melatonin: Novel Insights in the Treatment of Neurodegenerative Diseases","author":"Lashgari","year":"2026","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib29","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1007\/s00210-023-02939-y","article-title":"Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders","volume":"397","author":"Giri","year":"2024","journal-title":"Naunyn-Schmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.tice.2026.103884_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2018.04.027","article-title":"Melatonin decreases neuronal excitability in a sub-population of dorsal root ganglion neurons","volume":"1692","author":"Oliveira-Abreu","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.tice.2026.103884_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnmol.2018.00093","article-title":"Melatonin Regulates Apoptosis and Autophagy Via ROS-MST1 Pathway in Subarachnoid Hemorrhage","volume":"11","author":"Shi","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.tice.2026.103884_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fnagi.2017.00165","article-title":"Melatonin supplementation, a strategy to prevent neurological diseases through maintaining integrity of blood brain barrier in old people","volume":"9","author":"Liu","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23020509","article-title":"Mitochondria: Central Organelles for Melatonin's Antioxidant and Anti-Aging Actions","volume":"23","author":"Reiter","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12419","article-title":"Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis","volume":"63","author":"Zhai","year":"2017","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2021.08.010","article-title":"Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects","volume":"87","author":"Zakria","year":"2021","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tice.2026.103884_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.04.031","article-title":"Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism","volume":"73","author":"Ding","year":"2014","journal-title":"Free. Radic. Biol. Med."},{"issue":"3-4","key":"10.1016\/j.tice.2026.103884_bib38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pathophys.2019.11.003","article-title":"Wi-Fi decreases melatonin protective effect and increases hippocampal neuronal damage in pentylenetetrazole induced model seizures in rats","volume":"26","author":"Akkaya","year":"2019","journal-title":"Pathophysiology"},{"key":"10.1016\/j.tice.2026.103884_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2018.11.007","article-title":"Environmental enrichment restores oxidative balance in animals chronically exposed to toluene: Comparison with melatonin","volume":"144","author":"Montes","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/fcp.12181","article-title":"Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats","volume":"30","author":"Shang","year":"2016","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"9","key":"10.1016\/j.tice.2026.103884_bib41","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1007\/s12035-016-0209-4","article-title":"Phytanic Acid-Induced Neurotoxicological Manifestations and Apoptosis Ameliorated by Mitochondria-Mediated Actions of Melatonin","volume":"54","author":"Chaudhary","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/iep.12122","article-title":"The protective properties of melatonin against aluminium-induced neuronal injury","volume":"96","author":"Al-Olayan","year":"2015","journal-title":"Int. J. Exp. Pathol."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12463","article-title":"Melatonin prevents hypochlorous acid-mediated cyanocobalamin destruction and cyanogen chloride generation","volume":"64","author":"Jeelani","year":"2018","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-079X.1997.tb00331.x","article-title":"Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus)","volume":"23","author":"Guerrero","year":"1997","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.exger.2016.06.014","article-title":"Melatonin alleviates hyperthyroidism induced oxidative stress and neuronal cell death in hippocampus of aged female golden hamster, Mesocricetus auratus","volume":"82","author":"Rao","year":"2016","journal-title":"Exp. Gerontol."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2500\/ajra.2016.30.4313","article-title":"Protective effects of melatonin and selenium against apoptosis of olfactory sensory neurons: A rat model study","volume":"30","author":"Koc","year":"2016","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.tice.2026.103884_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1596362","article-title":"Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex","volume":"2022","author":"Suwannakot","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib48","doi-asserted-by":"crossref","first-page":"18886","DOI":"10.3390\/molecules201018886","article-title":"Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism","volume":"20","author":"Tan","year":"2015","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.tice.2026.103884_bib49","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.1002\/jcp.29722","article-title":"Neuroprotective effect of melatonin on radiation-induced oxidative stress and apoptosis in the brainstem of rats","volume":"235","author":"Motallebzadeh","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib50","first-page":"86","article-title":"Melatonin in Mitochondria: Mitigating Clear and Present Dangers","volume":"35","author":"Reiter","year":"2020","journal-title":"Physiol. (Bethesda)"},{"issue":"38","key":"10.1016\/j.tice.2026.103884_bib51","doi-asserted-by":"crossref","first-page":"E7997","DOI":"10.1073\/pnas.1705768114","article-title":"Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release","volume":"114","author":"Suofu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-079X.2011.00931.x","article-title":"Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations","volume":"52","author":"Venegas","year":"2012","journal-title":"J. Pineal Res."},{"issue":"1-2","key":"10.1016\/j.tice.2026.103884_bib53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0300-483X(02)00244-5","article-title":"Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro","volume":"179","author":"Yamamoto","year":"2002","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41398-021-01464-x","article-title":"Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders","volume":"11","author":"Melhuish Beaupre","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib55","doi-asserted-by":"crossref","first-page":"22167","DOI":"10.1038\/s41598-021-01746-w","article-title":"Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis","volume":"11","author":"Favrais","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103884_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134376","article-title":"Effect of melatonin on A\u03b242 induced changes in the mitochondrial function related to Alzheimer's disease in Drosophila melanogaster","volume":"711","author":"Khatoon","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12515","article-title":"Melatonin induces mechanisms of brain resilience against neurodegeneration","volume":"65","author":"Corpas","year":"2018","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib58","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/156802611794863517","article-title":"Melatonin-mitochondria interplay in health and disease","volume":"11","author":"Acu\u00f1a Castroviejo","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"issue":"12","key":"10.1016\/j.tice.2026.103884_bib59","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.99-0865fje","article-title":"Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress","volume":"14","author":"Mart\u00edn","year":"2000","journal-title":"Faseb J."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib60","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.18632\/aging.102930","article-title":"Gut microbiota and pro\/prebiotics in Alzheimer's disease","volume":"12","author":"Pluta","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.tice.2026.103884_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110887","article-title":"Melatonin regulates A\u03b2 production\/clearance balance and A\u03b2 neurotoxicity: A potential therapeutic molecule for Alzheimer's disease","volume":"132","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"10284","key":"10.1016\/j.tice.2026.103884_bib62","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib63","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1073\/pnas.0904532106","article-title":"Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity","volume":"107","author":"Friedrich","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"19","key":"10.1016\/j.tice.2026.103884_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197174","article-title":"Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases","volume":"21","author":"Luo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2025.e41841","article-title":"Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer's disease: Insights from cerebrospinal fluid analysis","volume":"11","author":"Artime-Naveda","year":"2025","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1745-7254.2006.00260.x","article-title":"Role of melatonin in Alzheimer-like neurodegeneration 1","volume":"27","author":"WANG","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib67","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-4889(00)00127-0","article-title":"N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin","volume":"1499","author":"Bordt","year":"2001","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Cell Research"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1034\/j.1600-079X.2000.290102.x","article-title":"PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells","volume":"29","author":"Ben\u00edtez-King","year":"2000","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib69","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-079X.2004.00136.x","article-title":"Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat","volume":"37","author":"Zhu","year":"2004","journal-title":"J. Pineal Res."},{"issue":"1-2","key":"10.1016\/j.tice.2026.103884_bib70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0304-3940(92)90839-Y","article-title":"Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments","volume":"148","author":"Ishiguro","year":"1992","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib71","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/excr.2001.5152","article-title":"A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons","volume":"264","author":"Alvarez","year":"2001","journal-title":"Exp. Cell. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib72","first-page":"183","article-title":"Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin","volume":"23","author":"Liu","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib73","first-page":"7","article-title":"Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng li xue bao","volume":"57","author":"Wang","year":"2005","journal-title":"Acta Physiol. Sin."},{"key":"10.1016\/j.tice.2026.103884_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110887","article-title":"Melatonin regulates A\u03b2 production\/clearance balance and A\u03b2 neurotoxicity: A potential therapeutic molecule for Alzheimer\u2019s disease","volume":"132","author":"Li","year":"2020","journal-title":"Biomed. & Pharmacother."},{"issue":"4558","key":"10.1016\/j.tice.2026.103884_bib75","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1745-7254.2006.00260.x","article-title":"Role of melatonin in Alzheimer-like neurodegeneration","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib77","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0026-895X(24)12312-7","article-title":"Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants","volume":"60","author":"Guermonprez","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib78","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.neuropharm.2009.01.005","article-title":"A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia","volume":"56","author":"Agrawal","year":"2009","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib79","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/jpi.12097","article-title":"Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of D own syndrome","volume":"56","author":"Corrales","year":"2014","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib80","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1750-3639.1993.tb00729.x","article-title":"Synapsin I, synapsin II, and synaptophysin: marker proteins of synaptic vesicles","volume":"3","author":"Thiel","year":"1993","journal-title":"Brain Pathol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib81","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/hipo.22358","article-title":"Acute melatonin treatment alters dendritic morphology and circadian clock gene expression in the hippocampus of S iberian H amsters","volume":"25","author":"Ikeno","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.tice.2026.103884_bib82","doi-asserted-by":"crossref","first-page":"8255","DOI":"10.1007\/s12035-019-01660-3","article-title":"Melatonin in Alzheimer\u2019s disease: a latent endogenous regulator of neurogenesis to mitigate Alzheimer\u2019s neuropathology","volume":"56","author":"Hossain","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.tice.2026.103884_bib83","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2174\/1570159X15666170313123454","article-title":"Mechanisms of Melatonin in Alleviating Alzheimer's Disease","volume":"15","author":"Shukla","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.tice.2026.103884_bib84","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1750-1326-5-46","article-title":"Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model","volume":"5","author":"Wang","year":"2010","journal-title":"Mol. Neurodegener."},{"issue":"7","key":"10.1016\/j.tice.2026.103884_bib85","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1096\/fj.03-1031fje","article-title":"Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin","volume":"18","author":"Andrabi","year":"2004","journal-title":"Faseb J."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib86","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/(SICI)1097-4644(19970601)65:3<430::AID-JCB12>3.0.CO;2-J","article-title":"Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin","volume":"65","author":"Pozo","year":"1997","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib87","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-079X.1999.tb00575.x","article-title":"Melatonin affects the metabolism of the \u03b2-amyloid precursor protein in different cell types","volume":"26","author":"Lahiri","year":"1999","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib88","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02736852","article-title":"Melatonin alters the metabolism of the \u03b2-amyloid precursor protein in the neuroendocrine cell line PC12","volume":"9","author":"Song","year":"1997","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib89","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/jpi.12200","article-title":"Melatonin stimulates the nonamyloidogenic processing of \u03b2APP through the positive transcriptional regulation of ADAM10 and ADAM17","volume":"58","author":"Shukla","year":"2015","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib90","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/jpi.12260","article-title":"Melatonin regulates the transcription of \u03b2APP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells","volume":"59","author":"Panmanee","year":"2015","journal-title":"J. Pineal Res."},{"issue":"49","key":"10.1016\/j.tice.2026.103884_bib91","doi-asserted-by":"crossref","first-page":"14995","DOI":"10.1021\/bi0114269","article-title":"Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid A\u03b2 peptide","volume":"40","author":"Poeggeler","year":"2001","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib92","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-079X.2011.00937.x","article-title":"Alzheimer\u2019s disease: pathological mechanisms and the beneficial role of melatonin","volume":"52","author":"Rosales-Corral","year":"2012","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib93","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0009-2797(00)00319-7","article-title":"Melatonin reduces interleukin secretion in amyloid-beta stressed mouse brain slices","volume":"134","author":"Clapp-Lilly","year":"2001","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib94","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/cbin.70013","article-title":"A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous \u03b2-amyloid-42 Induced Mitochondrial Impairment, Intracellular \u03b2-amyloid Accumulation and Tau Hyperphosphorylation in Human SH-SY5Y Cells","volume":"49","author":"Panmanee","year":"2025","journal-title":"Cell. Biol. Int."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib95","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF03033887","article-title":"Role of melatonin in neurodegenerative diseases","volume":"7","author":"Srinivasan","year":"2005","journal-title":"Neurotox. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib96","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/biology15020189","article-title":"Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases","volume":"15","author":"Bao","year":"2026","journal-title":"Biology"},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib97","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-079X.1999.tb00619.x","article-title":"Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin","volume":"27","author":"Pappolla","year":"1999","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib98","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00018-023-04736-5","article-title":"Brain washing and neural health: Role of age, sleep, and the cerebrospinal fluid melatonin rhythm","volume":"80","author":"Reiter","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib99","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1272\/jnms.70.334","article-title":"Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia","volume":"70","author":"Asayama","year":"2003","journal-title":"J. Nippon. Med. Sch."},{"key":"10.1016\/j.tice.2026.103884_bib100","first-page":"947","article-title":"Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial","volume":"9","author":"Wade","year":"2014","journal-title":"Clin. Interv. Aging"},{"issue":"7","key":"10.1016\/j.tice.2026.103884_bib101","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/sleep\/26.7.893","article-title":"A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease","volume":"26","author":"Singer","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.tice.2026.103884_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.784314","article-title":"Melatonin Treatment for Sleep Disorders in Parkinson's Disease: A Meta-Analysis and Systematic Review","volume":"14","author":"Ma","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"10423","key":"10.1016\/j.tice.2026.103884_bib103","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib104","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ncl.2024.12.003","article-title":"Pathogenesis of Parkinson's Disease","volume":"43","author":"Xiao","year":"2025","journal-title":"Neurol. Clin."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13060914","article-title":"Parkinson's Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, REM Behavior Disorder, and Melatonin","volume":"13","author":"Samizadeh","year":"2023","journal-title":"Brain Sci."},{"issue":"16","key":"10.1016\/j.tice.2026.103884_bib106","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: a review","volume":"311","author":"Connolly","year":"2014","journal-title":"Jama"},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib107","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24033022","article-title":"Oxidative Stress and Aging as Risk Factors for Alzheimer's Disease and Parkinson's Disease: The Role of the Antioxidant Melatonin","volume":"24","author":"Tchekalarova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103884_bib108","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.09.012","article-title":"Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease","volume":"155","author":"Zucca","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"2-3","key":"10.1016\/j.tice.2026.103884_bib109","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tox.2008.01.020","article-title":"Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells","volume":"246","author":"Wang","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tice.2026.103884_bib110","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5577541","article-title":"Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease","volume":"2021","author":"Jim\u00e9nez-Delgado","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103884_bib111","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.lfs.2017.11.016","article-title":"Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease","volume":"192","author":"Paul","year":"2018","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib112","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.sleep.2005.04.004","article-title":"Melatonin for sleep disturbances in Parkinson's disease","volume":"6","author":"Dowling","year":"2005","journal-title":"Sleep. Med."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib113","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2869.2010.00848.x","article-title":"A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder","volume":"19","author":"Kunz","year":"2010","journal-title":"J. Sleep. Res."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib114","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/jpi.12212","article-title":"Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinsonism in mice","volume":"58","author":"Naskar","year":"2015","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib115","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1034\/j.1600-079X.2002.01871.x","article-title":"Melatonin attenuates MPP+-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway","volume":"32","author":"Chen","year":"2002","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib116","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-079X.2005.00209.x","article-title":"Melatonin protects against MPTP\/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro","volume":"39","author":"Chen","year":"2005","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib117","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-079X.2010.00819.x","article-title":"Melatonin or silymarin reduces maneb-and paraquat-induced Parkinson\u2019s disease phenotype in the mouse","volume":"50","author":"Singhal","year":"2011","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib118","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.pbb.2011.06.026","article-title":"Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease","volume":"99","author":"Patki","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib119","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10571-019-00720-5","article-title":"Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms","volume":"40","author":"Tamtaji","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib120","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(02)02551-9","article-title":"Protective effect of melatonin in a chronic experimental model of Parkinson's disease","volume":"943","author":"Antol\u00edn","year":"2002","journal-title":"Brain Res."},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib121","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1080\/15548627.2015.1082020","article-title":"Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA\/\u03b1-synuclein aggregation","volume":"11","author":"Su","year":"2015","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib122","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/jpi.12343","article-title":"Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment","volume":"61","author":"Chuang","year":"2016","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib123","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-079X.2011.00945.x","article-title":"Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and \u03b1-synuclein aggregation","volume":"52","author":"Chang","year":"2012","journal-title":"J. Pineal Res."},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib124","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1007\/s10072-022-06188-4","article-title":"Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders: a randomized, double-blind trial","volume":"43","author":"Hadi","year":"2022","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.tice.2026.103884_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.105878","article-title":"Melatonin supplementation and the effects on clinical and metabolic status in Parkinson's disease: A randomized, double-blind, placebo-controlled trial","volume":"195","author":"Daneshvar Kakhaki","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib126","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12909","article-title":"Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease","volume":"75","author":"Kim","year":"2023","journal-title":"J. Pineal Res."},{"issue":"8","key":"10.1016\/j.tice.2026.103884_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/biom10081158","article-title":"Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases","volume":"10","author":"Chen","year":"2020","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.tice.2026.103884_bib128","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/mds.26003","article-title":"Plasma melatonin is reduced in Huntington's disease","volume":"29","author":"Kalliolia","year":"2014","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib129","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12624","article-title":"Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?","volume":"68","author":"Morton","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbr.2014.01.048","article-title":"Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease","volume":"264","author":"Chakraborty","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.tice.2026.103884_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1637881","article-title":"Dysregulation of melatonin rhythm in Parkinson's and Huntington's disease: a systematic review and meta-analysis","volume":"17","author":"Suram","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tice.2026.103884_bib132","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnmol.2017.00049","article-title":"Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance","volume":"10","author":"Xue","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"38","key":"10.1016\/j.tice.2026.103884_bib133","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1523\/JNEUROSCI.1867-08.2008","article-title":"Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib134","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1755-5949.2009.00105.x","article-title":"The antiapoptotic activity of melatonin in neurodegenerative diseases","volume":"15","author":"Wang","year":"2009","journal-title":"CNS Neurosci. Ther."},{"issue":"41","key":"10.1016\/j.tice.2026.103884_bib135","doi-asserted-by":"crossref","first-page":"14496","DOI":"10.1523\/JNEUROSCI.3059-11.2011","article-title":"The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity","volume":"31","author":"Wang","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.103884_bib136","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.sleep.2025.02.032","article-title":"Melatonin for Huntington's Disease (HD) gene carriers with HD-related sleep disturbance - A pilot study","volume":"129","author":"Zadegan","year":"2025","journal-title":"Sleep. Med."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib137","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/jnr.24820","article-title":"Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial","volume":"99","author":"Verma","year":"2021","journal-title":"J. Neurosci. Res."},{"issue":"9","key":"10.1016\/j.tice.2026.103884_bib138","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41573-024-00981-w","article-title":"New epilepsy therapies in development","volume":"23","author":"Klein","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib139","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1055\/s-0040-1718719","article-title":"Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology.","volume":"40","author":"Falco-Walter","year":"2020","journal-title":"Semin. Neurol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib140","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2860","article-title":"Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial","volume":"13","author":"Maghbooli","year":"2023","journal-title":"Brain Behav."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib141","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2860","article-title":"Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial","volume":"13","author":"Maghbooli","year":"2023","journal-title":"Brain Behav."},{"issue":"9","key":"10.1016\/j.tice.2026.103884_bib142","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41573-024-00981-w","article-title":"New epilepsy therapies in development","volume":"23","author":"Klein","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"12","key":"10.1016\/j.tice.2026.103884_bib143","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1177\/0883073811435916","article-title":"Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study","volume":"27","author":"Goldberg-Stern","year":"2012","journal-title":"J. Child. Neurol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib144","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-079X.2010.00828.x","article-title":"Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy","volume":"50","author":"Uberos","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135713","article-title":"Combined melatonin and adrenocorticotropic hormone treatment attenuates N-methyl-d-aspartate-induced infantile spasms in a rat model by regulating activation of the HPA axis","volume":"748","author":"Wan","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib146","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yebeh.2012.08.012","article-title":"Melatonin secretion in children with epilepsy","volume":"25","author":"Praninskiene","year":"2012","journal-title":"Epilepsy Behav."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib147","article-title":"Relationship between Juvenile Myoclonic Epilepsy and Melatonin","volume":"39","author":"ATLAS","year":"2023","journal-title":"Sel. \u00e7uk T\u0131p Derg."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib148","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.900","article-title":"Melatonin regulates microglial polarization to M2 cell via RhoA\/ROCK signaling pathway in epilepsy","volume":"11","author":"Li","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib149","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.900","article-title":"Melatonin regulates microglial polarization to M2 cell via RhoA\/ROCK signaling pathway in epilepsy","volume":"11","author":"Li","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.tice.2026.103884_bib150","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9997582","article-title":"Melatonin ameliorates valproic acid-induced neurogenesis impairment: the role of oxidative stress in adult rats","volume":"2021","author":"Aranarochana","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(11)70393-0","article-title":"Melatonin in experimental seizures and epilepsy","volume":"63","author":"Banach","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tice.2026.103884_bib152","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2013.05.058","article-title":"Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration","volume":"548","author":"Dardiotis","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tice.2026.103884_bib153","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fnins.2019.01310","article-title":"ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?","volume":"13","author":"Mejzini","year":"2019","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib154","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/01.NURSE.0000905700.44849.f4","article-title":"Navigating ALS: An overlooked disease","volume":"53","author":"Kiper","year":"2023","journal-title":"Nursing2023"},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib155","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/ene.14393","article-title":"Amyotrophic lateral sclerosis: a clinical review","volume":"27","author":"Masrori","year":"2020","journal-title":"Eur. J. Neurol."},{"issue":"10360","key":"10.1016\/j.tice.2026.103884_bib156","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic lateral sclerosis","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib157","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41573-022-00612-2","article-title":"Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation","volume":"22","author":"Mead","year":"2023","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib158","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/mus.27168","article-title":"Melatonin may slow disease progression in amyotrophic lateral sclerosis: Findings from the Pooled Resource Open-Access ALS Clinic Trials database","volume":"63","author":"Bald","year":"2021","journal-title":"Muscle Nerve"},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib159","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1034\/j.1600-079X.2002.02943.x","article-title":"Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients","volume":"33","author":"Jacob","year":"2002","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib160","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2013.03.008","article-title":"Melatonin inhibits the caspase-1\/cytochrome c\/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis","volume":"55","author":"Zhang","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib161","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-079X.2006.00377.x","article-title":"Reduced oxidative damage in ALS by high-dose enteral melatonin treatment","volume":"41","author":"Weishaupt","year":"2006","journal-title":"J. Pineal Res."},{"issue":"8","key":"10.1016\/j.tice.2026.103884_bib162","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and Treatment of Multiple Sclerosis: A Review","volume":"325","author":"McGinley","year":"2021","journal-title":"Jama"},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib163","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10787-022-01011-0","article-title":"Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action","volume":"30","author":"Mu\u00f1oz-Jurado","year":"2022","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib164","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10787-022-01011-0","article-title":"Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action: A. Mu\u00f1oz-Jurado et al","volume":"30","author":"Mu\u00f1oz-Jurado","year":"2022","journal-title":"Inflammopharmacology"},{"issue":"8","key":"10.1016\/j.tice.2026.103884_bib165","article-title":"Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment","volume":"103","author":"Haki","year":"2024","journal-title":"Med. (Baltim. )"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib166","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/2319-4170.125885","article-title":"Serum levels of melatonin and cytokines in multiple sclerosis","volume":"37","author":"Farhadi","year":"2014","journal-title":"Biomed. J."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib167","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/fcp.12337","article-title":"Melatonin therapy reduces the risk of osteoporosis and normalizes bone formation in multiple sclerosis","volume":"32","author":"Ghareghani","year":"2018","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib168","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.msard.2014.12.001","article-title":"Multiple sclerosis: the role of melatonin and N-acetylserotonin","volume":"4","author":"Anderson","year":"2015","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.tice.2026.103884_bib169","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1007\/s00221-014-3946-5","article-title":"Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis","volume":"232","author":"Kashani","year":"2014","journal-title":"Exp. brain Res."},{"key":"10.1016\/j.tice.2026.103884_bib170","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s40261-019-00793-6","article-title":"Melatonin and multiple sclerosis: from plausible neuropharmacological mechanisms of action to experimental and clinical evidence","volume":"39","author":"Yeganeh Salehpour","year":"2019","journal-title":"Clin. Drug. Investig."},{"key":"10.1016\/j.tice.2026.103884_bib171","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10571-018-0580-y","article-title":"Spasticity treatment ameliorates the efficacy of melatonin therapy in experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis","volume":"38","author":"Ghareghani","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib172","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11481-016-9702-9","article-title":"Efficacy of N-acetylserotonin and melatonin in the EAE model of multiple sclerosis","volume":"11","author":"Wen","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.tice.2026.103884_bib173","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbi.2015.06.021","article-title":"Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector\/regulatory balance","volume":"50","author":"\u00c1lvarez-S\u00e1nchez","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.tice.2026.103884_bib174","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.intimp.2015.12.020","article-title":"Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis","volume":"31","author":"Chen","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tice.2026.103884_bib175","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1007\/s12035-015-9404-y","article-title":"The effect of melatonin on behavioral, molecular, and histopathological changes in cuprizone model of demyelination","volume":"53","author":"Vakilzadeh","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tice.2026.103884_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115191","article-title":"12-week melatonin supplementation improved dynamic postural stability and walking performance in persons living with multiple sclerosis: A randomized controlled trial","volume":"476","author":"Jallouli","year":"2025","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib177","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.arcmed.2018.12.004","article-title":"Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis","volume":"49","author":"S\u00e1nchez-L\u00f3pez","year":"2018","journal-title":"Arch. Med. Res."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib178","first-page":"589","article-title":"Impact of Melatonin on Motor, Cognitive and Neuroimaging Indices in Patients with Multiple Sclerosis","volume":"14","author":"Roostaei","year":"2015","journal-title":"Iran. J. Allergy Asthma Immunol."},{"issue":"6","key":"10.1016\/j.tice.2026.103884_bib179","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304043","article-title":"Systematic review and meta-analysis on the prevalence and associated factors of depression among hypertensive patients in Ethiopia","volume":"19","author":"Tassew","year":"2024","journal-title":"PLoS. One"},{"key":"10.1016\/j.tice.2026.103884_bib180","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.2147\/NDT.S384879","article-title":"Study on the Changes in Circadian Rhythm Before and After Treatment and the Influencing Factors in Patients with Depression","author":"Guo","year":"2022","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib181","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41398-023-02614-z","article-title":"Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization","volume":"13","author":"Yao","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.tice.2026.103884_bib182","author":"Srinivasan","year":"2010","journal-title":"Sleep. mood Disord. antidepressants melatonergic antidepressant agomelatine Offers a New. Strategy Treat."},{"key":"10.1016\/j.tice.2026.103884_bib183","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113724","article-title":"Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment","volume":"420","author":"Wang","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.tice.2026.103884_bib184","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.smrv.2016.06.007","article-title":"Chronotype and circadian rhythm in bipolar disorder: a systematic review","volume":"34","author":"Melo","year":"2017","journal-title":"Sleep. Med. Rev."},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152814","article-title":"Salivary melatonin in relation to depressive symptom severity in young adults","volume":"11","author":"Sundberg","year":"2016","journal-title":"PLoS. One"},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib186","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3109\/07420528.2014.992525","article-title":"Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder","volume":"32","author":"Nagy","year":"2015","journal-title":"Chronobiol. Int."},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib187","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1177\/02698811211032439","article-title":"Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction","volume":"35","author":"Thomson","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib188","first-page":"35","article-title":"Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility","volume":"49","author":"Soria","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tice.2026.103884_bib189","first-page":"905","article-title":"ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder","volume":"20","author":"Talarowska","year":"2014","journal-title":"Medical science monitor international medical journal experimental clinical research"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib190","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-1781(97)00128-5","article-title":"Melatonin treatment of winter depression: a pilot study","volume":"77","author":"Lewy","year":"1998","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.tice.2026.103884_bib191","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jpsychires.2015.04.024","article-title":"Changes in cognitive symptoms after a buspirone\u2013melatonin combination treatment for major depressive disorder","volume":"68","author":"Targum","year":"2015","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib192","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.sleep.2009.07.013","article-title":"Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome","volume":"11","author":"Rahman","year":"2010","journal-title":"Sleep. Med."},{"issue":"5332","key":"10.1016\/j.tice.2026.103884_bib193","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","article-title":"Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress","volume":"277","author":"Liu","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tice.2026.103884_bib194","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1241894","article-title":"Melatonin alleviates neuroinflammation and metabolic disorder in DSS-induced depression rats","volume":"2020","author":"Lv","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib195","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/WNR.0000000000001554","article-title":"Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus","volume":"32","author":"Wang","year":"2020","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib196","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.pnpbp.2011.03.021","article-title":"Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: a 24-week follow-up study","volume":"35","author":"Kotan","year":"2011","journal-title":"Progress. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.tice.2026.103884_bib197","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1080\/01480545.2020.1858853","article-title":"Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat","volume":"45","author":"Lamtai","year":"2022","journal-title":"Drug. Chem. Toxicol."},{"key":"10.1016\/j.tice.2026.103884_bib198","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.pharep.2016.04.003","article-title":"Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity","volume":"68","author":"Og\u0142odek","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tice.2026.103884_bib199","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12264-017-0189-z","article-title":"Melatonin augments the effects of fluoxetine on depression-like behavior and hippocampal BDNF\u2013TrkB signaling","volume":"34","author":"Li","year":"2018","journal-title":"Neurosci. Bull."},{"issue":"7","key":"10.1016\/j.tice.2026.103884_bib200","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.euroneuro.2006.01.005","article-title":"Melatonin affects the immobility time of rats in the forced swim test: the role of serotonin neurotransmission","volume":"16","author":"Micale","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"10","key":"10.1016\/j.tice.2026.103884_bib201","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.euroneuro.2016.07.005","article-title":"Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels","volume":"26","author":"Stefanovic","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.tice.2026.103884_bib202","doi-asserted-by":"crossref","unstructured":"Giannoni-Guzm\u00e1n, M.A., , 2020. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons. bioRxiv, 2020: p. 2020.06. 24.169532.","DOI":"10.1101\/2020.06.24.169532"},{"key":"10.1016\/j.tice.2026.103884_bib203","article-title":"Calmodulin Dependent Protein Kinase II: An Effector in the Signaling Pathway of Antidepressant-like Behavior Elicited by Ketamine in Combination with Melatonin","author":"Ben\u00edtez-King","year":"2023","journal-title":"ASPET"},{"key":"10.1016\/j.tice.2026.103884_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108368","article-title":"The protective role of melatonin in citalopram-induced reproductive toxicity via modulating nitro-oxidative stress and apoptosis in male mice","volume":"118","author":"Moradi","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tice.2026.103884_bib205","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.freeradbiomed.2017.01.005","article-title":"Ischemic brain injury: New insights on the protective role of melatonin","volume":"104","author":"Ramos","year":"2017","journal-title":"Free. Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.tice.2026.103884_bib206","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/jnr.24220","article-title":"The neuroprotective role of melatonin in neurological disorders","volume":"96","author":"Alghamdi","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.tice.2026.103884_bib207","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuro.2016.09.002","article-title":"Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices","volume":"57","author":"Pati\u00f1o","year":"2016","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib208","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1080\/10717544.2022.2104405","article-title":"Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality","volume":"29","author":"Bseiso","year":"2022","journal-title":"Drug. Deliv."},{"issue":"2-3","key":"10.1016\/j.tice.2026.103884_bib209","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0005-2728(99)00030-4","article-title":"Roles of nitric oxide in brain hypoxia-ischemia","volume":"1411","author":"Bola\u00f1os","year":"1999","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Bioenerg."},{"key":"10.1016\/j.tice.2026.103884_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111593","article-title":"Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain","volume":"139","author":"Yip","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib211","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/jpi.12148","article-title":"Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin","volume":"57","author":"Li","year":"2014","journal-title":"J. Pineal Res."},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib212","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s12031-022-01995-y","article-title":"Delayed Therapeutic Administration of Melatonin Enhances Neuronal Survival Through AKT and MAPK Signaling Pathways Following Focal Brain Ischemia in Mice","volume":"72","author":"Kilic","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.tice.2026.103884_bib213","article-title":"Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK\/FoxO3a\/Bim Pathway","volume":"2022","author":"Chen","year":"2022","journal-title":"Comput. Math. Methods Med."},{"issue":"11","key":"10.1016\/j.tice.2026.103884_bib214","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3923\/javaa.2010.1633.1638","article-title":"Melatonin potentiates cells proliferation in the dentate gyrus following ischemic brain injury in adult rats","volume":"9","author":"Ajao","year":"2010","journal-title":"J. Anim. Vet. Adv."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib215","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/aws285","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model","volume":"136","author":"Robertson","year":"2013","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib216","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1600-079X.2006.00351.x","article-title":"Melatonin decreases neurovascular oxidative\/nitrosative damage and protects against early increases in the blood\u2013brain barrier permeability after transient focal cerebral ischemia in mice","volume":"41","author":"Chen","year":"2006","journal-title":"J. Pineal Res."},{"issue":"3","key":"10.1016\/j.tice.2026.103884_bib217","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-079X.2007.00420.x","article-title":"Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats","volume":"42","author":"Lee","year":"2007","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib218","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1203\/PDR.0b013e3181fcb40b","article-title":"Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke","volume":"69","author":"Villapol","year":"2011","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib219","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1203\/01.pdr.0000252546.20451.1a","article-title":"Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion","volume":"61","author":"Welin","year":"2007","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103884_bib220","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/biores.2015.0032","article-title":"Melatonin counteracts at a transcriptional level the inflammatory and apoptotic response secondary to ischemic brain injury induced by middle cerebral artery blockade in aging rats","volume":"4","author":"Paredes","year":"2015","journal-title":"BioResearch Open. Access."},{"issue":"2","key":"10.1016\/j.tice.2026.103884_bib221","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-079X.2007.00503.x","article-title":"Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats","volume":"44","author":"Carloni","year":"2008","journal-title":"J. Pineal Res."},{"issue":"5","key":"10.1016\/j.tice.2026.103884_bib222","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s12031-022-01995-y","article-title":"Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice","volume":"72","author":"Kilic","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.tice.2026.103884_bib223","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ctim.2018.11.003","article-title":"Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence","volume":"42","author":"Foley","year":"2019","journal-title":"Complement. Ther. Med."},{"issue":"12","key":"10.1016\/j.tice.2026.103884_bib224","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s40263-019-00680-w","article-title":"Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review","volume":"33","author":"Besag","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.tice.2026.103884_bib225","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3389\/fendo.2019.00480","article-title":"Melatonin: Clinical Perspectives in Neurodegeneration","volume":"10","author":"Cardinali","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.tice.2026.103884_bib226","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00228-015-1873-4","article-title":"Clinical pharmacokinetics of melatonin: a systematic review","volume":"71","author":"Harps\u00f8e","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:24:11Z","timestamp":1789489451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626005793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":226,"alternative-id":["S0040816626005793"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103884","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin: A versatile neuroprotective molecule in neurodegenerative diseases: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103884"}}