{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:35:27Z","timestamp":1793126127838,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005071","name":"Shiraz University","doi-asserted-by":"publisher","award":["88-GR-SCST-117"],"award-info":[{"award-number":["88-GR-SCST-117"]}],"id":[{"id":"10.13039\/501100005071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103897","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:51:41Z","timestamp":1787640701000},"page":"103897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P2","title":["Enhanced renoprotective effects of remote ischemic postconditioning and alpha-lipoic acid via modulation of TLR4\/MyD88\/NF-\u03baB and Nrf2\/HO-1 pathways in renal ischemia-reperfusion injury"],"prefix":"10.1016","volume":"104","author":[{"given":"Murtadha Ghafil Jasim","family":"Hamdan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-0352","authenticated-orcid":false,"given":"Firouzeh","family":"Gholampour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Daryabor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103897_bib1","first-page":"559","article-title":"Cytotoxic and antimicrobial analysis of biosynthesized selenium nanoparticles from Solanum tuberosum peels","volume":"9","author":"Aktepe","year":"2025","journal-title":"Int. J. Agric. Environ. Food Sci."},{"key":"10.1016\/j.tice.2026.103897_bib2","doi-asserted-by":"crossref","first-page":"F272","DOI":"10.1152\/ajprenal.00352.2007","article-title":"Effects of \u03b1-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats","volume":"294","author":"Bae","year":"2008","journal-title":"Am. J. Physiol. -Ren. Physiol."},{"key":"10.1016\/j.tice.2026.103897_bib3","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/j.2040-4603.2012.tb00431.x","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.tice.2026.103897_bib4","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tice.2026.103897_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/1753944718803309","article-title":"Remote post-conditioning and allopurinol reduce ischemia-reperfusion injury in an infra-renal ischemia model","volume":"12","author":"Brand\u00e3o","year":"2018","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"10.1016\/j.tice.2026.103897_bib6","first-page":"R1362","article-title":"Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice","volume":"281","author":"Brown","year":"2001","journal-title":"Am. J. Physiol. -Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tice.2026.103897_bib7","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.12659\/MSM.908247","article-title":"Remote Ischemic Postconditioning (RIPC) of the upper arm results in protection from cardiac ischemia-reperfusion injury following Primary Percutaneous Coronary Intervention (PCI) for Acute ST-Segment Elevation Myocardial Infarction (STEMI)","volume":"24","author":"Cao","year":"2018","journal-title":"Med Sci Monit."},{"issue":"4","key":"10.1016\/j.tice.2026.103897_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/10520295.2013.847498","article-title":"The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model","volume":"89","author":"Cavdar","year":"2014","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.tice.2026.103897_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.tice.2026.103897_bib10","series-title":"Pediatric Kidney Disease","first-page":"1365","article-title":"Acute Kidney Injury: Pathophysiology, Diagnosis and Prevention","author":"Devarajan","year":"2023"},{"key":"10.1016\/j.tice.2026.103897_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5093216","article-title":"Effects of lipoic acid on ischemia-reperfusion injury","volume":"2021","author":"Ding","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tice.2026.103897_bib12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/HCO.0000000000000447","article-title":"Protecting the heart from ischemia\/reperfusion injury: an update on remote ischemic preconditioning and postconditioning","volume":"32","author":"Donato","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.tice.2026.103897_bib13","first-page":"1182","volume":"9","author":"Fatma","year":"2025","journal-title":"'Phytochem. Antioxid. Charact. myrtle (Myrtus communis L. ) Fruit. ' ISPEC J. Agric. Sci."},{"key":"10.1016\/j.tice.2026.103897_bib14","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1681\/ASN.V1081658","article-title":"Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats","volume":"10","author":"Fernandez-Llama","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tice.2026.103897_bib15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1523-1755.2004.761_3.x","article-title":"Inflammatory cells in ischemic acute renal failure","volume":"66","author":"Friedewald","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.tice.2026.103897_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.intimp.2016.06.020","article-title":"Remote ischemic postconditioning protects against renal ischemia\/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)\/PTEN\/Akt signaling pathway mediated anti-oxidation and anti-inflammation","volume":"38","author":"Gao","year":"2016","journal-title":"Int. Immunopharmacol"},{"key":"10.1016\/j.tice.2026.103897_bib17","article-title":"Remote ischemic per-conditioning mitigates renal ischemia-reperfusion injury via hydrogen sulfide\u2013mediated upregulation of Gclc and Gclm genes in male rats","volume":"376","author":"Ghahramani","year":"2025","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.103897_bib18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s40200-022-01034-y","article-title":"Alpha-lipoic acid potentiates the anti-arrhythmic effects of ischemic postconditioning in the setting of cardiac ischemia\/reperfusion injury in diabetic rats","volume":"21","author":"Gholami","year":"2022","journal-title":"J Diabetes Metab Disord."},{"key":"10.1016\/j.tice.2026.103897_bib19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jss.2019.09.063","article-title":"Remote ischemic perconditioning modulates apelin expression after renal ischemia-reperfusion injury","volume":"247","author":"Gholampour","year":"2020","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.tice.2026.103897_bib20","article-title":"Desloratadine attenuates renal ischemia-reperfusion injury through activation of the Nrf2-GCL-GSH antioxidant pathway","volume":"10","author":"Gholampour","year":"2026","journal-title":"CRPHAR"},{"key":"10.1016\/j.tice.2026.103897_bib21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11033-024-10109-3","article-title":"Remote limb ischemic pre-conditioning prevents renal Ischemia\/reperfusion injury in rats by modulating oxidative stress and TNF-\u03b1\/NF-\u03baB\/TGF-\/\u03b2apelin signaling pathway","volume":"52","author":"Gholampour","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.tice.2026.103897_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jss.2018.05.036","article-title":"Hepatorenal protection during renal ischemia by quercetin and remote ischemic perconditioning","volume":"231","author":"Gholampour","year":"2018","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.tice.2026.103897_bib23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1523-1755.2004.00791.x","article-title":"EPO and \u03b1-MSH prevent ischemia\/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney","volume":"66","author":"Gong","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.tice.2026.103897_bib24","first-page":"113","article-title":"Mesenchymal stem cells cause telomere length reduction of molt-4 cells via caspase-3, BAD and P53 apoptotic pathway","volume":"10","author":"Heidari","year":"2021","journal-title":"Int. J. Mol. Cell. Med."},{"key":"10.1016\/j.tice.2026.103897_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2014.10.031","article-title":"Remote ischemic conditioning","volume":"65","author":"Heusch","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tice.2026.103897_bib26","first-page":"206","article-title":"Evaluation of in vivo wound healing activity of Pistacia vera L. hull extract on excision wound model in rats","volume":"11","author":"Ipek","year":"2026","journal-title":"MAS. J. Appl. Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103897_bib27","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1007\/s00068-022-01910-5","article-title":"Remote ischemic postconditioning protects against crush-induced acute kidney injury via down-regulation of apoptosis and senescence","volume":"48","author":"Jin","year":"2022","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.tice.2026.103897_bib28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.ijsu.2014.09.007","article-title":"Classical and remote post-conditioning effects on ischemia\/reperfusion-induced acute oxidant kidney injury","volume":"12","author":"Kadkhodaee","year":"2014","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.tice.2026.103897_bib29","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.3390\/nu15071732","article-title":"Renal-protective roles of lipoic acid in kidney disease","volume":"15","author":"Kamt","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103897_bib30","article-title":"Therapeutic effects of the combination of alpha-lipoic acid (ALA) and coenzyme Q10 (CoQ10) on cisplatin-induced nephrotoxicity","volume":"2020","author":"Khalifa","year":"2020","journal-title":"Int. J. Inflam."},{"key":"10.1016\/j.tice.2026.103897_bib31","first-page":"142","article-title":"Pathophysiology of acute renal failure","volume":"12","author":"Kribben","year":"1999","journal-title":"J. Nephrol."},{"key":"10.1016\/j.tice.2026.103897_bib32","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12865","article-title":"'Remote ischemic perconditioning attenuates ischemia\/reperfusion-induced downregulation of AQP2 in rat kidney'","volume":"4","author":"Kristensen","year":"2016","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.tice.2026.103897_bib33","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1096\/fasebj.29.1_supplement.970.5","article-title":"Effect of Remote Ischemic Perconditioning on Renal Water and Salt Handling in Rats Subjected to Renal Ischemia\/Reperfusion","volume":"29","author":"Kristensen","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2026.103897_bib34","first-page":"20","article-title":"Renal ischemia\/reperfusion injury; from pathophysiology to treatment","volume":"4","author":"Malek","year":"2015","journal-title":"J. Ren. Inj. Prev."},{"key":"10.1016\/j.tice.2026.103897_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2026.103521","article-title":"Time-dependent renal protection by remote ischemic preconditioning through a hydrogen sulfide\u2013mediated antioxidative and anti-inflammatory pathway","volume":"101","author":"Malekmohammad","year":"2026","journal-title":"Tissue Cell."},{"key":"10.1016\/j.tice.2026.103897_bib36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/01913123.2022.2035875","article-title":"Ameliorative role of alpha-lipoic acid in renal cortical structural damage, induced by limb ischemia-reperfusion injury in the rat","volume":"46","author":"Othman","year":"2022","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.tice.2026.103897_bib37","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1177\/0960327121993224","article-title":"'Renoprotective effects of prazosin on ischemia-reperfusion injury in rats'","volume":"40","author":"Rahimi","year":"2021","journal-title":"Human. & Exp. Toxicol."},{"key":"10.1016\/j.tice.2026.103897_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1681.2007.04810.x","article-title":"\u03b1-Lipoic acid protects against renal ischaemia\u2013reperfusion injury in rats","volume":"35","author":"\u015eehirli","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tice.2026.103897_bib39","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2174\/0113894501322228240830063605","article-title":"Therapeutic correlation of TLR-4 mediated NF-\u03baB inflammatory pathways in ischemic injuries","volume":"25","author":"Sharma","year":"2024","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.tice.2026.103897_bib40","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/CIRCULATIONAHA.105.558122","article-title":"Postconditioning the human heart","volume":"112","author":"Staat","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.tice.2026.103897_bib41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1440-1681.2002.03624.x","article-title":"Protective Effect Of \u03b1-LIPOIC acid against ischaemic acute renal failure in rats","volume":"29","author":"Takaoka","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tice.2026.103897_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.clim.2006.09.008","article-title":"Triggers of inflammation after renal ischemia\/reperfusion","volume":"123","author":"Thurman","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.tice.2026.103897_bib43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/jcm12010375","article-title":"Acute kidney injury: medical causes and pathogenesis","volume":"12","author":"Turgut","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tice.2026.103897_bib44","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/ijms22020816","article-title":"Toll-like receptors in acute kidney injury","volume":"22","author":"V\u00e1zquez-Carballo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103897_bib45","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1016\/j.fct.2011.07.065","article-title":"Alpha-lipoic acid protects against myocardial ischemia\/reperfusion injury via multiple target effects","volume":"49","author":"Wang","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tice.2026.103897_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000443008","article-title":"Acute kidney injury epidemiology: from recognition to intervention","volume":"187","author":"Wang","year":"2016","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.tice.2026.103897_bib47","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/medicina58030340","article-title":"Acute kidney injury: biomarker-guided diagnosis and management","volume":"58","author":"Yoon","year":"2022","journal-title":"Medicina"},{"key":"10.1016\/j.tice.2026.103897_bib48","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1159\/000495593","article-title":"Alpha-lipoic acid preconditioning and ischemic postconditioning synergistically protect rats from cerebral injury induced by ischemia and reperfusion partly via inhibition TLR4\/MyD88\/NF-\u03baB signaling pathway'","volume":"51","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.tice.2026.103897_bib49","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4103\/0366-6999.229892","article-title":"Remote ischemic postconditioning for ischemic stroke: A systematic review and meta-analysis of randomized controlled trials","volume":"131","author":"Zhao","year":"2018","journal-title":"Chin Med. J. (Engl)"},{"key":"10.1016\/j.tice.2026.103897_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0039-6109(16)45628-8","article-title":"Reperfusion injury","volume":"72","author":"Zimmerman","year":"1992","journal-title":"Surg. Clin. North. Am."}],"updated-by":[{"DOI":"10.1016\/j.tice.2026.103947","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000}}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626005926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:31:16Z","timestamp":1789489876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626005926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":50,"alternative-id":["S0040816626005926"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103897","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced renoprotective effects of remote ischemic postconditioning and alpha-lipoic acid via modulation of TLR4\/MyD88\/NF-\u03baB and Nrf2\/HO-1 pathways in renal ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103897"}}