{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:53:07Z","timestamp":1791064387878,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["4001774"],"award-info":[{"award-number":["4001774"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103922","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:12:33Z","timestamp":1788451953000},"page":"103922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Evaluation of the protective effects of Syzygium aromaticum L. against doxorubicin-induced cardiotoxicity in rats"],"prefix":"10.1016","volume":"104","author":[{"given":"Zahra","family":"Shahinfar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoorak","family":"Poorzand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid Reza","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Khodadadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir","family":"Sobhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ahmad","family":"Mohajeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faeze","family":"Keihanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vafa","family":"Baradaran Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103922_bib1","article-title":"Renoprotective effect of N-acetylcystein and vitamin E in bisphenol A-induced rat nephrotoxicity; modulators of Nrf2\/ NF-\u03baB and ROS signaling pathway","volume":"93","author":"Abdelrazik","year":"2022","journal-title":"Acta Biomed."},{"key":"10.1016\/j.tice.2026.103922_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/biom15010151","article-title":"The role of quercetin, a flavonoid in the management of pathogenesis through regulation of oxidative stress, inflammation, and biological activities","volume":"15","author":"Alharbi","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.tice.2026.103922_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27031536","article-title":"Unveiling the therapeutic potential of gallic acid: mechanistic insights into the management of pathogenesis: a narrative review","volume":"27","author":"Alharbi","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103922_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312541","article-title":"Syzygium aromaticum extract mitigates doxorubicin-induced hepatotoxicity in male rats","volume":"25","author":"Alsirhani","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103922_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33241","article-title":"The interactive effect of seven weeks aerobic exercise training and piperine against paraquat-induced lung damage in male Wistar rats: Investigating role of oxidative and inflammatory indices","volume":"10","author":"Ariyanasab","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.tice.2026.103922_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/9781394167197.ch26","article-title":"Syzygium aromaticum \u2013 role in oral health and dental care","author":"Askari","year":"2023","journal-title":"Pharmacological Studies in Natural Oral Care"},{"key":"10.1016\/j.tice.2026.103922_bib7","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1007\/s11033-020-05607-z","article-title":"Melatonin and vitamin E alleviate homocysteine-induced oxidative injury and apoptosis in endothelial cells","volume":"47","author":"Aykutoglu","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.tice.2026.103922_bib8","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.2042-7158.2011.01440.x","article-title":"Clove and eugenol in noncytotoxic concentrations exert immunomodulatory\/anti-inflammatory action on cytokine production by murine macrophages","volume":"64","author":"Bachiega","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.tice.2026.103922_bib9","article-title":"Syzygium aromaticum L. (Myrtaceae): traditional uses, bioactive chemical constituents, pharmacological and toxicological activities","volume":"10","author":"Batiha","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.tice.2026.103922_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17142303","article-title":"Advances in doxorubicin chemotherapy: emerging polymeric nanocarriers for drug loading and delivery","volume":"17","author":"Bhadran","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tice.2026.103922_bib11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ptr.2124","article-title":"The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review","volume":"21","author":"Chaieb","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.tice.2026.103922_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S2221-1691(14)60215-X","article-title":"Clove (Syzygium aromaticum): a precious spice","volume":"4","author":"Cort\u00e9s-Rojas","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.tice.2026.103922_bib13","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/cbin.70086","article-title":"Esculetin attenuates doxorubicin-induced cardiotoxicity via modulation of apoptotic and mitochondrial gene expression networks","volume":"49","author":"Demir","year":"2025","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.tice.2026.103922_bib14","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/cbin.70086","article-title":"Esculetin attenuates doxorubicin-induced cardiotoxicity via modulation of apoptotic and mitochondrial gene expression networks","volume":"49","author":"Demir","year":"2025","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.tice.2026.103922_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2025.108654","article-title":"Esculetin attenuates doxorubicin-induced cardiac toxicity: evidence from gene expression, enzyme activity, and molecular docking analyses","volume":"120","author":"Demir","year":"2026","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.tice.2026.103922_bib16","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3109\/13880209.2015.1078381","article-title":"Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats","volume":"54","author":"El-Hadary","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.tice.2026.103922_bib17","first-page":"1918","article-title":"Linearization of the bradford protein assay","author":"Ernst","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tice.2026.103922_bib18","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.foodchem.2010.12.007","article-title":"Identification of bioactive compounds from jambol\u00e3o (Syzygium cumini) and antioxidant capacity evaluation in different pH conditions","volume":"126","author":"Faria","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.tice.2026.103922_bib19","article-title":"Identification of nonvolatile compounds in clove (Syzygium aromaticum) from Manado","author":"Fathoni","year":"2017","journal-title":"AIP Conf. Proc. 1862"},{"key":"10.1016\/j.tice.2026.103922_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.afres.2023.100283","article-title":"The application of clove extracts as a potential functional component in active food packaging materials and model food systems: a mini-review","volume":"3","author":"Gengatharan","year":"2023","journal-title":"Appl. Food Res."},{"key":"10.1016\/j.tice.2026.103922_bib21","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1007\/s00210-024-03280-8","article-title":"Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed","volume":"397","author":"Ghazaee","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.tice.2026.103922_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26216387","article-title":"Clove essential oil (Syzygium aromaticum L. Myrtaceae): extraction, chemical composition, food applications, and essential bioactivity for human health","volume":"26","author":"Haro-Gonz\u00e1lez","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103922_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8437753","article-title":"Evaluation of the therapeutic effects of the hydroethanolic extract of Portulaca oleracea on surgical-induced peritoneal adhesion","volume":"2021","author":"Jaafari","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.tice.2026.103922_bib24","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.20546\/ijcmas.2017.607.476","article-title":"Phytochemical screening and antimicrobial evaluation of Syzygium aromaticum extract and essential oil","volume":"6","author":"Jimoh","year":"2017","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"10.1016\/j.tice.2026.103922_bib25","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/jpp\/rgac063","article-title":"Doxorubicin-induced cardiotoxicity: causative factors and possible interventions","volume":"74","author":"Jones","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.tice.2026.103922_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/15376516.2018.1506849","article-title":"Syzygium aromaticum alleviates cerium chloride-induced neurotoxic effect in the adult mice","volume":"29","author":"Kadri","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.tice.2026.103922_bib27","article-title":"Cardioprotective properties of kaempferol: a review","volume":"12","author":"Kamisah","year":"2023","journal-title":"Plants (Basel)"},{"key":"10.1016\/j.tice.2026.103922_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105159","article-title":"Esculetin improves inflammation of the kidney via gene expression against doxorubicin-induced nephrotoxicity in rats: in vivo and in silico studies","volume":"62","author":"Kara\u011fa\u00e7","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.tice.2026.103922_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202504774","article-title":"Bioactive potential of Hippophae rhamnoides L. extracts: comparative antioxidant, antimicrobial, and enzyme inhibitory effects","volume":"11","author":"Kasapo\u011flu","year":"2026","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.tice.2026.103922_bib30","first-page":"398","article-title":"Phytochemistry and pharmacological aspects of Syzygium aromaticum: a review","volume":"8","author":"Kaur","year":"2019","journal-title":"J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.tice.2026.103922_bib31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/bab.70054","article-title":"Evaluation of 2-aminothiazoles as \u03b1-glucosidase inhibitors: DFT, molecular docking, and antioxidant studies","volume":"73","author":"Kesebir","year":"2026","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.tice.2026.103922_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/375294","article-title":"simultaneous determination of gallic acid, ellagic acid, and eugenol in Syzygium aromaticum and verification of chemical antagonistic effect by the combination with curcuma aromatica using regression analysis","volume":"2013","author":"Kim","year":"2013","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.tice.2026.103922_bib33","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1080\/14786419.2019.1698570","article-title":"Novel ferulic acid and benzophenone derivatives from the flower buds of Syzygium aromaticum","volume":"35","author":"Kiran","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.tice.2026.103922_bib34","first-page":"42","article-title":"Antibacterial activities of the buds essential oil of Syzygium aromaticum (L.) Merr. & Perry from Togo","volume":"1","author":"Koba","year":"2011","journal-title":"J. Biol. Act. Prod. Nat."},{"key":"10.1016\/j.tice.2026.103922_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23702","article-title":"Protective effects of esculetin against doxorubicin-induced toxicity correlated with oxidative stress in rat liver: in vivo and in silico studies","volume":"38","author":"K\u00f6ro\u011flu","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tice.2026.103922_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3892\/etm.2020.9539","article-title":"Eugenol protects cells against oxidative stress via Nrf2","volume":"21","author":"Ma","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.tice.2026.103922_bib37","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15584","article-title":"HPLC\/MS characterization of Syzygium aromaticum L. and evaluation of its effects on peritoneal adhesion: investigating the role of inflammatory cytokines, oxidative factors, and fibrosis and angiogenesis biomarkers","volume":"11","author":"Moradi","year":"2023","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.tice.2026.103922_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1621409","article-title":"Utilization of dexrazoxane in patients treated with doxorubicin: a retrospective, propensity matched analysis of cardiac function and toxicity","volume":"15","author":"Neiman","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tice.2026.103922_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70714","article-title":"Phenolic compounds in exercise physiology: dual role in oxidative stress and recovery adaptation","volume":"13","author":"\u00d6zdemir","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.tice.2026.103922_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2026.103406","article-title":"Biochemical markers of muscle damage and recovery: insights from exercise physiology and molecular biology","volume":"101","author":"\u00d6zdemir","year":"2026","journal-title":"Tissue Cell."},{"key":"10.1016\/j.tice.2026.103922_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23798","article-title":"The hepatoprotective potential of tannic acid against doxorubicin-induced hepatotoxicity: insights into its antioxidative, anti-inflammatory, and antiapoptotic mechanisms","volume":"38","author":"\u00d6zturk","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tice.2026.103922_bib42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/01635581.2021.1931362","article-title":"In vivo and in vitro protective effects of rosmarinic acid against doxorubicin-induced cardiotoxicity","volume":"74","author":"Rahbardar","year":"2022","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.tice.2026.103922_bib43","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.3390\/molecules27186075","article-title":"Protective effect of Portulaca oleracea on streptozotocin-induced Type I diabetes-associated reproductive system dysfunction and inflammation","volume":"27","author":"Rakhshandeh","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2026.103922_bib44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.lfs.2016.06.012","article-title":"Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats","volume":"157","author":"Razmaraii","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103922_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.lfs.2016.06.012","article-title":"Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats","volume":"157","author":"Razmaraii","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.tice.2026.103922_bib46","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.clnu.2022.04.032","article-title":"Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity - a narrative review","volume":"41","author":"Rychter","year":"2022","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tice.2026.103922_bib47","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00204-022-03262-w","article-title":"Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation","volume":"96","author":"Sangweni","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tice.2026.103922_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.907266","article-title":"Prevention of anthracycline-induced cardiotoxicity: the good and bad of current and alternative therapies","volume":"9","author":"Sangweni","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.tice.2026.103922_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165667","article-title":"Protective effects of essential oils as natural antioxidants against hepatotoxicity induced by cyclophosphamide in mice","volume":"11","author":"Sheweita","year":"2016","journal-title":"PLoS. One"},{"key":"10.1016\/j.tice.2026.103922_bib50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","article-title":"Oxidative stress injury in doxorubicin-induced cardiotoxicity","volume":"307","author":"Songbo","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tice.2026.103922_bib51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4314\/ajtcam.v5i2.31275","article-title":"Anti-nociceptive and anti-inflammatory activities of ethanol extract of Syzygium aromaticum flower bud in Wistar rats and mice","volume":"5","author":"Tanko","year":"2008","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"10.1016\/j.tice.2026.103922_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2024.107607","article-title":"Pharmacodynamic, pharmacokinetic, toxicity, and recent advances in Eugenol's potential benefits against natural and chemical noxious agents: a mechanistic review","volume":"238","author":"Tavvabi-Kashani","year":"2024","journal-title":"Toxicon"},{"key":"10.1016\/j.tice.2026.103922_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2026.107391","article-title":"Evaluation of the protective effects of Artemisia dracunculus L. against doxorubicin-induced chronic cardio-toxicity in rat","volume":"193","author":"Toumari","year":"2026","journal-title":"Fitoterapia"},{"key":"10.1016\/j.tice.2026.103922_bib54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.14744\/AnatolJCardiol.2023.2825","article-title":"Dapagliflozin may protect against doxorubicin-induced cardiotoxicity","volume":"27","author":"Ulusan","year":"2023","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.tice.2026.103922_bib55","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00210-023-02638-8","article-title":"Protective role of vitamin E against acrylamide-induced testicular toxicity from pregnancy to adulthood: insights into oxidative stress and aromatase regulation","volume":"397","author":"\u00dcremi\u015f","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.tice.2026.103922_bib56","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1111\/bph.70085","article-title":"Dexrazoxane protects against doxorubicin-induced cardiotoxicity in susceptible human living myocardial slices: a proof-of-concept study","volume":"182","author":"van der Geest","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tice.2026.103922_bib57","article-title":"Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tice.2026.103922_bib58","article-title":"Advances in targeted delivery of doxorubicin for cancer chemotherapy","volume":"12","author":"Xia","year":"2025","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.tice.2026.103922_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/nu14112214","article-title":"Vitamin supplementation protects against nanomaterial-induced oxidative stress and inflammation damages: a meta-analysis of in vitro and in vivo studies","volume":"14","author":"Xie","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103922_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1002147","article-title":"Recent advances in nutritional composition, phytochemistry, bioactive, and potential applications of Syzygium aromaticum L. (Myrtaceae)","volume":"9","author":"Xue","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tice.2026.103922_bib61","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpba.2015.07.032","article-title":"A sensitive LC\u2013MS\/MS method for the quantitative determination of biflorin in rat plasma and its application to pharmacokinetic studies","volume":"115","author":"Yang","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.tice.2026.103922_bib62","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s00210-021-02132-z","article-title":"Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options","volume":"394","author":"Yarmohammadi","year":"2021","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:22:13Z","timestamp":1791062533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626006178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":62,"alternative-id":["S0040816626006178"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103922","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the protective effects of Syzygium aromaticum L. against doxorubicin-induced cardiotoxicity in rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103922"}}