{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:05:32Z","timestamp":1790798732648,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","award":["2023048"],"award-info":[{"award-number":["2023048"]}],"id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270794"],"award-info":[{"award-number":["82270794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["TJWJ2024MS024"],"award-info":[{"award-number":["TJWJ2024MS024"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2025QN08002"],"award-info":[{"award-number":["2025QN08002"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","award":["XH202402"],"award-info":[{"award-number":["XH202402"]}],"id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["25JCYBJC00500"],"award-info":[{"award-number":["25JCYBJC00500"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103935","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:37:50Z","timestamp":1788795470000},"page":"103935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Clusterin deficiency aggravates colitis-associated oxidative injury by disrupting mitochondrial function and intestinal barrier integrity"],"prefix":"10.1016","volume":"104","author":[{"given":"Bo","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-hua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-da","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2011yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2011lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang-gang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9990-2714","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.tice.2026.103935_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2559.2009.03258.x","article-title":"Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis","volume":"54","author":"Aigelsreiter","year":"2009","journal-title":"Histopathology"},{"issue":"9","key":"10.1016\/j.tice.2026.103935_bib2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2018.04.002","article-title":"The intestinal epithelium: central coordinator of mucosal immunity","volume":"39","author":"Allaire","year":"2018","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.tice.2026.103935_bib3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/sj.jcbfm.9600419","article-title":"Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system","volume":"27","author":"Bell","year":"2007","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"5","key":"10.1016\/j.tice.2026.103935_bib4","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1007\/s10753-025-02282-9","article-title":"TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhibiting the ROS\/TXNIP\/TRX\/NLRP3 and TLR4\/MyD88\/NF-kappaB\/NLRP3 Pathways","volume":"48","author":"Cao","year":"2025","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.tice.2026.103935_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1164\/rccm.200512-1835OC","article-title":"Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke","volume":"174","author":"Carnevali","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tice.2026.103935_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"issue":"7889","key":"10.1016\/j.tice.2026.103935_bib7","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-021-04183-x","article-title":"Exercise plasma boosts memory and dampens brain inflammation via clusterin","volume":"600","author":"De Miguel","year":"2021","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.tice.2026.103935_bib8","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.crohns.2012.09.003","article-title":"Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis","volume":"6","author":"Dignass","year":"2012","journal-title":"J. Crohns Colitis"},{"issue":"4","key":"10.1016\/j.tice.2026.103935_bib9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.7150\/ijms.107159","article-title":"Clusterin: structure, function and roles in disease","volume":"22","author":"Du","year":"2025","journal-title":"Int. J. Med. Sci."},{"issue":"12","key":"10.1016\/j.tice.2026.103935_bib10","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.stem.2025.10.008","article-title":"Injury-induced Clusterin(+) cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages","volume":"32","author":"Fan","year":"2025","journal-title":"Cell. Stem Cell."},{"key":"10.1016\/j.tice.2026.103935_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fnins.2019.00164","article-title":"Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies","volume":"13","author":"Foster","year":"2019","journal-title":"Front. Neurosci."},{"issue":"4","key":"10.1016\/j.tice.2026.103935_bib12","doi-asserted-by":"crossref","first-page":"F703","DOI":"10.1152\/ajprenal.00060.2001","article-title":"Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity","volume":"282","author":"Girton","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12035-025-05517-w","article-title":"Nrf2\/Keap1 Signaling Axis in the Brain: Master Regulator of Oxidative Stress in Neurodegenerative and Psychiatric Disorders","volume":"63","author":"Goel","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12882-016-0348-x","article-title":"Relationship of clusterin with renal inflammation and fibrosis after the recovery phase of ischemia-reperfusion injury","volume":"17","author":"Guo","year":"2016","journal-title":"BMC Nephrol."},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10555-024-10173-y","article-title":"Clusterin: a marker and mediator of chemoresistance in colorectal cancer","volume":"43","author":"Hlavca","year":"2024","journal-title":"Cancer Metastas-.-. Rev."},{"issue":"5","key":"10.1016\/j.tice.2026.103935_bib16","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.ajpath.2012.01.025","article-title":"Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation","volume":"180","author":"Jeong","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"6775","key":"10.1016\/j.tice.2026.103935_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.adz4712","article-title":"An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis","volume":"390","author":"Jiang","year":"2025","journal-title":"Science"},{"issue":"14","key":"10.1016\/j.tice.2026.103935_bib18","article-title":"H(2)S-Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation","volume":"11","author":"Jin","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"8","key":"10.1016\/j.tice.2026.103935_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105635","article-title":"Clusterin\/apolipoprotein J attenuates angiotensin II-induced renal fibrosis","volume":"9","author":"Jung","year":"2014","journal-title":"PLoS. One"},{"issue":"24","key":"10.1016\/j.tice.2026.103935_bib20","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1158\/0008-5472.CAN-06-3562","article-title":"Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis","volume":"66","author":"Khor","year":"2006","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.tice.2026.103935_bib21","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1136\/bjo.2007.115220","article-title":"The role of clusterin in retinal development and free radical damage","volume":"91","author":"Kim","year":"2007","journal-title":"Br. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.tice.2026.103935_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.anai.2013.12.012","article-title":"Clusterin expression level correlates with increased oxidative stress in asthmatics","volume":"112","author":"Kwon","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"10401","key":"10.1016\/j.tice.2026.103935_bib23","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.tice.2026.103935_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24101906","article-title":"Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K\/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model","volume":"24","author":"Liao","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/BJ20051190","article-title":"Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes","volume":"395","author":"Loison","year":"2006","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/alr.22222","article-title":"Deletion of Nrf2 enhances susceptibility to eosinophilic sinonasal inflammation in a murine model of rhinosinusitis","volume":"9","author":"London","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2023.2294564","article-title":"Clusterin protects mature dendritic cells from reactive oxygen species mediated cell death","volume":"13","author":"Lopez Malizia","year":"2024","journal-title":"Oncoimmunology"},{"issue":"4","key":"10.1016\/j.tice.2026.103935_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/pros.20087","article-title":"Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen","volume":"61","author":"Miyake","year":"2004","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib29","first-page":"CD011450","article-title":"Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis","volume":"1","author":"Mohammed Vashist","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"10.1016\/j.tice.2026.103935_bib30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.gie.2018.08.018","article-title":"The emerging role of histologic disease activity assessment in ulcerative colitis","volume":"88","author":"Pai","year":"2018","journal-title":"Gastrointest. Endosc."},{"issue":"7","key":"10.1016\/j.tice.2026.103935_bib31","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1007\/s12035-023-03801-1","article-title":"Clusterin is a Potential Therapeutic Target in Alzheimer's Disease","volume":"61","author":"Palihati","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"7746","key":"10.1016\/j.tice.2026.103935_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41586-019-0992-y","article-title":"Colonic epithelial cell diversity in health and inflammatory bowel disease","volume":"567","author":"Parikh","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11154-013-9275-3","article-title":"The physiological roles of apolipoprotein J\/clusterin in metabolic and cardiovascular diseases","volume":"15","author":"Park","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.tice.2026.103935_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2016.12.048","article-title":"Redox signaling in the gastrointestinal tract","volume":"104","author":"Perez","year":"2017","journal-title":"Free. Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.tice.2026.103935_bib35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0014-5793(01)03150-7","article-title":"Clusterin\/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts","volume":"509","author":"Petropoulou","year":"2001","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.tice.2026.103935_bib36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4103\/mgr.MEDGASRES-D-24-00120","article-title":"Oxygen targets in critically ill patients: from pathophysiology to population enrichment strategies","volume":"15","author":"Ripa","year":"2025","journal-title":"Med. Gas. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103935_bib37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4103\/mgr.MEDGASRES-D-24-00083","article-title":"Theoretical evaluation of the biological activity of hydrogen","volume":"15","author":"Russell","year":"2025","journal-title":"Med. Gas. Res."},{"issue":"2","key":"10.1016\/j.tice.2026.103935_bib38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1152\/physrev.00044.2023","article-title":"Redox signaling in the pancreas in health and disease","volume":"105","author":"Sastre","year":"2025","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.tice.2026.103935_bib39","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1111\/jam.15504","article-title":"Balancing reactive oxygen species generation by rebooting gut microbiota","volume":"132","author":"Singh","year":"2022","journal-title":"J. Appl. Microbiol."},{"issue":"11","key":"10.1016\/j.tice.2026.103935_bib40","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.neurobiolaging.2005.09.019","article-title":"Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells","volume":"27","author":"Strocchi","year":"2006","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.tice.2026.103935_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14348\/molcells.2023.0028","article-title":"Molecular Basis of the KEAP1-NRF2 Signaling Pathway","volume":"46","author":"Suzuki","year":"2023","journal-title":"Mol. Cells"},{"key":"10.1016\/j.tice.2026.103935_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111326","article-title":"Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca(2+)-ROS-Drp1-mitochondrial fission axis","volume":"205","author":"Tang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.tice.2026.103935_bib43","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000351207","article-title":"The molecular chaperone apolipoprotein J\/clusterin as a sensor of oxidative stress: implications in therapeutic approaches - a mini-review","volume":"59","author":"Trougakos","year":"2013","journal-title":"Gerontology"},{"key":"10.1016\/j.tice.2026.103935_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120111","article-title":"Nrf2\/Keap1\/ARE signaling: Towards specific regulation","volume":"291","author":"Ulasov","year":"2022","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103935_bib45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1046\/j.1523-1747.1999.00531.x","article-title":"Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress","volume":"112","author":"Viard","year":"1999","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.tice.2026.103935_bib46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1053\/j.gastro.2025.08.022","article-title":"Clusterin drives fiber endocytosis by mesothelial cells to resolve liver fibrosis","volume":"170","author":"Wang","year":"2026","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tice.2026.103935_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101032","article-title":"Clusterin, other extracellular chaperones, and eye disease","volume":"89","author":"Wilson","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"7","key":"10.1016\/j.tice.2026.103935_bib48","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"issue":"33","key":"10.1016\/j.tice.2026.103935_bib49","doi-asserted-by":"crossref","first-page":"E6962","DOI":"10.1073\/pnas.1701137114","article-title":"Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways","volume":"114","author":"Wojtas","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103935_bib50","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.tice.2026.103935_bib51","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4103\/mgr.MEDGASRES-D-24-00144","article-title":"Nitric oxide: a gas transmitter in healthy and diseased skin","volume":"15","author":"Zaborova","year":"2025","journal-title":"Med. Gas. Res."},{"key":"10.1016\/j.tice.2026.103935_bib52","article-title":"Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.103935_bib53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13024-025-00840-1","article-title":"Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication","volume":"20","author":"Zhao","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.tice.2026.103935_bib54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-3-031-27681-1_31","article-title":"Gene expression of clusterin, tissue inhibitor of metalloproteinase-1, and their receptors in retinal pigment epithelial cells and muller glial cells is modulated by inflammatory stresses","volume":"1415","author":"Zheng","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tice.2026.103935_bib55","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2147\/DDDT.S223742","article-title":"Desflurane preconditioning protects against renal ischemia-reperfusion injury and inhibits inflammation and oxidative stress in rats through regulating the Nrf2-Keap1-ARE signaling pathway","volume":"14","author":"Zheng","year":"2020","journal-title":"Drug. Des. Devel Ther."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:49:33Z","timestamp":1790797773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626006300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":55,"alternative-id":["S0040816626006300"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103935","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clusterin deficiency aggravates colitis-associated oxidative injury by disrupting mitochondrial function and intestinal barrier integrity","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103935"}}