{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:10:51Z","timestamp":1789668651735,"version":"4.0.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103968","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:32:56Z","timestamp":1789572776000},"page":"103968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Puerarin inhibits thyroid cancer cell survival and enhances autophagy by regulating the FOXO1\/GABARAPL1 signaling pathway"],"prefix":"10.1016","volume":"104","author":[{"given":"Shasha","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103968_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2026.1692980","article-title":"Pilot study: predicting the interplay between FOXO1 and its downstream long non-coding RNAs in HCC","volume":"16","author":"Abdelbary","year":"2026","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tice.2026.103968_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2147\/CMAR.S233567","article-title":"Molecular mechanisms of anticancer activities of puerarin","volume":"12","author":"Ahmad","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.tice.2026.103968_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1480950","article-title":"The role of autophagy in Graves disease: knowns and unknowns","volume":"12","author":"Al-Kuraishy","year":"2025","journal-title":"Front. Cell. Dev. Biol."},{"issue":"5","key":"10.1016\/j.tice.2026.103968_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.2023.26348","article-title":"Thyroid cancer: a review","volume":"331","author":"Boucai","year":"2024","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.tice.2026.103968_bib5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bulcan.2020.11.004","article-title":"An overview of autophagy: mechanism, regulation and research progress","volume":"108","author":"Cao","year":"2021","journal-title":"Bull. Cancer"},{"issue":"4","key":"10.1016\/j.tice.2026.103968_bib6","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/nar\/gky1230","article-title":"FOXO1 degradation via G9a-mediated methylation promotes cell proliferation in colon cancer","volume":"47","author":"Chae","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tice.2026.103968_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1186\/s12951-025-03730-2","article-title":"Neuron-targeted ROS-responsive liposomes for puerarin delivery remodel ischemic microenvironment via microglial modulation and neurovascular regeneration","volume":"23","author":"Chen","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.tice.2026.103968_bib9","article-title":"Cardioprotective effects of puerarin against myocardial ischemia-reperfusion injury: a preclinical systematic review and meta-analysis","volume":"17","author":"Chen","year":"2026","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.tice.2026.103968_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.tice.2026.103968_bib11","first-page":"435","article-title":"Puerarin inhibits the progression of bladder cancer by regulating circ_0020394\/miR-328-3p\/NRBP1 axis","volume":"37","author":"Du","year":"2022","journal-title":"Cancer Biother. Radiopharm."},{"issue":"9","key":"10.1016\/j.tice.2026.103968_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211040762","article-title":"Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1","volume":"49","author":"Duan","year":"2021","journal-title":"J. Int. Med. Res."},{"issue":"15","key":"10.1016\/j.tice.2026.103968_bib13","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.3390\/ijms26157035","article-title":"Biological modulation of autophagy by nanoplastics: a current overview","volume":"26","author":"Fanghella","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"34","key":"10.1016\/j.tice.2026.103968_bib14","doi-asserted-by":"crossref","first-page":"38452","DOI":"10.1021\/acsomega.5c00667","article-title":"Nanopuerarin improves doxorubicin therapeutic efficacy by inhibiting angiogenesis via regulating NSUN2 in hepatocellular carcinoma","volume":"10","author":"Feng","year":"2025","journal-title":"ACS Omega"},{"issue":"7","key":"10.1016\/j.tice.2026.103968_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/jpp\/rgae033","article-title":"FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption","volume":"76","author":"Feng","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib16","article-title":"Trends in metastatic thyroid cancer survival from 1992 to 2022: a SEER database analysis","volume":"6","author":"Govindan","year":"2026","journal-title":"Endocr. Oncol."},{"issue":"10","key":"10.1016\/j.tice.2026.103968_bib17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/mc.23240","article-title":"Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1","volume":"59","author":"Hahm","year":"2020","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.tice.2026.103968_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.121126","article-title":"Puerarin from Pueraria montana var. lobata (Willd.) alleviates hepatic steatosis and inflammation in MAFLD through suppressing STING-IRF3\/NF-\u03baB signaling in macrophages","volume":"360","author":"Han","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.tice.2026.103968_bib19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1055\/a-2119-3301","article-title":"Insulin inhibits autophagy by inhibiting the binding of FoXO1 to the promoter region of GABARAPL1","volume":"55","author":"Hong","year":"2023","journal-title":"Horm. Metab. Res."},{"issue":"8","key":"10.1016\/j.tice.2026.103968_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101157","article-title":"The integration of machine learning into traditional Chinese medicine","volume":"15","author":"Hong","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.tice.2026.103968_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155813","article-title":"Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4\/MyD88-mediated NF-kappaB p65 and JNK\/FoxO1 activation","volume":"132","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.tice.2026.103968_bib22","first-page":"157","article-title":"Targeting GABARAPL1\/HIF-2a axis to induce tumor cell apoptosis in nasopharyngeal carcinoma","volume":"27","author":"Huang","year":"2024","journal-title":"Iran. J. Basic. Med. Sci."},{"issue":"4","key":"10.1016\/j.tice.2026.103968_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1530\/ERC-20-0004","article-title":"FOXO1 as a tumor suppressor inactivated via AR\/ERbeta signals in urothelial cells","volume":"27","author":"Ide","year":"2020","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.tice.2026.103968_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109847","article-title":"Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model","volume":"124","author":"Jeon","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib25","first-page":"167","article-title":"Puerarin inhibits bladder cancer cell proliferation through the mTOR\/p70S6K signaling pathway","volume":"15","author":"Jiang","year":"2018","journal-title":"Oncol. Lett."},{"issue":"19","key":"10.1016\/j.tice.2026.103968_bib26","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.tice.2026.103968_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ecl.2025.03.007","article-title":"Update in papillary thyroid cancer","volume":"54","author":"Kuenstner","year":"2025","journal-title":"Endocrinol. Metab. Clin. North. Am."},{"key":"10.1016\/j.tice.2026.103968_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fendo.2020.00082","article-title":"New therapies for advanced thyroid cancer","volume":"11","author":"Laha","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.tice.2026.103968_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tem.2013.01.008","article-title":"Autophagy: a targetable linchpin of cancer cell metabolism","volume":"24","author":"Leone","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/21655979.2020.1868733","article-title":"Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1\/Nrf2\/ARE signaling pathway","volume":"12","author":"Li","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12943-024-02213-6","article-title":"Tailoring traditional Chinese medicine in cancer therapy","volume":"24","author":"Li","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tice.2026.103968_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.115297","article-title":"Platelet membrane-fused and cardiac homing peptide-modified liposomes deliver puerarin to attenuate myocardial ischemia\/reperfusion injury by inhibiting pyroptosis","volume":"259","author":"Li","year":"2026","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.tice.2026.103968_bib34","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1080\/01635581.2023.2216922","article-title":"Puerarin Induces Ferroptosis in Colorectal Cancer Cells via Triggering NCOA4 Upregulation","volume":"75","author":"Lian","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"5","key":"10.1016\/j.tice.2026.103968_bib35","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1007\/s10753-025-02274-9","article-title":"Puerarin ameliorates sarcopenia in aged mice via modulation of inflammation and oxidative stress: Insights from proteomics and transcriptomics","volume":"48","author":"Lin","year":"2025","journal-title":"Inflammation"},{"issue":"Pt 1","key":"10.1016\/j.tice.2026.103968_bib36","article-title":"Traditional Chinese Medicine in the treatment of chronic atrophic gastritis, precancerous lesions and gastric cancer","volume":"337","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.tice.2026.103968_bib37","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s12033-025-01518-1","article-title":"Network pharmacology and experimental validation unravel how puerarin improves chronic postoperative pain","volume":"68","author":"Lu","year":"2026","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.tice.2026.103968_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114246","article-title":"Puerarin triggers sensitivity to ferroptosis in glioblastoma cells by activating SIRT3\/NCOA4-dependent autophagy","volume":"149","author":"Lv","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.tice.2026.103968_bib39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s40618-025-02746-7","article-title":"Puerarin suppress adipogenesis and inflammation on orbital fibroblasts from patients with thyroid eye disease","volume":"49","author":"Ma","year":"2026","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.tice.2026.103968_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2026.214819","article-title":"ROS-responsive puerarin-loaded MOF hydrogel coating: Reprogramming the pathological microenvironment for enhanced diabetic bone regeneration","volume":"184","author":"Mao","year":"2026","journal-title":"Biomater. Adv."},{"issue":"7","key":"10.1016\/j.tice.2026.103968_bib41","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.devcel.2021.02.010","article-title":"Autophagy and organelle homeostasis in cancer","volume":"56","author":"Miller","year":"2021","journal-title":"Dev. Cell."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib42","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12672-026-04849-w","article-title":"FOXO1 in cancer: context-dependent roles, microRNA regulation, and therapeutic opportunities","volume":"17","author":"Ngu","year":"2026","journal-title":"Discov. Oncol."},{"issue":"16","key":"10.1016\/j.tice.2026.103968_bib43","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.31335","article-title":"Targeting autophagy in cancer","volume":"124","author":"Onorati","year":"2018","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.tice.2026.103968_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.71070","article-title":"Regulation of autophagy and metabolism in hepatocellular carcinoma: Involvement of Wnt-\u03b2-catenin pathway","volume":"30","author":"Roy","year":"2026","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10059-013-0140-8","article-title":"Autophagy: a critical regulator of cellular metabolism and homeostasis","volume":"36","author":"Ryter","year":"2013","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib46","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s12967-023-04265-6","article-title":"The new insights into autophagy in thyroid cancer progression","volume":"21","author":"Shi","year":"2023","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.tice.2026.103968_bib47","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.18632\/oncotarget.13879","article-title":"GABARAPL1 suppresses metastasis by counteracting PI3K\/Akt pathway in prostate cancer","volume":"8","author":"Su","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib48","article-title":"NOX4 serves as a pan-cancer prognostic biomarker and therapeutic target in tumorigenesis","volume":"15","author":"Sun","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.103968_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2026.151404","article-title":"Puerarin promotes nerve regeneration and functional recovery after peripheral nerve injury by inhibiting ACSL4-dependent ferroptosis","volume":"357","author":"Sun","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib50","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s12035-026-05971-0","article-title":"Puerarin as a modulator of synaptic plasticity: Molecular mechanisms underlying learning and memory restoration in neurodegenerative disorders","volume":"63","author":"Tang","year":"2026","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.tice.2026.103968_bib51","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1002\/cbin.11696","article-title":"FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression","volume":"45","author":"Tang","year":"2021","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.tice.2026.103968_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158324","article-title":"Activation of PPAR\u03b3\/FGF21 signaling axis with Puerarin reprograms tumor lipid metabolism, attenuating malignancy in colon cancer","volume":"158","author":"Tang","year":"2026","journal-title":"Phytomedicine"},{"issue":"6352","key":"10.1016\/j.tice.2026.103968_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.tice.2026.103968_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.71926","article-title":"Research progress of puerarin and its benefits in nonalcoholic fatty liver disease: a bibliometric analysis","volume":"14","author":"Wang","year":"2026","journal-title":"Food Sci. Nutr."},{"issue":"10","key":"10.1016\/j.tice.2026.103968_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70517","article-title":"Puerarin enhances the sensitivity of colorectal cancer to 5-fluorouracil and oxaliplatin by inhibiting the PTEN\/PI3K\/AKT signaling pathway","volume":"39","author":"Wang","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tice.2026.103968_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109570","article-title":"Antitumor effects of immunity-enhancing traditional Chinese medicine","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2026.103968_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.119699","article-title":"Puerarin ameliorates alcoholic liver disease by regulating intestinal flora and MAPK\/Nrf2 signalling pathways","volume":"309","author":"Wang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tice.2026.103968_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156849","article-title":"Mechanism of puerarin alleviating myocardial remodeling through NSUN2-mediated m5C methylation modification","volume":"143","author":"Wu","year":"2025","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.tice.2026.103968_bib59","article-title":"Puerarin alleviates oxidative stress, mitochondrial dysfunction, and apoptosis in corpus cavernosum smooth muscle cells through AKT\/Nrf2\/HO-1 pathway activation","volume":"14","author":"Xi","year":"2026","journal-title":"Sex. Med."},{"issue":"21","key":"10.1016\/j.tice.2026.103968_bib60","doi-asserted-by":"crossref","first-page":"21706","DOI":"10.18632\/aging.103976","article-title":"Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6\/ROS-dependent MAPK\/NF-kappaB signaling pathways","volume":"12","author":"Xiao","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"10.1016\/j.tice.2026.103968_bib61","doi-asserted-by":"crossref","first-page":"8727","DOI":"10.1007\/s13277-015-3542-8","article-title":"Gabarapl1 mediates androgen-regulated autophagy in prostate cancer","volume":"36","author":"Xie","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.tice.2026.103968_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2025.106360","article-title":"Puerarin enhances the efficacy of carboplatin in oral squamous cell carcinoma via dual targeting","volume":"178","author":"Xie","year":"2025","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.tice.2026.103968_bib63","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.freeradbiomed.2025.06.013","article-title":"Puerarin mitigates cerebral ischemia\/reperfusion (CIR)-induced ferroptosis by suppressing Ser15 phosphorylation-mediated p53 activation","volume":"237","author":"Xu","year":"2025","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.tice.2026.103968_bib64","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.2147\/DDDT.S379794","article-title":"Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo","volume":"16","author":"Yang","year":"2022","journal-title":"Drug. Des. Devel. Ther."},{"key":"10.1016\/j.tice.2026.103968_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1712682","article-title":"The anti-osteoporotic effect of puerarin on the femoral bone in rat models of osteoporosis: a systematic review and meta-analysis","volume":"16","author":"Yang","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103968_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158025","article-title":"Puerarin mitigates tumor necrosis factor-nuclear factor-\u03baB axis-driven macrophage inflammation and atherogenesis: Integrative network pharmacology and experimental validation","volume":"154","author":"Yao","year":"2026","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.tice.2026.103968_bib67","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.21037\/tcr-24-1910","article-title":"YWHAE affects proliferation, migration and apoptosis of colorectal cancer by regulating extracellular vesicles secretion and Wnt\/\u03b2-catenin signaling pathway","volume":"14","author":"Ye","year":"2025","journal-title":"Transl. Cancer Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12672-021-00427-4","article-title":"Selenite-induced ROS\/AMPK\/FoxO3a\/GABARAPL-1 signaling pathway modulates autophagy that antagonize apoptosis in colorectal cancer cells","volume":"12","author":"Yu","year":"2021","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.tice.2026.103968_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2026.101437","article-title":"Autophagy in thyroid cancer: Immune suppression and drug resistance","volume":"88","author":"Zhai","year":"2026","journal-title":"Drug. Resist. Updat."},{"issue":"1","key":"10.1016\/j.tice.2026.103968_bib70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12906-019-2691-5","article-title":"Puerarin inhibits the osteoclastogenesis by inhibiting RANKL-dependent and -independent autophagic responses","volume":"19","author":"Zhang","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.tice.2026.103968_bib71","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.2147\/IJGM.S543824","article-title":"Traditional Chinese Medicine treatment of thyroid cancer: a review","volume":"18","author":"Zhang","year":"2025","journal-title":"Int. J. Gen. Med."},{"issue":"4","key":"10.1016\/j.tice.2026.103968_bib72","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/15548627.2015.1023981","article-title":"Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways","volume":"11","author":"Zhang","year":"2015","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.tice.2026.103968_bib73","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000329952","article-title":"GABARAPL1 negatively regulates Wnt\/beta-catenin signaling by mediating Dvl2 degradation through the autophagy pathway","volume":"27","author":"Zhang","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.tice.2026.103968_bib74","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/cr.2013.2","article-title":"XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells","volume":"23","author":"Zhao","year":"2013","journal-title":"Cell. Res."},{"issue":"11","key":"10.1016\/j.tice.2026.103968_bib75","doi-asserted-by":"crossref","first-page":"10137","DOI":"10.1039\/D0FO02356F","article-title":"Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels","volume":"11","author":"Zhou","year":"2020","journal-title":"Food Funct."},{"issue":"196","key":"10.1016\/j.tice.2026.103968_bib76","doi-asserted-by":"crossref","first-page":"894","DOI":"10.24976\/Discov.Med.202537196.79","article-title":"Puerarin inhibits the development of thyroid cancer through KLF2\/NOTCH1 signaling","volume":"37","author":"Zhou","year":"2025","journal-title":"Discov. Med."},{"key":"10.1016\/j.tice.2026.103968_bib77","article-title":"SIRT1 mediated gastric cancer progression under glucose deprivation through the FoxO1-Rab7-autophagy axis","volume":"13","author":"Zhu","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tice.2026.103968_bib78","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molimm.2026.04.011","article-title":"Puerarin and DHEA combination therapy alleviates primary dysmenorrhea via inhibition of the Hsp90ab1\/p38\/JNK pathway","volume":"194","author":"Zhu","year":"2026","journal-title":"Mol. Immunol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:55:56Z","timestamp":1789667756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626006634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":78,"alternative-id":["S0040816626006634"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103968","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Puerarin inhibits thyroid cancer cell survival and enhances autophagy by regulating the FOXO1\/GABARAPL1 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103968"}}