{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:46:04Z","timestamp":1791801964698,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012905","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103996","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:19:34Z","timestamp":1790576374000},"page":"103996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["ENTR1 ameliorates osteoarthritis through decreasing FAS expression by binding PTPN13"],"prefix":"10.1016","volume":"104","author":[{"given":"Nan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.103996_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.virol.2018.06.002","article-title":"Fas activity mediates airway inflammation during mouse adenovirus type 1 respiratory infection","volume":"521","author":"Adkins","year":"2018","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.tice.2026.103996_bib2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S1471-4892(02)00148-0","article-title":"Aggrecanase-mediated cartilage degradation","volume":"2","author":"Arner","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"issue":"8","key":"10.1016\/j.tice.2026.103996_bib3","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.7150\/ijbs.108832","article-title":"TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis","volume":"21","author":"Chang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103996_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41584-019-0221-y","article-title":"Therapeutic options for targeting inflammatory osteoarthritis pain","volume":"15","author":"Conaghan","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.tice.2026.103996_bib5","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqad190","article-title":"NGAL mediates anaplastic thyroid carcinoma cells survival through FAS\/CD95 inhibition","volume":"165","author":"Crescenzi","year":"2023","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.tice.2026.103996_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.it.2011.10.004","article-title":"TNF superfamily in inflammatory disease: translating basic insights","volume":"33","author":"Croft","year":"2012","journal-title":"Trends Immunol."},{"issue":"469","key":"10.1016\/j.tice.2026.103996_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat8800","article-title":"Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis","volume":"10","author":"Geiger","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.tice.2026.103996_bib8","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"39","key":"10.1016\/j.tice.2026.103996_bib9","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1038\/onc.2012.485","article-title":"The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis","volume":"32","author":"Hagemann","year":"2013","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.tice.2026.103996_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s44466-025-00022-0","article-title":"Pathogenesis and therapeutic strategies of osteoarthritis: roles of immune cells, inflammatory mediators, and pathogenic signaling pathways","volume":"2","author":"He","year":"2026","journal-title":"Immun. Inflamm."},{"issue":"5","key":"10.1016\/j.tice.2026.103996_bib11","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1159\/000430148","article-title":"The role of MicroRNA-381 in chondrogenesis and interleukin-1-\u03b2 induced chondrocyte responses","volume":"36","author":"Hou","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tice.2026.103996_bib12","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.2147\/JIR.S514002","article-title":"Osteoimmunology in osteoarthritis: unraveling the interplay of immunity, inflammation, and joint degeneration","volume":"18","author":"Hu","year":"2025","journal-title":"J. Inflamm. Res."},{"issue":"10182","key":"10.1016\/j.tice.2026.103996_bib13","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.tice.2026.103996_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100772","article-title":"SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3\/SMURF1\/PPAR\u03b3 axis","volume":"66","author":"Huo","year":"2025","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.tice.2026.103996_bib15","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1074\/jbc.M509866200","article-title":"Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis","volume":"281","author":"Ivanov","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tice.2026.103996_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/med4.70004","article-title":"Diacerein's role in alleviating inflammation and synovial effusion in knee osteoarthritis: a novel therapeutic approach","volume":"3","author":"Khan","year":"2025","journal-title":"Med. Adv."},{"issue":"12","key":"10.1016\/j.tice.2026.103996_bib17","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41584-020-00518-6","article-title":"Emerging pharmaceutical therapies for osteoarthritis","volume":"16","author":"Latourte","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.tice.2026.103996_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/mdr2.70072","article-title":"Osteoarthritis: an immuno-inflammatory disease-mechanisms of immune cell dysregulation and potential therapeutic strategies","author":"Lei","year":"2026","journal-title":"Med Research."},{"key":"10.1016\/j.tice.2026.103996_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.22203\/eCM.v047a02","article-title":"Establishment of a coculture system with osteochondral and synovial explants as anex vivoinflammatory osteoarthritis model","volume":"47","author":"Li","year":"2024","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.tice.2026.103996_bib20","article-title":"Aloe-emodin alleviates osteoarthritis and maintains cytoskeletal homeostasis via targeting Septin7 ubiquitination","author":"Li","year":"2026","journal-title":"J. Adv. Res."},{"issue":"7","key":"10.1016\/j.tice.2026.103996_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/biom12070959","article-title":"The mechanism and role of ADAMTS protein family in osteoarthritis","volume":"12","author":"Li","year":"2022","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.tice.2026.103996_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202410525","article-title":"Dipeptidyl peptidase 4 (DPP4) exacerbates osteoarthritis progression in an enzyme-independent manner","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.tice.2026.103996_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41413-018-0041-8","article-title":"Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12","volume":"7","author":"Lin","year":"2019","journal-title":"Bone Res."},{"issue":"6","key":"10.1016\/j.tice.2026.103996_bib24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11914-017-0411-y","article-title":"Immune contributions to osteoarthritis","volume":"15","author":"Lopes","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"issue":"5203","key":"10.1016\/j.tice.2026.103996_bib25","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.tice.2026.103996_bib26","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.4049\/jimmunol.170.12.6209","article-title":"Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages","volume":"170","author":"Park","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2026.103996_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"issue":"13","key":"10.1016\/j.tice.2026.103996_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137461","article-title":"Quercetin modulates ferroptosis via the SIRT1\/Nrf-2\/HO-1 pathway and attenuates cartilage destruction in an osteoarthritis rat model","volume":"25","author":"Ruan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tice.2026.103996_bib29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017","volume":"79","author":"Safiri","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"5209","key":"10.1016\/j.tice.2026.103996_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.7536343","article-title":"FAP-1: a protein tyrosine phosphatase that associates with Fas","volume":"268","author":"Sato","year":"1995","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.tice.2026.103996_bib31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P","article-title":"Characterization of human colon cancer antigens recognized by autologous antibodies","volume":"76","author":"Scanlan","year":"1998","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.tice.2026.103996_bib32","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1038\/s41467-019-11025-y","article-title":"Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas\/CD95","volume":"10","author":"Sharma","year":"2019","journal-title":"Nat. Commun."},{"issue":"Pt 15","key":"10.1016\/j.tice.2026.103996_bib33","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1242\/jcs.114.15.2735","article-title":"FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis","volume":"114","author":"Ungefroren","year":"2001","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.tice.2026.103996_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.joca.2023.12.005","article-title":"Inflammation in osteoarthritis: our view on its presence and involvement in disease development over the years","volume":"32","author":"van den Bosch","year":"2024","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.tice.2026.103996_bib35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.joca.2021.11.014","article-title":"Joint synovial macrophages as a potential target for intra-articular treatment of osteoarthritis-related pain","volume":"30","author":"Wang","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.tice.2026.103996_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123525","article-title":"ENTR1 regulates periodontitis by modulating macrophage M1 polarization via AMPK activation","volume":"369","author":"Wang","year":"2025","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103996_bib37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.diff.2011.11.013","article-title":"Characterisation of FAP-1 expression and CD95 mediated apoptosis in the A818-6 pancreatic adenocarcinoma differentiation system","volume":"83","author":"Winterhoff","year":"2012","journal-title":"Differentiation"},{"key":"10.1016\/j.tice.2026.103996_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijbiomac.2021.02.029","article-title":"SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K\/Akt\/mTOR pathway","volume":"175","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"13","key":"10.1016\/j.tice.2026.103996_bib39","doi-asserted-by":"crossref","first-page":"8539","DOI":"10.1074\/jbc.272.13.8539","article-title":"The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis","volume":"272","author":"Yanagisawa","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tice.2026.103996_bib40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.tice.2026.103996_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2025.110865","article-title":"ENTR1 stabilizes MAVS by inhibiting NIX-mediated mitophagy to restrict BPIV3 and VSV replication","volume":"313","author":"Yao","year":"2026","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.tice.2026.103996_bib42","article-title":"cGAS-STING\/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis","volume":"17","author":"Zhang","year":"2026","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tice.2026.103996_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2026.05.014","article-title":"SESN2 drives osteoarthritis progression by inducing MFN2-dependent mitochondrial hyperfusion in rats","author":"Zhang","year":"2026","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.tice.2026.103996_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41434-025-00515-y","article-title":"Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models","volume":"32","author":"Zhou","year":"2025","journal-title":"Gene Ther."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:01:41Z","timestamp":1791799301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626006920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":44,"alternative-id":["S0040816626006920"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103996","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ENTR1 ameliorates osteoarthritis through decreasing FAS expression by binding PTPN13","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103996"}}