{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:45:55Z","timestamp":1791827155074,"version":"4.3.4"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30891"],"award-info":[{"award-number":["2021JJ30891"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.103997","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:26:31Z","timestamp":1791613591000},"page":"103997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["FFAs secreted by A1 astrocytes contribute to RGCs apoptosis via PERK\/eIF2\u03b1\/ATF4\/CHOP pathway in retinal ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"104","author":[{"given":"Wenjia","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangcheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangshi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junle","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-5986","authenticated-orcid":false,"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tice.2026.103997_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020265","article-title":"Role of antioxidants in neonatal hypoxic-ischemic brain injury: new therapeutic approaches","volume":"18","author":"Arteaga","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052474","article-title":"Integrated metabolomics and lipidomics reveal high accumulation of glycerophospholipids in human astrocytes under the lipotoxic effect of palmitic acid and tibolone protection","volume":"23","author":"Cabezas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.103997_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.chembiol.2019.03.001","article-title":"Saturated fatty acids, mufas and pufas regulate ferroptosis","volume":"26","author":"Das","year":"2019","journal-title":"Cell. Chem. Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103997_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000513678","article-title":"Simvastatin prevents neurodegeneration in the mptp mouse model of parkinson's disease via inhibition of a1 reactive astrocytes","volume":"28","author":"Du","year":"2021","journal-title":"Neuroimmunomodulation"},{"issue":"6619","key":"10.1016\/j.tice.2026.103997_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/science.adc9020","article-title":"Molecular basis of astrocyte diversity and morphology across the CNS in health and disease","volume":"378","author":"Endo","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12974-022-02389-y","article-title":"Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT(2B)R\/\u03b2-arrestin2 pathway","volume":"19","author":"Fang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.tice.2026.103997_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.700854","article-title":"CTRP1 Attenuates cerebral ischemia\/reperfusion injury via the PERK signaling pathway","volume":"9","author":"Fei","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics7010001","article-title":"Fatty acids in membranes as homeostatic, metabolic and nutritional biomarkers: recent advancements in analytics and diagnostics","volume":"7","author":"Ferreri","year":"2016","journal-title":"Diagnostics"},{"issue":"21","key":"10.1016\/j.tice.2026.103997_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112983","article-title":"Valdecoxib protects against cell apoptosis induced by endoplasmic reticulum stress via the inhibition of perk-atf4-chop pathway in experimental glaucoma","volume":"23","author":"Gao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.tice.2026.103997_bib10","first-page":"1399","article-title":"Morphological and functional changes in experimental ocular hypertension and role of neuroprotective drugs","volume":"22","author":"Garc\u00eda-Campos","year":"2007","journal-title":"J. ]. Histol. Histopathol."},{"issue":"7883","key":"10.1016\/j.tice.2026.103997_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","article-title":"Neurotoxic reactive astrocytes induce cell death via saturated lipids","volume":"599","author":"Guttenplan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tice.2026.103997_bib12","article-title":"Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity","volume":"163","author":"He","year":"2022","journal-title":"Food Chem. Toxicol. international journal published British Industrial Biological Research Association"},{"key":"10.1016\/j.tice.2026.103997_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41420-018-0077-y","article-title":"Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA\/2J spontaneous glaucoma mouse model","volume":"4","author":"Hirt","year":"2018","journal-title":"Cell. death Discov."},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13578-022-00932-1","article-title":"Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia\/reperfusion injury","volume":"12","author":"Hu","year":"2022","journal-title":"J. ]. Cell. Biosci."},{"key":"10.1016\/j.tice.2026.103997_bib15","article-title":"The neuroprotective effect of dexmedetomidine and its mechanism","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.103997_bib16","article-title":"c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation\/recovery via a GSDMD-mediated pathway","volume":"235","author":"Huang","year":"2021","journal-title":"Ann. Anat. = Anat. Anz. Off. Organ. Anat. Ges."},{"issue":"6","key":"10.1016\/j.tice.2026.103997_bib17","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.tice.2026.103997_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/15548627.2020.1731270","article-title":"The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs\/GABA(A) receptors in rat glaucoma models","volume":"17","author":"Ishikawa","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.tice.2026.103997_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2013.10.002","article-title":"Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration","volume":"53","author":"Janssen","year":"2014","journal-title":"Progress. Lipid Res."},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s10495-006-5425-3","article-title":"Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells","volume":"11","author":"Landau","year":"2006","journal-title":"Apoptosis international journal programmed cell death"},{"key":"10.1016\/j.tice.2026.103997_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semcdb.2020.07.017","article-title":"Lipid metabolism in astrocytic structure and function","volume":"112","author":"Lee","year":"2021","journal-title":"Semin. Cell. Dev. Biol."},{"issue":"7638","key":"10.1016\/j.tice.2026.103997_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.tice.2026.103997_bib24","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte Crosstalk in CNS Inflammation","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12974-020-01946-7","article-title":"Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.tice.2026.103997_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125997","article-title":"Microglia-derived IL-1\u03b2 promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK\/eIF2\u03b1\/ATF4\/CHOP upon arsenic exposure","volume":"417","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tice.2026.103997_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpnec.2021.100048","article-title":"LPS and palmitic acid Co-upregulate microglia activation and neuroinflammatory response","volume":"6","author":"Lu","year":"2021","journal-title":"Compr. psychoneuroendocrinology"},{"key":"10.1016\/j.tice.2026.103997_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-61779-452-0_8","article-title":"Isolation and culture of astrocytes from the retina and optic nerve","volume":"814","author":"Lukas","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tice.2026.103997_bib29","article-title":"Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes","author":"Ma","year":"2022","journal-title":"Cell. Biol. Toxicol."},{"key":"10.1016\/j.tice.2026.103997_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biomaterials.2019.01.016","article-title":"Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion","volume":"197","author":"Mathew","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.tice.2026.103997_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fnins.2019.00265","article-title":"Diet-derived fatty acids, brain inflammation, and mental health","volume":"13","author":"Melo","year":"2019","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.tice.2026.103997_bib32","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/jcmm.16255","article-title":"Regulation of lipid metabolism by the unfolded protein response","volume":"25","author":"Moncan","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/jnc.15038","article-title":"Docosahexaenoic acid protection against palmitic acid-induced lipotoxicity in NGF-differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis","volume":"155","author":"Montero","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tice.2026.103997_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110002","article-title":"Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: targeting the GRP78\/PERK\/eIF2\u03b1\/CHOP pathway and miR-211-5p","volume":"362","author":"Motawi","year":"2022","journal-title":"Chem. -Biol. Interact."},{"issue":"6","key":"10.1016\/j.tice.2026.103997_bib35","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1600-0854.2009.00903.x","article-title":"Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acids","volume":"10","author":"Pineau","year":"2009","journal-title":"Traffic (Cph. Den. )"},{"key":"10.1016\/j.tice.2026.103997_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.782569","article-title":"Understanding the connection between common stroke comorbidities, their associated inflammation, and the course of the cerebral ischemia\/reperfusion cascade","volume":"12","author":"Przykaza","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","article-title":"Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury","volume":"13","author":"Qin","year":"2022","journal-title":"Cell. death Dis."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib38","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1667\/RR14173.1","article-title":"Inhibition of fatty acid synthase sensitizes prostate cancer cells to radiotherapy","volume":"184","author":"Rae","year":"2015","journal-title":"Radiat. Res."},{"issue":"4","key":"10.1016\/j.tice.2026.103997_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu10040432","article-title":"Obesity, inflammation, toll-like receptor 4 and fatty acids","volume":"10","author":"Rogero","year":"2018","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.tice.2026.103997_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.tice.2026.103997_bib41","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1566524016666160523143937","article-title":"The role of the PERK\/eIF2\u03b1\/ATF4\/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress","volume":"16","author":"Rozpedek","year":"2016","journal-title":"Curr. Mol. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1194\/jlr.M086843","article-title":"Chain length of saturated fatty acids regulates mitochondrial trafficking and function in sensory neurons","volume":"60","author":"Rumora","year":"2019","journal-title":"J. Lipid Res."},{"issue":"14","key":"10.1016\/j.tice.2026.103997_bib43","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.00192-13","article-title":"Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production","volume":"33","author":"Sassa","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.tice.2026.103997_bib44","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbalip.2014.12.005","article-title":"Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis","volume":"1851","author":"Schackmann","year":"2015","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051518","article-title":"Interplay of dietary fatty acids and cholesterol impacts brain mitochondria and insulin action [J]","volume":"12","author":"Schell","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tice.2026.103997_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105050","article-title":"How the brain fights fatty acids' toxicity","volume":"148","author":"Sch\u00f6nfeld","year":"2021","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.tice.2026.103997_bib47","first-page":"261","article-title":"Potential relationship between dietary long-chain saturated fatty acids and hypothalamic dysfunction in obesity","volume":"78","author":"Sergi","year":"2020","journal-title":"Nutr. Rev."},{"issue":"51","key":"10.1016\/j.tice.2026.103997_bib48","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1073\/pnas.1712555114","article-title":"Metabolic activity induces membrane phase separation in endoplasmic reticulum","volume":"114","author":"Shen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.tice.2026.103997_bib49","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41419-021-04274-7","article-title":"Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis","volume":"12","author":"Shu","year":"2021","journal-title":"Cell. death Dis."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108271","article-title":"GLP-1 receptor agonist NLY01 reduces retinal inflammation and neuron death secondary to ocular hypertension [J]","volume":"33","author":"Sterling","year":"2020","journal-title":"Cell. Rep."},{"issue":"4","key":"10.1016\/j.tice.2026.103997_bib51","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41418-020-00668-w","article-title":"RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages","volume":"28","author":"Tao","year":"2021","journal-title":"Cell. death Differ."},{"issue":"16","key":"10.1016\/j.tice.2026.103997_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22169093","article-title":"Palmitic acid lipotoxicity in microglia cells is ameliorated by unsaturated fatty acids","volume":"22","author":"Urso","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.tice.2026.103997_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052577","article-title":"Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential","volume":"23","author":"Vesga-Jim\u00e9nez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.103997_bib54","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/bjophthalmol-2017-310333","article-title":"Burden of vision loss associated with eye disease in China 1990-2020: findings from the Global Burden of Disease Study 2015","volume":"102","author":"Wang","year":"2018","journal-title":"Br. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.tice.2026.103997_bib55","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s12035-020-02171-2","article-title":"Estrogen attenuates traumatic brain injury by inhibiting the activation of microglia and astrocyte-mediated neuroinflammatory responses","volume":"58","author":"Wang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tice.2026.103997_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2015.06.001","article-title":"Autophagy in glaucoma: crosstalk with apoptosis and its implications","volume":"117","author":"Wang","year":"2015","journal-title":"Brain Res. Bull."},{"issue":"18","key":"10.1016\/j.tice.2026.103997_bib57","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.tice.2026.103997_bib58","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/jcp.26918","article-title":"MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-\u03baB and PI3K-Akt pathways","volume":"234","author":"Xu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tice.2026.103997_bib59","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fncel.2019.00190","article-title":"Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways","volume":"13","author":"Yi","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.tice.2026.103997_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2016.08.008","article-title":"ER stress and impaired autophagy flux in neuronal degeneration and brain injury","volume":"34","author":"Yin","year":"2017","journal-title":"Ageing Res. Rev."},{"issue":"18","key":"10.1016\/j.tice.2026.103997_bib61","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.tice.2026.103997_bib62","article-title":"Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy","volume":"141","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"key":"10.1016\/j.tice.2026.103997_bib63","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.biopha.2017.05.132","article-title":"An oasis in the desert of cancer chemotherapeutic resistance: The enlightenment from reciprocal crosstalk between signaling pathways of UPR and autophagy in cancers","volume":"92","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother. = Biomedecine & Pharmacother."},{"issue":"11","key":"10.1016\/j.tice.2026.103997_bib64","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113074119","article-title":"Destabilization of \u03b2 Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes","volume":"119","author":"Zheng","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626006932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:00:31Z","timestamp":1791824431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626006932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":64,"alternative-id":["S0040816626006932"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.103997","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FFAs secreted by A1 astrocytes contribute to RGCs apoptosis via PERK\/eIF2\u03b1\/ATF4\/CHOP pathway in retinal ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.103997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103997"}}