{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:57:45Z","timestamp":1791489465486,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004077","name":"Kocaeli University","doi-asserted-by":"publisher","award":["TSA-2024-3610"],"award-info":[{"award-number":["TSA-2024-3610"]}],"id":[{"id":"10.13039\/501100004077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.104004","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:39:07Z","timestamp":1790869147000},"page":"104004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Early preventive effects of a Cathepsin S inhibitor on inflammation in a rat model of endotoxin-induced uveitis"],"prefix":"10.1016","volume":"104","author":[{"given":"B\u00fc\u015fra","family":"Y\u0131lmaz Tu\u011fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semil Selcen","family":"G\u00f6\u00e7mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Duruksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fen","family":"\u00c7elebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selenay","family":"Furat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kasap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcrler","family":"Akpinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecem","family":"\u00d6nder Toku\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus Emre","family":"Bayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Karaba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furkan \u00d6mer","family":"Halis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6zde","family":"T\u00fcfek\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur\u015fen","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusufhan","family":"Yaz\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijen","family":"Utkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.104004_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/978-1-60761-720-4_22","article-title":"Rodent models of experimental autoimmune uveitis","volume":"900","author":"Agarwal","year":"2012","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.tice.2026.104004_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.exer.2004.06.001","article-title":"Etanercept treatment in the endotoxin-induced uveitis of rats","volume":"79","author":"Avunduk","year":"2004","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.tice.2026.104004_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1006\/exer.1997.0364","article-title":"Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats","volume":"65","author":"Behar-Cohen","year":"1997","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.tice.2026.104004_bib4","first-page":"897","article-title":"Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis","volume":"39","author":"Behar-Cohen","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.tice.2026.104004_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nrrheum.2013.207","article-title":"Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis","volume":"10","author":"Bernard","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.tice.2026.104004_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/jsxmed\/qdae030","article-title":"Immunohistochemical staining with CD117 and PGP9.5 of excised vestibular tissue from patients with neuroproliferative vestibulodynia","volume":"21","author":"Drian","year":"2024","journal-title":"J. Sex. Med."},{"issue":"1","key":"10.1016\/j.tice.2026.104004_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29411-9","article-title":"Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjogren's Syndrome patients","volume":"8","author":"Edman","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.104004_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13048-018-0427-7","article-title":"Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study","volume":"11","author":"Furat Rencber","year":"2018","journal-title":"J. ovarian Res."},{"issue":"7","key":"10.1016\/j.tice.2026.104004_bib9","first-page":"475","article-title":"Evidence-based treatment for uveitis","volume":"21","author":"Gamalero","year":"2019","journal-title":"Isr. Med. Assoc. J."},{"issue":"12","key":"10.1016\/j.tice.2026.104004_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.4103\/0301-4738.198864","article-title":"Systemic administration of an anti-tumor necrosis factor-alpha monoclonal antibody protects against endotoxin-induced uveitis in rats","volume":"64","author":"Ge","year":"2016","journal-title":"Indian. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.tice.2026.104004_bib11","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/art.38633","article-title":"Tear cathepsin S as a candidate biomarker for Sjogren's syndrome","volume":"66","author":"Hamm-Alvarez","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.tice.2026.104004_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jaut.2009.07.003","article-title":"Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse","volume":"34","author":"Hsing","year":"2010","journal-title":"J. Autoimmun."},{"issue":"3","key":"10.1016\/j.tice.2026.104004_bib13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using ImageJ","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat. Rec. (Hoboken N. J. 2007)"},{"key":"10.1016\/j.tice.2026.104004_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.740057","article-title":"TNF-\u03b1 in Uveitis: from bench to Clinic","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.tice.2026.104004_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113530","article-title":"Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells","volume":"19","author":"Klinngam","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.104004_bib16","doi-asserted-by":"crossref","first-page":"9559","DOI":"10.1038\/s41598-019-45966-7","article-title":"Inhibition of Cathepsin S reduces lacrimal gland inflammation and increases tear flow in a mouse model of sjogren's syndrome","volume":"9","author":"Klinngam","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.104004_bib17","first-page":"1","article-title":"Candidate tear-based uveitis biomarkers in children with JIA based on arthritis activity and topical corticosteroid use","author":"Maccora","year":"2024","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"4","key":"10.1016\/j.tice.2026.104004_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1074-7613(00)80249-6","article-title":"Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading","volume":"4","author":"Riese","year":"1996","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.tice.2026.104004_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000267163","article-title":"Retino-choroidal changes in endotoxin-induced uveitis in the rat","volume":"24","author":"Ruiz-Moreno","year":"1992","journal-title":"Ophthalmic Res."},{"issue":"2","key":"10.1016\/j.tice.2026.104004_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1074-7613(00)80020-5","article-title":"Cathepsin S required for normal MHC class II peptide loading and germinal center development","volume":"10","author":"Shi","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.tice.2026.104004_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fimmu.2015.00364","article-title":"Role of tumor necrosis factor superfamily in neuroinflammation and autoimmunity","volume":"6","author":"Sonar","year":"2015","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2026.104004_bib22","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1038\/s41598-017-01894-y","article-title":"Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury","volume":"7","author":"Tato","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.104004_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.14245\/ns.1836010.005","article-title":"The effect of recombinant tyrosine hydroxylase expression on the neurogenic differentiation potency of mesenchymal stem cells","volume":"15","author":"Turac","year":"2018","journal-title":"Neurospine"},{"issue":"2","key":"10.1016\/j.tice.2026.104004_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.iio.0000155938.83083.94","article-title":"Epidemiology of uveitis","volume":"45","author":"Wakefield","year":"2005","journal-title":"Int. Ophthalmol. Clin."},{"issue":"2","key":"10.1016\/j.tice.2026.104004_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1006\/bbrc.2000.3311","article-title":"Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S","volume":"275","author":"Walker","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2026.104004_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-4939-9167-9_14","article-title":"Endotoxin-induced uveitis in rodents","volume":"1960","author":"Yadav","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.tice.2026.104004_bib27","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.4049\/jimmunol.174.3.1729","article-title":"Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis","volume":"174","author":"Yang","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.tice.2026.104004_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00417-023-06251-6","article-title":"Is tear proteome profile a predictor of developing uveitis in ANA-positive patients with oligoarticular juvenile idiopathic arthritis?","volume":"262","author":"Yilmaz Tugan","year":"2024","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.tice.2026.104004_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109565","article-title":"T cells in ocular autoimmune uveitis: pathways and therapeutic approaches","volume":"114","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626007007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626007007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:31:54Z","timestamp":1791487914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626007007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":29,"alternative-id":["S0040816626007007"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.104004","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early preventive effects of a Cathepsin S inhibitor on inflammation in a rat model of endotoxin-induced uveitis","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.104004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104004"}}