{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:49:10Z","timestamp":1791665350701,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["37(1735)\/19\/EMR-II"],"award-info":[{"award-number":["37(1735)\/19\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["CRG\/2022\/001582"],"award-info":[{"award-number":["CRG\/2022\/001582"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/FST\/LSI-560\/2013"],"award-info":[{"award-number":["SR\/FST\/LSI-560\/2013"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.104007","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:41:04Z","timestamp":1791092464000},"page":"104007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["The levels of Twist1 homodimerization over heterodimerization with E proteins control osteogenic differentiation and calcification in the adult porcine aortic cusps"],"prefix":"10.1016","volume":"104","author":[{"given":"Madhurima","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pabitra","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srerupa","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-3996","authenticated-orcid":false,"given":"Santanu","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ydbio.2016.02.003","article-title":"Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development","volume":"412","author":"Ahuja","year":"2016","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.tice.2026.104007_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.0000141146.95728.da","article-title":"Heart valve development: endothelial cell signaling and differentiation","volume":"95","author":"Armstrong","year":"2004","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49016-0","article-title":"Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties","volume":"9","author":"Bogdanova","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.104007_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.835825","article-title":"Models and techniques to study aortic valve calcification in Vitro, ex Vivo and in Vivo. An overview","volume":"13","author":"Bogdanova","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tice.2026.104007_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2013.04.001","article-title":"Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease","volume":"60","author":"Bosse","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"16","key":"10.1016\/j.tice.2026.104007_bib6","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1242\/dev.128.16.3145","article-title":"Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development","volume":"128","author":"Castanon","year":"2001","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ydbio.2010.08.021","article-title":"Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves","volume":"347","author":"Chakraborty","year":"2010","journal-title":"Dev. Biol."},{"issue":"6","key":"10.1016\/j.tice.2026.104007_bib8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1101\/gad.242842.114","article-title":"An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors","volume":"29","author":"Chang","year":"2015","journal-title":"Genes Dev."},{"issue":"24","key":"10.1016\/j.tice.2026.104007_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037991","article-title":"Global, regional, and national burden of valvular heart disease, 1990\u20132021","volume":"13","author":"Chen","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.tice.2026.104007_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.734692","article-title":"Organ culture model of aortic valve calcification","volume":"8","author":"Chester","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.tice.2026.104007_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ydbio.2008.03.037","article-title":"Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure","volume":"318","author":"Connerney","year":"2008","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.tice.2026.104007_bib12","first-page":"1345","article-title":"Twist1 dimer selection regulates cranial suture patterning and fusion","volume":"235","author":"Connerney","year":"2006","journal-title":"Dev. Dyn. Off. Publ. Am. Assoc. Anat."},{"issue":"2","key":"10.1016\/j.tice.2026.104007_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1089\/can.2019.0081","article-title":"Cannabidiol treatment results in a common gene expression response across aggressive cancer cells from various origins","volume":"6","author":"Desprez","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.tice.2026.104007_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1659847","article-title":"Functional analysis of TWIST1 domains regulating smooth muscle cell phenotype","volume":"12","author":"Dy","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"11","key":"10.1016\/j.tice.2026.104007_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00663-19","article-title":"TWIST1 homodimers and heterodimers orchestrate lineage-specific differentiation","volume":"40","author":"Fan","year":"2020","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.tice.2026.104007_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ng1525","article-title":"Altered twist1 and hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities","volume":"37","author":"Firulli","year":"2005","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.tice.2026.104007_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/ATVBAHA.119.313248","article-title":"NF\u03baB (Nuclear Factor \u03ba-Light-Chain Enhancer of Activated B Cells) activity regulates cell-type-specific and context-specific susceptibility to calcification in the aortic valve","volume":"40","author":"Gee","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.tice.2026.104007_bib18","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/ATVBAHA.116.307526","article-title":"Bone morphogenetic protein signaling is required for aortic valve calcification","volume":"36","author":"Gomez-Stallons","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.tice.2026.104007_bib19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/ATVBAHA.119.313067","article-title":"Aortic valve stenosis: from basic mechanisms to novel therapeutic targets","volume":"40","author":"Goody","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11596-014-1228-x","article-title":"Role of Wnt\/\u03b2-catenin signaling pathway in the mechanism of calcification of aortic valve","volume":"34","author":"Gu","year":"2014","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"3","key":"10.1016\/j.tice.2026.104007_bib21","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/jcm14030903","article-title":"Aortic stenosis prevention: is a new cardiovascular disease paradigm coming of age?","volume":"14","author":"Halapas","year":"2025","journal-title":"J. Clin. Med."},{"issue":"Pt 8","key":"10.1016\/j.tice.2026.104007_bib22","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1242\/jcs.000067","article-title":"Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling","volume":"120","author":"Hayashi","year":"2007","journal-title":"J. Cell. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12964-019-0365-z","article-title":"Inhibitor of DNA binding in heart development and cardiovascular diseases","volume":"17","author":"Hu","year":"2019","journal-title":"Cell commun. signal. CCS"},{"issue":"Pt 2","key":"10.1016\/j.tice.2026.104007_bib24","article-title":"Harmine attenuates renal fibrosis via Twist1 suppression: a novel anti-fibrotic strategy for chronic kidney disease with efficacy\/safety profiling","volume":"168","author":"Huang","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.tice.2026.104007_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neo.2016.03.007","article-title":"The heterodimeric TWIST1-E12 complex drives the oncogenic potential of TWIST1 in human mammary epithelial cells","volume":"18","author":"Jacqueroud","year":"2016","journal-title":"Neoplasia"},{"issue":"4","key":"10.1016\/j.tice.2026.104007_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jacbts.2021.12.006","article-title":"Differential BMP signaling mediates the interplay between genetics and leaflet numbers in aortic valve calcification","volume":"7","author":"Jung","year":"2022","journal-title":"Jacc. Basic. Transl. Sci."},{"key":"10.1016\/j.tice.2026.104007_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.654340","article-title":"Cannabidiol induces autophagy to protects neural cells from mitochondrial dysfunction by upregulating SIRT1 to inhibits NF-\u03baB and NOTCH pathways","volume":"15","author":"Kang","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib28","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1186\/s12885-022-10252-9","article-title":"TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma","volume":"22","author":"Khales","year":"2022","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ydbio.2010.08.015","article-title":"Twist1 activity thresholds define multiple functions in limb development","volume":"347","author":"Krawchuk","year":"2010","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1083\/jcb.201012085","article-title":"The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1","volume":"194","author":"Lander","year":"2011","journal-title":"J. Cell. Biol."},{"issue":"12","key":"10.1016\/j.tice.2026.104007_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029758","article-title":"Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves","volume":"6","author":"Lee","year":"2011","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.tice.2026.104007_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe3706","article-title":"Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling","volume":"7","author":"Majumdar","year":"2021","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.tice.2026.104007_bib33","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1158\/1535-7163.MCT-07-0371","article-title":"Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells","volume":"6","author":"McAllister","year":"2007","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61685-0","article-title":"Deep-learning survival analysis for patients with calcific aortic valve disease undergoing valve replacement","volume":"14","author":"Mohammadyari","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.tice.2026.104007_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247652","article-title":"Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1","volume":"16","author":"Nafie","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.tice.2026.104007_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1151028","article-title":"Human and porcine aortic valve endothelial and interstitial cell isolation and characterization","volume":"10","author":"Nehl","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"21","key":"10.1016\/j.tice.2026.104007_bib37","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.3390\/molecules26216714","article-title":"Harmine Hydrochloride Mediates the Induction of G2\/M Cell Cycle Arrest in Breast Cancer Cells by Regulating the MAPKs and AKT\/FOXO3a Signaling Pathways","volume":"26","author":"Ock","year":"2021","journal-title":"Molecules"},{"issue":"23","key":"10.1016\/j.tice.2026.104007_bib38","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1001\/jama.2024.16477","article-title":"Calcific Aortic Stenosis: A Review","volume":"332","author":"Otto","year":"2024","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/cr.2011.144","article-title":"Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms","volume":"22","author":"Qin","year":"2012","journal-title":"Cell. Res."},{"issue":"167","key":"10.1016\/j.tice.2026.104007_bib40","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2019.0893","article-title":"The role of stress concentration in calcified bicuspid aortic valve","volume":"17","author":"Qin","year":"2020","journal-title":"J. R. Soc. Interface"},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib41","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ydbio.2008.02.037","article-title":"Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development","volume":"317","author":"Shelton","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tice.2026.104007_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114775","article-title":"Oxidative stress and valvular endothelial cells in aortic valve calcification","volume":"163","author":"Shu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tice.2026.104007_bib43","article-title":"Animal models of calcific aortic valve disease","volume":"2011","author":"Sider","year":"2011","journal-title":"Int. J. Inflamm."},{"issue":"4","key":"10.1016\/j.tice.2026.104007_bib44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00109-014-1229-z","article-title":"BMP-2 and TGF-\u03b21 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells","volume":"93","author":"Song","year":"2015","journal-title":"J. Mol. Med."},{"issue":"5","key":"10.1016\/j.tice.2026.104007_bib45","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1158\/0008-5472.CAN-12-1943","article-title":"Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target","volume":"73","author":"Soroceanu","year":"2013","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib46","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/s41467-024-46639-4","article-title":"Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation","volume":"15","author":"Th\u00e9riault","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.tice.2026.104007_bib47","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/nar\/15.8.3439","article-title":"The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern","volume":"15","author":"Thisse","year":"1987","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.tice.2026.104007_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cbf.3173","article-title":"Large animal models of cardiovascular disease","volume":"34","author":"Tsang","year":"2016","journal-title":"Cell. Biochem. Funct."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib49","first-page":"8","article-title":"Emerging biological functions of Twist1 in cell differentiation","volume":"254","author":"Tu","year":"2025","journal-title":"Dev. Dyn. Off. Publ. Am. Assoc. Anat."},{"issue":"2","key":"10.1016\/j.tice.2026.104007_bib50","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/nu12020357","article-title":"Potency assessment of CBD oils by their effects on cell signaling pathways","volume":"12","author":"Urasaki","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.tice.2026.104007_bib51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cmet.2007.03.010","article-title":"The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression","volume":"5","author":"Waki","year":"2007","journal-title":"Cell. Metab."},{"issue":"11","key":"10.1016\/j.tice.2026.104007_bib52","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1016\/j.bbamcr.2014.07.017","article-title":"Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1-NF-\u03baB pathway in BMP-2 expression","volume":"1843","author":"Wang","year":"2014","journal-title":"Biochim. Et. Biophys. Acta"},{"key":"10.1016\/j.tice.2026.104007_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1544273","article-title":"Trends in the global burden of aortic valve calcification disease in the working-age population from 1992 to 2021","volume":"12","author":"Wu","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"7","key":"10.1016\/j.tice.2026.104007_bib54","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.tice.2026.104007_bib55","doi-asserted-by":"crossref","first-page":"12710","DOI":"10.18632\/aging.202942","article-title":"Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories","volume":"13","author":"Yi","year":"2021","journal-title":"Aging"},{"issue":"12","key":"10.1016\/j.tice.2026.104007_bib56","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1158\/1541-7786.MCR-17-0298","article-title":"A first-in-class TWIST1 inhibitor with activity in oncogene-driven lung cancer","volume":"15","author":"Yochum","year":"2017","journal-title":"Molecular cancer research MCR"},{"key":"10.1016\/j.tice.2026.104007_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1003233","article-title":"Global burden of calcific aortic valve disease and attributable risk factors from 1990 to 2019","volume":"9","author":"Yu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.tice.2026.104007_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.568764","article-title":"A novel Ex Vivo model of aortic valve calcification. A preliminary report","volume":"11","author":"Zabirnyk","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.tice.2026.104007_bib59","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.jtcvs.2014.02.084","article-title":"Twist-related protein 1 negatively regulated osteoblastic transdifferentiation of human aortic valve interstitial cells by directly inhibiting runt-related transcription factor 2","volume":"148","author":"Zhang","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.tice.2026.104007_bib60","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1038\/s41598-024-83536-8","article-title":"Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement","volume":"15","author":"Zhou","year":"2025","journal-title":"Sci. Rep."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626007032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626007032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:03:23Z","timestamp":1791662603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626007032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":60,"alternative-id":["S0040816626007032"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.104007","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The levels of Twist1 homodimerization over heterodimerization with E proteins control osteogenic differentiation and calcification in the adult porcine aortic cusps","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.104007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104007"}}