{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:05:54Z","timestamp":1791209154632,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.104014","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:01:36Z","timestamp":1790866896000},"page":"104014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Centripetal structural reorganization of the testis in experimental rheumatoid arthritis and its age-dependent restitution by meloxicam: A morphometric and immunohistochemical study in rats"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2265-1760","authenticated-orcid":false,"given":"Temurshoh U.","family":"Khabibullayev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1996-4275","authenticated-orcid":false,"given":"Shukhrat J.","family":"Teshayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0781-9285","authenticated-orcid":false,"given":"Tolibjon B.","family":"Tilavov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2026.104014_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tice.2026.104014_bib2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.esxm.2020.07.004","article-title":"Sexual health and dysfunction in patients with rheumatoid arthritis: a cross-sectional single-center study","volume":"8","author":"Bay","year":"2020","journal-title":"Sex. Med."},{"key":"10.1016\/j.tice.2026.104014_bib3","first-page":"906","article-title":"Animal anatomical teaching models for improved veterinary anatomy education and learning","volume":"45","author":"Choudhary","year":"2025","journal-title":"Pak. Vet. J."},{"key":"10.1016\/j.tice.2026.104014_bib4","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1097\/MS9.0000000000003400","article-title":"Animal models for surgeries and implants: a vital tool in medical research and development","volume":"87","author":"Choudhary","year":"2025","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.tice.2026.104014_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/vetsci13030221","article-title":"Animal anatomy teaching: new concepts, innovations and applications","volume":"13","author":"Choudhary","year":"2026","journal-title":"Vet. Sci."},{"key":"10.1016\/j.tice.2026.104014_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2026.152810","article-title":"Artificial intelligence in animal anatomy with special reference to diagnostic imaging","volume":"265","author":"Choudhary","year":"2026","journal-title":"Ann. Anat."},{"key":"10.1016\/j.tice.2026.104014_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2024.152366","article-title":"Exploring the potential and limitations of artificial intelligence in animal anatomy","volume":"258","author":"Choudhary","year":"2025","journal-title":"Ann. Anat."},{"key":"10.1016\/j.tice.2026.104014_bib8","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1530\/REP-14-0392","article-title":"Cyclooxygenase and prostaglandins in somatic cell populations of the testis","volume":"149","author":"Frungieri","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.tice.2026.104014_bib9","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1210\/en.2006-0090","article-title":"Cyclooxygenase-2 and prostaglandin F2\u03b1 in Syrian hamster Leydig cells: inhibitory role on luteinizing hormone\/human chorionic gonadotropin-stimulated testosterone production","volume":"147","author":"Frungieri","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.tice.2026.104014_bib10","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"5","author":"GBD 2021 Rheumatoid Arthritis Collaborators","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.tice.2026.104014_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ygcen.2012.08.020","article-title":"Cyclooxygenase-2 in testes of aging rats","volume":"179","author":"Matzkin","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.tice.2026.104014_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.semarthrit.2020.02.002","article-title":"Sexual function and reproduction can be impaired in men with rheumatic diseases: a systematic review","volume":"50","author":"Perez-Garcia","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.tice.2026.104014_bib13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/andr.12693","article-title":"Adjuvant-induced arthritis affects testes and ventral prostate of Wistar rats","volume":"8","author":"Santos","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.tice.2026.104014_bib14","first-page":"793","article-title":"Assessment of age-related morphological changes in the testes of Mali pig of Tripura, India","volume":"30","author":"Sarkar","year":"2024","journal-title":"Kafkas Univ. Vet. Fak. Derg."},{"key":"10.1016\/j.tice.2026.104014_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10787-023-01268-z","article-title":"Galantamine mitigates testicular injury and disturbed spermatogenesis in adjuvant arthritic rats via modulating apoptosis, inflammatory signals, and IL-6\/JAK\/STAT3\/SOCS3 signaling","volume":"32","author":"Shafiey","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.tice.2026.104014_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/molehr\/4.3.227","article-title":"The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and PCNA","volume":"4","author":"Steger","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.tice.2026.104014_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S1677-5538.IBJU.2014.0595","article-title":"Male fertility potential alteration in rheumatic diseases: a systematic review","volume":"42","author":"Tiseo","year":"2016","journal-title":"Int. Braz. J. Urol."},{"key":"10.1016\/j.tice.2026.104014_bib18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/0960327114542886","article-title":"Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats","volume":"34","author":"Uzun","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tice.2026.104014_bib19","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1210\/en.2005-0298","article-title":"Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis","volume":"146","author":"Wang","year":"2005","journal-title":"Endocrinology"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662600710X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004081662600710X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:24:48Z","timestamp":1791206688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004081662600710X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":19,"alternative-id":["S004081662600710X"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.104014","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Centripetal structural reorganization of the testis in experimental rheumatoid arthritis and its age-dependent restitution by meloxicam: A morphometric and immunohistochemical study in rats","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.104014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104014"}}