{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:48:57Z","timestamp":1791668937857,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070719"],"award-info":[{"award-number":["32070719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.tice.2026.104025","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:37:38Z","timestamp":1791329858000},"page":"104025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Msx1 orchestrates retinal progenitor cell homeostasis from mechanical locking to synthetic arrest through the PI3K\/AKT\/mTOR pathway"],"prefix":"10.1016","volume":"104","author":[{"given":"Yifan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Tong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjian","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0096-622X","authenticated-orcid":false,"given":"Caixia","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tice.2026.104025_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.devcel.2016.11.020","article-title":"Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals","volume":"40","author":"Belanger","year":"2017","journal-title":"Dev. Cell."},{"issue":"11","key":"10.1016\/j.tice.2026.104025_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/dvg.20671","article-title":"Msx1 and Dlx5 function synergistically to regulate frontal bone development","volume":"48","author":"Chung","year":"2010","journal-title":"Genesis"},{"issue":"6","key":"10.1016\/j.tice.2026.104025_bib3","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.neuron.2019.04.010","article-title":"Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification","volume":"102","author":"Clark","year":"2019","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.tice.2026.104025_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013136118","article-title":"Meis homeobox genes control progenitor competence in the retina","volume":"118","author":"Dupacova","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.tice.2026.104025_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/eos.12078","article-title":"Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture","volume":"121","author":"Feng","year":"2013","journal-title":"Eur. J. Oral. Sci."},{"issue":"1","key":"10.1016\/j.tice.2026.104025_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/(SICI)1097-0177(199705)209:1<70::AID-AJA7>3.0.CO;2-U","article-title":"Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development","volume":"209","author":"Foerst-Potts","year":"1997","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.tice.2026.104025_bib7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1186\/s13287-021-02630-0","article-title":"Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2","volume":"12","author":"Grise","year":"2021","journal-title":"Stem Cell. Res. Ther."},{"issue":"8","key":"10.1016\/j.tice.2026.104025_bib8","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.128.8.1313","article-title":"Roles of homeobox and bHLH genes in specification of a retinal cell type","volume":"128","author":"Hatakeyama","year":"2001","journal-title":"Development"},{"issue":"9","key":"10.1016\/j.tice.2026.104025_bib9","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.3390\/ijms26093941","article-title":"Dual Disruption of EGFR\/PI3K Signaling: IGF2BP2 Targeting Reverses Anti-EGFR Resistance in CAFs-Infiltrated Oral Squamous Cell Carcinoma","volume":"26","author":"Hu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.tice.2026.104025_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114610","article-title":"The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress","volume":"43","author":"Jansen","year":"2024","journal-title":"Cell. Rep."},{"issue":"1","key":"10.1016\/j.tice.2026.104025_bib11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s13287-018-1091-y","article-title":"The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells","volume":"9","author":"Jin","year":"2018","journal-title":"Stem Cell. Res. Ther."},{"issue":"26","key":"10.1016\/j.tice.2026.104025_bib12","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1073\/pnas.1202810109","article-title":"Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death","volume":"109","author":"Jo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.tice.2026.104025_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/bpa.12562","article-title":"Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke","volume":"28","author":"Karabiyik","year":"2018","journal-title":"Brain Pathol."},{"issue":"12","key":"10.1016\/j.tice.2026.104025_bib14","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/s41556-020-00605-6","article-title":"Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress","volume":"22","author":"Lamm","year":"2020","journal-title":"Nat. Cell. Biol."},{"issue":"24","key":"10.1016\/j.tice.2026.104025_bib15","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1242\/dev.068452","article-title":"Msx1 and Msx2 promote meiosis initiation","volume":"138","author":"Le Bouffant","year":"2011","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.tice.2026.104025_bib16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12886-021-01946-y","article-title":"PI3K\/AKT\/mTOR signaling participates in insulin-mediated regulation of pathological myopia-related factors in retinal pigment epithelial cells","volume":"21","author":"Li","year":"2021","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.tice.2026.104025_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109659","article-title":"Fluoride regulates chondrocyte proliferation and autophagy via PI3K\/AKT\/mTOR signaling pathway","volume":"349","author":"Ma","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"12","key":"10.1016\/j.tice.2026.104025_bib18","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1016\/j.celrep.2016.11.016","article-title":"The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells","volume":"17","author":"Marcucci","year":"2016","journal-title":"Cell. Rep."},{"issue":"15","key":"10.1016\/j.tice.2026.104025_bib19","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1080\/15384101.2016.1183852","article-title":"Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors","volume":"15","author":"Marei","year":"2016","journal-title":"Cell. Cycle"},{"key":"10.1016\/j.tice.2026.104025_bib20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fphys.2012.00375","article-title":"Wnt\/beta-catenin signaling and Msx1 promote outgrowth of the maxillary prominences","volume":"3","author":"Medio","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tice.2026.104025_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2023.04.070","article-title":"Actin cytoskeletal reorganization is involved in hyperosmotic stress-induced autophagy in tubular epithelial cells","volume":"663","author":"Miyano","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.tice.2026.104025_bib22","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/jbmr\/zjaf102","article-title":"Inhibition of histone deacetylase 3 in dental mesenchyme regulates the development of tooth root","volume":"40","author":"Niibe","year":"2025","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.tice.2026.104025_bib23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.kint.2023.01.016","article-title":"The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5","volume":"103","author":"Polat","year":"2023","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.tice.2026.104025_bib24","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/00207454.2020.1806836","article-title":"MiR-17-5p inhibits cerebral hypoxia\/reoxygenationinjury by targeting PTEN through regulation of PI3K\/AKT\/mTOR signaling pathway","volume":"132","author":"Ren","year":"2022","journal-title":"Int. J. Neurosci."},{"issue":"2","key":"10.1016\/j.tice.2026.104025_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-0854.2009.01015.x","article-title":"The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2","volume":"11","author":"Sandrock","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.tice.2026.104025_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73809","article-title":"Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types","volume":"11","author":"Shekhar","year":"2022","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.tice.2026.104025_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01345-23","article-title":"Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus","volume":"98","author":"Shen","year":"2024","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.tice.2026.104025_bib28","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.molcel.2024.02.031","article-title":"Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice","volume":"84","author":"Sirozh","year":"2024","journal-title":"Mol. Cell."},{"issue":"7","key":"10.1016\/j.tice.2026.104025_bib29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s13238-021-00864-5","article-title":"LIN28 coordinately promotes nucleolar\/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells","volume":"13","author":"Sun","year":"2022","journal-title":"Protein Cell."},{"issue":"3","key":"10.1016\/j.tice.2026.104025_bib30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.prp.2019.01.020","article-title":"miR-495 promotes apoptosis and inhibits proliferation in endometrial cells via targeting PIK3R1","volume":"215","author":"Tan","year":"2019","journal-title":"Pathol. Res. Pract."},{"issue":"31","key":"10.1016\/j.tice.2026.104025_bib31","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1039\/D4TB01335B","article-title":"PI3K\/AKT\/mTOR signaling regulates BCP ceramic-induced osteogenesis","volume":"12","author":"Tan","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"4","key":"10.1016\/j.tice.2026.104025_bib32","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1523\/JNEUROSCI.21-04-01292.2001","article-title":"Bmp4 mediates apoptotic cell death in the developing chick eye","volume":"21","author":"Trousse","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tice.2026.104025_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12935-020-1096-3","article-title":"Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma","volume":"20","author":"Wang","year":"2020","journal-title":"Cancer Cell. Int."},{"issue":"4","key":"10.1016\/j.tice.2026.104025_bib34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/15384101.2018.1431594","article-title":"Insulin-like growth factor-1 regulation of retinal progenitor cell proliferation and differentiation","volume":"17","author":"Wang","year":"2018","journal-title":"Cell. Cycle"},{"issue":"9-10","key":"10.1016\/j.tice.2026.104025_bib35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s10495-024-01989-8","article-title":"Disulfidptosis: A new type of cell death","volume":"29","author":"Xiao","year":"2024","journal-title":"Apoptosis"},{"issue":"11","key":"10.1016\/j.tice.2026.104025_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107877","article-title":"O-GlcNAcylation of ribosome-associated proteins is concomitant with translational reprogramming during proteotoxic stress","volume":"300","author":"Zeidan","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.tice.2026.104025_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aea0685","article-title":"DLX2 acts as a pioneer factor and drives Msx1(+) ectomesenchyme formation from embryonic stem cells","volume":"12","author":"Zhang","year":"2026","journal-title":"Sci. Adv."}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626007214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816626007214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:14:40Z","timestamp":1791666880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816626007214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":37,"alternative-id":["S0040816626007214"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2026.104025","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Msx1 orchestrates retinal progenitor cell homeostasis from mechanical locking to synthetic arrest through the PI3K\/AKT\/mTOR pathway","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2026.104025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104025"}}