{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:33:54Z","timestamp":1770417234255,"version":"3.49.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Genetics"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.tig.2021.03.004","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T05:48:05Z","timestamp":1618292885000},"page":"612-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines"],"prefix":"10.1016","volume":"37","author":[{"given":"Sudipto","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tig.2021.03.004_bb0005","doi-asserted-by":"crossref","first-page":"115563","DOI":"10.1016\/j.bone.2020.115563","article-title":"From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis","volume":"140","author":"P\u00e9rez-Machado","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.tig.2021.03.004_bb0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.spinee.2011.03.010","article-title":"Experimental animal models in scoliosis research: a review of the literature","volume":"11","author":"Janssen","year":"2011","journal-title":"Spine J."},{"key":"10.1016\/j.tig.2021.03.004_bb0015","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1093\/hmg\/ddv170","article-title":"Gpr126\/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice","volume":"24","author":"Karner","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2021.03.004_bb0020","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.devcel.2017.07.022","article-title":"The proprioceptive system masterminds spinal alignment: insight into the mechanism of scoliosis","volume":"42","author":"Blecher","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tig.2021.03.004_bb0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cbpc.2006.10.004","article-title":"Teleosts as models for human vertebral stability and deformity","volume":"145","author":"Gorman","year":"2007","journal-title":"Comp. Biochem. Physiol. - C Toxicol. Pharmacol."},{"key":"10.1016\/j.tig.2021.03.004_bb0030","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.aaf6419","article-title":"Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature","volume":"352","author":"Grimes","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.tig.2021.03.004_bb0035","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/s41588-018-0260-3","article-title":"Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis","volume":"50","author":"Zhang","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2021.03.004_bb0040","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.cub.2018.05.079","article-title":"The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis","volume":"28","author":"Cantaut-Belarif","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tig.2021.03.004_bb0045","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0169-328X(02)00565-X","article-title":"Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid","volume":"110","author":"Caprile","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.tig.2021.03.004_bb0050","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.mehy.2008.09.052","article-title":"Idiopathic-type scoliosis is not exclusive to bipedalism","volume":"72","author":"Gorman","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.tig.2021.03.004_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ppul.1950160103","article-title":"New associations of primary ciliary dyskinesia syndrome","volume":"16","author":"Engesaeth","year":"1993","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.tig.2021.03.004_bb0060","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1172\/JCI77262","article-title":"Functional variants of POC5 identified in patients with idiopathic scoliosis","volume":"125","author":"Patten","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tig.2021.03.004_bb0065","doi-asserted-by":"crossref","first-page":"582255","DOI":"10.3389\/fcell.2020.582255","article-title":"Coding variants coupled with rapid modeling in zebrafish implicate dynein genes, dnaaf1 and zmynd10, as adolescent idiopathic scoliosis candidate genes","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tig.2021.03.004_bb0070","series-title":"Rare Coding Variants in Axonemal Dynein Heavy Chain Genes are Associated With Adolescent Idiopathic Scoliosis","author":"Wang","year":"2020"},{"key":"10.1016\/j.tig.2021.03.004_bb0075","doi-asserted-by":"crossref","first-page":"E288","DOI":"10.1097\/BRS.0000000000003786","article-title":"Novel mutations in UTS2R are associated with adolescent idiopathic scoliosis in the Chinese population","volume":"46","author":"Dai","year":"2020","journal-title":"Spine"}],"container-title":["Trends in Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952521000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952521000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:11:07Z","timestamp":1759191067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168952521000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0168952521000731"],"URL":"https:\/\/doi.org\/10.1016\/j.tig.2021.03.004","relation":{},"ISSN":["0168-9525"],"issn-type":[{"value":"0168-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines","name":"articletitle","label":"Article Title"},{"value":"Trends in Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tig.2021.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}