{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:09:00Z","timestamp":1792595340387,"version":"4.5.0"},"reference-count":134,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["ZIAEY000450"],"award-info":[{"award-number":["ZIAEY000450"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["ZIAEY000546"],"award-info":[{"award-number":["ZIAEY000546"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Genetics"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.tig.2024.04.012","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T08:13:24Z","timestamp":1716365604000},"page":"718-729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Epigenome\u2013metabolism nexus in the retina: implications for aging and disease"],"prefix":"10.1016","volume":"40","author":[{"given":"Anupam K.","family":"Mondal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohita","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayshree","family":"Advani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-1141","authenticated-orcid":false,"given":"Anand","family":"Swaroop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tig.2024.04.012_bb0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature05918","article-title":"Stability and flexibility of epigenetic gene regulation in mammalian development","volume":"447","author":"Reik","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.tig.2024.04.012_bb0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","volume":"33","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2013.03.004","article-title":"Influence of metabolism on epigenetics and disease","volume":"153","author":"Kaelin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-cellbio-100814-125544","article-title":"Metabolism and epigenetics","volume":"31","author":"Janke","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0025","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tig.2024.04.012_bb0030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0035","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1021\/cb400689r","article-title":"Metabolic mechanisms of epigenetic regulation","volume":"8","author":"Meier","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrg2717","article-title":"Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait","volume":"11","author":"Wright","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0045","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cmet.2022.07.014","article-title":"Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer\u2019s disease","volume":"34","author":"Traxler","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.tig.2024.04.012_bb0050","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0055","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1146\/annurev-vision-100419-114940","article-title":"Aging of the retina: molecular and metabolic turbulences and potential interventions","volume":"7","author":"Campello","year":"2021","journal-title":"Annu. Rev. Vis. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cbpa.2015.10.030","article-title":"Metabolic control of methylation and acetylation","volume":"30","author":"Su","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0065","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019463","article-title":"Metabolic signaling to chromatin","volume":"8","author":"Berger","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0070","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature23263","article-title":"Allelic reprogramming of 3D chromatin architecture during early mammalian development","volume":"547","author":"Du","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tig.2024.04.012_bb0075","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1038\/s41467-022-33427-1","article-title":"High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci","volume":"13","author":"Marchal","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107525","article-title":"Genome-wide profiling identifies DNA methylation signatures of aging in rod photoreceptors associated with alterations in energy metabolism","volume":"31","author":"Corso-Diaz","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0085","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11613","article-title":"Epigenomic landscapes of retinal rods and cones","volume":"5","author":"Mo","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.tig.2024.04.012_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113543","article-title":"Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids","volume":"42","author":"Qu","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0095","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28899","article-title":"Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye","volume":"6","author":"Kanow","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.tig.2024.04.012_bb0100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25946","article-title":"Glycolytic reliance promotes anabolism in photoreceptors","volume":"6","author":"Chinchore","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.tig.2024.04.012_bb0105","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.celrep.2018.04.111","article-title":"Aerobic glycolysis is essential for normal rod function and controls secondary cone death in retinitis pigmentosa","volume":"23","author":"Petit","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1146\/annurev-vision-100419-115156","article-title":"Retina metabolism and metabolism in the pigmented epithelium: a busy intersection","volume":"7","author":"Hurley","year":"2021","journal-title":"Annu. Rev. Vis. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101029","article-title":"Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities","volume":"89","author":"Schneider","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0120","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0125","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0130","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82364","article-title":"Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock","volume":"12","author":"Ahadi","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.tig.2024.04.012_bb0135","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1038\/s41467-024-46063-8","article-title":"QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration","volume":"15","author":"Advani","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0140","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41588-019-0351-9","article-title":"Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration","volume":"51","author":"Ratnapriya","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0145","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.celrep.2019.12.082","article-title":"Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration","volume":"30","author":"Orozco","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008934","article-title":"A mega-analysis of expression quantitative trait loci in retinal tissue","volume":"16","author":"Strunz","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-020-03145-z","article-title":"Regulatory genomic circuitry of human disease loci by integrative epigenomics","volume":"590","author":"Boix","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tig.2024.04.012_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.03.002","article-title":"Epigenetic control of gene regulation during development and disease: a view from the retina","volume":"65","author":"Corso-Diaz","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0165","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13072-021-00384-w","article-title":"Epigenetic regulation of retinal development","volume":"14","author":"Raeisossadati","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.tig.2024.04.012_bb0170","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.neuron.2017.04.029","article-title":"Epigenomics of retinal development in mice and humans","volume":"94","author":"Lonfat","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.tig.2024.04.012_bb0175","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2017.04.022","article-title":"The dynamic epigenetic landscape of the retina during development, reprogramming, and tumorigenesis","volume":"94","author":"Aldiri","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.tig.2024.04.012_bb0180","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.devcel.2022.02.018","article-title":"Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids","volume":"57","author":"Thomas","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0185","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13059-023-03111-8","article-title":"Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation","volume":"24","author":"Wang","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0190","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ajhg.2020.09.002","article-title":"Structural variants create new topological-associated domains and ectopic retinal enhancer-gene contact in dominant retinitis pigmentosa","volume":"107","author":"de Bruijn","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0195","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1073\/pnas.1922501117","article-title":"Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease","volume":"117","author":"Cherry","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2024.04.012_bb0200","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41467-024-45381-1","article-title":"Multi-omics analysis in human retina uncovers ultraconserved cis-regulatory elements at rare eye disease loci","volume":"15","author":"Lopez Soriano","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.xgen.2023.100302","article-title":"A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration","volume":"3","author":"Orozco","year":"2023","journal-title":"Cell Genomics"},{"key":"10.1016\/j.tig.2024.04.012_bb0210","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2012.10.002","article-title":"The neuronal organization of the retina","volume":"76","author":"Masland","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.tig.2024.04.012_bb0215","doi-asserted-by":"crossref","first-page":"8599","DOI":"10.1073\/pnas.1002471107","article-title":"Flow of energy in the outer retina in darkness and in light","volume":"107","author":"Linton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2024.04.012_bb0220","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.tig.2024.04.012_bb0225","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fcell.2020.00266","article-title":"Aerobic glycolysis in the retina: functional roles of pyruvate kinase isoforms","volume":"8","author":"Rajala","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0230","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1074\/jbc.R111.304428","article-title":"Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?","volume":"287","author":"Punzo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tig.2024.04.012_bb0235","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1126\/science.982063","article-title":"Rod outer segment disk shedding in rat retina: relationship to cyclic lighting","volume":"194","author":"LaVail","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.tig.2024.04.012_bb0240","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.neuron.2019.04.004","article-title":"Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Muller glial cells","volume":"102","author":"Morshedian","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.tig.2024.04.012_bb0245","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/jnr.23583","article-title":"Glucose, lactate, and shuttling of metabolites in vertebrate retinas","volume":"93","author":"Hurley","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0250","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1096\/fj.201902961R","article-title":"Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: insight gained from cell-specific Bsg deletion","volume":"34","author":"Han","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.tig.2024.04.012_bb0255","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.TR120000618","article-title":"Fatty acid oxidation and photoreceptor metabolic needs","volume":"62","author":"Fu","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0260","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1194\/jlr.M044990","article-title":"Spatial organization of lipids in the human retina and optic nerve by MALDI imaging mass spectrometry","volume":"55","author":"Zemski Berry","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0265","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.4059","article-title":"Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1","volume":"22","author":"Joyal","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.tig.2024.04.012_bb0270","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1073\/pnas.1237052100","article-title":"D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors","volume":"100","author":"Stevens","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2024.04.012_bb0275","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.129398","article-title":"Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity","volume":"4","author":"Singh","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.tig.2024.04.012_bb0280","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tig.2024.04.012_bb0285","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1158\/2159-8290.CD-14-0250","article-title":"Serine catabolism regulates mitochondrial redox control during hypoxia","volume":"4","author":"Ye","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tig.2024.04.012_bb0290","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJMoa1815111","article-title":"Serine and lipid metabolism in macular disease and peripheral neuropathy","volume":"381","author":"Gantner","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tig.2024.04.012_bb0295","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13148-019-0608-2","article-title":"Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes","volume":"11","author":"Porter","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.tig.2024.04.012_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032602","article-title":"Cell-specific DNA methylation patterns of retina-specific genes","volume":"7","author":"Merbs","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tig.2024.04.012_bb0305","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.512","article-title":"DNA methylation and differential gene regulation in photoreceptor cell death","volume":"5","author":"Farinelli","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tig.2024.04.012_bb0310","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3390\/ijms23031408","article-title":"Regulation of opsin gene expression by DNA methylation and histone acetylation","volume":"23","author":"Song","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0315","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.cell.2009.01.052","article-title":"Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution","volume":"137","author":"Solovei","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0320","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj3035","article-title":"Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors","volume":"7","author":"Smith","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tig.2024.04.012_bb0325","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn2070","article-title":"Mitochondria in cone photoreceptors act as microlenses to enhance photon delivery and confer directional sensitivity to light","volume":"8","author":"Ball","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tig.2024.04.012_bb0330","article-title":"Methylation-dependent regulation of HIF-1alpha stability restricts retinal and tumour angiogenesis","volume":"7","author":"Kim","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006987","article-title":"Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways","volume":"13","author":"Seritrakul","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.827274","article-title":"The potential role of epigenetic mechanisms in the development of retinitis pigmentosa and related photoreceptor dystrophies","volume":"13","author":"Dvoriantchikova","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0345","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2110387118","article-title":"A genetic model of methionine restriction extends Drosophila health- and lifespan","volume":"118","author":"Parkhitko","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2024.04.012_bb0350","first-page":"51","article-title":"Epigenetic mechanisms of the aging human retina","volume":"9","author":"Pennington","year":"2015","journal-title":"J. Exp. Neurosci."},{"key":"10.1016\/j.tig.2024.04.012_bb0355","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.tibs.2022.03.008","article-title":"Mitochondrial-to-nuclear communication in aging: an epigenetic perspective","volume":"47","author":"Zhu","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0360","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.tig.2024.04.012_bb0365","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/bs.ircmb.2015.07.003","article-title":"Emerging roles of JmjC domain-containing proteins","volume":"319","author":"Accari","year":"2015","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0370","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.gendis.2020.01.003","article-title":"Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?","volume":"8","author":"Mohana Devi","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.tig.2024.04.012_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100127","article-title":"Quantitative proteomic and metabolomic profiling reveals altered mitochondrial metabolism and folate biosynthesis pathways in the aging Drosophila eye","volume":"20","author":"Hall","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.tig.2024.04.012_bb0380","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1089\/ars.2011.4333","article-title":"Damaged mitochondrial DNA replication system and the development of diabetic retinopathy","volume":"17","author":"Tewari","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tig.2024.04.012_bb0385","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/hmg\/ddac013","article-title":"Multiomics analyses reveal early metabolic imbalance and mitochondrial stress in neonatal photoreceptors leading to cell death in Pde6brd1\/rd1 mouse model of retinal degeneration","volume":"31","author":"Jiang","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0390","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.celrep.2018.01.075","article-title":"Retinal cell type DNA methylation and histone modifications predict reprogramming efficiency and retinogenesis in 3D organoid cultures","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0395","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exer.2013.07.017","article-title":"The role of SIRT1 in ocular aging","volume":"116","author":"Mimura","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0400","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3187594","article-title":"Sirtuins expression and their role in retinal diseases","volume":"2017","author":"Balaiya","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tig.2024.04.012_bb0405","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41598-017-00035-9","article-title":"Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0410","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.advms.2015.09.003","article-title":"The role of sirtuins in aging and age-related diseases","volume":"61","author":"Watroba","year":"2016","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0415","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152774","article-title":"Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism","volume":"22","author":"Nitsch","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0420","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tig.2024.04.012_bb0425","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-023-02931-y","article-title":"YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2","volume":"24","author":"Wang","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0430","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1038\/s41467-023-39672-2","article-title":"Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis","volume":"14","author":"Takata","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0435","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0440","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200049","article-title":"Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development","volume":"149","author":"Dai","year":"2022","journal-title":"Development"},{"key":"10.1016\/j.tig.2024.04.012_bb0445","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.preteyeres.2010.09.001","article-title":"Dietary hyperglycemia, glycemic index and metabolic retinal diseases","volume":"30","author":"Chiu","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0450","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ophtha.2020.08.018","article-title":"Dietary nutrient intake and progression to late age-related macular degeneration in the age-related eye disease studies 1 and 2","volume":"128","author":"Agron","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.tig.2024.04.012_bb0455","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/jhg.2013.57","article-title":"Metabolism-epigenome crosstalk in physiology and diseases","volume":"58","author":"Hino","year":"2013","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0460","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2015.08.024","article-title":"Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism","volume":"22","author":"Mentch","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.tig.2024.04.012_bb0465","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.18632\/oncotarget.24333","article-title":"Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration","volume":"9","author":"Elmasry","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.tig.2024.04.012_bb0470","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s13167-021-00263-0","article-title":"Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person","volume":"12","author":"Koklesova","year":"2021","journal-title":"EPMA J."},{"key":"10.1016\/j.tig.2024.04.012_bb0475","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1210\/en.2010-0505","article-title":"Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes","volume":"151","author":"Vucetic","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.tig.2024.04.012_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108979","article-title":"Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia","volume":"27","author":"Mondal","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.tig.2024.04.012_bb0485","doi-asserted-by":"crossref","first-page":"E4472","DOI":"10.1073\/pnas.1702302114","article-title":"Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration","volume":"114","author":"Rowan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2024.04.012_bb0490","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.2337\/diab.42.12.1809","article-title":"Primary prevention of diabetes mellitus by prevention of obesity in monkeys","volume":"42","author":"Hansen","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.tig.2024.04.012_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.xgen.2024.100509","article-title":"Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons","volume":"4","author":"Lin","year":"2024","journal-title":"Cell Genomics"},{"key":"10.1016\/j.tig.2024.04.012_bb0500","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/1673-5374.314308","article-title":"The promise of neuroprotection by dietary restriction in glaucoma","volume":"17","author":"Russo","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.tig.2024.04.012_bb0505","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bbrc.2003.08.020","article-title":"Caloric restriction retards age-related changes in rat retina","volume":"309","author":"Li","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0510","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrc2962","article-title":"SIRT1: recent lessons from mouse models","volume":"10","author":"Herranz","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tig.2024.04.012_bb0515","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12699","article-title":"Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina","volume":"17","author":"Izuta","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0520","article-title":"Alterations of the intestinal microbiota in age-related macular degeneration","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tig.2024.04.012_bb0525","article-title":"The microbiome stabilizes circadian rhythms in the gut","volume":"120","author":"Zhang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2024.04.012_bb0530","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tig.2024.04.012_bb0535","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-017-02651-5","article-title":"Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases","volume":"9","author":"Fellows","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101249","article-title":"Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism","volume":"53","author":"Yang","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tig.2024.04.012_bb0545","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413457","article-title":"Epigenetic age acceleration is not associated with age-related macular degeneration","volume":"22","author":"Saptarshi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0550","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1080\/15592294.2015.1060388","article-title":"Differential DNA methylation identified in the blood and retina of AMD patients","volume":"10","author":"Oliver","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.tig.2024.04.012_bb0555","doi-asserted-by":"crossref","DOI":"10.1038\/srep46330","article-title":"DNA methylation landscape of ocular tissue relative to matched peripheral blood","volume":"7","author":"Hewitt","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tig.2024.04.012_bb0560","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1080\/21655979.2021.1976502","article-title":"Integrated Analysis of DNA methylation and transcriptome profile to identify key features of age-related macular degeneration","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.tig.2024.04.012_bb0565","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1167\/iovs.11-8449","article-title":"DNA methylation is associated with altered gene expression in AMD","volume":"53","author":"Hunter","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0570","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","article-title":"Benefits and limitations of genome-wide association studies","volume":"20","author":"Tam","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0575","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-1-0716-0026-9_15","article-title":"Quantitative trait loci (QTL) mapping","volume":"2082","author":"Powder","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0580","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15452","article-title":"A complete tool set for molecular QTL discovery and analysis","volume":"8","author":"Delaneau","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2021.100017","article-title":"Genomic-metabolomic associations support the role of LIPC and glycerophospholipids in age-related macular degeneration","volume":"1","author":"Lains","year":"2021","journal-title":"Ophthalmol. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0590","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba3066","article-title":"The impact of sex on gene expression across human tissues","volume":"369","author":"Oliva","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tig.2024.04.012_bb0595","article-title":"Epigenetic mechanisms of brain sexual differentiation","volume":"14","author":"Gegenhuber","year":"2022","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0600","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molmet.2018.04.003","article-title":"Sex differences in obesity, lipid metabolism, and inflammation \u2013 a role for the sex chromosomes?","volume":"15","author":"Zore","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tig.2024.04.012_bb0605","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41467-023-35808-6","article-title":"Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tig.2024.04.012_bb0610","first-page":"707","article-title":"Retinal gene expression responses to aging are sexually divergent","volume":"23","author":"Du","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.tig.2024.04.012_bb0615","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.64.3.18","article-title":"Tissue-specific sex difference in mouse eye and brain metabolome under fed and fasted states","volume":"64","author":"Saravanan","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tig.2024.04.012_bb0620","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0625","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0630","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.tig.2024.04.012_bb0635","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.18632\/aging.101508","article-title":"Epigenetic clock for skin and blood cells applied to Hutchinson Gilford progeria syndrome and ex vivo studies","volume":"10","author":"Horvath","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.tig.2024.04.012_bb0640","article-title":"Novel epigenetic clock biomarkers of age-related macular degeneration","volume":"9","author":"Mallik","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.tig.2024.04.012_bb0645","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/pcmedi\/pbab012","article-title":"Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina","volume":"4","author":"Chen","year":"2021","journal-title":"Precis Clin. Med."},{"key":"10.1016\/j.tig.2024.04.012_bb0650","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13737","article-title":"Stress induced aging in mouse eye","volume":"21","author":"Xu","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.tig.2024.04.012_bb0655","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tig.2024.04.012_bb0660","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41576-018-0006-1","article-title":"A-to-I RNA editing \u2013 immune protector and transcriptome diversifier","volume":"19","author":"Eisenberg","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tig.2024.04.012_bb0665","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13059-021-02287-1","article-title":"Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes","volume":"22","author":"Park","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.tig.2024.04.012_bb0670","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3390\/ijms21030777","article-title":"RNA editing as a therapeutic approach for retinal gene therapy requiring long coding sequences","volume":"21","author":"Fry","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Trends in Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952524000994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952524000994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T15:38:54Z","timestamp":1722872334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168952524000994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":134,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0168952524000994"],"URL":"https:\/\/doi.org\/10.1016\/j.tig.2024.04.012","relation":{},"ISSN":["0168-9525"],"issn-type":[{"value":"0168-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenome\u2013metabolism nexus in the retina: implications for aging and disease","name":"articletitle","label":"Article Title"},{"value":"Trends in Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tig.2024.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}