{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:30:13Z","timestamp":1792477813563,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,6]],"date-time":"2027-04-06T00:00:00Z","timestamp":1806969600000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006060","name":"Spina Bifida Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Genetics"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.tig.2026.01.011","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:08:39Z","timestamp":1773810519000},"page":"339-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["De novo mutations and environmental modifiers: lessons from neural tube defects"],"prefix":"10.1016","volume":"42","author":[{"given":"Hong-Yu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Ioi","family":"Vong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher T.","family":"Kahle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-9220","authenticated-orcid":false,"given":"Joseph G.","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tig.2026.01.011_bb0005","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/bdra.23486","article-title":"Prevalence and trend of neural tube defects in five counties in Shanxi province of Northern China, 2000 to 2014","volume":"106","author":"Liu","year":"2016","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.tig.2026.01.011_bb0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/oxfordjournals.bmb.a071187","article-title":"Causation of neural tube defects: clues from epidemiology","volume":"30","author":"Leck","year":"1974","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.tig.2026.01.011_bb0015","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117075119","article-title":"Hinge point emergence in mammalian spinal neurulation","volume":"119","author":"de Goederen","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2026.01.011_bb0020","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1242\/dev.145904","article-title":"Neural tube closure: cellular, molecular and biomechanical mechanisms","volume":"144","author":"Nikolopoulou","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.tig.2026.01.011_bb0025","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1542\/peds.95.4.506","article-title":"Multiple sites of anterior neural tube closure in humans: evidence from anterior neural tube defects (anencephaly)","volume":"95","author":"Golden","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.tig.2026.01.011_bb0030","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.mod.2004.04.022","article-title":"Strategies of vertebrate neurulation and a re-evaluation of teleost neural tube formation","volume":"121","author":"Lowery","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.tig.2026.01.011_bb0035","doi-asserted-by":"crossref","first-page":"12843","DOI":"10.1073\/pnas.0501963102","article-title":"Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6","volume":"102","author":"Carter","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2026.01.011_bb0040","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0960-9822(03)00374-9","article-title":"Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse","volume":"13","author":"Curtin","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tig.2026.01.011_bb0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/hmg\/ddg014","article-title":"Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse","volume":"12","author":"Murdoch","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0050","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/90081","article-title":"Ltap, a mammalian homolog of Drosophila Strabismus\/Van Gogh, is altered in the mouse neural tube mutant Loop-tail","volume":"28","author":"Kibar","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0055","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0092-8674(91)90071-6","article-title":"Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3","volume":"67","author":"Epstein","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.tig.2026.01.011_bb0060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/bdra.23533","article-title":"Inositol, neural tube closure and the prevention of neural tube defects","volume":"109","author":"Greene","year":"2017","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.tig.2026.01.011_bb0065","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/bdra.20552","article-title":"Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants","volume":"85","author":"Harris","year":"2009","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.tig.2026.01.011_bb0070","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/bdra.23554","article-title":"Genetic backgrounds and modifier genes of NTD mouse models: an opportunity for greater understanding of the multifactorial etiology of neural tube defects","volume":"109","author":"Leduc","year":"2017","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.tig.2026.01.011_bb0075","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/hmg\/ddm333","article-title":"Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube","volume":"17","author":"Wong","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0080","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1056\/NEJMoa2033911","article-title":"A human pleiotropic multiorgan condition caused by deficient Wnt secretion","volume":"385","author":"Chai","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tig.2026.01.011_bb0085","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/tera.1420390312","article-title":"A mouse model for neural tube defects: the curtailed (Tc) mutation produces spina bifida occulta in Tc\/+ animals and spina bifida with meningomyelocele in Tc\/t","volume":"39","author":"Park","year":"1989","journal-title":"Teratology"},{"key":"10.1016\/j.tig.2026.01.011_bb0090","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.2023.9864","article-title":"Folic acid supplementation to prevent neural tube defects: updated evidence report and systematic review for the US Preventive Services Task Force","volume":"330","author":"Viswanathan","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.tig.2026.01.011_bb0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study","volume":"338","author":"MRC Vitamin Study Research Group","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.tig.2026.01.011_bb0100","article-title":"Global heterogeneity in folic acid fortification policies and implications for prevention of neural tube defects and stroke: a systematic review","volume":"67","author":"Quinn","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.tig.2026.01.011_bb0105","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1093\/hmg\/ddn262","article-title":"Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function","volume":"17","author":"Burren","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0110","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.celrep.2017.10.072","article-title":"Partitioning of one-carbon units in folate and methionine metabolism is essential for neural tube closure","volume":"21","author":"Leung","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.tig.2026.01.011_bb0115","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300202R","article-title":"Folate regulation of planar cell polarity pathway and F-actin through folate receptor alpha","volume":"38","author":"Han","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.tig.2026.01.011_bb0120","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1093\/hmg\/ddr289","article-title":"Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival","volume":"20","author":"Marean","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0125","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/13861","article-title":"Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development","volume":"23","author":"Piedrahita","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0130","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nm0197-60","article-title":"Inositol prevents folate-resistant neural tube defects in the mouse","volume":"3","author":"Greene","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.tig.2026.01.011_bb0135","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1017\/S0007114515005322","article-title":"Inositol for the prevention of neural tube defects: a pilot randomised controlled trial","volume":"115","author":"Greene","year":"2016","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tig.2026.01.011_bb0140","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","article-title":"5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review","volume":"151","author":"Botto","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tig.2026.01.011_bb0145","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/343617a0","article-title":"Cloning of the T gene required in mesoderm formation in the mouse","volume":"343","author":"Herrmann","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.tig.2026.01.011_bb0150","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1242\/dev.129.14.3311","article-title":"The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate","volume":"129","author":"Amacher","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.tig.2026.01.011_bb0155","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41586-024-07095-8","article-title":"On the genetic basis of tail-loss evolution in humans and apes","volume":"626","author":"Xia","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tig.2026.01.011_bb0160","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00439-015-1589-7","article-title":"T (brachyury) is linked to a Mendelian form of neural tube defects in humans","volume":"134","author":"Shaheen","year":"2015","journal-title":"Hum. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0165","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ajmg.10436","article-title":"T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families","volume":"110","author":"Speer","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0170","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1469-1809.1998.6250379.x","article-title":"Susceptibility to spina bifida; an association study of five candidate genes","volume":"62","author":"Morrison","year":"1998","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0175","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/ncb1966","article-title":"The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development","volume":"11","author":"Gray","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tig.2026.01.011_bb0180","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/hmg\/ddr359","article-title":"Mutations in the planar cell polarity gene, fuzzy, are associated with neural tube defects in humans","volume":"20","author":"Seo","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0185","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.0712126105","article-title":"Genetic interaction between members of the Vangl family causes neural tube defects in mice","volume":"105","author":"Torban","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2026.01.011_bb0190","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/hmg\/10.22.2593","article-title":"Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification","volume":"10","author":"Murdoch","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0195","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJMoa060651","article-title":"Mutations in VANGL1 associated with neural-tube defects","volume":"356","author":"Kibar","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tig.2026.01.011_bb0200","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1056\/NEJMc0910820","article-title":"VANGL2 mutations in human cranial neural-tube defects","volume":"362","author":"Lei","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tig.2026.01.011_bb0205","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/dvdy.23816","article-title":"Neural tube defects by NUAK1 and NUAK2 double mutation","volume":"241","author":"Ohmura","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.tig.2026.01.011_bb0210","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191561","article-title":"A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling","volume":"217","author":"Bonnard","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tig.2026.01.011_bb0215","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.3390\/diagnostics15182289","article-title":"NUAK2 pathogenic variants are definitively associated with neural tube defects in humans: new genotype-phenotype correlation and review of the literature","volume":"15","author":"Mastromoro","year":"2025","journal-title":"Diagnostics"},{"key":"10.1016\/j.tig.2026.01.011_bb0220","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1073\/pnas.90.2.532","article-title":"A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant","volume":"90","author":"Epstein","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tig.2026.01.011_bb0225","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/ajmg.a.38325","article-title":"Neural tube defects in Waardenburg syndrome: a case report and review of the literature","volume":"173","author":"Hart","year":"2017","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.tig.2026.01.011_bb0230","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1399-0004.1985.tb00370.x","article-title":"The cerebro-costo-mandibular syndrome: third report of familial occurrence","volume":"28","author":"Hennekam","year":"1985","journal-title":"Clin. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0235","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archderm.1987.01660280105034","article-title":"The CHILD syndrome. Histologic and ultrastructural studies","volume":"123","author":"Hebert","year":"1987","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.tig.2026.01.011_bb0240","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tins.2020.04.009","article-title":"Closing in on mechanisms of open neural tube defects","volume":"43","author":"Lee","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tig.2026.01.011_bb0245","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41586-025-08676-x","article-title":"The contribution of de novo coding mutations to meningomyelocele","volume":"641","author":"Ha","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tig.2026.01.011_bb0250","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1126\/science.adl1624","article-title":"Risk of meningomyelocele mediated by the common 22q11.2 deletion","volume":"384","author":"Vong","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.tig.2026.01.011_bb0255","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/ng.3970","article-title":"Contribution of rare inherited and de novo variants in 2.871 congenital heart disease probands","volume":"49","author":"Jin","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0260","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41588-022-01148-2","article-title":"Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes","volume":"54","author":"Zhou","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tig.2026.01.011_bb0265","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41436-021-01242-6","article-title":"Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG)","volume":"23","author":"Manickam","year":"2021","journal-title":"Genet.Med."},{"key":"10.1016\/j.tig.2026.01.011_bb0270","article-title":"Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning","author":"Liu","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.tig.2026.01.011_bb0275","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41551-022-00868-4","article-title":"Production of human spinal-cord organoids recapitulating neural-tube morphogenesis","volume":"6","author":"Lee","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.tig.2026.01.011_bb0280","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-021-04026-9","article-title":"Human neural tube morphogenesis in vitro by geometric constraints","volume":"599","author":"Karzbrun","year":"2021","journal-title":"Nature"}],"container-title":["Trends in Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952526000302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168952526000302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:09:07Z","timestamp":1776121747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168952526000302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0168952526000302"],"URL":"https:\/\/doi.org\/10.1016\/j.tig.2026.01.011","relation":{},"ISSN":["0168-9525"],"issn-type":[{"value":"0168-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"De novo mutations and environmental modifiers: lessons from neural tube defects","name":"articletitle","label":"Article Title"},{"value":"Trends in Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tig.2026.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}