{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:21:50Z","timestamp":1783621310336,"version":"3.55.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.tim.2006.02.006","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T12:41:16Z","timestamp":1142426476000},"page":"176-182","source":"Crossref","is-referenced-by-count":1633,"title":["Co-selection of antibiotic and metal resistance"],"prefix":"10.1016","volume":"14","author":[{"given":"Craig","family":"Baker-Austin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith S.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramunas","family":"Stepanauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.V.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2006.02.006_bib1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrmicro1181","article-title":"Do physiological roles foster persistence of drug\/multidrug- efflux transporters? A case study","volume":"3","author":"Krulwich","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib2","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1086\/340245","article-title":"Generally overlooked fundamentals of bacterial genetics and ecology","volume":"34","author":"Summers","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2006.02.006_bib3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1128\/AAC.37.4.825","article-title":"Mercury released from dental silver fillings provokes an increase in mercury-resistant and antibiotic-resistant bacteria in oral and intestinal floras of primates","volume":"37","author":"Summers","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1462-2920.2001.00161.x","article-title":"Environmental selection of antibiotic resistance genes","volume":"3","author":"Alonso","year":"2001","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib5","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1021\/es048468f","article-title":"Elevated microbial tolerance to metals and antibiotics in metal-contaminated industrial environments","volume":"39","author":"Stepanauskas","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tim.2006.02.006_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/10766290152773374","article-title":"Genetic linkage between resistance to quaternary ammonium compounds and \u03b2-lactam antibiotics in food-related Staphylococcus spp","volume":"7","author":"Sidhu","year":"2001","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.tim.2006.02.006_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0964-8305(03)00044-1","article-title":"Disinfectant resistance mechanisms, cross-resistance, and co-resistance","volume":"51","author":"Chapman","year":"2003","journal-title":"Int. Biodeterior. Biodegradation"},{"key":"10.1016\/j.tim.2006.02.006_bib8","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/JB.95.4.1335-1342.1968","article-title":"Plasmid-linked resistance to inorganic salts in Staphylococcus aureus","volume":"95","author":"Novick","year":"1968","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2006.02.006_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1128\/MMBR.47.3.361-409.1983","article-title":"Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria","volume":"47","author":"Foster","year":"1983","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.tim.2006.02.006_bib10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/bbrc.2000.2727","article-title":"Characterization of large plasmids encoding resistance to toxic heavy metals in Salmonella abortus equi","volume":"272","author":"Ghosh","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tim.2006.02.006_bib11","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1128\/AAC.46.5.1410-1416.2002","article-title":"tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance","volume":"46","author":"Hasman","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib12","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1128\/AEM.68.8.4127-4129.2002","article-title":"Antimicrobial resistance among Enterococci from pigs in three European countries","volume":"68","author":"Aarestrup","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib13","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1128\/AAC.49.1.454-456.2005","article-title":"Relationship between copper, glycopeptide, and macrolide resistance among Enterococcus faecium strains isolated from pigs in Denmark between 1997 and 2003","volume":"49","author":"Hasman","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib14","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1128\/AAC.43.12.2925","article-title":"Incidence and characterization of integrons, genetic elements mediating multiple-drug resistance, in avian Escherichia coli","volume":"43","author":"Bass","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/MMBR.63.3.507-522.1999","article-title":"Transposon Tn21, flagship of the floating genome","volume":"63","author":"Liebert","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.tim.2006.02.006_bib16","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1128\/AEM.63.11.4494-4503.1997","article-title":"Association of mercury resistance with antibiotic resistance in the Gram-negative fecal bacteria of primates","volume":"63","author":"Wireman","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib17","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/AAC.47.3.1115-1119.2003","article-title":"Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era","volume":"47","author":"Essa","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0378-1097(03)00559-7","article-title":"Tn5060 from the Siberian permafrost is most closely related to the ancestor of Tn21 prior to integron acquisition","volume":"226","author":"Kholodii","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.tim.2006.02.006_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1399-302X.2005.00218.x","article-title":"Isolation of silver- and antibiotic-resistant Enterobacter cloacae from teeth","volume":"20","author":"Davis","year":"2005","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.tim.2006.02.006_bib20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0923-2508(01)01265-7","article-title":"Mercury resistance transposons of Gram-negative environmental bacteria and their classification","volume":"152","author":"Mindlin","year":"2001","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib21","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1099\/mic.0.27773-0","article-title":"The 120\u2008592bp lncF plasmid pRSB107 isolated from a sewage-treatment plant encodes nine different antibiotic-resistance determinants, two iron-acquisition systems and other putative virulence-associated functions","volume":"151","author":"Szczepanowski","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2006.02.006_bib22","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1099\/mic.0.26570-0","article-title":"The 64\u2008508bp IncP-1 \u03b2 antibiotic multi-resistance plasmid pB10 isolated from a waste-water treatment plant provides evidence for recombination between members of different branches of the IncP-1 \u03b2 group","volume":"149","author":"Schluter","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2006.02.006_bib23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00438-002-0785-z","article-title":"The 79\u2008370bp conjugative plasmid pB4 consists of an IncP-1 \u03b2 backbone loaded with a chromate resistance transposon, the strA-strB streptomycin resistance gene pair, the oxacillinase gene bla(NPS-1), and a tripartite antibiotic efflux system of the resistance-nodulation-division family","volume":"268","author":"Tauch","year":"2003","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.tim.2006.02.006_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.plasmid.2004.09.004","article-title":"Sequence of the 68\u2008869bp IncP-1 \u03b1 plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements","volume":"53","author":"Tennstedt","year":"2005","journal-title":"Plasmid"},{"key":"10.1016\/j.tim.2006.02.006_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.copbio.2005.04.002","article-title":"The evolution of IncP catabolic plasmids","volume":"16","author":"Dennis","year":"2005","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.tim.2006.02.006_bib26","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/35101607","article-title":"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.tim.2006.02.006_bib27","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.resmic.2005.05.011","article-title":"Present-day mercury resistance transposons are common in bacteria preserved in permafrost grounds since the Upper Pleistocene","volume":"156","author":"Mindlin","year":"2005","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib28","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/302725a0","article-title":"Conjugative plasmids in bacteria of the \u2018pre- antibiotic\u2019 era","volume":"302","author":"Hughes","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.tim.2006.02.006_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1574-6968.2000.tb09158.x","article-title":"A multidrug efflux transporter in Listeria monocytogenes","volume":"187","author":"Mata","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.tim.2006.02.006_bib30","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1099\/00221287-148-8-2371","article-title":"Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium","volume":"148","author":"Aendekerk","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2006.02.006_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2000.tb01244.x","article-title":"The DsbA-DsbB disulfide bond formation system of Burkholderia cepacia is involved in the production of protease and alkaline phosphatase, motility, metal resistance, and multi-drug resistance","volume":"44","author":"Hayashi","year":"2000","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.tim.2006.02.006_bib32","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1128\/AEM.64.11.4317-4320.1998","article-title":"Metal accumulation and vanadium-induced multidrug resistance by environmental isolates of Escherichia hermannii and Enterobacter cloacae","volume":"64","author":"Hernandez","year":"1998","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib33","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/JB.187.3.1124-1134.2005","article-title":"Genome wide transcriptional response of chemostat-cultured Escherichia coli to zinc","volume":"187","author":"Lee","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2006.02.006_bib34","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1128\/JB.184.15.4168-4176.2002","article-title":"The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate","volume":"184","author":"Baranova","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2006.02.006_bib35","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1128\/AEM.61.6.2302-2307.1995","article-title":"Overexpression of the robA gene increases organic-solvent tolerance and multiple antibiotic and heavy-metal ion resistance in Escherichia-coli","volume":"61","author":"Nakajima","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib36","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.1074\/jbc.M312080200","article-title":"CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa","volume":"279","author":"Perron","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2006.02.006_bib37","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1128\/AAC.47.7.2313-2315.2003","article-title":"Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa","volume":"47","author":"Conejo","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0140-6736(01)05321-1","article-title":"Antibiotic resistance of bacteria in biofilms","volume":"358","author":"Stewart","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2006.02.006_bib39","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1172\/JCI200320365","article-title":"The application of biofilm science to the study and control of chronic bacterial infections","volume":"112","author":"Costerton","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tim.2006.02.006_bib40","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1128\/JB.185.9.2887-2900.2003","article-title":"Involvement of the adc operon and manganese homeostasis in Streptococcus gordonii biofilm formation","volume":"185","author":"Loo","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2006.02.006_bib41","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/AAC.49.6.2467-2473.2005","article-title":"The use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms","volume":"49","author":"Jefferson","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib42","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1128\/AEM.69.4.2313-2320.2003","article-title":"Heavy metal resistance of biofilm and planktonic Pseudomonas aeruginosa","volume":"69","author":"Teitzel","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib43","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1462-2920.2005.00777.x","article-title":"Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa","volume":"7","author":"Harrison","year":"2005","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib44","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1128\/AAC.44.12.3357-3363.2000","article-title":"Effect of subinhibitory antibiotic concentrations on polysaccharide intercellular adhesin expression in biofilm-forming Staphylococcus epidermidis","volume":"44","author":"Rachid","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1897\/04-064R.1","article-title":"Biofilm formation by algae as a mechanism for surviving on mine tailings","volume":"24","author":"Garcia-Meza","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tim.2006.02.006_bib46","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1128\/AEM.61.6.2172-2179.1995","article-title":"Copper as a signal for alginate synthesis in Pseudomonas syringae pv. syringae","volume":"61","author":"Kidambi","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2166\/wst.2001.0332","article-title":"A new method for extraction of extracellular polymeric substances from biofilms and activated sludge suitable for direct quantification of sorbed metals","volume":"43","author":"Wuertz","year":"2001","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.tim.2006.02.006_bib48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1023\/A:1016762613272","article-title":"Metal and antibiotic resistance traits in Bradyrhizobium sp. (cajanus) isolated from soil receiving oil refinery wastewater","volume":"17","author":"Ahmad","year":"2001","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.tim.2006.02.006_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/107662900419492","article-title":"Antibiotic- and metal-resistant strains of Vibrio parahaemolyticus isolated from shrimps","volume":"6","author":"Bhattacharya","year":"2000","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.tim.2006.02.006_bib50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1472-765X.1996.tb00073.x","article-title":"Incidence of antibiotic and metal resistance and plasmid carriage in Aeromonas isolated from brown bullhead (Ictalurus nebulosus)","volume":"23","author":"Pettibone","year":"1996","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00205197","article-title":"High levels of multiple metal resistance and its correlation to antibiotic-resistance in environmental isolates of Acinetobacter","volume":"7","author":"Dhakephalkar","year":"1994","journal-title":"Biometals"},{"key":"10.1016\/j.tim.2006.02.006_bib52","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2166\/wst.1993.0395","article-title":"Occurrence of resistance to antibiotics and metals and of plasmids in bacterial strains isolated from marine environments","volume":"27","author":"Aviles","year":"1993","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.tim.2006.02.006_bib53","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1139\/m91-087","article-title":"Occurrence of antibiotic and metal resistance and plasmids in Bacillus strains isolated from marine sediment","volume":"37","author":"Belliveau","year":"1991","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib54","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0188-4409(03)00006-7","article-title":"Occurrence of resistance to antibiotics, metals, and plasmids in clinical strains of Staphylococcus spp","volume":"34","author":"Ug","year":"2003","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.tim.2006.02.006_bib55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.envres.2004.05.012","article-title":"Occurrence of antibiotic and metal resistance in bacteria from organs of river fish","volume":"98","author":"Pathak","year":"2005","journal-title":"Environ. Res."},{"key":"10.1016\/j.tim.2006.02.006_bib56","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0043-1354(74)90019-0","article-title":"Resistance transfer fecal coliforms isolated from the Whippany River","volume":"8","author":"Koditschek","year":"1974","journal-title":"Water Res."},{"key":"10.1016\/j.tim.2006.02.006_bib57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/AAC.12.4.545","article-title":"Antibiotic-resistance patterns of metal-tolerant bacteria isolated from an estuary","volume":"12","author":"Allen","year":"1977","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib58","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/AEM.36.3.465-472.1978","article-title":"Heavy-metal and antibiotic resistance in the bacterial flora of sediments of New York Bight","volume":"36","author":"Timoney","year":"1978","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib59","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s002849900312","article-title":"The effect of long-term exposure to mercury on the bacterial community in marine sediment","volume":"36","author":"Rasmussen","year":"1998","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib60","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1128\/AEM.66.9.3722-3726.2000","article-title":"Spatial patterns in antibiotic resistance among stream bacteria: effects of industrial pollution","volume":"66","author":"McArthur","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib61","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1128\/AEM.47.6.1238-1242.1984","article-title":"Association of metal tolerance with multiple antibiotic- resistance of bacteria isolated from drinking-water","volume":"47","author":"Calomiris","year":"1984","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0038-0717(94)90201-1","article-title":"Effect of manuring practices and increased copper concentrations on soil microbial populations","volume":"26","author":"Huysman","year":"1994","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.tim.2006.02.006_bib63","doi-asserted-by":"crossref","unstructured":"Berg, J. et al. Copper amendment of agricultural soil selects for bacterial antibiotic resistance in the field. Lett. Appl. Microbiol. 40, 146\u2013151","DOI":"10.1111\/j.1472-765X.2004.01650.x"},{"key":"10.1016\/j.tim.2006.02.006_bib64","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/AAC.39.11.2499","article-title":"Antimicrobial and mercury resistance in aerobic Gram-negative bacilli in fecal flora among persons with and without dental amalgam fillings","volume":"39","author":"\u00d6sterblad","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/jac\/dkf019","article-title":"Prevalence and antibiotic resistance profile of mercury-resistant oral bacteria from children with and without mercury amalgam fillings","volume":"49","author":"Pike","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib66","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/AAC.44.2.456-457.2000","article-title":"Resistance to mercury and antimicrobial agents in Streptococcus mutans isolates from human subjects in relation to exposure to dental amalgam fillings","volume":"44","author":"Leistevuo","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2006.02.006_bib67","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(00)04519-0","article-title":"Persistence of sulphonamide resistance of Escherichia coli in the UK despite national prescribing restriction","volume":"357","author":"Enne","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2006.02.006_bib68","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.micro.50.1.753","article-title":"Bacterial heavy metal resistance: new surprises","volume":"50","author":"Silver","year":"1996","journal-title":"Ann. Rev. Microb."},{"key":"10.1016\/j.tim.2006.02.006_bib69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1089\/107662903322286463","article-title":"The role of Serratia marcescens porins in antibiotic resistance","volume":"9","author":"Ruiz","year":"2003","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.tim.2006.02.006_bib70","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1289\/ehp.02110s5745","article-title":"Arsenate reductases in prokaryotes and eukaryotes","volume":"110","author":"Mukhopadhyay","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tim.2006.02.006_bib71","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.addr.2005.04.002","article-title":"Bacterial resistance to antibiotics: enzymatic degradation and modification","volume":"57","author":"Wright","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.tim.2006.02.006_bib72","doi-asserted-by":"crossref","unstructured":"Nies, D.H. (2003) Efflux-mediated heavy metal resistance in prokaryotes. FEMS Microb Rev. 27, 3-3-39","DOI":"10.1016\/S0168-6445(03)00048-2"},{"key":"10.1016\/j.tim.2006.02.006_bib73","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2672.92.5s1.4.x","article-title":"Active efflux, a common mechanism for biocide and antibiotic resistance","volume":"92","author":"Levy","year":"2002","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.tim.2006.02.006_bib74","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0168-6445(03)00046-9","article-title":"Bacterial mercury resistance from atoms to ecosystems","volume":"27","author":"Barkay","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.tim.2006.02.006_bib75","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.femsle.2005.02.034","article-title":"Update on acquired tetracycline resistance genes","volume":"245","author":"Roberts","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.tim.2006.02.006_bib76","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0162-0134(99)00234-2","article-title":"Bacterial metal-resistance proteins and their use in biosensors for the detection of bioavailable heavy metals","volume":"79","author":"Bontidean","year":"2000","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.tim.2006.02.006_bib77","doi-asserted-by":"crossref","first-page":"8860","DOI":"10.1073\/pnas.88.19.8860","article-title":"An unusual mechanism for resistance to the antibiotic coumermycin-A1","volume":"88","author":"del Castillo","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X06000515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X06000515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T06:14:30Z","timestamp":1586758470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X06000515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0966842X06000515"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2006.02.006","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}