{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:54:04Z","timestamp":1789725244465,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.tim.2007.03.002","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T11:17:49Z","timestamp":1174994269000},"page":"191-195","source":"Crossref","is-referenced-by-count":15,"title":["Putative type IV secretion genes in Bacillus anthracis"],"prefix":"10.1016","volume":"15","author":[{"given":"Marcin","family":"Grynberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Szczurek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Godzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2007.03.002_bib1","series-title":"Anthrax","year":"2002"},{"key":"10.1016\/j.tim.2007.03.002_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1128\/JB.186.2.307-315.2004","article-title":"atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpB","volume":"186","author":"Drysdale","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib3","first-page":"143","article-title":"Bacillus anthracis genetics and virulence gene regulation","volume":"271","author":"Koehler","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.tim.2007.03.002_bib4","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/IAI.71.5.2736-2743.2003","article-title":"Global effects of virulence gene regulators in a Bacillus anthracis strain with both virulence plasmids","volume":"71","author":"Bourgogne","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2007.03.002_bib5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","article-title":"Anthrax","volume":"55","author":"Mock","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.tim.2007.03.002_bib6","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1099\/00221287-147-12-3201","article-title":"Conjugal type IV macromolecular transfer systems of Gram-negative bacteria: organismal distribution, structural constraints and evolutionary conclusions","volume":"147","author":"Cao","year":"2001","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2007.03.002_bib7","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/molbev\/msi124","article-title":"Functional divergence and horizontal transfer of type IV secretion systems","volume":"22","author":"Frank","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.tim.2007.03.002_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.micro.58.030603.123630","article-title":"Biogenesis, architecture, and function of bacterial type IV secretion systems","volume":"59","author":"Christie","year":"2005","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.tim.2007.03.002_bib9","doi-asserted-by":"crossref","first-page":"26349","DOI":"10.1074\/jbc.M502347200","article-title":"Identification of the VirB4-VirB8-VirB5-VirB2 pilus assembly sequence of type IV secretion systems","volume":"280","author":"Yuan","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2007.03.002_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/MMBR.67.2.277-301.2003","article-title":"Conjugative plasmid transfer in Gram-positive bacteria","volume":"67","author":"Grohmann","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.tim.2007.03.002_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1471-2164-6-103","article-title":"Conjugative plasmid pAW63 brings new insights into the genesis of the Bacillus anthracis virulence plasmid pXO2 and of the Bacillus thuringiensis plasmid pBT9727","volume":"6","author":"Van der Auwera","year":"2005","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tim.2007.03.002_bib12","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1126\/science.1071837","article-title":"Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis","volume":"296","author":"Read","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tim.2007.03.002_bib13","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1128\/JB.181.20.6509-6515.1999","article-title":"Sequence and organization of pXO1, the large Bacillus anthracis plasmid harboring the anthrax toxin genes","volume":"181","author":"Okinaka","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib14","doi-asserted-by":"crossref","first-page":"W284","DOI":"10.1093\/nar\/gki418","article-title":"FFAS03: a server for profile\u2013profile sequence alignments","volume":"33","author":"Jaroszewski","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2007.03.002_bib15","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1128\/JB.182.21.6169-6176.2000","article-title":"Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea","volume":"182","author":"Kachlany","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib16","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1073\/pnas.1237223100","article-title":"Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model","volume":"100","author":"Schreiner","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2007.03.002_bib17","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1093\/emboj\/19.13.3223","article-title":"Identification and cell cycle control of a novel pilus system in Caulobacter crescentus","volume":"19","author":"Skerker","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.tim.2007.03.002_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0966-842X(01)02161-8","article-title":"Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum","volume":"9","author":"Kachlany","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.tim.2007.03.002_bib19","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1073\/pnas.0409399102","article-title":"Predicted hexameric structure of the Agrobacterium VirB4C terminus suggests VirB4 acts as a docking site during type IV secretion","volume":"102","author":"Middleton","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2007.03.002_bib20","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1093\/emboj\/cdf454","article-title":"A dynamically localized histidine kinase controls the asymmetric distribution of polar pili proteins","volume":"21","author":"Viollier","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.tim.2007.03.002_bib21","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1073\/pnas.061029298","article-title":"Complete genome sequence of Caulobacter crescentus","volume":"98","author":"Nierman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2007.03.002_bib22","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1073\/pnas.86.12.4357","article-title":"The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus","volume":"86","author":"Hultgren","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2007.03.002_bib23","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1128\/jb.171.11.6052-6058.1989","article-title":"PapD, a periplasmic transport protein in P-pilus biogenesis","volume":"171","author":"Lindberg","year":"1989","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib24","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1126\/science.285.5430.1058","article-title":"Structural basis of chaperone function and pilus biogenesis","volume":"285","author":"Sauer","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.tim.2007.03.002_bib25","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1128\/JB.183.16.4823-4838.2001","article-title":"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum","volume":"183","author":"Nolling","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-2958.1994.tb00338.x","article-title":"An inner-membrane-associated virulence protein essential for T-DNA transfer from Agrobacterium tumefaciens to plants exhibits ATPase activity and similarities to conjugative transfer genes","volume":"11","author":"Shirasu","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2007.03.002_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1128\/jb.179.2.453-462.1997","article-title":"The VirB4 ATPase of Agrobacterium tumefaciens is a cytoplasmic membrane protein exposed at the periplasmic surface","volume":"179","author":"Dang","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.micpath.2004.12.004","article-title":"Apoptotic activity and sub-cellular localization of a T4SS-associated CagE-homologue in Actinobacillus actinomycetemcomitans","volume":"38","author":"Teng","year":"2005","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.tim.2007.03.002_bib29","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1128\/AEM.68.10.5082-5095.2002","article-title":"Complete sequence and organization of pBtoxis, the toxin-coding plasmid of Bacillus thuringiensis subsp. israelensis","volume":"68","author":"Berry","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2007.03.002_bib30","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1093\/nar\/gkh562","article-title":"Whole genome comparisons of serotype 4b and 1\/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species","volume":"32","author":"Nelson","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2007.03.002_bib31","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1128\/JB.00656-06","article-title":"Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine kinase","volume":"188","author":"White","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/JB.145.1.613-619.1981","article-title":"Isolation and properties of pili from spores of Bacillus cereus","volume":"145","author":"DesRosier","year":"1981","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2007.03.002_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.py.32.090194.001145","article-title":"Secretion of extracellular virulence factors by plant pathogenic bacteria","volume":"32","author":"Salmond","year":"1994","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.tim.2007.03.002_bib34","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2007.03.002_bib35","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/bioinformatics\/btg124","article-title":"3D-Jury: a simple approach to improve protein structure predictions","volume":"19","author":"Ginalski","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tim.2007.03.002_bib36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","article-title":"Protein secondary structure prediction based on position-specific scoring matrices","volume":"292","author":"Jones","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tim.2007.03.002_bib37","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gki408","article-title":"The HHpred interactive server for protein homology detection and structure prediction","volume":"33","author":"Soding","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2007.03.002_bib38","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gkh468","article-title":"Protein structure prediction and analysis using the Robetta server","volume":"32","author":"Kim","year":"2004","journal-title":"Nucleic Acids Res."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X07000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X07000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T02:52:04Z","timestamp":1587437524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X07000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0966842X07000455"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2007.03.002","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}