{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:22:19Z","timestamp":1791300139256,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.tim.2012.10.003","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T20:01:06Z","timestamp":1351886466000},"page":"23-30","source":"Crossref","is-referenced-by-count":101,"title":["Integrative mobile elements exploiting Xer recombination"],"prefix":"10.1016","volume":"21","author":[{"given":"Bhabatosh","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriel","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Midonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Xavier","family":"Barre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2012.10.003_bib0005","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1093\/nar\/25.18.3605","article-title":"The integrase family of tyrosine recombinases: evolution of a conserved active site domain","volume":"25","author":"Esposito","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2012.10.003_bib0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/nar\/26.2.391","article-title":"Similarities and differences among 105 members of the Int family of site-specific recombinases","volume":"26","author":"Nunes-Duby","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2012.10.003_bib0250","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00438-012-0700-1","article-title":"Site-specific recombination systems in filamentous phages","volume":"287","author":"Askora","year":"2012","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.tim.2012.10.003_bib0020","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1073\/pnas.18.12.677","article-title":"A correlation of ring-shaped chromosomes with variegation in Zea mays","volume":"18","author":"McClintock","year":"1932","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.003_bib0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0092-8674(93)80076-Q","article-title":"Two related recombinases are required for site-specific recombination at dif and cer in E. coli K12","volume":"75","author":"Blakely","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.tim.2012.10.003_bib0030","doi-asserted-by":"crossref","first-page":"e1000201","DOI":"10.1371\/journal.pgen.1000201","article-title":"FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae","volume":"4","author":"Val","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tim.2012.10.003_bib0035","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1128\/jb.176.11.3188-3195.1994","article-title":"Plasmid pSC101 harbors a recombination site, psi, which is able to resolve plasmid multimers and to substitute for the analogous chromosomal Escherichia coli site dif","volume":"176","author":"Cornet","year":"1994","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.10.003_bib0040","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1128\/jb.172.12.6973-6980.1990","article-title":"Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases","volume":"172","author":"Colloms","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.10.003_bib0045","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1101\/gad.188700","article-title":"FtsK functions in the processing of a Holliday junction intermediate during bacterial chromosome segregation","volume":"14","author":"Barre","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.tim.2012.10.003_bib0050","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1365-2958.2007.05755.x","article-title":"FtsK, a literate chromosome segregation machine","volume":"64","author":"Bigot","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0055","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nsmb1159","article-title":"Oriented loading of FtsK on KOPS","volume":"13","author":"Bigot","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.003_bib0060","doi-asserted-by":"crossref","first-page":"20263","DOI":"10.1073\/pnas.1007518107","article-title":"Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA","volume":"107","author":"Graham","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.003_bib0065","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1365-2958.2008.06586.x","article-title":"KOPS-guided DNA translocation by FtsK safeguards Escherichia coli chromosome segregation","volume":"71","author":"Sivanathan","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0070","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1093\/nar\/gkr078","article-title":"Activation of XerCD-dif recombination by the FtsK DNA translocase","volume":"39","author":"Grainge","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2012.10.003_bib0075","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1111\/j.1365-2958.2005.05033.x","article-title":"Dissection of a functional interaction between the DNA translocase, FtsK, and the XerD recombinase","volume":"59","author":"Yates","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(02)00624-4","article-title":"FtsK is a DNA motor protein that activates chromosome dimer resolution by switching the catalytic state of the XerC and XerD recombinases","volume":"108","author":"Aussel","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.tim.2012.10.003_bib0085","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1365-2958.2010.07412.x","article-title":"Multiple regions along the Escherichia coli FtsK protein are implicated in cell division","volume":"78","author":"Dubarry","year":"2010","journal-title":"Mol. Mic."},{"key":"10.1016\/j.tim.2012.10.003_bib0090","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/emboj.2009.381","article-title":"Fully efficient chromosome dimer resolution in Escherichia coli cells lacking the integral membrane domain of FtsK","volume":"29","author":"Dubarry","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.tim.2012.10.003_bib0095","doi-asserted-by":"crossref","first-page":"e1000288","DOI":"10.1371\/journal.pgen.1000288","article-title":"Asymmetry of chromosome Replichores renders the DNA translocase activity of FtsK essential for cell division and cell shape maintenance in Escherichia coli","volume":"4","author":"Lesterlin","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tim.2012.10.003_bib0100","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1365-2958.2008.06212.x","article-title":"Delayed activation of Xer recombination at dif by FtsK during septum assembly in Escherichia coli","volume":"68","author":"Kennedy","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0105","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(00)81931-5","article-title":"Topological selectivity in Xer site-specific recombination","volume":"88","author":"Colloms","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.tim.2012.10.003_bib0110","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1093\/emboj\/cdf379","article-title":"Accessory factors determine the order of strand exchange in Xer recombination at psi","volume":"21","author":"Bregu","year":"2002","journal-title":"Embo J."},{"key":"10.1016\/j.tim.2012.10.003_bib0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.molcel.2005.07.002","article-title":"The single stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae","volume":"19","author":"Val","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tim.2012.10.003_bib0120","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1038\/sj.emboj.7600898","article-title":"Integron cassette insertion: a recombination process involving a folded single strand substrate","volume":"24","author":"Bouvier","year":"2005","journal-title":"Embo J."},{"key":"10.1016\/j.tim.2012.10.003_bib0125","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1073\/pnas.0910212107","article-title":"Molecular keys of the tropism of integration of the cholera toxin phage","volume":"107","author":"Das","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.003_bib0130","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04643","article-title":"Structural basis for broad DNA-specificity in integron recombination","volume":"440","author":"MacDonald","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.tim.2012.10.003_bib0135","doi-asserted-by":"crossref","first-page":"8361","DOI":"10.1093\/nar\/gks620","article-title":"Replicative resolution of integron cassette insertion","volume":"40","author":"Loot","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2012.10.003_bib0140","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/jmbi.2000.3762","article-title":"Coordinated control of XerC and XerD catalytic activities during Holliday junction resolution","volume":"299","author":"Arciszewska","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.003_bib0145","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(00)80224-5","article-title":"Reciprocal control of catalysis by the tyrosine recombinases XerC and XerD: an enzymatic switch in site-specific recombination","volume":"4","author":"Hallet","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tim.2012.10.003_bib0150","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1038\/emboj.2012.219","article-title":"Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration","volume":"31","author":"Bischerour","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.tim.2012.10.003_bib0155","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1365-2958.2001.02517.x","article-title":"Evidence for a rolling-circle mechanism of phage DNA synthesis from both replicative and integrated forms of CTXphi","volume":"41","author":"Moyer","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0160","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1073\/pnas.1017061108","article-title":"VGJ\u03c6-integration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains","volume":"108","author":"Das","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.003_bib0165","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nature09469","article-title":"Satellite phage TLCphi enables toxigenic conversion by CTX phage through dif site alteration","volume":"467","author":"Hassan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tim.2012.10.003_bib0170","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1099\/mic.0.032235-0","article-title":"VEJ{phi}, a novel filamentous phage of Vibrio cholerae able to transduce the cholera toxin genes","volume":"156","author":"Campos","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2012.10.003_bib0175","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1128\/JB.185.24.7231-7240.2003","article-title":"Novel type of specialized transduction for CTX phi or its satellite phage RS1 mediated by filamentous phage VGJ phi in Vibrio cholerae","volume":"185","author":"Campos","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.10.003_bib0180","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1128\/JB.185.19.5685-5696.2003","article-title":"VGJ phi, a novel filamentous phage of Vibrio cholerae, integrates into the same chromosomal site as CTX phi","volume":"185","author":"Campos","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.10.003_bib0185","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1046\/j.1365-2958.1998.00889.x","article-title":"Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage","volume":"28","author":"Rubin","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0190","doi-asserted-by":"crossref","first-page":"15442","DOI":"10.1073\/pnas.0907787106","article-title":"Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae","volume":"106","author":"Chun","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.003_bib0195","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1126\/science.272.5270.1910","article-title":"Lysogenic conversion by a filamentous phage encoding cholera toxin","volume":"272","author":"Waldor","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.tim.2012.10.003_bib0200","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature00782","article-title":"Filamentous phage integration requires the host recombinases XerC and XerD","volume":"417","author":"Huber","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tim.2012.10.003_bib0205","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature10392","article-title":"Evidence for several waves of global transmission in the seventh cholera pandemic","volume":"477","author":"Mutreja","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tim.2012.10.003_bib0210","first-page":"195","article-title":"Molecular mechanism of acquisition of the cholera toxin genes","volume":"133","author":"Das","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.tim.2012.10.003_bib0215","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1365-2958.2006.05570.x","article-title":"A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus","volume":"63","author":"Derbise","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.003_bib0220","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1128\/JB.184.21.6050-6055.2002","article-title":"Conserved filamentous prophage in Escherichia coli O18:K1:H7 and Yersinia pestis biovar orientalis","volume":"184","author":"Gonzalez","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.10.003_bib0225","first-page":"613","article-title":"Nucleotide sequences involved in the neolysogenic insertion of filamentous phage Cf16-v1 into the Xanthomonas campestris pv. citri chromosome","volume":"167","author":"Dai","year":"1988","journal-title":"Virology"},{"key":"10.1016\/j.tim.2012.10.003_bib0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s004380100532","article-title":"Plasmids carrying cloned fragments of RF DNA from the filamentous phage (phi)Lf can be integrated into the host chromosome via site-specific integration and homologous recombination","volume":"266","author":"Lin","year":"2001","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.tim.2012.10.003_bib0235","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/35018003","article-title":"The genome sequence of the plant pathogen Xylella fastidiosa. The Xylella fastidiosa Consortium of the Organization for Nucleotide Sequencing and Analysis","volume":"406","author":"Simpson","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tim.2012.10.003_bib0240","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/JB.00948-10","article-title":"XerCD-mediated site-specific recombination leads to loss of the 57kb gonococcal genetic island","volume":"193","author":"Dominguez","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.10.003_bib0245","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2958.2001.02520.x","article-title":"A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates","volume":"41","author":"Dillard","year":"2001","journal-title":"Mol. Microbiol."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X12001898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X12001898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T19:58:18Z","timestamp":1540151898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X12001898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0966842X12001898"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2012.10.003","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}