{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:42:27Z","timestamp":1791286947507,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.tim.2012.10.004","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T15:15:30Z","timestamp":1352301330000},"page":"73-81","source":"Crossref","is-referenced-by-count":289,"title":["Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections"],"prefix":"10.1016","volume":"21","author":[{"given":"Bal\u00e1zs","family":"Rada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Leto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2012.10.004_bib0005","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S1286-4579(00)01259-4","article-title":"Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist","volume":"2","author":"Lyczak","year":"2000","journal-title":"Microbes Infect."},{"key":"10.1016\/j.tim.2012.10.004_bib0010","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1086\/593187","article-title":"The many faces of Pseudomonas aeruginosa in chronic obstructive pulmonary disease","volume":"47","author":"Murphy","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2012.10.004_bib0015","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nm.2715","article-title":"Cystic fibrosis: a mucosal immunodeficiency syndrome","volume":"18","author":"Cohen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0020","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molmed.2008.01.002","article-title":"Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis","volume":"14","author":"Campodonico","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0025","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1128\/CMR.00068-09","article-title":"The changing microbial epidemiology in cystic fibrosis","volume":"23","author":"Lipuma","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.tim.2012.10.004_bib0030","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1574-6976.2011.00269.x","article-title":"Pseudomonas genomes: diverse and adaptable","volume":"35","author":"Silby","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.tim.2012.10.004_bib0035","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2217\/fmb.10.125","article-title":"Pseudomonas aeruginosa biofilms in cystic fibrosis","volume":"5","author":"Hoiby","year":"2010","journal-title":"Future Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0040","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.tim.2011.04.005","article-title":"Pseudomonas aeruginosa: all roads lead to resistance","volume":"19","author":"Breidenstein","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0045","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00253-010-2509-3","article-title":"Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes","volume":"86","author":"Pierson","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.tim.2012.10.004_bib0050","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.freeradbiomed.2004.03.011","article-title":"Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide","volume":"36","author":"Reszka","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nchembio764","article-title":"Rethinking \u2018secondary\u2019 metabolism: physiological roles for phenazine antibiotics","volume":"2","author":"Price-Whelan","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tim.2012.10.004_bib0060","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.4049\/jimmunol.181.7.4883","article-title":"The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells","volume":"181","author":"Rada","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.tim.2012.10.004_bib0065","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.1160619","article-title":"Redox-active antibiotics control gene expression and community behavior in divergent bacteria","volume":"321","author":"Dietrich","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.tim.2012.10.004_bib0070","doi-asserted-by":"crossref","first-page":"19996","DOI":"10.1073\/pnas.1117298108","article-title":"Discovery of a biofilm electrocline using real-time 3D metabolite analysis","volume":"108","author":"Koley","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.004_bib0075","doi-asserted-by":"crossref","first-page":"L25","DOI":"10.1152\/ajplung.00391.2007","article-title":"The DeltaF508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availability","volume":"295","author":"Moreau-Marquis","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0080","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1365-2958.2006.05306.x","article-title":"The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa","volume":"61","author":"Dietrich","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0085","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1073\/pnas.97.16.8815","article-title":"Plants and animals share functionally common bacterial virulence factors","volume":"97","author":"Rahme","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.004_bib0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80958-7","article-title":"Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model","volume":"96","author":"Mahajan-Miklos","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.tim.2012.10.004_bib0095","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1128\/IAI.71.7.4059-4066.2003","article-title":"The Drosophila melanogaster toll pathway participates in resistance to infection by the Gram-negative human pathogen Pseudomonas aeruginosa","volume":"71","author":"Lau","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.10.004_bib0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.phyto.39.1.259","article-title":"Common mechanisms for pathogens of plants and animals","volume":"39","author":"Cao","year":"2001","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.tim.2012.10.004_bib0105","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1128\/IAI.72.7.4275-4278.2004","article-title":"Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice","volume":"72","author":"Lau","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.10.004_bib0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12026-008-8071-8","article-title":"Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin","volume":"43","author":"Rada","year":"2009","journal-title":"Immunol. Res."},{"key":"10.1016\/j.tim.2012.10.004_bib0115","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.molmed.2004.10.002","article-title":"The role of pyocyanin in Pseudomonas aeruginosa infection","volume":"10","author":"Lau","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0120","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1462-5822.2011.01727.x","article-title":"Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2","volume":"14","author":"Hao","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0125","doi-asserted-by":"crossref","first-page":"e1001270","DOI":"10.1371\/journal.ppat.1001270","article-title":"Positive signature-tagged mutagenesis in Pseudomonas aeruginosa: tracking patho-adaptive mutations promoting airways chronic infection","volume":"7","author":"Bianconi","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2012.10.004_bib0130","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1128\/IAI.56.9.2515-2517.1988","article-title":"Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium","volume":"56","author":"Wilson","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.10.004_bib0135","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1165\/rcmb.2012-0088OC","article-title":"Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity","volume":"47","author":"Hunter","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.004_bib0140","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.2353\/ajpath.2009.090166","article-title":"Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis","volume":"175","author":"Caldwell","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tim.2012.10.004_bib0145","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1164\/rccm.201009-1430OC","article-title":"Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections","volume":"183","author":"Mowat","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2180-7-45","article-title":"Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain","volume":"7","author":"Fothergill","year":"2007","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0155","doi-asserted-by":"crossref","first-page":"e35648","DOI":"10.1371\/journal.pone.0035648","article-title":"Cystic fibrosis-niche adaptation of Pseudomonas aeruginosa reduces virulence in multiple infection hosts","volume":"7","author":"Lore","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.10.004_bib0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcf.2011.03.004","article-title":"Pseudomonas aeruginosa in cystic fibrosis: pyocyanin negative strains are associated with BPI-ANCA and progressive lung disease","volume":"10","author":"Carlsson","year":"2011","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.tim.2012.10.004_bib0165","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1365-2958.2008.06559.x","article-title":"Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection","volume":"71","author":"Bohn","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0170","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.phyto.44.013106.145710","article-title":"Phenazine compounds in fluorescent Pseudomonas spp. biosynthesis and regulation","volume":"44","author":"Mavrodi","year":"2006","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.tim.2012.10.004_bib0175","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.freeradbiomed.2008.09.011","article-title":"Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells","volume":"45","author":"Schwarzer","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0180","doi-asserted-by":"crossref","first-page":"L94","DOI":"10.1152\/ajplung.00025.2004","article-title":"Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells","volume":"287","author":"O\u2019Malley","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0185","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.freeradbiomed.2011.01.012","article-title":"Glutathione modulates the toxicity of, but is not a biologically relevant reductant for, the Pseudomonas aeruginosa redox toxin pyocyanin","volume":"50","author":"Muller","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0190","doi-asserted-by":"crossref","first-page":"L420","DOI":"10.1152\/ajplung.00316.2002","article-title":"Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells","volume":"284","author":"O\u2019Malley","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/MMBR.05007-11","article-title":"The multiple signaling systems regulating virulence in Pseudomonas aeruginosa","volume":"76","author":"Jimenez","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.tim.2012.10.004_bib0200","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1165\/rcmb.2011-0011RT","article-title":"Innate immunity in the respiratory epithelium","volume":"45","author":"Parker","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.004_bib0205","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1152\/jappl.1989.67.1.316","article-title":"Effect of pyocyanin and 1-hydroxyphenazine on in vivo tracheal mucus velocity","volume":"67","author":"Munro","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0210","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1128\/IAI.67.3.1207-1212.1999","article-title":"The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha(1) protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease","volume":"67","author":"Britigan","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.10.004_bib0215","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1462-5822.2006.00696.x","article-title":"Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization","volume":"8","author":"Kong","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0220","doi-asserted-by":"crossref","first-page":"L1077","DOI":"10.1152\/ajplung.00198.2003","article-title":"The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells","volume":"285","author":"O\u2019Malley","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0225","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1096\/fj.02-1104fje","article-title":"Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense","volume":"17","author":"Geiszt","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.tim.2012.10.004_bib0230","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1165\/rcmb.2004-0302OC","article-title":"Regulated hydrogen peroxide production by Duox in human airway epithelial cells","volume":"32","author":"Forteza","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.004_bib0235","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1073\/pnas.0408932102","article-title":"Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells","volume":"102","author":"Shao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.004_bib0240","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1074\/jbc.M809761200","article-title":"ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli","volume":"284","author":"Boots","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2012.10.004_bib0245","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.febslet.2010.01.025","article-title":"Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa","volume":"584","author":"Rada","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tim.2012.10.004_bib0250","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1164\/rccm.200607-1029OC","article-title":"A novel host defense system of airways is defective in cystic fibrosis","volume":"175","author":"Moskwa","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/mi.2010.62","article-title":"Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin","volume":"4","author":"Rada","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.tim.2012.10.004_bib0260","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.tiv.2011.05.004","article-title":"Pyocyanin-induced toxicity in A549 respiratory cells is causally linked to oxidative stress","volume":"25","author":"Gloyne","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tim.2012.10.004_bib0265","doi-asserted-by":"crossref","first-page":"27144","DOI":"10.1074\/jbc.M709693200","article-title":"Redox-independent activation of NF-kappaB by Pseudomonas aeruginosa pyocyanin in a cystic fibrosis airway epithelial cell line","volume":"283","author":"Schwarzer","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2012.10.004_bib0270","doi-asserted-by":"crossref","first-page":"L1077","DOI":"10.1152\/ajplung.00198.2003","article-title":"The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells","volume":"285","author":"O\u2019Malley","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0275","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1128\/IAI.66.12.5777-5784.1998","article-title":"Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells","volume":"66","author":"Denning","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.10.004_bib0280","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.4049\/jimmunol.175.6.4017","article-title":"Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms","volume":"175","author":"Look","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.tim.2012.10.004_bib0285","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.it.2011.06.008","article-title":"Neutrophils cascading their way to inflammation","volume":"32","author":"Sadik","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tim.2012.10.004_bib0290","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1165\/rcmb.2011-0399RT","article-title":"Immune responses in cystic fibrosis: are they intrinsically defective?","volume":"46","author":"Ratner","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.004_bib0295","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1152\/jappl.1998.85.6.2298","article-title":"Mechanism of pyocyanin- and 1-hydroxyphenazine-induced lung neutrophilia in sheep airways","volume":"85","author":"Lauredo","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0300","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jcf.2005.12.004","article-title":"Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia","volume":"5","author":"Jensen","year":"2006","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.tim.2012.10.004_bib0305","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1183\/09031936.99.14233999","article-title":"Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease","volume":"14","author":"Osika","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.tim.2012.10.004_bib0310","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/rmed.1999.0725","article-title":"Production of the potent neutrophil chemokine, growth-related protein alpha (GROalpha), is not elevated in cystic fibrosis children","volume":"94","author":"Wyatt","year":"2000","journal-title":"Respir. Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0315","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","article-title":"Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis","volume":"175","author":"McAllister","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.tim.2012.10.004_bib0320","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jaci.2005.09.023","article-title":"Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis","volume":"117","author":"Hartl","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.tim.2012.10.004_bib0325","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1164\/ajrccm.157.6.9704086","article-title":"Circulating immunoreactive interleukin-6 in cystic fibrosis","volume":"157","author":"Nixon","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0330","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1164\/rccm.200203-179OC","article-title":"Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis","volume":"167","author":"Carpagnano","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tim.2012.10.004_bib0335","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2125.1987.tb03004.x","article-title":"Detection of sputum eicosanoids in cystic fibrosis and in normal saliva by bioassay and radioimmunoassay","volume":"23","author":"Zakrzewski","year":"1987","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.tim.2012.10.004_bib0340","doi-asserted-by":"crossref","first-page":"L519","DOI":"10.1152\/ajplung.00312.2006","article-title":"IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice","volume":"292","author":"Dubin","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0345","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"Rose","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tim.2012.10.004_bib0350","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.physiol.70.113006.100441","article-title":"Regulation of airway mucin gene expression","volume":"70","author":"Thai","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tim.2012.10.004_bib0355","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1165\/rcmb.2007-0262OC","article-title":"The role of Nox4 in oxidative stress-induced MUC5AC overexpression in human airway epithelial cells","volume":"39","author":"Kim","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tim.2012.10.004_bib0360","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1073\/pnas.0408932102","article-title":"Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells","volume":"102","author":"Shao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.10.004_bib0365","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1183\/09031936.00172007","article-title":"Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases","volume":"32","author":"Burgel","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.tim.2012.10.004_bib0370","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1172\/JCI25167","article-title":"Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals","volume":"116","author":"Tyner","year":"2006","journal-title":"J. Clin. Invest."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X12001904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X12001904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T15:09:46Z","timestamp":1594825786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X12001904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0966842X12001904"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2012.10.004","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}