{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:56:05Z","timestamp":1790812565335,"version":"4.1.0"},"reference-count":102,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.tim.2012.11.005","type":"journal-article","created":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T11:00:41Z","timestamp":1356433241000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"title":["Influence of bacterial interactions on pneumococcal colonization of the nasopharynx"],"prefix":"10.1016","volume":"21","author":[{"given":"Joshua R.","family":"Shak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith P.","family":"Klugman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2012.11.005_bib0005","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(09)61114-4","article-title":"Pathogenesis, treatment, and prevention of pneumococcal pneumonia","volume":"374","author":"van der Poll","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2012.11.005_bib0010","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"O\u2019Brien","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2012.11.005_bib0015","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1016\/j.vaccine.2011.02.088","article-title":"Healthcare utilization and cost of pneumococcal disease in the United States","volume":"29","author":"Huang","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2012.11.005_bib0020","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0025","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1586\/erv.12.53","article-title":"The fundamental link between pneumococcal carriage and disease","volume":"11","author":"Simell","year":"2012","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.tim.2012.11.005_bib0030","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1462-5822.2011.01746.x","article-title":"Recognition of Streptococcus pneumoniae by the innate immune system","volume":"14","author":"Koppe","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.coi.2012.05.005","article-title":"Co-infection subverts mucosal immunity in the upper respiratory tract","volume":"24","author":"Lijek","year":"2012","journal-title":"Curr. Opin. Immunol."},{"issue":"Suppl. 3","key":"10.1016\/j.tim.2012.11.005_bib0040","doi-asserted-by":"crossref","first-page":"C9","DOI":"10.1016\/j.vaccine.2009.06.007","article-title":"Pneumococcal pneumonia and influenza: a deadly combination","volume":"27","author":"Klugman","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2012.11.005_bib0045","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/cid\/cis371","article-title":"Rates of acquisition of pneumococcal colonization and transmission probabilities, by serotype, among newborn infants in Kilifi district, Kenya","volume":"55","author":"Tigoi","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0050","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/01.inf.0000232705.49634.68","article-title":"Upper respiratory tract bacterial carriage in Aboriginal and non-Aboriginal children in a semi-arid area of Western Australia","volume":"25","author":"Watson","year":"2006","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0055","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1017\/S0950268805004012","article-title":"A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting","volume":"133","author":"Hussain","year":"2005","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.tim.2012.11.005_bib0060","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1752-699X.2009.00179.x","article-title":"Pneumococcal carriage is more common in asthmatic than in non-asthmatic young men","volume":"4","author":"Jounio","year":"2010","journal-title":"Clin. Respir. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0065","doi-asserted-by":"crossref","first-page":"e1001107","DOI":"10.1371\/journal.pmed.1001107","article-title":"Effects of community-wide vaccination with PCV-7 on pneumococcal nasopharyngeal carriage in the Gambia: a cluster-randomized trial","volume":"8","author":"Roca","year":"2011","journal-title":"PLoS Med."},{"key":"10.1016\/j.tim.2012.11.005_bib0070","doi-asserted-by":"crossref","first-page":"e30548","DOI":"10.1371\/journal.pone.0030548","article-title":"Pre-vaccination nasopharyngeal pneumococcal carriage in a Nigerian population: epidemiology and population biology","volume":"7","author":"Adetifa","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0075","doi-asserted-by":"crossref","first-page":"e38271","DOI":"10.1371\/journal.pone.0038271","article-title":"A longitudinal study of Streptococcus pneumoniae carriage in a cohort of infants and their mothers on the Thailand\u2013Myanmar border","volume":"7","author":"Turner","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0080","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1086\/652443","article-title":"Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study","volume":"50","author":"Hill","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0085","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/infdis\/jis447","article-title":"Rates of acquisition and clearance of pneumococcal serotypes in the nasopharynges of children in Kilifi district, Kenya","volume":"206","author":"Abdullahi","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00006454-199604000-00002","article-title":"Pathogenesis of otitis media: role of Eustachian tube","volume":"15","author":"Bluestone","year":"1996","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0095","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1097\/INF.0b013e3181b6d7ec","article-title":"Microbial interactions in the respiratory tract","volume":"28","author":"Murphy","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00008-11","article-title":"Pathogenesis and pathophysiology of pneumococcal meningitis","volume":"24","author":"Mook-Kanamori","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.tim.2012.11.005_bib0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00109-009-0557-x","article-title":"The pneumococcus: why a commensal misbehaves","volume":"88","author":"Weiser","year":"2010","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.tim.2012.11.005_bib0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/IAI.01775-05","article-title":"The blp bacteriocins of Streptococcus pneumoniae mediate intraspecies competition both in vitro and in vivo","volume":"75","author":"Dawid","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0115","doi-asserted-by":"crossref","first-page":"e28850","DOI":"10.1371\/journal.pone.0028850","article-title":"Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone","volume":"6","author":"Hiller","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0120","doi-asserted-by":"crossref","first-page":"e00200","DOI":"10.1128\/mBio.00200-12","article-title":"High levels of genetic recombination during nasopharyngeal carriage and biofilm formation in Streptococcus pneumoniae","volume":"3","author":"Marks","year":"2012","journal-title":"MBio"},{"key":"10.1016\/j.tim.2012.11.005_bib0125","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2010-11-10-r107","article-title":"Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species","volume":"11","author":"Donati","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.tim.2012.11.005_bib0130","doi-asserted-by":"crossref","first-page":"e1001108","DOI":"10.1371\/journal.ppat.1001108","article-title":"Generation of genic diversity among Streptococcus pneumoniae strains via horizontal gene transfer during a chronic polyclonal pediatric infection","volume":"6","author":"Hiller","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2012.11.005_bib0135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ijmm.2011.09.008","article-title":"Population genetics and evolution of the pan-genome of Streptococcus pneumoniae","volume":"301","author":"Muzzi","year":"2011","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0140","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.1198545","article-title":"Rapid pneumococcal evolution in response to clinical interventions","volume":"331","author":"Croucher","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.tim.2012.11.005_bib0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrmicro1613","article-title":"Cannibalism and fratricide: mechanisms and raisons d\u2019\u00eatre","volume":"5","author":"Claverys","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0150","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1073\/pnas.0500879102","article-title":"Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements","volume":"102","author":"Guiral","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.11.005_bib0155","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1099\/mic.0.026328-0","article-title":"Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC","volume":"155","author":"Eldholm","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2012.11.005_bib0160","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02183675","article-title":"Bakteriologische und epidemiologische Untersuchungen uber die Besiedlung der oberen Atmungswege Gesunder mit Pneumokokken","volume":"114","author":"Gundel","year":"1933","journal-title":"Zeitschr. Hyg. Infektkrankh"},{"key":"10.1016\/j.tim.2012.11.005_bib0165","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/00006454-200010000-00019","article-title":"Lack of utility of serotyping multiple colonies for detection of simultaneous nasopharyngeal carriage of different pneumococcal serotypes","volume":"19","author":"Huebner","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0170","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.mimet.2008.08.010","article-title":"An easy method for detection of nasopharyngeal carriage of multiple Streptococcus pneumoniae serotypes","volume":"75","author":"Kaltoft","year":"2008","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.tim.2012.11.005_bib0175","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/JCM.01877-08","article-title":"Detection of Streptococcus pneumoniae strain cocolonization in the nasopharynx","volume":"47","author":"Brugger","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0180","doi-asserted-by":"crossref","first-page":"e11638","DOI":"10.1371\/journal.pone.0011638","article-title":"Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine","volume":"5","author":"Brugger","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0185","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/528688","article-title":"Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study","volume":"46","author":"Hill","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0190","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1099\/jmm.0.006726-0","article-title":"Multiplex PCR reveals a high rate of nasopharyngeal pneumococcal 7-valent conjugate vaccine serotypes co-colonizing indigenous Warao children in Venezuela","volume":"58","author":"Rivera-Olivero","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0195","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1128\/JCM.00157-11","article-title":"Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray","volume":"49","author":"Turner","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0200","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1128\/JCM.06384-11","article-title":"Sequetyping: serotyping Streptococcus pneumoniae by a single PCR sequencing strategy","volume":"50","author":"Leung","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0205","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/aje\/154.1.85","article-title":"Interpreting results from trials of pneumococcal conjugate vaccines: a statistical test for detecting vaccine-induced increases in carriage of nonvaccine serotypes","volume":"154","author":"Lipsitch","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0210","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/S0264-410X(00)00046-3","article-title":"Competition among Streptococcus pneumoniae for intranasal colonization in a mouse model","volume":"18","author":"Lipsitch","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2012.11.005_bib0215","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/S0140-6736(10)62225-8","article-title":"Serotype replacement in disease after pneumococcal vaccination","volume":"378","author":"Weinberger","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2012.11.005_bib0220","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1098\/rstb.2011.0032","article-title":"Contribution of vaccines to our understanding of pneumococcal disease","volume":"366","author":"Klugman","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B: Biol. Sci."},{"key":"10.1016\/j.tim.2012.11.005_bib0225","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1001\/jama.297.16.1784","article-title":"Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage","volume":"297","author":"Singleton","year":"2007","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.tim.2012.11.005_bib0230","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/INF.0b013e31803df9ca","article-title":"Emergence of 19A as virulent and multidrug resistant pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine","volume":"26","author":"Pelton","year":"2007","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0235","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/infdis\/jir056","article-title":"The changing epidemiology of Streptococcus pneumoniae serotype 19A clonal complexes","volume":"203","author":"Tyrrell","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0240","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00222-11","article-title":"High levels of recombination among Streptococcus pneumoniae isolates from the Gambia","volume":"2","author":"Donkor","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.tim.2012.11.005_bib0245","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1128\/JCM.02243-09","article-title":"Revisiting pneumococcal carriage by use of broth enrichment and PCR techniques for enhanced detection of carriage and serotypes","volume":"48","author":"da Gloria Carvalho","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0250","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/INF.0b013e318270d850","article-title":"Density interactions between Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in the nasopharynx of young Peruvian children","volume":"32","author":"Chien","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0255","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/INF.0b013e3181f111a2","article-title":"Association between nasopharyngeal load of Streptococcus pneumoniae, viral coinfection, and radiologically confirmed pneumonia in Vietnamese children","volume":"30","author":"Vu","year":"2011","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.tim.2012.11.005_bib0260","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/cid\/cir859","article-title":"Use of a rapid test of pneumococcal colonization density to diagnose pneumococcal pneumonia","volume":"54","author":"Albrich","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0265","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1086\/516477","article-title":"Relationship between nasopharyngeal colonization and the development of otitis media in children","volume":"175","author":"Faden","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0270","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/jama.292.6.716","article-title":"Association between carriage of Streptococcus pneumoniae and Staphylococcus aureus in children","volume":"292","author":"Regev-Yochay","year":"2004","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.tim.2012.11.005_bib0275","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00245-10","article-title":"Microbial communities of the upper respiratory tract and otitis media in children","volume":"2","author":"Laufer","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.tim.2012.11.005_bib0280","doi-asserted-by":"crossref","first-page":"e17035","DOI":"10.1371\/journal.pone.0017035","article-title":"Variability and diversity of nasopharyngeal microbiota in children: a metagenomic analysis","volume":"6","author":"Bogaert","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0285","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/S0140-6736(11)61051-9","article-title":"Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis","volume":"378","author":"Nair","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2012.11.005_bib0290","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2334-9-110","article-title":"Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era","volume":"9","author":"Lee","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0295","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"David","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.tim.2012.11.005_bib0300","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0140-6736(04)16357-5","article-title":"Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children","volume":"363","author":"Bogaert","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2012.11.005_bib0305","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1086\/522164","article-title":"Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae \u2013 and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization \u2013 in HIV-infected and HIV-uninfected children","volume":"196","author":"Madhi","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0310","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1128\/JB.00006-08","article-title":"Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae","volume":"190","author":"Park","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.11.005_bib0315","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/JB.00317-06","article-title":"Interference between Streptococcus pneumoniae and Staphylococcus aureus: in vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae","volume":"188","author":"Regev-Yochay","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.11.005_bib0320","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1073\/pnas.0809600106","article-title":"Killing niche competitors by remote-control bacteriophage induction","volume":"106","author":"Selva","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2012.11.005_bib0325","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/JB.00950-08","article-title":"Hydrogen peroxide-mediated interference competition by Streptococcus pneumoniae has no significant effect on Staphylococcus aureus nasal colonization of neonatal rats","volume":"191","author":"Margolis","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.11.005_bib0330","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1086\/597040","article-title":"The pneumococcal pilus predicts the absence of Staphylococcus aureus co-colonization in pneumococcal carriers","volume":"48","author":"Regev-Yochay","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0335","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1128\/CVI.00435-09","article-title":"Impact of a pneumococcal conjugate vaccination program on carriage among children in Norway","volume":"17","author":"Vestrheim","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.tim.2012.11.005_bib0340","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1016\/j.vaccine.2011.05.034","article-title":"Nasopharyngeal carriage of Streptococcus pneumoniae in Taiwan before and after the introduction of a conjugate vaccine","volume":"29","author":"Kuo","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2012.11.005_bib0345","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1128\/JCM.06589-11","article-title":"Effect of pneumococcal vaccination on nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Fijian children","volume":"50","author":"Dunne","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0350","doi-asserted-by":"crossref","first-page":"e20229","DOI":"10.1371\/journal.pone.0020229","article-title":"Effect of seven-valent pneumococcal conjugate vaccine on Staphylococcus aureus colonisation in a randomised controlled trial","volume":"6","author":"van Gils","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0355","doi-asserted-by":"crossref","first-page":"e39730","DOI":"10.1371\/journal.pone.0039730","article-title":"Long-term effects of pneumococcal conjugate vaccine on nasopharyngeal carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis","volume":"7","author":"Spijkerman","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0360","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1086\/505076","article-title":"Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children","volume":"194","author":"McNally","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0365","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.mib.2012.08.003","article-title":"Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA)","volume":"15","author":"Mediavilla","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0370","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3201\/eid1410.080119","article-title":"Microbial interactions during upper respiratory tract infections","volume":"14","author":"Pettigrew","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0375","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1016\/j.vaccine.2006.09.020","article-title":"Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract","volume":"25","author":"Jacoby","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2012.11.005_bib0380","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/1471-2334-10-304","article-title":"Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease","volume":"10","author":"Mackenzie","year":"2010","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0385","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2180-10-59","article-title":"The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response","volume":"10","author":"Margolis","year":"2010","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0390","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1128\/IAI.68.7.3990-3997.2000","article-title":"Inhibitory and bactericidal effects of hydrogen peroxide production by Streptococcus pneumoniae on other inhabitants of the upper respiratory tract","volume":"68","author":"Pericone","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0395","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tim.2011.06.003","article-title":"Experimental human pneumococcal carriage models for vaccine research","volume":"19","author":"Ferreira","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0400","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1128\/JB.00474-07","article-title":"Diversity of bacteriocins and activity spectrum in Streptococcus pneumoniae","volume":"189","author":"Lux","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.11.005_bib0405","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1574-695X.2012.00928.x","article-title":"Bacteriocin-producing oral streptococci and inhibition of respiratory pathogens","volume":"65","author":"Santagati","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0410","doi-asserted-by":"crossref","first-page":"e28523","DOI":"10.1371\/journal.pone.0028523","article-title":"Regulation of virulence gene expression resulting from Streptococcus pneumoniae and nontypeable Haemophilus influenzae interactions in chronic disease","volume":"6","author":"Cope","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tim.2012.11.005_bib0415","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1574-6976.2012.00345.x","article-title":"AI-2-mediated signalling in bacteria","volume":"37","author":"Pereira","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.tim.2012.11.005_bib0420","doi-asserted-by":"crossref","first-page":"e1001044","DOI":"10.1371\/journal.ppat.1001044","article-title":"The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms","volume":"6","author":"Sanchez","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2012.11.005_bib0425","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1128\/IAI.00425-08","article-title":"Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonization","volume":"76","author":"Mu\u00f1oz-El\u00edas","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0430","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature09074","article-title":"Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization","volume":"465","author":"Iwase","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tim.2012.11.005_bib0435","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.micinf.2008.12.001","article-title":"Biofilm formation on human airway epithelia by encapsulated Neisseria meningitidis serogroup B","volume":"11","author":"Neil","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.tim.2012.11.005_bib0440","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1365-2958.2007.05864.x","article-title":"The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract","volume":"65","author":"Jurcisek","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0445","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1128\/JB.00673-06","article-title":"Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion","volume":"188","author":"Moscoso","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.11.005_bib0450","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1128\/IAI.05186-11","article-title":"The LuxS-dependent quorum-sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39","volume":"79","author":"Vidal","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0455","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1128\/JB.188.7.2325-2335.2006","article-title":"Phenotypic characterization of Streptococcus pneumoniae biofilm development","volume":"188","author":"Allegrucci","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2012.11.005_bib0460","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1462-2920.2012.02853.x","article-title":"Insight into the composition of the intercellular matrix of Streptococcus pneumoniae biofilms","volume":"15","author":"Domenech","year":"2013","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0465","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1574-6976.2009.00167.x","article-title":"Regulation of natural genetic transformation and acquisition of transforming DNA in Streptococcus pneumoniae","volume":"33","author":"Johnsborg","year":"2009","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.tim.2012.11.005_bib0470","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1128\/AEM.01343-12","article-title":"Fratricide is essential for efficient gene transfer between pneumococci in biofilms","volume":"78","author":"Wei","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2012.11.005_bib0475","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1128\/IAI.05644-11","article-title":"LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumoniae","volume":"79","author":"Trappetti","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0480","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1086\/656046","article-title":"Coinfection with Haemophilus influenzae promotes pneumococcal biofilm formation during experimental otitis media and impedes the progression of pneumococcal disease","volume":"202","author":"Weimer","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0485","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/infdis\/jiq087","article-title":"Divergent mechanisms for passive pneumococcal resistance to beta-lactam antibiotics in the presence of Haemophilus influenzae","volume":"203","author":"Weimer","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2012.11.005_bib0490","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/IAI.00320-09","article-title":"LuxS promotes biofilm maturation and persistence of nontypeable haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface","volume":"77","author":"Armbruster","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0495","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1128\/IAI.72.5.2964-2975.2004","article-title":"LuxS is required for persistent pneumococcal carriage and expression of virulence and biosynthesis genes","volume":"72","author":"Joyce","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2012.11.005_bib0500","doi-asserted-by":"crossref","first-page":"e00102","DOI":"10.1128\/mBio.00102-10","article-title":"Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling","volume":"1","author":"Armbruster","year":"2010","journal-title":"MBio"},{"key":"10.1016\/j.tim.2012.11.005_bib0505","doi-asserted-by":"crossref","first-page":"e1002358","DOI":"10.1371\/journal.pcbi.1002358","article-title":"Metabolic reconstruction for metagenomic data and its application to the human microbiome","volume":"8","author":"Abubucker","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.tim.2012.11.005_bib0510","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1084\/jem.20011576","article-title":"The immune response to pneumococcal proteins during experimental human carriage","volume":"195","author":"McCool","year":"2002","journal-title":"J. Exp. Med."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X12002119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X12002119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:38:04Z","timestamp":1760812684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X12002119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":102,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0966842X12002119"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2012.11.005","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of bacterial interactions on pneumococcal colonization of the nasopharynx","name":"articletitle","label":"Article Title"},{"value":"Trends in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tim.2012.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}