{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:30:14Z","timestamp":1791419414635,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.tim.2015.02.009","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T21:17:40Z","timestamp":1428355060000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":277,"title":["Collateral sensitivity of antibiotic-resistant microbes"],"prefix":"10.1016","volume":"23","author":[{"given":"Csaba","family":"P\u00e1l","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.tim.2015.02.009_bib0195","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1073\/pnas.0702117104","article-title":"An experimental test of evolutionary trade-offs during temperature adaptation","volume":"104","author":"Bennett","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2015.02.009_bib0200","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s002489900169","article-title":"Application of traditional and phylogenetically based comparative methods to test for a trade-off in bacterial growth rate at low versus high substrate concentration","volume":"38","author":"Velicer","year":"1999","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.tim.2015.02.009_bib0205","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/JB.64.4.489-499.1952","article-title":"Genetic studies on microbial cross resistance to toxic agents. I. Cross resistance of Escherichia coli to fifteen antibiotics","volume":"64","author":"Szybalski","year":"1952","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2015.02.009_bib0210","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1126\/science.1124410","article-title":"The competitive cost of antibiotic resistance in Mycobacterium tuberculosis","volume":"312","author":"Gagneux","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.tim.2015.02.009_bib0215","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.drup.2012.03.002","article-title":"Collateral sensitivity as a strategy against cancer multidrug resistance","volume":"15","author":"Pluchino","year":"2012","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.tim.2015.02.009_bib0220","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/msb.2013.57","article-title":"Bacterial evolution of antibiotic hypersensitivity","volume":"9","author":"Lazar","year":"2013","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.tim.2015.02.009_bib0225","doi-asserted-by":"crossref","first-page":"204ra132","DOI":"10.1126\/scitranslmed.3006609","article-title":"Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development","volume":"5","author":"Imamovic","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tim.2015.02.009_bib0230","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/molbev\/msu191","article-title":"Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolution","volume":"31","author":"Oz","year":"2014","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.tim.2015.02.009_bib0235","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nbt.2779","article-title":"Collateral damage","volume":"32","author":"Hancock","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tim.2015.02.009_bib0240","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1038\/ncomms5352","article-title":"Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network","volume":"5","author":"Lazar","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2015.02.009_bib0245","series-title":"Antimicrobial Drug Resistance","author":"Mayers","year":"2009"},{"key":"10.1016\/j.tim.2015.02.009_bib0250","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1038\/ncomms5296","article-title":"Opposing effects of target overexpression reveal drug mechanisms","volume":"5","author":"Palmer","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2015.02.009_bib0255","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ng.1034","article-title":"Evolutionary paths to antibiotic resistance under dynamically sustained drug selection","volume":"44","author":"Toprak","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tim.2015.02.009_bib0260","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/jac\/dks196","article-title":"Bacterial stress responses as determinants of antimicrobial resistance","volume":"67","author":"Poole","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.tim.2015.02.009_bib0265","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/msb.2012.76","article-title":"Evolutionary potential, cross-stress behavior and the genetic basis of acquired stress resistance in Escherichia coli","volume":"9","author":"Dragosits","year":"2013","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.tim.2015.02.009_bib0270","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2958.2002.03170.x","article-title":"Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12","volume":"46","author":"Oshima","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2015.02.009_bib0275","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1128\/JB.188.8.3088-3098.2006","article-title":"The Erwinia chrysanthemi 3937 PhoQ sensor kinase regulates several virulence determinants","volume":"188","author":"Venkatesh","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2015.02.009_bib0280","doi-asserted-by":"crossref","first-page":"e00273","DOI":"10.1128\/mBio.00273-13","article-title":"Clinically relevant mutant DNA gyrase alters supercoiling, changes the transcriptome, and confers multidrug resistance","volume":"4","author":"Webber","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.tim.2015.02.009_bib0285","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1128\/AAC.20.6.803","article-title":"Role of the membrane potential in bacterial resistance to aminoglycoside antibiotics","volume":"20","author":"Damper","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2015.02.009_bib0290","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/10766290260469507","article-title":"Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants","volume":"8","author":"Baumert","year":"2002","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.tim.2015.02.009_bib0295","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1128\/AAC.33.9.1549","article-title":"Aminoglycoside uptake increased by tet gene expression","volume":"33","author":"Merlin","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2015.02.009_bib0300","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1128\/AAC.38.6.1284","article-title":"Characterization of fluoroquinolone-resistant mutants of Escherichia coli selected in vitro","volume":"38","author":"Heisig","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tim.2015.02.009_bib0385","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/jac\/38.3.443","article-title":"gyrA mutations in high-level fluoroquinolone-resistant clinical isolates of Escherichia coli","volume":"38","author":"Conrad","year":"1996","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.tim.2015.02.009_bib0310","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2958.2003.03307.x","article-title":"Molecular analysis of fusidic acid resistance in Staphylococcus aureus","volume":"47","author":"Besier","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2015.02.009_bib0315","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1365-2958.2000.01967.x","article-title":"Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp","volume":"37","author":"Macvanin","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2015.02.009_bib0320","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1365-2958.2001.02389.x","article-title":"Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus","volume":"40","author":"Nagaev","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2015.02.009_bib0325","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.femsle.2005.05.007","article-title":"Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics","volume":"247","author":"Macvanin","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.tim.2015.02.009_bib0330","doi-asserted-by":"crossref","first-page":"13137","DOI":"10.1073\/pnas.182295999","article-title":"Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax","volume":"99","author":"Hastings","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2015.02.009_bib0335","doi-asserted-by":"crossref","first-page":"e1001692","DOI":"10.1371\/journal.pbio.1001692","article-title":"Fitness trade-offs restrict the evolution of resistance to amphotericin B","volume":"11","author":"Vincent","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tim.2015.02.009_bib0340","first-page":"CD008492","article-title":"Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria","volume":"10","author":"Gogtay","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.tim.2015.02.009_bib0345","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-3-642-28951-4_6","article-title":"Prevention of drug resistance by combined drug treatment of tuberculosis","volume":"211","author":"Mitchison","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tim.2015.02.009_bib0350","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.2012.7961","article-title":"Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society\u2013USA panel","volume":"308","author":"Thompson","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.tim.2015.02.009_bib0355","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nbt.1549","article-title":"Synergistic drug combinations tend to improve therapeutically relevant selectivity","volume":"27","author":"Lehar","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tim.2015.02.009_bib0360","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1073\/pnas.1320886110","article-title":"Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance","volume":"111","author":"Lukens","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2015.02.009_bib0365","doi-asserted-by":"crossref","first-page":"262ra156","DOI":"10.1126\/scitranslmed.3009940","article-title":"Prediction of resistance development against drug combinations by collateral responses to component drugs","volume":"6","author":"Munck","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tim.2015.02.009_bib0370","doi-asserted-by":"crossref","first-page":"14494","DOI":"10.1073\/pnas.1409800111","article-title":"Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tim.2015.02.009_bib0375","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1038\/ncomms6792","article-title":"Prediction of antibiotic resistance by gene expression profiles","volume":"5","author":"Suzuki","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2015.02.009_bib0380","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1128\/AAC.00437-10","article-title":"An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus","volume":"54","author":"Cui","year":"2010","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X15000505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X15000505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T10:41:16Z","timestamp":1598870476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X15000505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0966842X15000505"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2015.02.009","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Collateral sensitivity of antibiotic-resistant microbes","name":"articletitle","label":"Article Title"},{"value":"Trends in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tim.2015.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}