{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:16:14Z","timestamp":1790684174588,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["GM122079"],"award-info":[{"award-number":["GM122079"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.tim.2017.09.007","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T01:00:16Z","timestamp":1507942816000},"page":"6-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Transmissible Viral Vaccines"],"prefix":"10.1016","volume":"26","author":[{"given":"James J.","family":"Bull","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Smithson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Nuismer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2017.09.007_bib0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0165-2478(87)90153-2","article-title":"Recombinant live virus vaccines","volume":"16","author":"Mackett","year":"1987","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.tim.2017.09.007_bib0010","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.micro.58.030603.123625","article-title":"Vaccine-derived polioviruses and the endgame strategy for global polio eradication","volume":"59","author":"Kew","year":"2005","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.tim.2017.09.007_bib0015","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nbt.1635","article-title":"Rationalizing the development of live attenuated virus vaccines","volume":"28","author":"Lauring","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tim.2017.09.007_bib0020","first-page":"635","article-title":"The double-edged sword: How evolution can make or break a live-attenuated virus vaccine","volume":"4","author":"Hanley","year":"2011","journal-title":"Evolution"},{"key":"10.1016\/j.tim.2017.09.007_bib0025","doi-asserted-by":"crossref","first-page":"11097","DOI":"10.1128\/JVI.78.20.11097-11107.2004","article-title":"Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3","volume":"78","author":"Guest","year":"2004","journal-title":"J. Virol."},{"issue":"Suppl 1","key":"10.1016\/j.tim.2017.09.007_bib0030","doi-asserted-by":"crossref","first-page":"S283","DOI":"10.1093\/infdis\/jiu295","article-title":"Vaccine-derived polioviruses","volume":"210","author":"Burns","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2017.09.007_bib0035","doi-asserted-by":"crossref","first-page":"e1002015","DOI":"10.1371\/journal.pcbi.1002015","article-title":"Autonomous targeting of infectious superspreaders using engineered transmissible therapies","volume":"7","author":"Metzger","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.tim.2017.09.007_bib0040","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.vaccine.2013.12.026","article-title":"The delicate balance in genetically engineering live vaccines","volume":"32","author":"Galen","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2017.09.007_bib0045","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vev005","article-title":"Evolutionary reversion of live viral vaccines: Can genetic engineering subdue it?","volume":"1","author":"Bull","year":"2015","journal-title":"Virus Evol."},{"key":"10.1016\/j.tim.2017.09.007_bib0050","first-page":"495","article-title":"Current status of virally vectored immunocontraception for biological control of mice","volume":"63","author":"Hardy","year":"2007","journal-title":"Soc. Reprod. Fertil. Suppl."},{"key":"10.1016\/j.tim.2017.09.007_bib0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jri.2006.04.006","article-title":"Biological control of vertebrate pests using virally vectored immunocontraception","volume":"71","author":"Hardy","year":"2006","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.tim.2017.09.007_bib0060","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1128\/JVI.74.3.1114-1123.2000","article-title":"Horizontal transmissible protection against myxomatosis and rabbit hemorrhagic disease by using a recombinant myxoma virus","volume":"74","author":"B\u00e1rcena","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0065","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1016\/S0264-410X(01)00184-0","article-title":"First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease","volume":"19","author":"Torres","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2017.09.007_bib0070","first-page":"914","article-title":"Biological control using sterilizing viruses: host suppression and competition between viruses in non-spatial models","volume":"37","author":"Hood","year":"2000","journal-title":"J. Appl. Entomol."},{"key":"10.1016\/j.tim.2017.09.007_bib0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1586\/14760584.2016.1106942","article-title":"Self-disseminating vaccines for emerging infectious diseases","volume":"15","author":"Murphy","year":"2016","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.tim.2017.09.007_bib0080","unstructured":"Fenner, F. and Cairns, J. (1959) Variation in virulence in relation to adaptaton to new hosts. In The Viruses, vol. 3. Animal viruses 3 (Burnet, F.M. and Stanley, W.M., eds), pp. 225\u2013249, Academic Press"},{"key":"10.1016\/j.tim.2017.09.007_bib0085","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1128\/JVI.80.7.3259-3272.2006","article-title":"Modulation of poliovirus replicative fitness in HeLa cells by deoptimization of synonymous codon usage in the capsid region","volume":"80","author":"Burns","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0090","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1128\/JVI.00738-06","article-title":"Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity","volume":"80","author":"Mueller","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0095","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.1155761","article-title":"Virus attenuation by genome-scale changes in codon pair bias","volume":"320","author":"Coleman","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.tim.2017.09.007_bib0100","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/molbev\/mss119","article-title":"Slow fitness recovery in a codon-modified viral genome","volume":"29","author":"Bull","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.tim.2017.09.007_bib0105","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1073\/pnas.95.7.3501","article-title":"Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus","volume":"95","author":"Wertz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2017.09.007_bib0110","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1128\/JVI.75.13.6107-6114.2001","article-title":"Rearrangement of the genes of vesicular stomatitis virus eliminates clinical disease in the natural host: new strategy for vaccine development","volume":"75","author":"Flanagan","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0115","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1534\/g3.113.006403","article-title":"Evolutionarily stable attenuation by genome rearrangement in a virus","volume":"3","author":"Cecchini","year":"2013","journal-title":"G3 Bethesda Md"},{"key":"10.1016\/j.tim.2017.09.007_bib0120","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1128\/JVI.73.2.1138-1145.1999","article-title":"Genetic instability of live, attenuated human immunodeficiency virus type 1 vaccine strains","volume":"73","author":"Berkhout","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/viro.2000.0327","article-title":"Forced retroevolution of an RNA bacteriophage","volume":"271","author":"Licis","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.tim.2017.09.007_bib0130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.coviro.2012.02.006","article-title":"Reaching the last one per cent: progress and challenges in global polio eradication","volume":"2","author":"Kew","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0135","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1016\/j.vaccine.2011.04.022","article-title":"Shedding of Ann Arbor strain live attenuated influenza vaccine virus in children 6\u201359 months of age","volume":"29","author":"Mallory","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2017.09.007_bib0140","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S1473-3099(08)70231-7","article-title":"Rotavirus vaccines: viral shedding and risk of transmission","volume":"8","author":"Anderson","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tim.2017.09.007_bib0145","first-page":"42","article-title":"[Mumps vaccine virus transmission]","volume":"58","author":"Otrashevskaia","year":"2013","journal-title":"Vopr. Virusol."},{"key":"10.1016\/j.tim.2017.09.007_bib0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.virusres.2007.07.018","article-title":"Glycoprotein gene relocation in rabies virus","volume":"131","author":"Wu","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.tim.2017.09.007_bib0155","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tim.2017.09.007_bib0160","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4161\/hv.23220","article-title":"Applications and challenges of multivalent recombinant vaccines","volume":"9","author":"Naim","year":"2013","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.tim.2017.09.007_bib0165","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1128\/JVI.00413-13","article-title":"Generation of genetically stable recombinant rotaviruses containing novel genome rearrangements and heterologous sequences by reverse genetics","volume":"87","author":"Navarro","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0170","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nbt.2688","article-title":"Programming CMV for vaccine vector design","volume":"31","author":"Ranasinghe","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tim.2017.09.007_bib0175","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/824630","article-title":"An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines","volume":"2014","author":"Dong","year":"2014","journal-title":"J. Immunol. Res"},{"key":"10.1016\/j.tim.2017.09.007_bib0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1586\/14760584.2015.965690","article-title":"Self-replicating alphavirus RNA vaccines","volume":"14","author":"Ljungberg","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.tim.2017.09.007_bib0185","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1159\/000438531","article-title":"Ebolavirus vaccines: progress in the fight against Ebola virus disease","volume":"37","author":"Wu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tim.2017.09.007_bib0190","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2217\/imt.15.110","article-title":"Cytomegalovirus and immunotherapy: opportunistic pathogen, novel target for cancer and a promising vaccine vector","volume":"8","author":"Quinn","year":"2016","journal-title":"Immunotherapy"},{"key":"10.1016\/j.tim.2017.09.007_bib0195","series-title":"Infectious Diseases of Humans: Dynamics and Control","year":"1992"},{"key":"10.1016\/j.tim.2017.09.007_bib0200","doi-asserted-by":"crossref","DOI":"10.1098\/rspb.2016.1903","article-title":"Eradicating infectious disease using weakly transmissible vaccines","volume":"283","author":"Nuismer","year":"2016","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.tim.2017.09.007_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4684-5409-3_1","article-title":"Dynamics of interactions between bacteria and virulent bacteriophage","volume":"10","author":"Lenski","year":"1988","journal-title":"Adv. Microb. Ecol."},{"key":"10.1016\/j.tim.2017.09.007_bib0210","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature02104","article-title":"The role of evolution in the emergence of infectious diseases","volume":"426","author":"Antia","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tim.2017.09.007_bib0215","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.coviro.2012.02.006","article-title":"Reaching the last one per cent: progress and challenges in global polio eradication","volume":"2","author":"Kew","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0220","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0065-3527(08)60529-1","article-title":"Incomplete forms of influenza virus","volume":"2","author":"Von Magnus","year":"1954","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.tim.2017.09.007_bib0225","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.mi.27.100173.000533","article-title":"Defective interfering viruses","volume":"27","author":"Huang","year":"1973","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.tim.2017.09.007_bib0230","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1073\/pnas.70.7.2105","article-title":"Prophylaxis and immunization in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus","volume":"70","author":"Doyle","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2017.09.007_bib0235","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1128\/JVI.03193-13","article-title":"Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?","volume":"88","author":"Dimmock","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0240","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tibtech.2014.06.006","article-title":"The case for transmissible antivirals to control population-wide infectious disease","volume":"32","author":"Notton","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.tim.2017.09.007_bib0245","doi-asserted-by":"crossref","first-page":"e1005986","DOI":"10.1371\/journal.pgen.1005986","article-title":"Exploiting genetic interference for antiviral therapy","volume":"12","author":"Tanner","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tim.2017.09.007_bib0250","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/417452a","article-title":"Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite","volume":"417","author":"Ito","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tim.2017.09.007_bib0255","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature09937","article-title":"A synthetic homing endonuclease-based gene drive system in the human malaria mosquito","volume":"473","author":"Windbichler","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tim.2017.09.007_bib0260","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.aaa5945","article-title":"Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations","volume":"348","author":"Gantz","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tim.2017.09.007_bib0265","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1128\/AEM.01727-12","article-title":"Antiviral protection and the importance of Wolbachia density and tissue tropism in Drosophila simulans","volume":"78","author":"Osborne","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tim.2017.09.007_bib0270","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1371\/journal.pntd.0000516","article-title":"Wolbachia infection reduces blood-feeding success in the dengue fever mosquito, Aedes aegypti","volume":"3","author":"Turley","year":"2009","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1016\/j.tim.2017.09.007_bib0275","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1539-6924.2012.01864.x","article-title":"Expert review on poliovirus immunity and transmission","volume":"33","author":"Duintjer Tebbens","year":"2013","journal-title":"Risk Anal."},{"key":"10.1016\/j.tim.2017.09.007_bib0280","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chom.2008.08.003","article-title":"Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines","volume":"4","author":"Barnes","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tim.2017.09.007_bib0285","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1128\/JVI.01788-09","article-title":"Attenuation of vesicular stomatitis virus encephalitis through microRNA targeting","volume":"84","author":"Kelly","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0290","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/JVI.01940-12","article-title":"Attenuation of Semliki Forest virus neurovirulence by microRNA-mediated detargeting","volume":"87","author":"Yl\u00f6sm\u00e4ki","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2017.09.007_bib0295","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2014.04.001","article-title":"Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions","volume":"456\u2013457","author":"Teterina","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.tim.2017.09.007_bib0300","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1073\/pnas.93.6.2370","article-title":"Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants","volume":"93","author":"Gromeier","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2017.09.007_bib0305","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1006\/viro.1996.8344","article-title":"Two amino acid changes at the N-terminus of transmissible gastroenteritis coronavirus spike protein result in the loss of enteric tropism","volume":"227","author":"Ballesteros","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.tim.2017.09.007_bib0310","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0264-410X(93)90028-V","article-title":"Intestinal protection against challenge with transmissible gastroenteritis virus of pigs immune after infection with the porcine respiratory coronavirus","volume":"11","author":"Cox","year":"1993","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2017.09.007_bib0315","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-2427(94)90124-4","article-title":"Immunity to transmissible gastroenteritis virus and porcine respiratory coronavirus infections in swine","volume":"43","author":"Saif","year":"1994","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.tim.2017.09.007_bib0320","series-title":"Viral and Rickettsial Infections of Man","first-page":"430","article-title":"Polioviruses","author":"Bodian","year":"1965"}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X17302123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X17302123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T21:57:15Z","timestamp":1603144635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X17302123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0966842X17302123"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2017.09.007","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transmissible Viral Vaccines","name":"articletitle","label":"Article Title"},{"value":"Trends in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tim.2017.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}