{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:06:35Z","timestamp":1790409995827,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["R01AI120244"],"award-info":[{"award-number":["R01AI120244"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["R01AI140195"],"award-info":[{"award-number":["R01AI140195"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Commonwealth of Kentucky Research Challenge Trust Fund"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.tim.2018.12.012","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T23:36:44Z","timestamp":1547509004000},"page":"550-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Nutrition and Bipartite Metabolism of Intracellular Pathogens"],"prefix":"10.1016","volume":"27","author":[{"given":"Ashley","family":"Best","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-2078","authenticated-orcid":false,"given":"Yousef","family":"Abu Kwaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2018.12.012_bib0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen\u2013host interface","volume":"10","author":"Hood","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0010","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1212868","article-title":"Host proteasomal degradation generates amino acids essential for intracellular bacterial growth","volume":"334","author":"Price","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.tim.2018.12.012_bib0015","doi-asserted-by":"crossref","first-page":"20800","DOI":"10.1073\/pnas.1218674109","article-title":"Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection","volume":"109","author":"Niu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2018.12.012_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003562","article-title":"Francisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growth","volume":"9","author":"Steele","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2018.12.012_bib0025","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/cmi.12138","article-title":"Microbial quest for food in vivo: \u2018nutritional virulence\u2019 as an emerging paradigm","volume":"15","author":"Abu Kwaik","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/1758-2229.12236","article-title":"Nutrition-based evolution of intracellular pathogens","volume":"7","author":"Abu Kwaik","year":"2015","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.tim.2018.12.012_bib0035","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3389\/fcimb.2017.00523","article-title":"Francisella tularensis confronts the complement system","volume":"7","author":"Brock","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0040","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fcimb.2017.00499","article-title":"Growth of Chlamydia pneumoniae is enhanced in cells with impaired mitochondrial function","volume":"7","author":"Kading","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","article-title":"Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fcimb.2017.00285","article-title":"Multiple substrate usage of Coxiella burnetii to feed a bipartite-type metabolic network","volume":"7","author":"H\u00e4uslein","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/mmi.13313","article-title":"Pathway analysis using (13) C-glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila","volume":"100","author":"Hauslein","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0060","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/mmi.13603","article-title":"Metabolic adaptation of Chlamydia trachomatis to mammalian host cells","volume":"103","author":"Mehlitz","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0065","first-page":"156","article-title":"Analysis of carbon substrates used by Listeria monocytogenes during growth in J774A.1 macrophages suggests a bipartite intracellular metabolism","volume":"4","author":"Grubmuller","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0070","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1128\/jcm.11.3.286-291.1980","article-title":"Amino acid requirements of Legionella pneumophila","volume":"11","author":"George","year":"1980","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0075","doi-asserted-by":"crossref","first-page":"22232","DOI":"10.1074\/jbc.M110.128678","article-title":"Isotopologue profiling of Legionella pneumophila: role of serine and glucose as carbon substrates","volume":"285","author":"Eylert","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2018.12.012_bib0080","doi-asserted-by":"crossref","first-page":"21040","DOI":"10.1074\/jbc.M114.570085","article-title":"Amino acid uptake and metabolism of Legionella pneumophila hosted by Acanthamoeba castellanii","volume":"289","author":"Schunder","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2018.12.012_bib0085","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2018.00003","article-title":"The life cycle of L. pneumophila: cellular differentiation is linked to virulence and metabolism","author":"Oliva","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0090","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1074\/jbc.M115.693481","article-title":"Growth-related metabolism of the carbon storage poly-3-hydroxybutyrate in Legionella pneumophila","volume":"291","author":"Gillmaier","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2018.12.012_bib0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-24724-1","article-title":"A Legionella pneumophila amylase is essential for intracellular replication in human macrophages and amoebae","volume":"8","author":"Best","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tim.2018.12.012_bib0100","article-title":"Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila","volume":"21","author":"Best","year":"2018","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0105","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01313-18","article-title":"Evolution of the arsenal of Legionella pneumophila effectors to modulate protist hosts","volume":"9","author":"Best","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.tim.2018.12.012_bib0110","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1073\/pnas.0812074106","article-title":"Host cell-free growth of the Q fever bacterium Coxiella burnetii","volume":"106","author":"Omsland","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2018.12.012_bib0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fcimb.2017.00438","article-title":"Characterization of the growth of Chlamydia trachomatis in in vitro-generated stratified epithelium","volume":"7","author":"Nogueira","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0120","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1128\/IAI.01081-08","article-title":"The PmrA\/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa","volume":"77","author":"Al-Khodor","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2018.12.012_bib0125","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1128\/jb.147.3.1063-1076.1981","article-title":"Developmental cycle of Coxiella burnetii: structure and morphogenesis of vegetative and sporogenic differentiations","volume":"147","author":"McCaul","year":"1981","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2018.12.012_bib0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fcimb.2018.00153","article-title":"Comparative transcriptome profiling of virulent and attenuated Ehrlichia ruminantium strains highlighted strong regulation of map1- and metabolism related genes","volume":"8","author":"Pruneau","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0135","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1128\/IAI.72.7.4040-4051.2004","article-title":"Disruption of the phagosomal membrane and egress of Legionella pneumophila into the cytoplasm during late stages of the intracellular infection of macrophages and Acanthamoeba polyphaga","volume":"72","author":"Molmeret","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2018.12.012_bib0140","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1462-2920.2009.02114.x","article-title":"Temporal and spatial trigger of post-exponential virulence-associated regulatory cascades by Legionella pneumophila after bacterial escape into the host cell cytosol","volume":"12","author":"Molmeret","year":"2010","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0145","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1462-5822.2006.00703.x","article-title":"Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila","volume":"8","author":"Bruggemann","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0150","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1128\/IAI.68.11.6431-6440.2000","article-title":"Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila","volume":"68","author":"Alli","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2018.12.012_bib0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1462-2920.2000.00076.x","article-title":"The mechanism of killing and exiting the protozoan host Acanthamoeba polyphaga by Legionella pneumophila","volume":"2","author":"Gao","year":"2000","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tim.2012.03.005","article-title":"Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella","volume":"20","author":"Al-Quadan","year":"2012","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0165","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2958.2004.04129.x","article-title":"Differentiate to thrive: lessons from the Legionella pneumophila life cycle","volume":"53","author":"Molofsky","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0170","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1128\/JB.181.16.4879-4889.1999","article-title":"The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii","volume":"181","author":"Hales","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2018.12.012_bib0175","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2014.00125","article-title":"Metabolism of the vacuolar pathogen Legionella and implications for virulence","author":"Manske","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0180","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JB.186.21.7344-7352.2004","article-title":"Temporal analysis of Coxiella burnetii morphological differentiation","volume":"186","author":"Coleman","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tim.2018.12.012_bib0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3389\/fcimb.2017.00394","article-title":"Ironing out the unconventional mechanisms of iron acquisition and gene regulation in Chlamydia","volume":"7","author":"Pokorzynski","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0190","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fcimb.2017.00048","article-title":"High-content imaging reveals expansion of the endosomal compartment during Coxiella burnetii parasitophorous vacuole maturation","volume":"7","author":"Larson","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0195","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fcimb.2017.00201","article-title":"MicroRNA-21 limits uptake of Listeria monocytogenes by macrophages to reduce the intracellular niche and control infection","volume":"7","author":"Johnston","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0200","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fcimb.2017.00453","article-title":"Cold-shock domain family proteins (Csps) are involved in regulation of virulence, cellular aggregation, and flagella-based motility in Listeria monocytogenes","volume":"7","author":"Eshwar","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0205","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fcimb.2017.00287","article-title":"Thioredoxin A is essential for motility and contributes to host infection of Listeria monocytogenes via redox interactions","volume":"7","author":"Cheng","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0210","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fcimb.2018.00293","article-title":"Attenuation of Listeria monocytogenes virulence by Cannabis sativa L. essential oil","volume":"8","author":"Marini","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0215","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fcimb.2018.00020","article-title":"Genetic separation of Listeria monocytogenes causing central nervous system infections in animals","volume":"8","author":"Aguilar-Bultet","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0220","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3389\/fcimb.2017.00543","article-title":"Interaction of Coxiella burnetii strains of different sources and genotypes with bovine and human monocyte-derived macrophages","volume":"7","author":"Sobotta","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0225","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fcimb.2017.00174","article-title":"Horizontally acquired biosynthesis genes boost Coxiella burnetii\u2019s physiology","volume":"7","author":"Moses","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0230","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fcimb.2017.00112","article-title":"Alterations of the Coxiella burnetii replicative vacuole membrane integrity and interplay with the autophagy pathway","volume":"7","author":"Mansilla Pareja","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0235","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fcimb.2017.00190","article-title":"Physicochemical and nutritional requirements for axenic replication suggest physiological basis for Coxiella burnetii niche restriction","volume":"7","author":"Vallejo Esquerra","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0240","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1462-5822.2010.01467.x","article-title":"The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication","volume":"12","author":"Lomma","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000704","article-title":"Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa","volume":"5","author":"Price","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2018.12.012_bib0250","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1365-2958.2008.06453.x","article-title":"A Dot\/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa","volume":"70","author":"Al-Khodor","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0255","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fmicb.2010.00131","article-title":"Host-mediated post-translational prenylation of novel Dot\/Icm-translocated effectors of Legionella pneumophila","volume":"1","author":"Price","year":"2010","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0260","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fmicb.2010.00122","article-title":"Exploitation of host polyubiquitination machinery through molecular mimicry by eukaryotic-like bacterial F-box effectors","volume":"1","author":"Price","year":"2010","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0265","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tim.2009.11.004","article-title":"Functional diversity of ankyrin repeats in microbial proteins","volume":"18","author":"Al-Khodor","year":"2010","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0270","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20100771","article-title":"Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila","volume":"207","author":"Price","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tim.2018.12.012_bib0275","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/IAI.01450-09","article-title":"Indispensable role for the eukaryotic-like ankyrin domains of the ankyrin B effector of Legionella pneumophila within macrophages and amoebae","volume":"78","author":"Price","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2018.12.012_bib0280","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.str.2016.12.015","article-title":"Structural mimicry by a bacterial F box effector hijacks the host ubiquitin-proteasome system","volume":"25","author":"Wong","year":"2017","journal-title":"Structure"},{"key":"10.1016\/j.tim.2018.12.012_bib0285","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fmicb.2011.00023","article-title":"Molecular characterization of exploitation of the polyubiquitination and farnesylation machineries of Dictyostelium discoideum by the AnkB F-box effector of Legionella Pneumophila","volume":"2","author":"Al-Quadan","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0290","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fcimb.2017.00487","article-title":"Hijacking of the host ubiquitin network by Legionella pneumophila","volume":"7","author":"Qiu","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0295","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.celrep.2017.10.088","article-title":"Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectors","volume":"21","author":"De Leon","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.tim.2018.12.012_bib0300","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fcimb.2017.00096","article-title":"Importance of metabolic adaptations in Francisella pathogenesis","volume":"7","author":"Ziveri","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0305","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fcimb.2018.00188","article-title":"Galleria mellonella reveals niche differences between highly pathogenic and closely related strains of Francisella spp","volume":"8","author":"Thelaus","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0310","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fcimb.2017.00503","article-title":"The multiple localized glyceraldehyde-3-phosphate dehydrogenase contributes to the attenuation of the Francisella tularensis dsbA deletion mutant","volume":"7","author":"Pavkova","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0315","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fcimb.2017.00071","article-title":"Role of glycosylation\/deglycolysation processes in Francisella tularensis pathogenesis","volume":"7","author":"Barel","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0320","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcimb.2017.00107","article-title":"Iron and virulence in Francisella tularensis","volume":"7","author":"Ramakrishnan","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0325","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fcimb.2018.00121","article-title":"The Francisella type vi secretion system","volume":"8","author":"Clemens","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0330","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fcimb.2017.00303","article-title":"Isolation of F. novicida-containing phagosome from infected human monocyte derived macrophages","volume":"7","author":"Marecic","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0335","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fcimb.2017.00275","article-title":"Differential substrate usage and metabolic fluxes in Francisella tularensis subspecies holarctica and Francisella novicida","volume":"7","author":"Chen","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0340","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fcimb.2018.00258","article-title":"Phylogenetic lineages of Francisella tularensis in animals","volume":"8","author":"Pilo","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0345","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fcimb.2017.00282","article-title":"Nramp1 and NrampB contribute to resistance against Francisella in Dictyostelium","volume":"7","author":"Brenz","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0350","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fcimb.2017.00114","article-title":"Tick\u2013pathogen interactions and vector competence: identification of molecular drivers for tick-borne diseases","volume":"7","author":"de la Fuente","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0355","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3389\/fcimb.2017.00535","article-title":"Iron starvation conditions upregulate Ehrlichia ruminantium type IV secretion system, tr1 transcription factor and map1 genes family through the master regulatory protein ErxR","volume":"7","author":"Moumene","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0360","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fcimb.2017.00023","article-title":"Anaplasma phagocytophilum infection subverts carbohydrate metabolic pathways in the tick vector, Ixodes scapularis","volume":"7","author":"Cabezas-Cruz","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0365","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fcimb.2017.00375","article-title":"Ixodes scapularis tick cells control Anaplasma phagocytophilum infection by increasing the synthesis of phosphoenolpyruvate from tyrosine","volume":"7","author":"Cabezas-Cruz","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0370","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1073\/pnas.1406694111","article-title":"Shigella reroutes host cell central metabolism to obtain high-flux nutrient supply for vigorous intracellular growth","volume":"111","author":"Kentner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2018.12.012_bib0375","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1128\/IAI.00975-13","article-title":"Analysis of the proteome of intracellular Shigella flexneri reveals pathways important for intracellular growth","volume":"81","author":"Pieper","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2018.12.012_bib0380","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1128\/IAI.01575-13","article-title":"Role of intracellular carbon metabolism pathways in Shigella flexneri virulence","volume":"82","author":"Waligora","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2018.12.012_bib0385","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fcimb.2017.00064","article-title":"How do the virulence factors of Shigella work together to cause disease?","volume":"7","author":"Mattock","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0390","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fcimb.2017.00501","article-title":"Inhibition of Wnt signaling pathways impairs Chlamydia trachomatis infection in endometrial epithelial cells","volume":"7","author":"Kintner","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0395","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fcimb.2018.00136","article-title":"To be cytosolic or vacuolar: the double life of Listeria monocytogenes","volume":"8","author":"Bierne","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0400","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bbrc.2011.07.005","article-title":"Comprehensive analysis of localization of 78 solute carrier genes throughout the subsections of the rat gastrointestinal tract","volume":"411","author":"Cedernaes","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tim.2018.12.012_bib0405","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/clpt.2013.73","article-title":"SLC classification: an update","volume":"94","author":"Schlessinger","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.tim.2018.12.012_bib0410","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fcimb.2017.00180","article-title":"Productive and penicillin-stressed Chlamydia pecorum infection induces nuclear factor kappa B activation and interleukin-6 secretion in vitro","volume":"7","author":"Leonard","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0415","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fcimb.2017.00514","article-title":"Chlamydia abortus Pmp18.1 induces IL-1beta secretion by TLR4 activation through the MyD88 NF-kappaB, and caspase-1 signaling pathways","volume":"7","author":"Pan","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2018.00001","article-title":"Dysbiosis of the vaginal microbiota and higher vaginal kynurenine\/tryptophan ratio reveals an association with Chlamydia trachomatis genital infections","volume":"8","author":"Ziklo","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0425","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12552","article-title":"Sequestration of host metabolism by an intracellular pathogen","volume":"5","author":"Gehre","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.tim.2018.12.012_bib0430","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftx108","article-title":"Orchestration of the mammalian host cell glucose transporter proteins-1 and 3 by Chlamydia contributes to intracellular growth and infectivity","author":"Wang","year":"2017","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.tim.2018.12.012_bib0435","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fcimb.2017.00348","article-title":"Swiss army pathogen: the Salmonella entry toolkit","volume":"7","author":"Hume","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0440","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fcimb.2017.00363","article-title":"Methods to illuminate the role of Salmonella effector proteins during infection: a review","volume":"7","author":"Young","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0445","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fcimb.2017.00335","article-title":"What the SIF is happening \u2013 the role of intracellular Salmonella-induced filaments","volume":"7","author":"Knuff","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0450","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fcimb.2017.00432","article-title":"Salmonella populations inside host cells","volume":"7","author":"Castanheira","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0455","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fcimb.2018.00102","article-title":"Organoid and enteroid modeling of Salmonella infection","volume":"8","author":"Yin","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0460","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fcimb.2017.00069","article-title":"A Salmonella regulator modulates intestinal colonization and use of phosphonoacetic acid","volume":"7","author":"Elfenbein","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0465","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fcimb.2017.00428","article-title":"Evolution of Salmonella-host cell interactions through a dynamic bacterial genome","volume":"7","author":"Ilyas","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0470","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fcimb.2018.00078","article-title":"Autophagy and ubiquitination in Salmonella infection and the related inflammatory responses","volume":"8","author":"Wang","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015466","article-title":"Cationic amino acid transporters and Salmonella Typhimurium ArgT collectively regulate arginine availability towards intracellular Salmonella growth","volume":"5","author":"Das","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.tim.2018.12.012_bib0480","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fcimb.2018.00008","article-title":"Inorganic polyphosphate is essential for Salmonella Typhimurium virulence and survival in Dictyostelium discoideum","volume":"8","author":"Varas","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0485","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1365-2958.2005.04490.x","article-title":"Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5","volume":"55","author":"Wieland","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0490","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1021\/pr500765x","article-title":"The complete and ubiquitinated proteome of the Legionella-containing vacuole within human macrophages","volume":"14","author":"Bruckert","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.tim.2018.12.012_bib0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005408","article-title":"IFNs modify the proteome of Legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid","volume":"12","author":"Naujoks","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2018.12.012_bib0500","first-page":"1034","article-title":"Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages","volume":"16","author":"Hoffmann","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0505","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-26782-x","article-title":"Mammalian solute carrier (SLC)-like transporters of Legionella pneumophila","volume":"8","author":"Best","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tim.2018.12.012_bib0510","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fmicb.2011.00208","article-title":"Comparative and functional genomics of Legionella identified eukaryotic like proteins as key players in host\u2013pathogen interactions","volume":"2","author":"Gomez-Valero","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tim.2018.12.012_bib0515","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1128\/JB.187.22.7716-7726.2005","article-title":"Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer","volume":"187","author":"de Felipe","year":"2005","journal-title":"J. Bacteriol."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X18302889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X18302889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:41:15Z","timestamp":1760812875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X18302889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":103,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0966842X18302889"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2018.12.012","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nutrition and Bipartite Metabolism of Intracellular Pathogens","name":"articletitle","label":"Article Title"},{"value":"Trends in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tim.2018.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}