{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:12:34Z","timestamp":1792131154488,"version":"4.4.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001271-00"],"award-info":[{"award-number":["MOH-001271-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tim.2025.05.007","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T17:05:06Z","timestamp":1749143106000},"page":"1099-1109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetics of dengue epidemics"],"prefix":"10.1016","volume":"33","author":[{"given":"Allyson N.X.","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane J.","family":"Gubler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-1544","authenticated-orcid":false,"given":"Eng Eong","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2025.05.007_bb0005","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tim.2025.05.007_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanepe.2025.101231","article-title":"Transmission of autochthonous Aedes-borne arboviruses and related public health challenges in Europe 2007\u20132023: a systematic review and secondary analysis","volume":"51","author":"Cattaneo","year":"2025","journal-title":"Lancet Regional Health Europe"},{"key":"10.1016\/j.tim.2025.05.007_bb0015","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1126\/science.adj4427","article-title":"Indian Ocean temperature anomalies predict long-term global dengue trends","volume":"384","author":"Chen","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.tim.2025.05.007_bb0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2471\/BLT.07.040170","article-title":"Reconstructing historical changes in the force of infection of dengue fever in Singapore: implications for surveillance and control","volume":"86","author":"Egger","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.tim.2025.05.007_bb0025","article-title":"Current status of the development of dengue vaccines","volume":"X 22","author":"Lee","year":"2025","journal-title":"Vaccine"},{"key":"10.1016\/j.tim.2025.05.007_bb0030","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.4269\/ajtmh.14-0132","article-title":"Research on dengue during World War II revisited","volume":"91","author":"Snow","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4269\/ajtmh.1952.1.30","article-title":"Research on dengue during World War II","volume":"1","author":"Sabin","year":"1952","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002357","article-title":"Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year","volume":"7","author":"Montoya","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0045","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2013.0414","article-title":"Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity","volume":"10","author":"Reich","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.tim.2025.05.007_bb0050","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/infdis\/jit436","article-title":"A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand","volume":"209","author":"Anderson","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0055","first-page":"375","article-title":"Dengue haemorrhagic fever\/dengue shock syndrome: lessons from the Cuban epidemic, 1981","volume":"67","author":"Kouri","year":"1989","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.tim.2025.05.007_bb0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4269\/ajtmh.1990.42.179","article-title":"Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study","volume":"42","author":"Guzm\u00e1n","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0065","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0140-6736(99)04015-5","article-title":"Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever","volume":"354","author":"Watts","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2025.05.007_bb0070","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.meegid.2009.02.003","article-title":"Molecular evolution of dengue viruses: Contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease","volume":"9","author":"Weaver","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006282","article-title":"Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts","volume":"4","author":"Lobo","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.tim.2025.05.007_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002834","article-title":"A new lineage nomenclature to aid genomic surveillance of dengue virus","volume":"22","author":"Hill","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tim.2025.05.007_bb0085","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1038\/s41598-021-92783-y","article-title":"Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2","volume":"11","author":"Yenamandra","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tim.2025.05.007_bb0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1567-1348(03)00004-2","article-title":"The origin, emergence and evolutionary genetics of dengue virus","volume":"3","author":"Holmes","year":"2003","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0095","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/JVI.05985-11","article-title":"High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections","volume":"86","author":"Thai","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/MMBR.05023-11","article-title":"Viral quasispecies evolution","volume":"76","author":"Domingo","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.tim.2025.05.007_bb0105","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3390\/v11100929","article-title":"Flavivirus RNA-dependent RNA polymerase interacts with genome UTRs and viral proteins to facilitate flavivirus RNA replication","volume":"11","author":"Duan","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.tim.2025.05.007_bb0110","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1172\/JCI38050","article-title":"RNA virus genomics: a world of possibilities","volume":"119","author":"Holmes","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tim.2025.05.007_bb0115","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature04388","article-title":"Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population","volume":"439","author":"Vignuzzi","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.tim.2025.05.007_bb0120","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.chom.2016.03.002","article-title":"Genetic drift during systemic arbovirus infection of mosquito vectors leads to decreased relative fitness during host switching","volume":"19","author":"Grubaugh","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tim.2025.05.007_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004044","article-title":"Analysis of dengue virus genetic diversity during human and mosquito infection reveals genetic constraints","volume":"9","author":"Sessions","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0130","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jmv.25646","article-title":"Dengue proteins with their role in pathogenesis, and strategies for developing an effective anti-dengue treatment: a review","volume":"92","author":"Nasar","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0135","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3390\/v13101967","article-title":"Dengue virus infection: a tale of viral exploitations and host responses","volume":"13","author":"Nanaware","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.tim.2025.05.007_bb0140","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03205-23","article-title":"A review of virus host factor discovery using CRISPR screening","volume":"15","author":"See","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.tim.2025.05.007_bb0145","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.220227","article-title":"A fast-growing dengue virus mutant reveals a dual role of STING in response to infection","volume":"12","author":"Ng","year":"2022","journal-title":"Open Biol."},{"key":"10.1016\/j.tim.2025.05.007_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107617","article-title":"A non-structural 1 protein G53D substitution attenuates a clinically tested live dengue vaccine","volume":"31","author":"Choy","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.tim.2025.05.007_bb0155","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"Gubler","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.tim.2025.05.007_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2024.119682","article-title":"Mutation of conserved histidine residues of dengue virus envelope protein impairs viral like particle maturation and secretion","volume":"1871","author":"Rani","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.tim.2025.05.007_bb0165","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00854-23","article-title":"Dengue virus serotypic replacement of NS3 protease or helicase domain causes chimeric viral attenuation but can be recovered by a compensated mutation at helicase domain or NS2B, respectively","volume":"97","author":"Teramoto","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0170","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3390\/vaccines11050959","article-title":"NS1 protein N-linked glycosylation site affects the virulence and pathogenesis of dengue virus","volume":"11","author":"Fang","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.tim.2025.05.007_bb0175","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/07391102.2021.2008497","article-title":"Effect of mutation of NS2B cofactor residues on Dengue 2 NS2B-NS3 protease complex \u2013 an insight to viral replication","volume":"41","author":"Mohanty","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.tim.2025.05.007_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/2635383","article-title":"Differential infectivity of human neural cell lines by a dengue virus serotype-3 genotype-III with a distinct nonstructural protein 2A (NS2A) amino acid substitution isolated from the cerebrospinal fluid of a dengue encephalitis patient","volume":"2023","author":"Phu Ly","year":"2023","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"10.1016\/j.tim.2025.05.007_bb0185","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255671","article-title":"Neighboring mutation-mediated enhancement of dengue virus infectivity and spread","volume":"23","author":"Chen","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tim.2025.05.007_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.894200","article-title":"Impact of intrahost NS5 nucleotide variations on dengue virus replication","volume":"13","author":"Cheng","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tim.2025.05.007_bb0195","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.jiph.2023.10.005","article-title":"Novel mutations in structural proteins of dengue virus genomes","volume":"16","author":"Mushtaq","year":"2023","journal-title":"J. Infection Publ. Health"},{"key":"10.1016\/j.tim.2025.05.007_bb0200","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3390\/v14071569","article-title":"Genetic adaptation by dengue virus serotype 2 to enhance infection of Aedes aegypti mosquito midguts","volume":"14","author":"Erb","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.tim.2025.05.007_bb0205","doi-asserted-by":"crossref","first-page":"18404","DOI":"10.1038\/s41598-020-75042-4","article-title":"Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection","volume":"10","author":"Bellone","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tim.2025.05.007_bb0210","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S1201-9712(99)90033-4","article-title":"Fatal dengue hemorrhagic fever in Cuba, 1997","volume":"3","author":"Guzm\u00e1n","year":"1999","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0215","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/aje\/152.9.793","article-title":"Epidemiologic studies on dengue in Santiago de Cuba, 1997","volume":"152","author":"Guzman","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tim.2025.05.007_bb0220","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/S0140-6736(00)02303-5","article-title":"Do escape mutants explain rapid increases in dengue casefatality rates within epidemics?","volume":"355","author":"Guzm\u00e1n","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2025.05.007_bb0225","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00705-004-0445-1","article-title":"Dengue virus type 2 in Cuba, 1997: conservation of E gene sequence in isolates obtained at different times during the epidemic","volume":"150","author":"Rodriguez-Roche","year":"2005","journal-title":"Arch. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0230","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.virol.2005.01.037","article-title":"Virus evolution during a severe dengue epidemic in Cuba, 1997","volume":"334","author":"Rodriguez-Roche","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.tim.2025.05.007_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat7726","article-title":"A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice","volume":"11","author":"Chan","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tim.2025.05.007_bb0240","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153600","article-title":"Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins","volume":"23","author":"Benfrid","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tim.2025.05.007_bb0245","series-title":"Dengue and Zika: Control and Antiviral Treatment Strategies","first-page":"89","article-title":"Plugging the leak in dengue shock","volume":"1062","author":"Watterson","year":"2018"},{"key":"10.1016\/j.tim.2025.05.007_bb0250","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.celrep.2019.01.036","article-title":"Flavivirus NS1 triggers tissue-specific vascular endothelial dysfunction reflecting disease tropism","volume":"26","author":"Puerta-Guardo","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.tim.2025.05.007_bb0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4269\/ajtmh.1984.33.158","article-title":"Mosquito cell cultures and specific monoclonal antibodies in surveillance for dengue viruses","volume":"33","author":"Gubler","year":"1984","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0260","first-page":"397","article-title":"Surveillance for dengue and dengue hemorrhagic fever","volume":"23","author":"Gubler","year":"1989","journal-title":"Bull. Pan Am. Health Organ."},{"key":"10.1016\/j.tim.2025.05.007_bb0265","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1099\/vir.0.81309-0","article-title":"Molecular evolution of dengue 2 virus in Puerto Rico: positive selection in the viral envelope accompanies clade reintroduction","volume":"87","author":"Bennett","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0270","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/molbev\/msg182","article-title":"Selection-driven evolution of emergent dengue virus","volume":"20","author":"Bennett","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0275","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.aab3369","article-title":"Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness","volume":"350","author":"Manokaran","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tim.2025.05.007_bb0280","doi-asserted-by":"crossref","first-page":"11038","DOI":"10.1073\/pnas.1919287117","article-title":"Positive epistasis between viral polymerase and the 3\u2032 untranslated region of its genome reveals the epidemiologic fitness of dengue virus","volume":"117","author":"Syenina","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.05.007_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006535","article-title":"Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission","volume":"13","author":"Pompon","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.05.007_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003084","article-title":"Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity","volume":"3","author":"OhAinle","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tim.2025.05.007_bb0295","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4269\/ajtmh.1974.23.495","article-title":"Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island","volume":"23","author":"Barnes","year":"1974","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0300","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4269\/ajtmh.1977.26.337","article-title":"The Emperor\u2019s new clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever *","volume":"26","author":"Rosen","year":"1977","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0305","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4269\/ajtmh.1978.27.581","article-title":"Epidemiological, clinical and virological observations on dengue in the Kingdom of Tonga","volume":"27","author":"Gubler","year":"1978","journal-title":"Am. J. Trop. Med. Hyg. J Trop Med Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0310","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S0022172400024116","article-title":"Mosquito-borne infections in Fiji V. The 1971\u201373 dengue epidemic","volume":"73","author":"Maguire","year":"1974","journal-title":"J. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0315","first-page":"67","article-title":"A recent outbreak of dengue in French Polynesia","volume":"20","author":"Rosen","year":"1967","journal-title":"Jpn J. Med. Sci. Biol."},{"key":"10.1016\/j.tim.2025.05.007_bb0320","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/jmedent\/13.4-5.469","article-title":"Quantitative aspects of replication of dengue viruses in Aedes albopictus (Diptera: Culicidae) after oral and parenteral infection1","volume":"13","author":"Gubler","year":"1977","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.tim.2025.05.007_bb0325","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.virol.2010.05.033","article-title":"Natural attenuation of dengue virus type-2 after a series of island outbreaks: A retrospective phylogenetic study of events in the South Pacific three decades ago","volume":"405","author":"Steel","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.tim.2025.05.007_bb0330","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adk4769","article-title":"A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes","volume":"16","author":"Choi","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tim.2025.05.007_bb0335","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1128\/JVI.06458-11","article-title":"Dengue-1 virus clade replacement in Thailand associated with enhanced mosquito transmission","volume":"86","author":"Lambrechts","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-012-0756-3","article-title":"Complete genome sequencing and evolutionary analysis of dengue virus serotype 1 isolates from an outbreak in Kerala, South India","volume":"45","author":"Anoop","year":"2012","journal-title":"Virus Genes"},{"key":"10.1016\/j.tim.2025.05.007_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006525","article-title":"Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil","volume":"12","author":"Pinheiro","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0350","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1080\/22221751.2021.1944789","article-title":"Potential role of vector-mediated natural selection in dengue virus genotype\/lineage replacements in two epidemiologically contrasted settings","volume":"10","author":"O\u2019Connor","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.tim.2025.05.007_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212947","article-title":"Tracking dengue virus type 1 genetic diversity during lineage replacement in an hyperendemic area in Colombia","volume":"14","author":"Salvo","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.tim.2025.05.007_bb0360","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/ijmm.IJMM_17_30","article-title":"Molecular characterisation and phylogenetic analysis of dengue outbreak in Pasighat, Arunachal Pradesh, Northeast India","volume":"36","author":"Borkakoty","year":"2018","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.tim.2025.05.007_bb0365","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fcimb.2018.00148","article-title":"Complete genome characterization of the 2017 dengue outbreak in Xishuangbanna, a border city of China, Burma and Laos","volume":"8","author":"Wen","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.tim.2025.05.007_bb0370","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/microorganisms11030666","article-title":"Association of dengue virus serotypes 1&2 with severe dengue having deletions in their 3\u2032untranslated regions (3\u2032UTRs)","volume":"11","author":"Maisnam","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.tim.2025.05.007_bb0375","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4269\/ajtmh.2008.79.495","article-title":"Evolution of dengue virus type 2 during two consecutive outbreaks with an increase in severity in Southern Taiwan in 2001\u20132002","volume":"79","author":"Chen","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110899","article-title":"Emergence and increased epidemic potential of dengue variants with the NS5V357E mutation after consecutive years of transmission","volume":"27","author":"Ko","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.tim.2025.05.007_bb0385","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2180-8-117","article-title":"Specific genetic markers for detecting subtypes of dengue virus serotype-2 in isolates from the states of Oaxaca and Veracruz, Mexico","volume":"8","author":"Gardella-Garcia","year":"2008","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.tim.2025.05.007_bb0390","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/tmi.12898","article-title":"Genetic signatures coupled with lineage shift characterise endemic evolution of Dengue virus serotype 2 during 2015 outbreak in Delhi, India","volume":"22","author":"Choudhary","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.tim.2025.05.007_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198358","article-title":"Complete genome characterization of the 2018 dengue outbreak in Hunan, an inland province in central South China","volume":"297","author":"Guan","year":"2021","journal-title":"Virus Res."},{"key":"10.1016\/j.tim.2025.05.007_bb0400","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12879-021-05823-3","article-title":"Molecular characterization of the viral structural protein genes in the first outbreak of dengue virus type 2 in Hunan Province, inland China in 2018","volume":"21","author":"Guan","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2023.105487","article-title":"Dengue virus serotype 2 genotype III evolution during the 2019 outbreak in Mato Grosso, Midwestern Brazil","volume":"113","author":"Dos Santos","year":"2023","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0410","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/20477724.2023.2246712","article-title":"Continued dominance of dengue virus serotype 2 during the recent Central India outbreaks (2019-2021) with evidence of genetic divergence","volume":"118","author":"Agarwal","year":"2024","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.tim.2025.05.007_bb0415","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.4269\/ajtmh.1981.30.1094","article-title":"Epidemic dengue 3 in Central Java, associated with low viremia in man","volume":"30","author":"Gubler","year":"1981","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0420","first-page":"931","article-title":"Virological surveillance for dengue haemorrhagic fever in Indonesia using the mosquito inoculation technique","volume":"57","author":"Gubler","year":"1979","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.tim.2025.05.007_bb0425","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3201\/eid0907.030038","article-title":"Emergence and global spread of a dengue serotype 3, subtype III virus","volume":"9","author":"Messer","year":"2003","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.tim.2025.05.007_bb0430","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1743-422X-7-329","article-title":"Evolution of dengue virus type 3 genotype III in Venezuela: diversification, rates and population dynamics","volume":"7","author":"Ram\u00edrez","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.tim.2025.05.007_bb0435","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1128\/JVI.02647-15","article-title":"Increasing clinical severity during a dengue virus type 3 Cuban epidemic: deep sequencing of evolving viral populations","volume":"90","author":"Rodriguez-Roche","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2025.05.007_bb0440","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.meegid.2011.09.010","article-title":"A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation","volume":"11","author":"Schmidt","year":"2011","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/a8dfd4ee-f4b7-443e-bf78-ebb0dab4e55b","article-title":"An explosive epidemic of DENV-3 in Cairns, Australia","volume":"8","author":"Ritchie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tim.2025.05.007_bb0450","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1743-422X-10-37","article-title":"Lineage shift in Indian strains of Dengue virus serotype-3 (Genotype III), evidenced by detection of lineage IV strains in clinical cases from Kerala","volume":"10","author":"Manakkadan","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.tim.2025.05.007_bb0455","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.meegid.2018.10.016","article-title":"Emergence of dengue virus type 1 and type 3 as dominant serotypes during 2017 in Pune and Nashik regions of Maharashtra, Western India","volume":"66","author":"Patil","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0460","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3390\/v13061152","article-title":"Emergence of a novel dengue virus 3 (DENV-3) genotype-I coincident with increased DENV-3 cases in Yangon, Myanmar between 2017 and 2019","volume":"13","author":"Soe","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.tim.2025.05.007_bb0465","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.virusres.2015.11.009","article-title":"Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence","volume":"213","author":"Martin","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.tim.2025.05.007_bb0470","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11262-022-01942-4","article-title":"Genetic characterization of dengue virus 4 complete genomes from East Java, Indonesia","volume":"59","author":"Wardhani","year":"2023","journal-title":"Virus Genes"},{"key":"10.1016\/j.tim.2025.05.007_bb0475","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61921","article-title":"Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells","volume":"10","author":"Dolan","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.tim.2025.05.007_bb0480","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1073\/pnas.93.2.548","article-title":"Population dynamics of flaviviruses revealed by molecular phylogenies","volume":"93","author":"Zanotto","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.05.007_bb0485","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006111","article-title":"Genetic drift, purifying selection and vector genotype shape dengue virus intra-host genetic diversity in mosquitoes","volume":"12","author":"Lequime","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tim.2025.05.007_bb0490","doi-asserted-by":"crossref","first-page":"14688","DOI":"10.1073\/pnas.1508114112","article-title":"Asymptomatic humans transmit dengue virus to mosquitoes","volume":"112","author":"Duong","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.05.007_bb0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007187","article-title":"Epidemiological significance of dengue virus genetic variation in mosquito infection dynamics","volume":"14","author":"Fontaine","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.05.007_bb0500","doi-asserted-by":"crossref","first-page":"886","DOI":"10.4269\/ajtmh.2006.75.886","article-title":"Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus","volume":"75","author":"Anderson","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0505","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4269\/ajtmh.2003.68.539","article-title":"Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti","volume":"68","author":"Armstrong","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tim.2025.05.007_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.ympev.2019.106607","article-title":"Influence of directional positive Darwinian selection-driven evolution on arboviruses Dengue and Zika virulence and pathogenesis","volume":"140","author":"Dur\u00e3es-Carvalho","year":"2019","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.tim.2025.05.007_bb0515","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01957-18","article-title":"Development of a standardized Sanger-based method for partial sequencing and genotyping of dengue viruses","volume":"57","author":"Santiago","year":"2019","journal-title":"J. Clin. Microbiol."}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X25001544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X25001544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T22:28:43Z","timestamp":1759876123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X25001544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":103,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0966842X25001544"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2025.05.007","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetics of dengue epidemics","name":"articletitle","label":"Article Title"},{"value":"Trends in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tim.2025.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}