{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:16:54Z","timestamp":1782771414786,"version":"3.54.5"},"reference-count":92,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01KX2324"],"award-info":[{"award-number":["01KX2324"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["259130777"],"award-info":[{"award-number":["259130777"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Microbiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tim.2025.12.001","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:28:43Z","timestamp":1766492923000},"page":"677-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["More than just membranes: membrane contact sites as crossroads for infections"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0582-5135","authenticated-orcid":false,"given":"Britta","family":"Bonde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-227X","authenticated-orcid":false,"given":"Lina","family":"Herhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tim.2025.12.001_bb0005","doi-asserted-by":"crossref","first-page":"e2004","DOI":"10.1073\/pnas.1503191112","article-title":"Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum\u2013plasma membrane contact sites","volume":"112","author":"Fern\u00e1ndez-Busnadiego","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0010","doi-asserted-by":"crossref","first-page":"19358","DOI":"10.1073\/pnas.0911280106","article-title":"STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum","volume":"106","author":"Orci","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0015","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.devcel.2016.10.022","article-title":"A tether is a tether is a tether: tethering at membrane contact sites","volume":"39","author":"Eisenberg-Bord","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tim.2025.12.001_bb0020","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07485","article-title":"The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix","volume":"4","author":"Barneda","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.tim.2025.12.001_bb0025","doi-asserted-by":"crossref","first-page":"19330","DOI":"10.1074\/jbc.RA118.004892","article-title":"Polybasic RKKR motif in the linker region of lipid droplet (LD)\u2013associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids","volume":"293","author":"Wang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tim.2025.12.001_bb0030","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1600-0854.2012.01356.x","article-title":"Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins","volume":"13","author":"Bonekamp","year":"2012","journal-title":"Traffic"},{"key":"10.1016\/j.tim.2025.12.001_bb0035","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1242\/jcs.113.20.3663","article-title":"Real time imaging reveals a peroxisomal reticulum in living cells","volume":"113","author":"Schrader","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tim.2025.12.001_bb0040","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.bbalip.2017.06.005","article-title":"A different kind of love \u2013 lipid droplet contact sites","volume":"1862","author":"Schuldiner","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.tim.2025.12.001_bb0045","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00418-018-1722-5","article-title":"The peroxisome: an update on mysteries 2.0","volume":"150","author":"Islinger","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0050","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/1873-3468.14893","article-title":"Emerging functions of the mitochondria-ER-lipid droplet three-way junction in coordinating lipid transfer, metabolism, and storage in cells","volume":"598","author":"Monteiro-Cardoso","year":"2024","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tim.2025.12.001_bb0055","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1083\/jcb.201702022","article-title":"Mitochondria-driven assembly of a cortical anchor for mitochondria and dynein","volume":"216","author":"Kraft","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0060","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1126\/science.aax6089","article-title":"Golgi-derived PI (4) P-containing vesicles drive late steps of mitochondrial division","volume":"367","author":"Nagashima","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tim.2025.12.001_bb0065","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/s41556-024-01457-0","article-title":"Functional multi-organelle units control inflammatory lipid metabolism of macrophages","volume":"26","author":"Zimmermann","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0070","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1038\/s41467-020-17451-7","article-title":"PDZD8 interacts with protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria","volume":"11","author":"Elbaz-Alon","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2023.11.040","article-title":"Making the connection: how membrane contact sites have changed our view of organelle biology","volume":"187","author":"Voeltz","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.tim.2025.12.001_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.988014","article-title":"ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport","volume":"10","author":"Sassano","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104758","article-title":"ER membranes associated with mitochondria: possible therapeutic targets in heart-associated diseases","volume":"156","author":"Silva-Palacios","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tim.2025.12.001_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.622215","article-title":"Relevance of membrane contact sites in cancer progression","volume":"8","author":"Gil-Hern\u00e1ndez","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0095","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41467-021-22113-3","article-title":"Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson\u2019s disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER-mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tim.2025.12.001_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqad018","article-title":"Pathogen vacuole membrane contact sites \u2013 close encounters of the fifth kind","volume":"4","author":"Vormittag","year":"2023","journal-title":"microLife"},{"key":"10.1016\/j.tim.2025.12.001_bb0110","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1473-3099(24)00158-0","article-title":"Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"24","author":"Naghavi","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tim.2025.12.001_bb0115","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.001187","article-title":"The Legionella pneumophila Dot\/Icm type IV secretion system and its effectors","volume":"168","author":"Lockwood","year":"2022","journal-title":"Microbiology"},{"key":"10.1016\/j.tim.2025.12.001_bb0120","doi-asserted-by":"crossref","first-page":"ar3","DOI":"10.1091\/mbc.E24-06-0283","article-title":"Salmonella-induced cholesterol accumulation in infected macrophages suppresses autophagy via mTORC1 activation","volume":"36","author":"Torsilieri","year":"2025","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tim.2025.12.001_bb0125","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1086\/650733","article-title":"The global burden of nontyphoidal Salmonella gastroenteritis","volume":"50","author":"Majowicz","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tim.2025.12.001_bb0130","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s44319-024-00328-x","article-title":"Salmonella typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol","volume":"26","author":"Desh","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tim.2025.12.001_bb0135","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.celrep.2019.04.021","article-title":"Salmonella translocated effectors recruit OSBP1 to the phagosome to promote vacuolar membrane integrity","volume":"27","author":"Kolodziejek","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.tim.2025.12.001_bb0140","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.chom.2021.06.004","article-title":"Global mapping of Salmonella enterica-host protein-protein interactions during infection","volume":"29","author":"Walch","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tim.2025.12.001_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.649875","article-title":"Membrane-interacting antifungal peptides","volume":"9","author":"Struyfs","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0150","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/s41564-023-01459-y","article-title":"Parkinson\u2019s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella","volume":"8","author":"Lian","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.tim.2025.12.001_bb0155","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1126\/science.aaz1333","article-title":"Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella","volume":"369","author":"Chen","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tim.2025.12.001_bb0160","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1073\/pnas.90.22.10544","article-title":"Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells","volume":"90","author":"Garcia-Del Portillo","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008220","article-title":"A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-\/lysosomal vesicle fusion machinery by intracellular Salmonella","volume":"16","author":"Kehl","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0170","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr8005","article-title":"Bacterial pathogens hijack host cell peroxisomes for replication vacuole expansion and integrity","volume":"11","author":"Hossain","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tim.2025.12.001_bb0175","article-title":"Salmonella typhimurium manipulates macrophage cholesterol homeostasis through the SseJ-mediated suppression of the host cholesterol transport protein ABCA1","volume":"23","author":"Greene","year":"2021","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tim.2025.12.001_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006227","article-title":"Salmonella typhimurium disrupts Sirt1\/AMPK checkpoint control of mTOR to impair autophagy","volume":"13","author":"Ganesan","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0185","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fmicb.2020.00721","article-title":"Salmonella Interacts with autophagy to offense or defense","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tim.2025.12.001_bb0190","article-title":"In situ snapshots along a mammalian selective autophagy pathway","volume":"120","author":"Li","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0195","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00114-25","article-title":"Endoplasmic reticulum facilitates the coordinated division of Salmonella-containing vacuoles","volume":"16","author":"Chopra","year":"2025","journal-title":"MBio"},{"key":"10.1016\/j.tim.2025.12.001_bb0200","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s42255-022-00605-w","article-title":"TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages","volume":"4","author":"Schuster","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tim.2025.12.001_bb0205","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/mmi.15172","article-title":"Molecular regulation of virulence in Legionella pneumophila","volume":"121","author":"Graham","year":"2024","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.tim.2025.12.001_bb0210","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00839-13","article-title":"Live-cell imaging of phosphoinositide dynamics and membrane architecture during Legionella infection","volume":"5","author":"Weber","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.tim.2025.12.001_bb0215","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1128\/iai.63.9.3609-3620.1995","article-title":"Association of Legionella pneumophila with the macrophage endoplasmic reticulum","volume":"63","author":"Swanson","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tim.2025.12.001_bb0220","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202256007","article-title":"Legionella - and host-driven lipid flux at LCV-ER membrane contact sites promotes vacuole remodeling","volume":"24","author":"Vormittag","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tim.2025.12.001_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004222","article-title":"The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins","volume":"10","author":"Hubber","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020046","article-title":"Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole","volume":"2","author":"Weber","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/tra.12554","article-title":"Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport","volume":"19","author":"Del Bel","year":"2018","journal-title":"Traffic"},{"key":"10.1016\/j.tim.2025.12.001_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009437","article-title":"Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionella-containing vacuole with the ER","volume":"17","author":"Kawabata","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0245","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.158.4.1319","article-title":"Formation of a novel phagosome by the Legionnaires\u2019 disease bacterium (Legionella pneumophila) in human monocytes","volume":"158","author":"Horwitz","year":"1983","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tim.2025.12.001_bb0250","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chom.2017.07.020","article-title":"Legionella pneumophila modulates mitochondrial dynamics to trigger metabolic repurposing of infected macrophages","volume":"22","author":"Escoll","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tim.2025.12.001_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15406","article-title":"Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17","volume":"8","author":"Arasaki","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0260","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.devcel.2014.12.011","article-title":"A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division","volume":"32","author":"Arasaki","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tim.2025.12.001_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003261","article-title":"Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins","volume":"23","author":"Yek","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013026","article-title":"Inter-kingdom signaling by the Legionella autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBP","volume":"21","author":"Solger","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0275","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/s12879-020-05307-w","article-title":"Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis","volume":"20","author":"Huai","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.tim.2025.12.001_bb0280","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1073\/pnas.92.11.4877","article-title":"Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion","volume":"92","author":"Hackstadt","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0285","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1038\/s41467-024-53443-7","article-title":"Specialized contact sites regulate the fusion of chlamydial inclusion membranes","volume":"15","author":"Linton","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002092","article-title":"The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites","volume":"7","author":"Derr\u00e9","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0295","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature02188","article-title":"Molecular machinery for non-vesicular trafficking of ceramide","volume":"426","author":"Hanada","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tim.2025.12.001_bb0300","doi-asserted-by":"crossref","first-page":"12039","DOI":"10.1073\/pnas.1709060114","article-title":"IncV, a FFAT motif-containing Chlamydia protein, tethers the endoplasmic reticulum to the pathogen-containing vacuole","volume":"114","author":"Stanhope","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0305","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74535","article-title":"Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites","volume":"11","author":"Ende","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.tim.2025.12.001_bb0310","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1038\/s44319-024-00266-8","article-title":"A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets","volume":"25","author":"Angara","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tim.2025.12.001_bb0315","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00104-23","article-title":"Host lipid transport protein ORP1 is necessary for Coxiella burnetii growth and vacuole expansion in macrophages","volume":"8","author":"Schuler","year":"2023","journal-title":"mSphere"},{"key":"10.1016\/j.tim.2025.12.001_bb0320","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/BST20240899","article-title":"Mechanisms of lipid homeostasis in the Coxiella containing vacuole","volume":"53","author":"Angara","year":"2025","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tim.2025.12.001_bb0325","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.0406873102","article-title":"Brucella coopts the small GTPase Sar1 for intracellular replication","volume":"102","author":"Celli","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003785","article-title":"Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages","volume":"9","author":"Smith","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0335","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1093\/jimmun\/vkaf198","article-title":"Brucella abortus induces dynamin-related protein 1 (DRP1)\u2013dependent mitochondrial fission in infected macrophages via stress sensor IRE1\u03b1 altering metabolic function","volume":"214","author":"Guimar\u00e3es","year":"2025","journal-title":"J. Immunol."},{"key":"10.1016\/j.tim.2025.12.001_bb0340","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.bi.52.070183.001255","article-title":"Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis","volume":"52","author":"Brown","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.tim.2025.12.001_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"Peyron","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005687","article-title":"The formation of lipid droplets favors intracellular Mycobacterium leprae survival in SW-10, non-myelinating Schwann cells","volume":"11","author":"Jin","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.tim.2025.12.001_bb0355","article-title":"Rab7 controls lipid droplet-phagosome association during mycobacterial infection","volume":"1865","author":"Roque","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.tim.2025.12.001_bb0360","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01196-17","article-title":"Hepatitis C virus replication depends on endosomal cholesterol homeostasis","volume":"92","author":"Stoeck","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.tim.2025.12.001_bb0365","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1038\/s41467-022-32488-6","article-title":"Restructured membrane contacts rewire organelles for human cytomegalovirus infection","volume":"13","author":"Cook","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0370","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41467-020-14967-w","article-title":"Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry","volume":"11","author":"Bagchi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005220","article-title":"Calcium regulation of hemorrhagic fever virus budding: mechanistic implications for host-oriented therapeutic intervention","volume":"11","author":"Han","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tim.2025.12.001_bb0380","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00608-13","article-title":"Annexin A6-balanced late endosomal cholesterol controls influenza A replication and propagation","volume":"4","author":"Musiol","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.tim.2025.12.001_bb0385","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/cns.14011","article-title":"Disruption of mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging","volume":"29","author":"Arjona","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tim.2025.12.001_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111599","article-title":"Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis","volume":"28","author":"Freppel","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.tim.2025.12.001_bb0395","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/1873-3468.14166","article-title":"Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR","volume":"595","author":"Furuita","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tim.2025.12.001_bb0400","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-04835-6","article-title":"The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle","volume":"606","author":"Ricciardi","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.tim.2025.12.001_bb0405","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1242\/jcs.110.17.2117","article-title":"Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction","volume":"110","author":"Sinai","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tim.2025.12.001_bb0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001845","article-title":"Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response","volume":"12","author":"Pernas","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tim.2025.12.001_bb0415","doi-asserted-by":"crossref","DOI":"10.1126\/science.abi4343","article-title":"Mitochondria shed their outer membrane in response to infection-induced stress","volume":"375","author":"Li","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.tim.2025.12.001_bb0420","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00260-21","article-title":"Proximity-labeling reveals novel host and parasite proteins at the Toxoplasma parasitophorous vacuole membrane","volume":"12","author":"Cygan","year":"2021","journal-title":"MBio"},{"key":"10.1016\/j.tim.2025.12.001_bb0425","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00670-22","article-title":"Host MOSPD2 enrichment at the parasitophorous vacuole membrane varies between Toxoplasma strains and involves complex interactions","volume":"8","author":"Ferrel","year":"2023","journal-title":"mSphere"},{"key":"10.1016\/j.tim.2025.12.001_bb0430","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41564-019-0504-8","article-title":"The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration","volume":"4","author":"Drewry","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.tim.2025.12.001_bb0435","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.4049\/jimmunol.1601662","article-title":"Identification of motile sperm domain\u2013containing protein 2 as regulator of human monocyte migration","volume":"198","author":"Mendel","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.tim.2025.12.001_bb0440","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1038\/s41467-023-43215-0","article-title":"3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen Encephalitozoon intestinalis","volume":"14","author":"Antao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tim.2025.12.001_bb0445","article-title":"Ergosterol distribution controls surface structure formation and fungal pathogenicity","volume":"14","author":"Choy","year":"2023","journal-title":"MBio"},{"key":"10.1016\/j.tim.2025.12.001_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102372","article-title":"Interorganellar communication and membrane contact sites in protozoan parasites","volume":"83","author":"Santos","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.tim.2025.12.001_bb0455","doi-asserted-by":"crossref","first-page":"14590","DOI":"10.1073\/pnas.1110133108","article-title":"Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus","volume":"108","author":"Horner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2025.12.001_bb0460","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41597-024-03104-7","article-title":"MCSdb, a database of proteins residing in membrane contact sites","volume":"11","author":"Pan","year":"2024","journal-title":"Sci. Data"}],"container-title":["Trends in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X25003646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966842X25003646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:24:41Z","timestamp":1780935881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966842X25003646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":92,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0966842X25003646"],"URL":"https:\/\/doi.org\/10.1016\/j.tim.2025.12.001","relation":{},"ISSN":["0966-842X"],"issn-type":[{"value":"0966-842X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"More than just membranes: membrane contact sites as crossroads for infections","name":"articletitle","label":"Article Title"},{"value":"Trends in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tim.2025.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}