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Res."},{"key":"10.1016\/j.tim.2026.04.010_bb0390","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/nar\/gkn1015","article-title":"The A-rich RNA sequences of HIV-1 are important for the synthesis of viral cDNA","volume":"37","author":"Keating","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2026.04.010_bb0395","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01337-19","article-title":"CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms","volume":"94","author":"Ficarelli","year":"2020","journal-title":"J. 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A."},{"key":"10.1016\/j.tim.2026.04.010_bb0445","article-title":"Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2026.04.010_bb0450","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/vaccines11020255","article-title":"A live attenuated COVID-19 candidate vaccine for children: protection against SARS-CoV-2 challenge in hamsters","volume":"11","author":"Mehla","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.tim.2026.04.010_bb0455","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1073\/pnas.1502864112","article-title":"Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference","volume":"112","author":"Shen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2026.04.010_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109493","article-title":"Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding","volume":"36","author":"Trimpert","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.tim.2026.04.010_bb0465","article-title":"Genome-wide codon reprogramming enables a multifactorially attenuated influenza vaccine with broad cross-protection","volume":"13","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tim.2026.04.010_bb0470","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.tibtech.2004.04.006","article-title":"Codon bias and heterologous protein expression","volume":"22","author":"Gustafsson","year":"2004","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.tim.2026.04.010_bb0475","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(16)32621-6","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ca Suffit!)","volume":"389","author":"Henao-Restrepo","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.tim.2026.04.010_bb0480","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.4049\/jimmunol.161.10.5594","article-title":"Optimization of codon usage of plasmid DNA vaccine is required for the effective MHC class I-restricted T cell responses against an intracellular bacterium","volume":"161","author":"Uchijima","year":"1998","journal-title":"J. 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Commun."},{"key":"10.1016\/j.tim.2026.04.010_bb0515","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2014.08.011","article-title":"A dual program for translation regulation in cellular proliferation and differentiation","volume":"158","author":"Gingold","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tim.2026.04.010_bb0520","doi-asserted-by":"crossref","first-page":"11572","DOI":"10.1073\/pnas.1104104108","article-title":"Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation","volume":"108","author":"Apcher","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2026.04.010_bb0525","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.it.2006.06.008","article-title":"The DRiP hypothesis decennial: support, controversy, refinement and extension","volume":"27","author":"Yewdell","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tim.2026.04.010_bb0530","doi-asserted-by":"crossref","first-page":"E6117","DOI":"10.1073\/pnas.1606724113","article-title":"Codon usage is an important determinant of gene expression levels largely through its effects on transcription","volume":"113","author":"Zhou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tim.2026.04.010_bb0535","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/nar\/gkaa1253","article-title":"Effects of codon usage on gene expression are promoter context dependent","volume":"49","author":"Yang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2026.04.010_bb0540","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1101\/gad.351800.124","article-title":"Decoding biology with massively parallel reporter assays and machine learning","volume":"38","author":"La Fleur","year":"2024","journal-title":"Genes Dev."},{"key":"10.1016\/j.tim.2026.04.010_bb0545","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2026.04.010_bb0550","doi-asserted-by":"crossref","first-page":"W126","DOI":"10.1093\/nar\/gkm219","article-title":"OPTIMIZER: a web server for optimizing the codon usage of DNA sequences","volume":"35","author":"Puigb\u00f2","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tim.2026.04.010_bb0555","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13059-023-02868-2","article-title":"Using protein-per-mRNA differences among human tissues in codon optimization","volume":"24","author":"Hernandez-alt-name","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.tim.2026.04.010_bb0560","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41586-023-06127-z","article-title":"Algorithm for optimized mRNA design improves stability and immunogenicity","volume":"621","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.tim.2026.04.010_bb0565","article-title":"Predicting the translation efficiency of messenger RNA in mammalian cells","author":"Zheng","year":"2025","journal-title":"Nat. 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