{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:43:20Z","timestamp":1782301400783,"version":"3.54.5"},"reference-count":15,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SCHI 1330\/2-1"],"award-info":[{"award-number":["SCHI 1330\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PCEFP3_194609"],"award-info":[{"award-number":["PCEFP3_194609"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["FG-1708-28871"],"award-info":[{"award-number":["FG-1708-28871"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["FG- 1902-33617"],"award-info":[{"award-number":["FG- 1902-33617"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003493","name":"Hertie Foundation","doi-asserted-by":"publisher","award":["P1180016"],"award-info":[{"award-number":["P1180016"]}],"id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016071","name":"Margot und Erich Goldschmidt und Peter Ren\u00e9 Jacobson-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.tins.2021.10.006","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T18:57:10Z","timestamp":1634583430000},"page":"933-935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["SARS-CoV-2-specific neuropathology: fact or fiction?"],"prefix":"10.1016","volume":"44","author":[{"given":"Anne-Katrin","family":"Pr\u00f6bstel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-4116","authenticated-orcid":false,"given":"Lucas","family":"Schirmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2021.10.006_bb0005","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S2215-0366(21)00084-5","article-title":"6-Month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records","volume":"8","author":"Taquet","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.tins.2021.10.006_bb0010","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00401-020-02213-y","article-title":"Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology","volume":"140","author":"Deigendesch","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2021.10.006_bb0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41593-020-00758-5","article-title":"Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19","volume":"24","author":"Meinhardt","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2021.10.006_bb0020","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1474-4422(20)30308-2","article-title":"Neuropathology of patients with COVID-19 in Germany: a post-mortem case series","volume":"19","author":"Matschke","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tins.2021.10.006_bb0025","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.abd2985","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity","volume":"370","author":"Cantuti-Castelvetri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.10.006_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf8396","article-title":"COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters","volume":"13","author":"de Melo","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tins.2021.10.006_bb0035","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMc2019373","article-title":"Neuropathological features of Covid-19","volume":"383","author":"Solomon","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tins.2021.10.006_bb0040","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1093\/brain\/awab148","article-title":"COVID-19 neuropathology at Columbia University Irving Medical Center\/New York Presbyterian Hospital","volume":"144","author":"Thakur","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.tins.2021.10.006_bb0045","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.immuni.2021.06.002","article-title":"Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia\u2013T cell interactions","volume":"54","author":"Schwabenland","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.tins.2021.10.006_bb0050","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-021-03710-0","article-title":"Dysregulation of brain and choroid plexus cell types in severe COVID-19","volume":"595","author":"Yang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.10.006_bb0055","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000957","article-title":"Presence of SARS-CoV-2 transcripts in the choroid plexus of MS and non-MS patients with COVID-19","volume":"8","author":"Fuchs","year":"2021","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.tins.2021.10.006_bb0060","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.stem.2020.10.001","article-title":"SARS-CoV-2 infects the brain choroid plexus and disrupts the blood\u2013CSF barrier in human brain organoids","volume":"27","author":"Pellegrini","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tins.2021.10.006_bb0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.immuni.2020.12.011","article-title":"Neurological manifestations of COVID-19 feature T cell exhaustion and dedifferentiated monocytes in cerebrospinal fluid","volume":"54","author":"Heming","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.tins.2021.10.006_bb0070","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001029","article-title":"Encephalopathies associated with severe COVID-19 present neurovascular unit alterations without evidence for strong neuroinflammation","volume":"8","author":"Bernard-Valnet","year":"2021","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.tins.2021.10.006_bb0075","article-title":"Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms","volume":"2","author":"Song","year":"2021","journal-title":"Cell Rep. Med."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223621002046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223621002046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:09:04Z","timestamp":1777496944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223621002046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0166223621002046"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2021.10.006","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SARS-CoV-2-specific neuropathology: fact or fiction?","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2021.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}