{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:47:55Z","timestamp":1794217675134,"version":"4.8.0"},"reference-count":178,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.tins.2021.12.004","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T16:40:54Z","timestamp":1642092054000},"page":"184-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":269,"title":["Lysosomal dysfunction in neurodegeneration: emerging concepts and methods"],"prefix":"10.1016","volume":"45","author":[{"given":"Vinod","family":"Udayar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Sidransky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Jagasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2021.12.004_bb0005","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals for the lysosome: a control center for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41556-018-0244-7","article-title":"The lysosome as a cellular centre for signalling, metabolism and quality control","volume":"21","author":"Lawrence","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0015","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1523\/JNEUROSCI.3085-18.2019","article-title":"Increased lysosomal exocytosis induced by lysosomal Ca2+ channel agonists protects human dopaminergic neurons from \u03b1-Synuclein toxicity","volume":"39","author":"Tsunemi","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.645244","article-title":"The P2X7 receptor in microglial cells modulates the endolysosomal axis, autophagy, and phagocytosis","volume":"15","author":"Campagno","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/emmm.202012836","article-title":"The rapidly evolving view of lysosomal storage diseases","volume":"13","author":"Parenti","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0030","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.tins.2019.10.002","article-title":"Lysosomal dysfunction at the centre of Parkinson\u2019s disease and frontotemporal dementia\/amyotrophic lateral sclerosis","volume":"42","author":"Wallings","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0035","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/mds.27642","article-title":"SMPD1 mutations, activity, and \u03b1-synuclein accumulation in Parkinson\u2019s disease","volume":"34","author":"Alcalay","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tins.2021.12.004_bb0040","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ana.25629","article-title":"Genetic, structural, and functional evidence link TMEM175 to synucleinopathies","volume":"87","author":"Krohn","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0045","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41586-020-1968-7","article-title":"ATP13A2 deficiency disrupts lysosomal polyamine export","volume":"578","author":"van Veen","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0050","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0055","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0060","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/ng.536","article-title":"Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions","volume":"42","author":"Van Deerlin","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-019-0323-7","article-title":"Endo-lysosomal dysregulations and late-onset Alzheimer\u2019s disease: impact of genetic risk factors","volume":"14","author":"Van Acker","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.tins.2021.12.004_bb0070","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1016\/j.cell.2021.03.048","article-title":"Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome","volume":"184","author":"Bourdenx","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0075","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/15548627.2019.1633862","article-title":"MAPT\/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration","volume":"16","author":"Feng","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.tins.2021.12.004_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a033993","article-title":"The autophagy lysosomal pathway and neurodegeneration","volume":"12","author":"Finkbeiner","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109259","article-title":"SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network","volume":"35","author":"Hung","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0090","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.celrep.2015.07.050","article-title":"Presenilin 1 maintains lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification","volume":"12","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0095","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1080\/15548627.2019.1596489","article-title":"PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis","volume":"15","author":"Fedeli","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.tins.2021.12.004_bb0100","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","article-title":"TREM2 maintains microglial metabolic fitness in Alzheimer\u2019s disease","volume":"170","author":"Ulland","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-020-02253-4","article-title":"In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics","volume":"141","author":"Xu","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2021.12.004_bb0110","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nbd.2013.12.019","article-title":"Spreading of amyloid-\u03b2 peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance","volume":"65","author":"Domert","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0120","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.4161\/auto.29647","article-title":"Autophagy in microglia degrades extracellular \u03b2-amyloid fibrils and regulates the NLRP3 inflammasome","volume":"10","author":"Cho","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.tins.2021.12.004_bb0125","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/15548627.2017.1395992","article-title":"Autophagy inhibition promotes SNCA\/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype","volume":"14","author":"Minakaki","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.tins.2021.12.004_bb0130","doi-asserted-by":"crossref","first-page":"ra44","DOI":"10.1126\/scisignal.2001450","article-title":"Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response","volume":"4","author":"He","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tins.2021.12.004_bb0135","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/08830185.2014.936587","article-title":"The roles of lysosomes in inflammation and autoimmune diseases","volume":"34","author":"Ge","year":"2015","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.tins.2021.12.004_bb0140","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1091\/mbc.e16-01-0003","article-title":"C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling","volume":"72","author":"Amick","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0145","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.aaf1064","article-title":"C9orf72 is required for proper macrophage and microglial function in mice","volume":"351","author":"O\u2019Rourke","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.12.004_bb0150","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-018-1933-9","article-title":"Inflammation in ALS\/FTD pathogenesis","volume":"137","author":"McCauley","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2021.12.004_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.13126","article-title":"C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis","volume":"19","author":"Wang","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105360","article-title":"Lysosome dysfunction as a cause of neurodegenerative diseases: lessons from frontotemporal dementia and amyotrophic lateral sclerosis","volume":"154","author":"Root","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0165","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2013.06.049","article-title":"Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice","volume":"250","author":"Tanaka","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.tins.2021.12.004_bb0175","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1742-2094-8-65","article-title":"Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients","volume":"8","author":"Boss\u00f9","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.tins.2021.12.004_bb0180","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbi.2015.05.006","article-title":"Inflammatory molecules in frontotemporal dementia: cerebrospinal fluid signature of progranulin mutation carriers","volume":"49","author":"Galimberti","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.tins.2021.12.004_bb0185","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1172\/JCI63113","article-title":"Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury","volume":"122","author":"Martens","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tins.2021.12.004_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aah5642","article-title":"Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis","volume":"9","author":"Ward","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0195","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41573-019-0036-1","article-title":"Lysosomes as a therapeutic target","volume":"18","author":"Bonam","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tins.2021.12.004_bb0200","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41582-020-00434-z","article-title":"Improving clinical trial outcomes in amyotrophic lateral sclerosis","volume":"17","author":"Kiernan","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0205","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","article-title":"Aging and neurodegeneration are associated with increased mutations in single human neurons","volume":"559","author":"Lodato","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.12.004_bb0210","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A single-cell atlas of entorhinal cortex from individuals with Alzheimer\u2019s disease reveals cell-type-specific gene expression regulation","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0215","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ajhg.2018.02.001","article-title":"Single-cell RNA-Seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson disease","volume":"102","author":"Hook","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0220","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/EBC20160083","article-title":"Proteomics and metabolomics in ageing research: from biomarkers to systems biology","volume":"61","author":"Hoffman","year":"2017","journal-title":"Essays Biochem."},{"key":"10.1016\/j.tins.2021.12.004_bb0225","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/01.wnl.0000230215.41296.18","article-title":"Glucocerebrosidase mutations are an important risk factor for Lewy body disorders","volume":"67","author":"Goker-Alpan","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.tins.2021.12.004_bb0230","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/acn3.228","article-title":"GBA mutations are associated with rapid eye movement sleep behavior disorder","volume":"2","author":"Gan-Or","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0235","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/jnc.13517","article-title":"Parkinson\u2019s disease: acid-glucocerebrosidase activity and alpha-synuclein clearance","volume":"139","author":"Blanz","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tins.2021.12.004_bb0240","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2017.01.018","article-title":"The complicated relationship between Gaucher disease and parkinsonism: insights from a rare disease","volume":"93","author":"Aflaki","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-019-0336-2","article-title":"Glucocerebrosidase and its relevance to Parkinson disease","volume":"14","author":"Do","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.tins.2021.12.004_bb0250","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1523\/JNEUROSCI.0636-16.2016","article-title":"A new glucocerebrosidase chaperone reduces \u03b1-synuclein and glycolipid levels in iPSC-derived dopaminergic neurons from patients with Gaucher disease and parkinsonism","volume":"36","author":"Aflaki","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0255","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1038\/ncomms5028","article-title":"IPSC-derived neurons from GBA1-associated Parkinson\u2019s disease patients show autophagic defects and impaired calcium homeostasis","volume":"5","author":"Sch\u00f6ndorf","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0260","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/mds.26278","article-title":"No evidence for substrate accumulation in Parkinson brains with GBA mutations","volume":"30","author":"Gegg","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tins.2021.12.004_bb0265","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.nbd.2018.09.015","article-title":"Path mediation analysis reveals GBA impacts Lewy body disease status by increasing \u03b1-synuclein levels","volume":"121","author":"G\u00fcndner","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0270","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and \u03b1-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0275","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1523\/JNEUROSCI.0628-16.2016","article-title":"Activation of \u03b2-glucocerebrosidase reduces pathological \u03b1-synuclein and restores lysosomal function in Parkinson\u2019s patient midbrain neurons","volume":"36","author":"Mazzulli","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0280","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016857","article-title":"The complex ultrastructure of the endolysosomal system","volume":"6","author":"Klumperman","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0285","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.aan6298","article-title":"Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes","volume":"358","author":"Abu-Remaileh","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.12.004_bb0290","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2017.09.046","article-title":"mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient","volume":"171","author":"Wyant","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0295","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.devcel.2020.11.016","article-title":"NPC1-mTORC1 signaling couples cholesterol sensing to organelle homeostasis and is a targetable pathway in Niemann-Pick Type C","volume":"56","author":"Davis","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0300","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/acs.jproteome.9b00580","article-title":"Systematic comparison of strategies for the enrichment of lysosomes by data independent acquisition","volume":"19","author":"Singh","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.tins.2021.12.004_bb0305","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1126\/science.aar2663","article-title":"NUFIP1 is a ribosome receptor for starvation-induced ribophagy","volume":"360","author":"Wyant","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.12.004_bb0310","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1016\/j.cell.2021.08.002","article-title":"Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic","volume":"184","author":"Logan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0315","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.celrep.2017.08.056","article-title":"Lipidomic and transcriptomic basis of lysosomal dysfunction in progranulin deficiency","volume":"20","author":"Evers","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0320","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0100-17.2017","article-title":"Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN mutations","volume":"4","author":"Holler","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.tins.2021.12.004_bb0325","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/jnc.14110","article-title":"The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C","volume":"143","author":"Zhou","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tins.2021.12.004_bb0330","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature07311","article-title":"The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel","volume":"455","author":"Dong","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0335","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cell.2013.01.023","article-title":"mTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state","volume":"152","author":"Cang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0340","first-page":"E1373","article-title":"Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2021.12.004_bb0345","doi-asserted-by":"crossref","first-page":"C481","DOI":"10.1152\/ajpcell.00150.2019","article-title":"Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes","volume":"317","author":"Li","year":"2019","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.tins.2021.12.004_bb0350","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1021\/acssensors.0c02318","article-title":"Genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH","volume":"6","author":"Chin","year":"2021","journal-title":"ACS Sensors"},{"key":"10.1016\/j.tins.2021.12.004_bb0355","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1093\/hmg\/ddz136","article-title":"Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease","volume":"28","author":"Jinn","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0360","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41588-021-00785-3","article-title":"Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture","volume":"53","author":"Chia","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0365","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.cell.2015.08.002","article-title":"TMEM175 is an organelle K+ channel regulating lysosomal function","volume":"162","author":"Cang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0370","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41586-021-03185-z","article-title":"A growth-factor-activated lysosomal K+ channel regulates Parkinson\u2019s pathology","volume":"591","author":"Wie","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0375","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1073\/pnas.1616332114","article-title":"TMEM175 deficiency impairs lysosomal and mitochondrial function and increases \u03b1-synuclein aggregation","volume":"114","author":"Jinn","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2021.12.004_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062143","article-title":"Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis","volume":"8","author":"Freeman","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tins.2021.12.004_bb0385","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1038\/s41598-017-08149-w","article-title":"Impaired endo-lysosomal membrane integrity accelerates the seeding progression of \u03b1-synuclein aggregates","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0390","doi-asserted-by":"crossref","first-page":"18952","DOI":"10.1074\/jbc.RA119.009432","article-title":"Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation","volume":"294","author":"Chen","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2021.12.004_bb0395","article-title":"PIKfyve inhibition blocks endolysosomal escape of \u03b1-synuclein fibrils and spread of \u03b1-synuclein aggregation","author":"See","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2021.12.004_bb0400","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-020-02254-3","article-title":"Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol","volume":"141","author":"Polanco","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2021.12.004_bb0405","doi-asserted-by":"crossref","first-page":"32926","DOI":"10.1074\/jbc.M114.579961","article-title":"The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation","volume":"289","author":"Okada","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2021.12.004_bb0410","first-page":"985","article-title":"Immunomodulation of the NLRP3 inflammasome through structure-based activator design and functional regulation via lysosomal rupture","volume":"4","author":"Manna","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.tins.2021.12.004_bb0415","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb2454","article-title":"LRRK2 mediates tubulation and vesicle sorting from lysosomes","volume":"6","author":"Bonet-Ponce","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2021.12.004_bb0420","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature25486","article-title":"Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis","volume":"554","author":"Wong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0425","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41467-021-22113-3","article-title":"Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson\u2019s disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0430","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-444-63432-0.00003-7","article-title":"The blood\u2013brain barrier","volume":"133","author":"Obermeier","year":"2016","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0435","first-page":"441","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tins.2021.12.004_bb0440","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuron.2020.10.025","article-title":"Untangling complexities of glial-neuronal communications\u202f: astroglial metabolic cascades orchestrate tonic inhibition in the thalamus","volume":"108","author":"Verkhratsky","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0445","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1016\/j.nbd.2019.104647","article-title":"A characterization of Gaucher iPS-derived astrocytes: potential implications for Parkinson disease","volume":"134","author":"Aflaki","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0450","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.nbd.2011.12.027","article-title":"Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann-Pick type C1 mice","volume":"45","author":"Pressey","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0455","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41467-021-21428-5","article-title":"Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia","volume":"12","author":"Colombo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0460","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1016\/j.celrep.2017.11.061","article-title":"Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can be targeted to enhance anti-tumor response","volume":"21","author":"Gonugunta","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0465","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41586-021-03762-2","article-title":"Tonic prime-boost of STING signalling mediates Niemann\u2013Pick disease type C","volume":"596","author":"Chu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0470","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/brain\/awx024","article-title":"C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"140","author":"Aoki","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.tins.2021.12.004_bb0475","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nm.4490","article-title":"Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS\/FTD human induced motor neurons","volume":"24","author":"Shi","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0480","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cub.2018.03.063","article-title":"A C9orf72 ALS\/FTD ortholog acts in endolysosomal degradation and lysosomal homeostasis","volume":"28","author":"Corrionero","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0485","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6038","article-title":"Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease","volume":"8","author":"Burberry","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0490","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.1232927","article-title":"The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD\/ALS","volume":"339","author":"Mori","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.12.004_bb0495","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2013.02.004","article-title":"Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD\/ALS","volume":"77","author":"Ash","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0500","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuron.2013.10.015","article-title":"RNA toxicity from the ALS\/FTD C9ORF72 expansion is mitigated by antisense intervention","volume":"80","author":"Donnelly","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0505","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41593-020-0619-5","article-title":"Reduced C9ORF72 function exacerbates gain of toxicity from ALS\/FTD-causing repeat expansion in C9orf72","volume":"23","author":"Zhu","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0510","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41586-020-2625-x","article-title":"C9orf72 in myeloid cells suppresses STING-induced inflammation","volume":"585","author":"McCauley","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0515","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.neuron.2021.05.020","article-title":"C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation","volume":"109","author":"Lall","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0520","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1007\/s12035-021-02327-8","article-title":"Parkinson\u2019s disease-associated LRRK2 interferes with astrocyte-mediated alpha-synuclein clearance","volume":"58","author":"Streubel-Gallasch","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tins.2021.12.004_bb0525","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-020-2709-7","article-title":"Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency","volume":"588","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2021.12.004_bb0530","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006320","article-title":"Animal models of Alzheimer disease","volume":"2","author":"LaFerla","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0535","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BST20160238","article-title":"LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis","volume":"45","author":"Volta","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tins.2021.12.004_bb0540","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41593-018-0236-8","article-title":"Animal models of neurodegenerative diseases","volume":"21","author":"Dawson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0545","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.stemcr.2016.01.013","article-title":"ER stress and autophagic perturbations lead to elevated extracellular a-synuclein in GBA-N370S Parkinson\u2019s iPSC-derived dopamine neurons","volume":"6","author":"Fernandes","year":"2016","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.tins.2021.12.004_bb0550","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","article-title":"Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson\u2019s disease","volume":"357","author":"Burbulla","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.tins.2021.12.004_bb0555","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.stemcr.2018.06.022","article-title":"Genetically engineered iPSC-derived FTDP-17 MAPT neurons display mutation-specific neurodegenerative and neurodevelopmental phenotypes","volume":"11","author":"Verheyen","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.tins.2021.12.004_bb0560","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.stemcr.2018.12.011","article-title":"Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson\u2019s disease","volume":"12","author":"di Domenico","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.tins.2021.12.004_bb0565","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.stem.2018.10.023","article-title":"Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes","volume":"24","author":"Lang","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-67091-6","article-title":"Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation","volume":"10","author":"Okarmus","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0575","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1091\/mbc.E20-06-0382","article-title":"Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons","volume":"32","author":"Gowrishankar","year":"2021","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0580","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1038\/s41598-017-09362-3","article-title":"Excess \u03b1-synuclein compromises phagocytosis in iPSC-derived macrophages","volume":"7","author":"Haenseler","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0585","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.celrep.2018.07.094","article-title":"Human induced pluripotent stem cell-derived microglia-like cells harboring TREM2 missense mutations show specific deficits in phagocytosis","volume":"24","author":"Garcia-Reitboeck","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0161969","article-title":"Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer\u2019s disease phenotypes","volume":"11","author":"Raja","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tins.2021.12.004_bb0595","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41531-019-0078-4","article-title":"Modeling Parkinson\u2019s disease in midbrain-like organoids","volume":"5","author":"Smits","year":"2019","journal-title":"NPJ Parkinson\u2019s Disease"},{"key":"10.1016\/j.tins.2021.12.004_bb0600","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.stemcr.2019.01.020","article-title":"Modeling G2019S-LRRK2 sporadic Parkinson\u2019s disease in 3D midbrain organoids","volume":"12","author":"Kim","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.tins.2021.12.004_bb0605","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1038\/s41467-020-19264-0","article-title":"APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer\u2019s disease patient iPSC-derived cerebral organoids","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.abb1540","article-title":"Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson\u2019s disease-linked DNAJC6 mutations","volume":"7","author":"Wulansari","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2021.12.004_bb0615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-017-1250-y","article-title":"Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era","volume":"18","author":"Do","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105155","article-title":"Epigenetic mechanisms underlying enhancer modulation of neuronal identity, neuronal activity and neurodegeneration","volume":"147","author":"Alcal\u00e0-Vida","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0625","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ymgme.2017.07.012","article-title":"The role of epigenetics in lysosomal storage disorders: uncharted territory","volume":"122","author":"Hassan","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.tins.2021.12.004_bb0630","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41572-018-0025-4","article-title":"Lysosomal storage diseases","volume":"4","author":"Platt","year":"2018","journal-title":"Nat. Rev. Disease Primers"},{"key":"10.1016\/j.tins.2021.12.004_bb0635","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fnins.2019.00277","article-title":"Entanglement of genetics and epigenetics in Parkinson\u2019s disease","volume":"13","author":"van Heesbeen","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0640","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s40142-018-0133-1","article-title":"Genetic modifiers in neurodegeneration","volume":"6","author":"Jain","year":"2018","journal-title":"Curr. Genet. Med. Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0645","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Resource genome-scale CRISPR-mediated control of gene repression and activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2018.04.005","article-title":"Neuronal lysosomes","volume":"697","author":"Ferguson","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2021.12.004_bb0655","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom11030400","article-title":"Lysosomal functions in glia associated with neurodegeneration","volume":"11","author":"Kreher","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.tins.2021.12.004_bb0660","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1083\/jcb.201612148","article-title":"Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology","volume":"216","author":"Gowrishankar","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0665","doi-asserted-by":"crossref","first-page":"E2955","DOI":"10.1073\/pnas.1616363114","article-title":"BORC\/kinesin-1 ensemble drives polarized transport of lysosomes into the axon","volume":"114","author":"Far\u00edas","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2021.12.004_bb0670","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.celrep.2019.06.013","article-title":"Neuronal soma-derived degradative lysosomes are continuously delivered to distal axons to maintain local degradation capacity","volume":"28","author":"Farfel-Becker","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0675","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.devcel.2021.03.032","article-title":"Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C","volume":"56","author":"Roney","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0680","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2018.00464","article-title":"An overview of the role of lipofuscin in age-related neurodegeneration","volume":"12","author":"Moreno-Garc\u00eda","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0685","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13023-016-0414-2","article-title":"Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis","volume":"11","author":"Geraets","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.tins.2021.12.004_bb0690","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s004010000247","article-title":"\u03b1-Synuclein immunopositive Parkinson\u2019s disease-related inclusion bodies in lower brain stem nuclei","volume":"101","author":"Braak","year":"2001","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2021.12.004_bb0695","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00702-010-0434-3","article-title":"Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson\u2019s disease","volume":"118","author":"Lv","year":"2011","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.tins.2021.12.004_bb0700","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1007\/s00221-017-5092-3","article-title":"Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson\u2019s disease","volume":"235","author":"Wellings","year":"2017","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.tins.2021.12.004_bb0705","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146601","article-title":"Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72","volume":"1728","author":"Chai","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.tins.2021.12.004_bb0710","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41593-021-00862-0","article-title":"Genome-wide CRISPRi\/a screens in human neurons link lysosomal failure to ferroptosis","volume":"24","author":"Tian","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0715","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00439-005-1288-x","article-title":"A mutation within the saposin D domain in a Gaucher disease patient with normal glucocerebrosidase activity","volume":"117","author":"Diaz-Font","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0720","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/brain\/awaa064","article-title":"Variants in saposin D domain of prosaposin gene linked to Parkinson\u2019s disease","volume":"143","author":"Oji","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.tins.2021.12.004_bb0725","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006180","article-title":"Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes","volume":"220","author":"Kanfer","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0730","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cell.2013.11.009","article-title":"Isogenic human iPSC Parkinson\u2019s model shows nitrosative stress-induced dysfunction in MEF2-PGC1\u03b1 transcription","volume":"155","author":"Ryan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0735","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.stem.2013.01.008","article-title":"Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression","volume":"12","author":"Reinhardt","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tins.2021.12.004_bb0740","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.parkreldis.2019.09.018","article-title":"Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients","volume":"67","author":"Nickels","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.tins.2021.12.004_bb0745","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1038\/s41467-019-13413-w","article-title":"LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson\u2019s disease patients","volume":"10","author":"Ysselstein","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0750","doi-asserted-by":"crossref","first-page":"142.e1","DOI":"10.1016\/j.neurobiolaging.2021.02.018","article-title":"LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson\u2019s disease","volume":"103","author":"Sosero","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2021.12.004_bb0755","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.06.031","article-title":"Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration","volume":"71","author":"Saxena","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0760","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101311","article-title":"Region-specific vulnerability in neurodegeneration: lessons from normal ageing","volume":"67","author":"Pandya","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.tins.2021.12.004_bb0765","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13195-019-0524-x","article-title":"A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain","volume":"11","author":"Del-Aguila","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.tins.2021.12.004_bb0770","first-page":"2087","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0775","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-scale proteomic analysis of Alzheimer\u2019s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0780","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","article-title":"Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer\u2019s disease","volume":"26","author":"Zhou","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0785","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mds.27818","article-title":"Higher urine bis(monoacylglycerol)phosphate levels in LRRK2 G2019S mutation carriers: implications for therapeutic development","volume":"35","author":"Alcalay","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tins.2021.12.004_bb0790","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3634","article-title":"Effect of selective LRRK2 kinase inhibition on nonhuman primate lung","volume":"7","author":"Fuji","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0795","article-title":"ER-lysosome lipid transfer protein VPS13C\/PARK23 prevents aberrant mtDNA-dependent STING signaling","author":"Hancock-Cerutti","year":"2021","journal-title":"BioRxiv"},{"key":"10.1016\/j.tins.2021.12.004_bb0800","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2020.00807","article-title":"Pharmacodynamic biomarkers for emerging LRRK2 therapeutics","volume":"14","author":"Kelly","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0805","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41531-020-00138-7","article-title":"Exosome markers of LRRK2 kinase inhibition","volume":"6","author":"Wang","year":"2020","journal-title":"NPJ Parkinson\u2019s Disease"},{"key":"10.1016\/j.tins.2021.12.004_bb0810","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/bs.mie.2017.06.014","article-title":"Fluorescence-quenched substrates for quantitative live cell imaging of glucocerebrosidase activity","volume":"598","author":"Ashmus","year":"2018","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tins.2021.12.004_bb0815","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multi-center analysis of glucocerebrosidase mutations in Parkinson disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tins.2021.12.004_bb0820","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/jamaneurol.2014.313","article-title":"Comparison of Parkinson risk in Ashkenazi Jewish Gaucher patients and GBA heterozygotes","volume":"71","author":"Alcalay","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0825","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1474-4422(08)70117-0","article-title":"Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson\u2019s disease: a case-control study","volume":"7","author":"Healy","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0830","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2021.12.004_bb0835","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ng1884","article-title":"Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase","volume":"38","author":"Ramirez","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0840","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00401-020-02145-7","article-title":"Mutated ATP10B increases Parkinson\u2019s disease risk by compromising lysosomal glucosylceramide export","volume":"139","author":"Martin","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2021.12.004_bb0845","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1083\/jcb.201807019","article-title":"VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites","volume":"217","author":"Kumar","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tins.2021.12.004_bb0850","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/mds.27516","article-title":"Identification of a large homozygous VPS13C deletion in a patient with early-onset parkinsonism","volume":"33","author":"Darvish","year":"2019","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tins.2021.12.004_bb0855","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.226241","article-title":"Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells","volume":"131","author":"Bussi","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tins.2021.12.004_bb0860","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11910-017-0737-y","article-title":"\u03b1-Synuclein and parkinsonism: updates and future perspectives","volume":"17","author":"Rosborough","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.tins.2021.12.004_bb0865","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-24081-0","article-title":"Structural basis for the ARF GAP activity and specificity of the C9orf72 complex","volume":"12","author":"Su","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2021.12.004_bb0870","doi-asserted-by":"crossref","first-page":"9876","DOI":"10.1073\/pnas.2002110117","article-title":"Cryo-EM structure of C9ORF72\u2013SMCR8\u2013WDR41 reveals the role as a GAP for Rab8a and Rab11a","volume":"117","author":"Tang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2021.12.004_bb0875","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1468-1331.2008.02144.x","article-title":"Frontotemporal dementia linked to chromosome 3 (FTD-3) - current concepts and the detection of a previously unknown branch of the Danish FTD-3 family","volume":"15","author":"Lindquist","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.tins.2021.12.004_bb0880","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2021.12.004_bb0885","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.mcn.2014.07.006","article-title":"Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B","volume":"61","author":"Stagi","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.tins.2021.12.004_bb0890","first-page":"450","article-title":"The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes","volume":"33","author":"Schwenk","year":"2014","journal-title":"EMBO J."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223621002526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223621002526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:20:26Z","timestamp":1759062026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223621002526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":178,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0166223621002526"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2021.12.004","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosomal dysfunction in neurodegeneration: emerging concepts and methods","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2021.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}