{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:58:20Z","timestamp":1792277900371,"version":"4.4.0"},"reference-count":137,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS078168"],"award-info":[{"award-number":["R01NS078168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS079737"],"award-info":[{"award-number":["R01NS079737"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.tins.2022.08.004","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T17:58:53Z","timestamp":1660931933000},"page":"809-819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":180,"title":["Neurovascular coupling: motive unknown"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-7378","authenticated-orcid":false,"given":"Patrick J.","family":"Drew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2022.08.004_bb0005","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41593-021-00904-7","article-title":"Revisiting the neurovascular unit","volume":"24","author":"Schaeffer","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.conb.2019.06.004","article-title":"Vascular and neural basis of the BOLD signal","volume":"58","author":"Drew","year":"2019","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0015","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41593-020-0686-7","article-title":"Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration","volume":"23","author":"Park","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0020","doi-asserted-by":"crossref","first-page":"10081","DOI":"10.1523\/JNEUROSCI.1357-19.2019","article-title":"Neurovascular coupling under chronic stress is modified by altered GABAergic interneuron activity","volume":"39","author":"Han","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0025","doi-asserted-by":"crossref","first-page":"E10206","DOI":"10.1073\/pnas.1804340115","article-title":"The brain's hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers","volume":"115","author":"Elbau","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/japplphysiol.00966.2005","article-title":"Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease","volume":"100","author":"Girouard","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0035","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41593-020-0663-1","article-title":"Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice","volume":"23","author":"Ouellette","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0040","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1073\/pnas.1907467117","article-title":"Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice","volume":"117","author":"Wenzel","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0045","article-title":"Structural and functional features of developing brain capillaries, and their alteration in schizophrenia","volume":"14","author":"Carrier","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0050","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1073\/pnas.83.4.1140","article-title":"Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects","volume":"83","author":"Fox","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0055","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/jcbfm.2012.23","article-title":"Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals","volume":"32","author":"Kim","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0060","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1126\/science.156.3780.1392","article-title":"Oxygen tension changes evoked in the brain by visual stimulation","volume":"156","author":"Gijsbers","year":"1967","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0065","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1073\/pnas.111164398","article-title":"Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data","volume":"98","author":"Mintun","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/jcbfm.2013.181","article-title":"The oxygen paradox of neurovascular coupling","volume":"34","author":"Leithner","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62071","article-title":"Neurovascular coupling and bilateral connectivity during NREM and REM sleep","volume":"9","author":"Turner","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.tins.2022.08.004_bb0080","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1038\/s41467-018-07752-3","article-title":"Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep","volume":"9","author":"Bergel","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2022.08.004_bb0085","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.272.5261.551","article-title":"Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping","volume":"272","author":"Malonek","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0090","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1152\/jn.01366.2006","article-title":"The hemo-neural hypothesis: on the role of blood flow in information processing","volume":"99","author":"Moore","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0095","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1073\/pnas.97.13.7603","article-title":"Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation","volume":"97","author":"Yablonskiy","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0100","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.neuron.2021.02.006","article-title":"Brain microvasculature has a common topology with local differences in geometry that match metabolic load","volume":"109","author":"Ji","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2022.08.004_bb0105","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2020.01.028","article-title":"Mapping the fine-scale organization and plasticity of the brain vasculature","volume":"180","author":"Kirst","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.tins.2022.08.004_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110978","article-title":"Quantitative relationship between cerebrovascular network and neuronal cell types in mice","volume":"39","author":"Wu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2022.08.004_bb0115","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.neuroimage.2011.09.050","article-title":"Neurovascular coupling is brain region-dependent","volume":"59","author":"Devonshire","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.tins.2022.08.004_bb0120","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1523\/JNEUROSCI.3447-08.2009","article-title":"A new scenario for negative functional magnetic resonance imaging signals: endogenous neurotransmission","volume":"29","author":"Shih","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0125","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/jcbfm.2010.173","article-title":"Striatal and cortical BOLD, blood flow, blood volume, oxygen consumption, and glucose consumption changes in noxious forepaw electrical stimulation","volume":"31","author":"Shih","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0130","doi-asserted-by":"crossref","first-page":"10975","DOI":"10.1523\/JNEUROSCI.1369-14.2014","article-title":"Neurovascular coupling and decoupling in the cortex during voluntary locomotion","volume":"34","author":"Huo","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0135","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1038\/s41467-020-19948-7","article-title":"Adaptive modulation of brain hemodynamics across stereotyped running episodes","volume":"11","author":"Bergel","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2022.08.004_bb0140","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1038\/s41467-019-13523-5","article-title":"Cerebral oxygenation during locomotion is modulated by respiration","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2022.08.004_bb0145","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1038\/s41467-021-23508-y","article-title":"Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences","volume":"12","author":"Shaw","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2022.08.004_bb0150","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1523\/JNEUROSCI.3146-10.2011","article-title":"What does local functional hyperemia tell about local neuronal activation?","volume":"31","author":"Jukovskaya","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0155","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature07664","article-title":"Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity","volume":"457","author":"Sirotin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tins.2022.08.004_bb0160","doi-asserted-by":"crossref","first-page":"14347","DOI":"10.1523\/JNEUROSCI.4307-08.2008","article-title":"Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex","volume":"28","author":"Devor","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109925","article-title":"Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge","volume":"37","author":"Roy","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2022.08.004_bb0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/11.5.12","article-title":"Spikes, BOLD, attention, and awareness: a comparison of electrophysiological and fMRI signals in V1","volume":"11","author":"Boynton","year":"2011","journal-title":"J. Vis."},{"key":"10.1016\/j.tins.2022.08.004_bb0175","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nn.4533","article-title":"Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow","volume":"20","author":"Longden","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0180","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neubiorev.2018.11.011","article-title":"What is the key mediator of the neurovascular coupling response?","volume":"96","author":"Hosford","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tins.2022.08.004_bb0185","first-page":"31","article-title":"Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species","volume":"6","author":"Dittrich","year":"2012","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.tins.2022.08.004_bb0190","first-page":"36","article-title":"Characterization of type I and type II nNOS-expressing interneurons in the barrel cortex of mouse","volume":"6","author":"Perrenoud","year":"2012","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.tins.2022.08.004_bb0195","doi-asserted-by":"crossref","first-page":"60533","DOI":"10.7554\/eLife.60533","article-title":"nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice","volume":"9","author":"Echagarruga","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.tins.2022.08.004_bb0200","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1177\/0271678X19870105","article-title":"Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex","volume":"40","author":"Krawchuk","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0205","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1093\/cercor\/bhz251","article-title":"Key aspects of neurovascular control mediated by specific populations of inhibitory cortical interneurons","volume":"30","author":"Lee","year":"2020","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.tins.2022.08.004_bb0210","article-title":"Functional MRI in the Nile crocodile: a new avenue for evolutionary neurobiology","volume":"285","author":"Behroozi","year":"2018","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.tins.2022.08.004_bb0215","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","article-title":"Updated energy budgets for neural computation in the neocortex and cerebellum","volume":"32","author":"Howarth","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0220","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/0002-9343(81)90834-2","article-title":"Brain dysfunction in mild to moderate hypoxia","volume":"70","author":"Gibson","year":"1981","journal-title":"Am. J. Med."},{"key":"10.1016\/j.tins.2022.08.004_bb0225","first-page":"C1131","article-title":"Oxygen in mammalian tissue: methods of measurement and affinities of various reactions","volume":"260","author":"Vanderkooi","year":"1991","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.tins.2022.08.004_bb0230","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1073\/pnas.96.16.9403","article-title":"Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex","volume":"96","author":"Hoge","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0235","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/jmri.10111","article-title":"Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans","volume":"15","author":"St Lawrence","year":"2002","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.tins.2022.08.004_bb0240","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0304-3940(96)13210-9","article-title":"Effects of indomethacin on cerebral blood flow and oxygen metabolism: a positron emission tomographic investigation in the anaesthetized baboon","volume":"220","author":"Schumann","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2022.08.004_bb0245","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1113\/JP280118","article-title":"Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults","volume":"599","author":"Shoemaker","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0250","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuroimage.2007.10.049","article-title":"Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study","volume":"40","author":"Perthen","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.tins.2022.08.004_bb0255","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroimage.2015.01.046","article-title":"Does acute caffeine ingestion alter brain metabolism in young adults?","volume":"110","author":"Xu","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.tins.2022.08.004_bb0260","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1002\/hbm.20732","article-title":"The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate?","volume":"30","author":"Addicott","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.tins.2022.08.004_bb0265","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1471-4159.1981.tb02373.x","article-title":"Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide","volume":"36","author":"Gibson","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tins.2022.08.004_bb0270","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1021\/bi00848a005","article-title":"Kinetic studies of the enzymatic dopamine beta-hydroxylation reaction","volume":"7","author":"Goldstein","year":"1968","journal-title":"Biochemistry"},{"key":"10.1016\/j.tins.2022.08.004_bb0275","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1471-4159.1981.tb05308.x","article-title":"Decreases in amino acids and acetylcholine metabolism during hypoxia","volume":"37","author":"Gibson","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tins.2022.08.004_bb0280","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00582147","article-title":"The effect of various stimulated altitudes on the turnover of norepinephrine and dopamine in the central nervous system of rats","volume":"380","author":"Prioux-Guyonneau","year":"1979","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.tins.2022.08.004_bb0285","doi-asserted-by":"crossref","first-page":"C743","DOI":"10.1152\/ajpcell.00019.2011","article-title":"Hypoxia. 3. Hypoxia and neurotransmitter synthesis","volume":"300","author":"Kumar","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0290","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0028-3908(76)90001-0","article-title":"The measurement of acetylcholine turnover rate in brain structures","volume":"15","author":"Racagni","year":"1976","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tins.2022.08.004_bb0295","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1126\/science.142.3590.394","article-title":"Norepinephrine and 3,4-dihydroxyphenethylamine turnover in guinea pig brain in vivo","volume":"142","author":"Udenfriend","year":"1963","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0300","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fphys.2012.00365","article-title":"pCO(2) and pH regulation of cerebral blood flow","volume":"3","author":"Yoon","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0305","first-page":"8","article-title":"Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism","volume":"2","author":"Buxton","year":"2010","journal-title":"Front. Neuroenerg."},{"key":"10.1016\/j.tins.2022.08.004_bb0310","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00004647-199904000-00005","article-title":"Cerebral oxygen\/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue","volume":"19","author":"Madsen","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0315","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0006-8993(97)00354-5","article-title":"Excessive oxygen or glucose supply does not alter the blood flow response to somatosensory stimulation or spreading depression in rats","volume":"761","author":"Wolf","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.tins.2022.08.004_bb0320","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00000542-200201000-00027","article-title":"Functional cerebral hyperemia is unaffected by isovolemic hemodilution","volume":"96","author":"Shen","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tins.2022.08.004_bb0325","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-021-04183-x","article-title":"Exercise plasma boosts memory and dampens brain inflammation via clusterin","volume":"600","author":"De Miguel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tins.2022.08.004_bb0330","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41586-020-2453-z","article-title":"Physiological blood\u2013brain transport is impaired with age by a shift in transcytosis","volume":"583","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2022.08.004_bb0335","doi-asserted-by":"crossref","first-page":"15741","DOI":"10.1073\/pnas.95.26.15741","article-title":"Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex","volume":"95","author":"Kleinfeld","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0340","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/01.RES.75.1.55","article-title":"Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study","volume":"75","author":"Villringer","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.tins.2022.08.004_bb0345","doi-asserted-by":"crossref","first-page":"13081","DOI":"10.1073\/pnas.2133652100","article-title":"Two-photon imaging of capillary blood flow in olfactory bulb glomeruli","volume":"100","author":"Chaigneau","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0350","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nmeth.1530","article-title":"Chronic optical access through a polished and reinforced thinned skull","volume":"7","author":"Drew","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.tins.2022.08.004_bb0355","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models","volume":"22","author":"Cruz Hernandez","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0360","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/0271678X17743877","article-title":"Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells","volume":"39","author":"Erdener","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0365","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1177\/0271678X19895245","article-title":"Susceptibility to capillary plugging can predict brain region specific vessel loss with aging","volume":"40","author":"Schager","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001298","article-title":"Origins of 1\/f-like tissue oxygenation fluctuations in the murine cortex","volume":"19","author":"Zhang","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tins.2022.08.004_bb0375","doi-asserted-by":"crossref","first-page":"13676","DOI":"10.1523\/JNEUROSCI.1968-11.2011","article-title":"\"Overshoot\" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels","volume":"31","author":"Devor","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0380","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021840118","article-title":"Control of low flow regions in the cortical vasculature determines optimal arterio-venous ratios","volume":"118","author":"Qi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2022.08.004_bb0385","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nn.3426","article-title":"The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow","volume":"16","author":"Blinder","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0390","doi-asserted-by":"crossref","first-page":"12670","DOI":"10.1073\/pnas.1007239107","article-title":"Topological basis for the robust distribution of blood to rodent neocortex","volume":"107","author":"Blinder","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tins.2022.08.004_bb0395","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/s41593-017-0007-y","article-title":"Weak correlations between hemodynamic signals and ongoing neural activity during the resting state","volume":"20","author":"Winder","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0400","article-title":"Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow","volume":"376","author":"Das","year":"2021","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.tins.2022.08.004_bb0405","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1152\/japplphysiol.00319.2006","article-title":"How the body controls brain temperature: the temperature shielding effect of cerebral blood flow","volume":"101","author":"Zhu","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0410","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1152\/ajplegacy.1968.215.2.389","article-title":"Role of cerebral arterial blood in the regulation of brain temperature in the monkey","volume":"215","author":"Hayward","year":"1968","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0415","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/scientificamerican0579-130","article-title":"A brain-cooling system in mammals","volume":"240","author":"Baker","year":"1979","journal-title":"Sci. Am."},{"key":"10.1016\/j.tins.2022.08.004_bb0420","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.neuroimage.2008.01.041","article-title":"Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen","volume":"40","author":"Royl","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.tins.2022.08.004_bb0425","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47324","article-title":"In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation","volume":"8","author":"Roche","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.tins.2022.08.004_bb0430","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0435","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neuron.2019.10.033","article-title":"Vasomotion as a driving force for paravascular clearance in the awake mouse brain","volume":"105","author":"van Veluw","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2022.08.004_bb0440","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.aax5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep","volume":"366","author":"Fultz","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0445","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12987-020-00214-3","article-title":"Functional hyperemia drives fluid exchange in the paravascular space","volume":"17","author":"Kedarasetti","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tins.2022.08.004_bb0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2019.00001","article-title":"Cerebrovascular smooth muscle cells as the drivers of intramural periarterial drainage of the brain","volume":"11","author":"Aldea","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0455","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12987-022-00326-y","article-title":"Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model","volume":"19","author":"Kedarasetti","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tins.2022.08.004_bb0460","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0465","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00031.2020","article-title":"Fluid transport in the brain","volume":"102","author":"Rasmussen","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tins.2022.08.004_bb0470","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12987-016-0040-3","article-title":"Fluid and ion transfer across the blood\u2013brain and blood\u2013cerebrospinal fluid barriers; a comparative account of mechanisms and roles","volume":"13","author":"Hladky","year":"2016","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tins.2022.08.004_bb0475","doi-asserted-by":"crossref","first-page":"13272","DOI":"10.1523\/JNEUROSCI.3337-11.2011","article-title":"Adenosine receptor signaling modulates permeability of the blood\u2013brain barrier","volume":"31","author":"Carman","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0480","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0166-4328(96)00170-2","article-title":"Probable involvement of serotonin in the increased permeability of the blood\u2013brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat","volume":"72","author":"Sharma","year":"1995","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.tins.2022.08.004_bb0485","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-8993(94)90403-0","article-title":"Opening of the blood\u2013brain barrier during cortical superfusion with histamine","volume":"653","author":"Schilling","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.tins.2022.08.004_bb0490","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2045-8118-11-26","article-title":"Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence","volume":"11","author":"Hladky","year":"2014","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tins.2022.08.004_bb0495","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12987-021-00282-z","article-title":"The glymphatic hypothesis: the theory and the evidence","volume":"19","author":"Hladky","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tins.2022.08.004_bb0500","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain \u2013 implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.tins.2022.08.004_bb0505","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.3949\/ccjm.76.s2.16","article-title":"Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro","volume":"76","author":"Cao","year":"2009","journal-title":"Cleve. Clin. J. Med."},{"key":"10.1016\/j.tins.2022.08.004_bb0510","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/10739680802010070","article-title":"Nitric oxide bioavailability in the microcirculation: insights from mathematical models","volume":"15","author":"Tsoukias","year":"2008","journal-title":"Microcirculation"},{"key":"10.1016\/j.tins.2022.08.004_bb0515","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1008069","article-title":"Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics","volume":"16","author":"Haselden","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.tins.2022.08.004_bb0520","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1523\/JNEUROSCI.23-02-00367.2003","article-title":"Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade","volume":"23","author":"Smith","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0525","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1523\/JNEUROSCI.19-13-05528.1999","article-title":"Arginine analogs modify signal detection by neurons in the visual cortex","volume":"19","author":"Kara","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0530","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1523\/JNEUROSCI.1528-06.2006","article-title":"Signaling from blood vessels to CNS axons through nitric oxide","volume":"26","author":"Garthwaite","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0535","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.2004.062281","article-title":"Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing","volume":"557","author":"Perez-Garcia","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0540","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1113\/jphysiol.2013.262022","article-title":"Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells","volume":"591","author":"Turner","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0545","article-title":"Could respiration-driven blood oxygen changes modulate neural activity?","author":"Zhang","year":"2022","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0550","doi-asserted-by":"crossref","first-page":"12624","DOI":"10.1523\/JNEUROSCI.1300-16.2016","article-title":"Vasculo-neuronal coupling: retrograde vascular communication to brain neurons","volume":"36","author":"Kim","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109405","article-title":"Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback","volume":"36","author":"Haidey","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2022.08.004_bb0560","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1523\/JNEUROSCI.4486-14.2015","article-title":"Astrocyte contributions to flow\/pressure-evoked parenchymal arteriole vasoconstriction","volume":"35","author":"Kim","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0565","doi-asserted-by":"crossref","first-page":"9364","DOI":"10.1523\/JNEUROSCI.1249-20.2020","article-title":"Mechanosensory signaling in astrocytes","volume":"40","author":"Turovsky","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2022.08.004_bb0570","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41467-019-13956-y","article-title":"Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow","volume":"11","author":"Marina","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2022.08.004_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116592","article-title":"Imaging brain function with simultaneous BOLD and viscoelasticity contrast: fMRI\/fMRE","volume":"211","author":"Lan","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.tins.2022.08.004_bb0580","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroimage.2015.04.054","article-title":"Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response","volume":"115","author":"Gao","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.tins.2022.08.004_bb0585","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1113\/jphysiol.2010.201541","article-title":"The microcirculation: physiology at the mesoscale","volume":"589","author":"Secomb","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2022.08.004_bb0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007231","article-title":"Red blood cells stabilize flow in brain microvascular networks","volume":"15","author":"Schmid","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.tins.2022.08.004_bb0595","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41567-019-0486-8","article-title":"Oscillating droplet trains in microfluidic networks and their suppression in blood flow","volume":"15","author":"Cybulski","year":"2019","journal-title":"Nat. Phys."},{"key":"10.1016\/j.tins.2022.08.004_bb0600","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mvr.2012.06.006","article-title":"Spontaneous oscillations of capillary blood flow in artificial microvascular networks","volume":"84","author":"Forouzan","year":"2012","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.tins.2022.08.004_bb0605","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.bpj.2017.10.020","article-title":"Direct numerical simulation of cellular-scale blood flow in 3D microvascular networks","volume":"113","author":"Balogh","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.tins.2022.08.004_bb0610","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1021\/acs.chemrev.1c00985","article-title":"Nonlinear phenomena in microfluidics","volume":"122","author":"Battat","year":"2022","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tins.2022.08.004_bb0615","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature13701","article-title":"Piezo1 integration of vascular architecture with physiological force","volume":"515","author":"Li","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.tins.2022.08.004_bb0620","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001374","article-title":"Haemodynamics-driven developmental pruning of brain vasculature in zebrafish","volume":"10","author":"Chen","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tins.2022.08.004_bb0625","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1177\/0271678X16682508","article-title":"Cerebral vascular structure in the motor cortex of adult mice is stable and is not altered by voluntary exercise","volume":"37","author":"Cudmore","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0630","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/jcbfm.2012.152","article-title":"In vivo imaging of cerebral microvascular plasticity from birth to death","volume":"33","author":"Harb","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0635","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.104.048704","article-title":"Damage and fluctuations induce loops in optimal transport networks","volume":"104","author":"Katifori","year":"2010","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.tins.2022.08.004_bb0640","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1038\/s41598-018-27910-3","article-title":"The pial vasculature of the mouse develops according to a sensory-independent program","volume":"8","author":"Adams","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2022.08.004_bb0645","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2010.01.006","article-title":"Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice","volume":"65","author":"Gentet","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2022.08.004_bb0650","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/jcbfm.2012.115","article-title":"The locus coeruleus\u2013norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand","volume":"32","author":"Bekar","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tins.2022.08.004_bb0655","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000080","article-title":"Task-related hemodynamic responses are modulated by reward and task engagement","volume":"17","author":"Cardoso","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tins.2022.08.004_bb0660","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.aav7893","article-title":"Spontaneous behaviors drive multidimensional, brainwide activity","volume":"364","author":"Stringer","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.tins.2022.08.004_bb0665","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuron.2020.07.020","article-title":"Ultra-slow oscillations in fMRI and resting-state connectivity: neuronal and vascular contributions and technical confounds","volume":"107","author":"Drew","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2022.08.004_bb0670","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/1073858418805427","article-title":"Twitches, blinks, and fidgets: important generators of ongoing neural activity","volume":"25","author":"Drew","year":"2019","journal-title":"Neuroscientist"},{"key":"10.1016\/j.tins.2022.08.004_bb0675","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/mi.3.2.79","article-title":"Vasomotion: mechanisms and physiological importance","volume":"3","author":"Nilsson","year":"2003","journal-title":"Mol. Interv."},{"key":"10.1016\/j.tins.2022.08.004_bb0680","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archneurpsyc.1943.02290230022002","article-title":"Acute arrest of cerebral circulation in man","volume":"50","author":"Rosen","year":"1943","journal-title":"Arch. Neurol. Psychiatr."},{"key":"10.1016\/j.tins.2022.08.004_bb0685","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1177\/0271678X17702156","article-title":"Variability of physiological brain perfusion in healthy subjects \u2013 a systematic review of modifiers. Considerations for multi-center ASL studies","volume":"38","author":"Clement","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223622001618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223622001618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:21:16Z","timestamp":1759062076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223622001618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":137,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0166223622001618"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2022.08.004","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurovascular coupling: motive unknown","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2022.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}