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Neurochem."},{"key":"10.1016\/j.tins.2024.06.005_bb0365","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/mdc3.13710","article-title":"\u03b1-Synuclein seed amplification assays in the diagnosis of synucleinopathies using cerebrospinal fluid\u2014a systematic review and meta-analysis","volume":"10","author":"Grossauer","year":"2023","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.tins.2024.06.005_bb0370","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3109\/00207454.2014.961454","article-title":"Cerebrospinal fluid \u03b1-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis","volume":"125","author":"Gao","year":"2015","journal-title":"Int. J. 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Rep."},{"key":"10.1016\/j.tins.2024.06.005_bb0390","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000506480","article-title":"A comparative study of the diagnostic potential of plasma and erythrocytic \u03b1-synuclein in Parkinson's disease","volume":"19","author":"Wang","year":"2019","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.tins.2024.06.005_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.827493","article-title":"Erythrocytic \u03b1-synuclein species for Parkinson's disease diagnosis and the correlations with clinical characteristics","volume":"14","author":"Yu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tins.2024.06.005_bb0400","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.parkreldis.2022.09.011","article-title":"Erythrocytic \u03b1-synuclein in early Parkinson's disease: a 3-year longitudinal study","volume":"104","author":"Liu","year":"2022","journal-title":"Parkinsonism Relat. 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Lett."},{"key":"10.1016\/j.tins.2024.06.005_bb0425","first-page":"2933","article-title":"Alterations in erythrocytic oligomeric \u03b1-synuclein in patients with Parkinson's disease and multiple system atrophy","volume":"103","author":"Yan","year":"2023","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.tins.2024.06.005_bb0430","first-page":"10470","article-title":"Levels of oligomeric \u03b1-synuclein in red blood cells are elevated in patients with Parkinson\u2019s disease and affected by brain alpha-synuclein expression","volume":"12","author":"Li","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.tins.2024.06.005_bb0435","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jb\/mvac100","article-title":"Post-translational modification of lysine residues in erythrocyte \u03b1-synuclein","volume":"173","author":"Amagai","year":"2023","journal-title":"J. Biochem."},{"key":"10.1016\/j.tins.2024.06.005_bb0440","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14175-5","article-title":"Posttranslational modifications of blood-derived \u03b1-synuclein as biochemical markers for Parkinson's disease","volume":"7","author":"Vicente Miranda","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2024.06.005_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.623977","article-title":"Alterations of erythrocytic phosphorylated \u03b1-synuclein in different subtypes and stages of Parkinson's disease","volume":"13","author":"Li","year":"2021","journal-title":"Front. 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Lett."},{"key":"10.1016\/j.tins.2024.06.005_bb0465","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fnmol.2018.00053","article-title":"\u03b1-Synuclein heterocomplexes with \u03b2-amyloid are increased in red blood cells of Parkinson's disease patients and correlate with disease severity","volume":"11","author":"Daniele","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.tins.2024.06.005_bb0470","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2017.11.012","article-title":"\u03b1-Synuclein dimerization in erythrocytes of patients with genetic and non-genetic forms of Parkinson's disease","volume":"672","author":"Papagiannakis","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2024.06.005_bb0475","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40035-019-0155-y","article-title":"Erythrocytic \u03b1-synuclein as a potential biomarker for Parkinson's disease","volume":"8","author":"Tian","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.tins.2024.06.005_bb0480","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.parkreldis.2018.09.012","article-title":"\u03b1-Synuclein in erythrocyte membrane of patients with multiple system atrophy: a pilot study","volume":"60","author":"Liu","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.tins.2024.06.005_bb0485","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/mds.29246","article-title":"Salivary \u03b1-synuclein RT-QuIC correlates with disease severity in de novo Parkinson's disease","volume":"38","author":"Vivacqua","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tins.2024.06.005_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112366","article-title":"Pathological \u03b1-synuclein detected by real-time quaking-induced conversion in synucleinopathies","volume":"187","author":"Huang","year":"2024","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tins.2024.06.005_bb0495","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.tins.2024.06.005_bb0500","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/srep00954","article-title":"DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease","volume":"2","author":"Lin","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2024.06.005_bb0505","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2009.08.074","article-title":"Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients","volume":"465","author":"Saito","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2024.06.005_bb0510","doi-asserted-by":"crossref","DOI":"10.1038\/srep30793","article-title":"Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients","volume":"6","author":"Saito","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2024.06.005_bb0515","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neulet.2010.08.007","article-title":"Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals","volume":"483","author":"Akazawa","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2024.06.005_bb0520","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neures.2017.06.008","article-title":"Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein","volume":"128","author":"Yamagishi","year":"2018","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.tins.2024.06.005_bb0525","doi-asserted-by":"crossref","first-page":"716","DOI":"10.18632\/aging.100361","article-title":"Polyamines in aging and disease","volume":"3","author":"Minois","year":"2011","journal-title":"Aging"},{"key":"10.1016\/j.tins.2024.06.005_bb0530","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2018.02.015","article-title":"Micellar electrokinetic chromatography with laser induced fluorescence detection shows increase of putrescine in erythrocytes of Parkinson's disease patients","volume":"1081-1082","author":"Betancourt","year":"2018","journal-title":"J. Chromatography. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tins.2024.06.005_bb0535","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0304-3940(84)90050-8","article-title":"Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid","volume":"48","author":"Foster","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2024.06.005_bb0540","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jns.2005.07.006","article-title":"Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease","volume":"239","author":"Hartai","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.tins.2024.06.005_bb0545","first-page":"111","article-title":"Erythrocyte antioxidant enzymes in Parkinson's disease","volume":"121","author":"Abraham","year":"2005","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.tins.2024.06.005_bb0550","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s007020170003","article-title":"Parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients","volume":"108","author":"Serra","year":"2001","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.tins.2024.06.005_bb0555","first-page":"63","article-title":"Superoxide dismutase activity and zinc and copper concentrations in Parkinson's disease","volume":"7","author":"Kocat\u00fcrk","year":"2000","journal-title":"Pathophysiol. Off. J. Int. Soc. Pathophysiol."},{"key":"10.1016\/j.tins.2024.06.005_bb0560","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000103641","article-title":"Peripheral blood markers of oxidative stress in Parkinson's disease","volume":"58","author":"Younes-Mhenni","year":"2007","journal-title":"Eur. 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