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Neurol."},{"key":"10.1016\/j.tins.2024.08.011_bb0320","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41586-018-0654-5","article-title":"Shared and distinct transcriptomic cell types across neocortical areas","volume":"563","author":"Tasic","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.tins.2024.08.011_bb0325","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255263","article-title":"Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function","volume":"345","author":"Hu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.tins.2024.08.011_bb0330","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1150516","article-title":"The antidepressant fluoxetine restores plasticity in the adult visual cortex","volume":"320","author":"Maya-Vetencourt","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.tins.2024.08.011_bb0335","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/ejn.15929","article-title":"Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release tropomyosin-related kinase B from inhibitory control without reducing perineuronal nets enwrapping parvalbumin interneurons","volume":"57","author":"Cannarozzo","year":"2023","journal-title":"Eur. 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Neurosci."},{"key":"10.1016\/j.tins.2024.08.011_bb0360","doi-asserted-by":"crossref","first-page":"13822","DOI":"10.1074\/jbc.M111.314070","article-title":"Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein","volume":"287","author":"Kurihara","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2024.08.011_bb0365","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1523\/JNEUROSCI.2228-20.2020","article-title":"Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTP\u03c3 in parvalbumin neurons","volume":"41","author":"Lesnikova","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2024.08.011_bb0370","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.1072699","article-title":"Reactivation of ocular dominance plasticity in the adult visual cortex","volume":"298","author":"Pizzorusso","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tins.2024.08.011_bb0375","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.1174146","article-title":"Perineuronal nets protect fear memories from erasure","volume":"325","author":"Gogolla","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.tins.2024.08.011_bb0380","doi-asserted-by":"crossref","first-page":"18150","DOI":"10.1074\/jbc.RA119.008837","article-title":"Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2","volume":"294","author":"Fred","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2024.08.011_bb0385","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/jn.1963.26.6.1003","article-title":"Single-cell responses in striate cortex of kittens deprived of vision in one eye","volume":"26","author":"Wiesel","year":"1963","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tins.2024.08.011_bb0390","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.1970.sp009022","article-title":"The period of susceptibility to the physiological effects of unilateral eye closure in kittens","volume":"206","author":"Hubel","year":"1970","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2024.08.011_bb0395","doi-asserted-by":"crossref","first-page":"14964","DOI":"10.1523\/JNEUROSCI.4812-10.2010","article-title":"Removing brakes on adult brain plasticity: from molecular to behavioral interventions","volume":"30","author":"Bavelier","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2024.08.011_bb0400","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/pcn.12683","article-title":"iPlasticity: induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants","volume":"72","author":"Umemori","year":"2018","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.tins.2024.08.011_bb0405","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/mp.2015.142","article-title":"Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment","volume":"22","author":"Alboni","year":"2017","journal-title":"Mol. 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