{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:35:38Z","timestamp":1789137338960,"version":"build-2803163510"},"reference-count":112,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"am","delay-in-days":376,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32-NS007292"],"award-info":[{"award-number":["T32-NS007292"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21-AG081759"],"award-info":[{"award-number":["R21-AG081759"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R00-AG058748"],"award-info":[{"award-number":["R00-AG058748"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F32-AG085890"],"award-info":[{"award-number":["F32-AG085890"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG074330"],"award-info":[{"award-number":["R01-AG074330"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.tins.2024.09.004","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T16:18:28Z","timestamp":1728058708000},"page":"892-903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Examining resilience to Alzheimer\u2019s disease through the lens of monoaminergic neuromodulator systems"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-361X","authenticated-orcid":false,"given":"Jennifer L.","family":"Crawford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-3643","authenticated-orcid":false,"given":"Anne S.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2024.09.004_bb0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(19)30440-5","article-title":"Preclinical Alzheimer\u2019s disease: a valid concept","volume":"19","author":"Jack","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tins.2024.09.004_bb0010","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/jamaneurol.2020.0387","article-title":"Association of factors with elevated amyloid burden in clinically normal older individuals","volume":"77","author":"Sperling","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.tins.2024.09.004_bb0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-018-0299-8","article-title":"Advances in developing novel therapeutic strategies for Alzheimer\u2019s disease","volume":"13","author":"Cao","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.tins.2024.09.004_bb0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tins.2024.09.004_bb0025","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Sch\u00f6ll","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2024.09.004_bb0030","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.tins.2024.09.004_bb0035","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1002\/alz.13654","article-title":"Tau accumulation and atrophy predict amyloid independent cognitive decline in aging","volume":"20","author":"Fonseca","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer\u2019s disease-related neurofibrillary changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0045","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 Years","volume":"70","author":"Braak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.tins.2024.09.004_bb0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcdb.2020.12.010","article-title":"The \u2018a, b, c\u2019s of pretangle tau and their relation to aging and the risk of Alzheimer\u2019s disease","volume":"116","author":"Harley","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.tins.2024.09.004_bb0055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neurobiolaging.2024.02.001","article-title":"Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline","volume":"136","author":"Karalija","year":"2024","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0060","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s43587-023-00469-z","article-title":"The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance","volume":"3","author":"Dahl","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0065","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00213-021-05937-1","article-title":"The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice","volume":"238","author":"Wu","year":"2021","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tins.2024.09.004_bb0070","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1093\/cercor\/bht096","article-title":"Serotonin regulates performance nonmonotonically in a spatial working memory network","volume":"24","author":"Cano-Colino","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.tins.2024.09.004_bb0075","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1177\/02698811231177287","article-title":"The histamine system and cognitive function: an in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia","volume":"37","author":"Arumuham","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.tins.2024.09.004_bb0080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuropsychologia.2017.07.003","article-title":"The anatomy of apathy: a neurocognitive framework for amotivated behaviour","volume":"118","author":"Heron","year":"2018","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.tins.2024.09.004_bb0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12974-022-02508-9","article-title":"A tale of two transmitters: serotonin and histamine as in vivo biomarkers of chronic stress in mice","volume":"19","author":"Hersey","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.tins.2024.09.004_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105571","article-title":"Role of trace amine-associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice","volume":"167","author":"Zhang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tins.2024.09.004_bb0095","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00213-015-4084-x","article-title":"The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1\u03b2-induced elevated leptin levels in mice","volume":"233","author":"Kurosawa","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tins.2024.09.004_bb0100","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.cub.2014.10.019","article-title":"Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture","volume":"24","author":"Yu","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tins.2024.09.004_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz4232","article-title":"Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep","volume":"6","author":"Hayat","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2024.09.004_bb0110","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3758\/s13415-018-00678-9","article-title":"Age-related variability in decision-making: insights from neurochemistry","volume":"19","author":"Berry","year":"2018","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tics.2016.01.001","article-title":"The locus coeruleus: essential for maintaining cognitive function and the aging brain","volume":"20","author":"Mather","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.tins.2024.09.004_bb0120","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0091-3057(96)00431-5","article-title":"Acetylcholine, aging, and Alzheimer\u2019s disease","volume":"56","author":"Muir","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tins.2024.09.004_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105192","article-title":"New perspectives on the basal forebrain cholinergic system in Alzheimer\u2019s disease","volume":"150","author":"Berry","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tins.2024.09.004_bb0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pneurobio.2016.04.001","article-title":"Monoaminergic neuropathology in Alzheimer\u2019s disease","volume":"151","author":"\u0160imi\u0107","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.tins.2024.09.004_bb0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JAD-142682","article-title":"Turning on the light within: subcortical nuclei of the isodentritic core and their role in Alzheimer\u2019s disease pathogenesis","volume":"46","author":"Theofilas","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tins.2024.09.004_bb0140","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/alz.12937","article-title":"Priorities for research on neuromodulatory subcortical systems in Alzheimer\u2019s disease: position paper from the NSS PIA of ISTAART","volume":"19","author":"Ehrenberg","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00401-020-02248-1","article-title":"The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer\u2019s disease","volume":"141","author":"Matchett","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2024.09.004_bb0150","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tins.2018.01.010","article-title":"Long road to ruin: noradrenergic dysfunction in neurodegenerative disease","volume":"41","author":"Weinshenker","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JAD-180688","article-title":"Neuropathologic correlates of psychiatric symptoms in Alzheimer\u2019s disease","volume":"1","author":"Ehrenberg","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tins.2024.09.004_bb0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2019.10.008","article-title":"Apathy and anxiety are early markers of Alzheimer\u2019s disease","volume":"85","author":"Johansson","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0165","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/nan.12387","article-title":"Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer\u2019s disease","volume":"43","author":"Ehrenberg","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.tins.2024.09.004_bb0170","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bpa.12289","article-title":"Precortical phases of AD","volume":"26","author":"Stratmann","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.tins.2024.09.004_bb0175","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jalz.2016.06.2362","article-title":"Locus coeruleus volume and cell population changes during Alzheimer\u2019s disease progression: a stereological study in human postmortem brains with potential implication for early-stage biomarker discovery","volume":"13","author":"Theofilas","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0180","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1093\/brain\/awx232","article-title":"Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer\u2019s disease","volume":"140","author":"Rorabaugh","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.tins.2024.09.004_bb0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13195-019-0511-2","article-title":"An experimental model of Braak\u2019s pretangle proposal for the origin of Alzheimer\u2019s disease: the role of locus coeruleus in early symptom development","volume":"11","author":"Ghosh","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.tins.2024.09.004_bb0190","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1172\/JCI130513","article-title":"Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus","volume":"130","author":"Kang","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tins.2024.09.004_bb0195","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41380-019-0437-x","article-title":"Alzheimer\u2019s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms","volume":"26","author":"Jacobs","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.tins.2024.09.004_bb0200","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neurobiolaging.2017.09.024","article-title":"Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer\u2019s disease","volume":"61","author":"Pentkowski","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0205","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neurobiolaging.2023.01.016","article-title":"Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer\u2019s disease","volume":"125","author":"Kelberman","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0210","article-title":"Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects","volume":"7","author":"Omoluabi","year":"2021","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Intervent."},{"key":"10.1016\/j.tins.2024.09.004_bb0215","doi-asserted-by":"crossref","first-page":"14727","DOI":"10.1038\/ncomms14727","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2024.09.004_bb0220","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-020-00194-2","article-title":"Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer\u2019s disease mice","volume":"9","author":"Ai","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.tins.2024.09.004_bb0225","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/brain\/awad300","article-title":"Neuromelanin-sensitive MRI as a promising biomarker of catecholamine function","volume":"147","author":"Trujillo","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.tins.2024.09.004_bb0230","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1093\/brain\/awz193","article-title":"Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases","volume":"142","author":"Betts","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.tins.2024.09.004_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj2511","article-title":"In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer\u2019s disease pathology and cognitive decline","volume":"13","author":"Jacobs","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tins.2024.09.004_bb0240","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/alz.12656","article-title":"Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer\u2019s disease","volume":"19","author":"Jacobs","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0245","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s43587-024-00626-y","article-title":"Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition","volume":"4","author":"Bueichek\u00fa","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0250","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41386-022-01293-6","article-title":"Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer\u2019s disease","volume":"47","author":"Cassidy","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tins.2024.09.004_bb0255","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/alz.12261","article-title":"MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction","volume":"17","author":"Elman","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0260","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00429-024-02797-1","article-title":"The degeneration of locus coeruleus occurring during Alzheimer\u2019s disease clinical progression: a neuroimaging follow-up investigation","volume":"229","author":"Galgani","year":"2024","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.tins.2024.09.004_bb0265","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1038\/s41467-022-28986-2","article-title":"Lower novelty-related locus coeruleus function is associated with A\u03b2-related cognitive decline in clinically healthy individuals","volume":"13","author":"Prokopiou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2024.09.004_bb0270","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neurobiolaging.2018.08.012","article-title":"In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer\u2019s disease","volume":"72","author":"Serra","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0275","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nbd.2017.05.007","article-title":"Molecular imaging of serotonin degeneration in mild cognitive impairment","volume":"105","author":"Smith","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2024.09.004_bb0280","doi-asserted-by":"crossref","DOI":"10.1002\/syn.22235","article-title":"Decreased 5-HT1A binding in mild Alzheimer\u2019s disease \u2013 a positron emission tomography study","volume":"76","author":"Mattsson","year":"2022","journal-title":"Synapse"},{"key":"10.1016\/j.tins.2024.09.004_bb0285","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1002\/hbm.23595","article-title":"Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment","volume":"38","author":"Barrett","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.tins.2024.09.004_bb0290","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JAD-230570","article-title":"Serotonin degeneration and amyloid-\u03b2 deposition in mild cognitive impairment: relationship to cognitive deficits","volume":"96","author":"Smith","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tins.2024.09.004_bb0295","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13195-021-00925-1","article-title":"In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer\u2019s disease phases","volume":"13","author":"Sala","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.tins.2024.09.004_bb0300","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1002\/alz.13379","article-title":"Effects of amyloid beta and dopaminergic depletion on perfusion and clinical symptoms","volume":"19","author":"Lee","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0305","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41386-022-01269-6","article-title":"Associations among locus coeruleus catecholamines, tau pathology, and memory in aging","volume":"47","author":"Ciampa","year":"2022","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.tins.2024.09.004_bb0310","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1093\/cercor\/bhab379","article-title":"Elevated dopamine synthesis as a mechanism of cognitive resilience in aging","volume":"32","author":"Ciampa","year":"2021","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.tins.2024.09.004_bb0315","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1093\/brain\/awab452","article-title":"A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment","volume":"145","author":"Levey","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.tins.2024.09.004_bb0320","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3233\/JAD-170387","article-title":"Serotonin selective reuptake inhibitor treatment improves cognition and grey matter atrophy but not amyloid burden during two-year follow-up in mild cognitive impairment and Alzheimer\u2019s disease patients with depressive symptoms","volume":"65","author":"Brendel","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tins.2024.09.004_bb0325","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1017\/S135561772200042X","article-title":"Unsupervised high-frequency smartphone-based cognitive assessments are reliable, valid, and feasible in older adults at risk for Alzheimer\u2019s disease","volume":"29","author":"Nicosia","year":"2023","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.tins.2024.09.004_bb0330","article-title":"Current advances in digital cognitive assessment for preclinical Alzheimer\u2019s disease","volume":"13","author":"\u00d6hman","year":"2021","journal-title":"Alzheimer\u2019s Dement. Diagn. Assess. Dis. Monit."},{"key":"10.1016\/j.tins.2024.09.004_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.clinpsy.3.022806.091415","article-title":"Ecological momentary assessment","volume":"4","author":"Shiffman","year":"2008","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.tins.2024.09.004_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112197","article-title":"Mobile technologies in the early detection of cognitive decline","volume":"9","author":"Allard","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tins.2024.09.004_bb0345","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1037\/neu0000905","article-title":"Relationships between hourly cognitive variability and risk of Alzheimer\u2019s disease revealed with mixed-effects location scale models","volume":"38","author":"Aschenbrenner","year":"2023","journal-title":"Neuropsychology"},{"key":"10.1016\/j.tins.2024.09.004_bb0350","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.neuropsychologia.2009.01.016","article-title":"Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning","volume":"47","author":"MacDonald","year":"2009","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.tins.2024.09.004_bb0355","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1037\/a0017798","article-title":"Neural underpinnings of within-person variability in cognitive functioning","volume":"24","author":"MacDonald","year":"2009","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0360","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.trci.2017.07.001","article-title":"Neuropsychiatric signs and symptoms of Alzheimer\u2019s disease: new treatment paradigms","volume":"3","author":"Lanct\u00f4t","year":"2017","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"10.1016\/j.tins.2024.09.004_bb0365","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/2167702621992082","article-title":"Everyday emotional experiences in current and remitted major depressive disorder: an experience-sampling study","volume":"9","author":"Thompson","year":"2020","journal-title":"Clin. Psychol. Sci."},{"key":"10.1016\/j.tins.2024.09.004_bb0370","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1017\/S0033291720000689","article-title":"Affect fluctuations examined with ecological momentary assessment in patients with current or remitted depression and anxiety disorders","volume":"51","author":"Schoevers","year":"2021","journal-title":"Psychol. Med."},{"key":"10.1016\/j.tins.2024.09.004_bb0375","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neurobiolaging.2012.05.019","article-title":"A noradrenergic theory of cognitive reserve: implications for Alzheimer\u2019s disease","volume":"34","author":"Robertson","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0380","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/archneurol.2011.2748","article-title":"Association of lifetime cognitive engagement and low \u03b2-amyloid deposition","volume":"69","author":"Landau","year":"2012","journal-title":"Arch. Neurol. Chicago"},{"key":"10.1016\/j.tins.2024.09.004_bb0385","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1038\/s41380-024-02467-y","article-title":"Social activity mediates locus coeruleus tangle-related cognition in older adults","volume":"29","author":"Zide","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.tins.2024.09.004_bb0390","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1037\/pspp0000248","article-title":"How was your day? Convergence of aggregated momentary and retrospective end-of-day affect ratings across the adult life span","volume":"119","author":"Neubauer","year":"2020","journal-title":"J. Pers. Soc. Psychol."},{"key":"10.1016\/j.tins.2024.09.004_bb0395","article-title":"Features of daily social interactions that discriminate between older adults with and without mild cognitive impairment","volume":"79","author":"Zhaoyang","year":"2021","journal-title":"J. Gerontol. Ser. B Psychol. Sci. Soc. Sci."},{"key":"10.1016\/j.tins.2024.09.004_bb0400","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1093\/brain\/awab272","article-title":"Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer\u2019s disease","volume":"144","author":"Lucey","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.tins.2024.09.004_bb0405","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13195-024-01411-0","article-title":"Impaired 24-h activity patterns are associated with an increased risk of Alzheimer\u2019s disease, Parkinson\u2019s disease, and cognitive decline","volume":"16","author":"Winer","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.tins.2024.09.004_bb0410","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41746-024-00999-9","article-title":"A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices","volume":"7","author":"Berron","year":"2024","journal-title":"npj Digit. Med."},{"key":"10.1016\/j.tins.2024.09.004_bb0415","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1037\/pag0000646","article-title":"Incorporating ecological momentary assessment into multimethod investigations of cognitive aging: promise and practical considerations","volume":"37","author":"Crawford","year":"2022","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0420","article-title":"Rationale and design of the ABOARD project (a personalized medicine approach for Alzheimer\u2019s disease)","volume":"9","author":"Dreves","year":"2023","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"10.1016\/j.tins.2024.09.004_bb0425","first-page":"631","article-title":"Personalizing the care and treatment of Alzheimer\u2019s disease: an overview","volume":"14","author":"Strac","year":"2021","journal-title":"Pharmacogenomics Pers. Med."},{"key":"10.1016\/j.tins.2024.09.004_bb0430","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3233\/JAD-215546","article-title":"Consequences of hyperphosphorylated tau in the locus coeruleus on behavior and cognition in a rat model of Alzheimer\u2019s disease","volume":"86","author":"Kelberman","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tins.2024.09.004_bb0435","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neurobiolaging.2021.11.006","article-title":"Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer\u2019s disease","volume":"112","author":"Dahl","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0440","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1523\/JNEUROSCI.1483-17.2017","article-title":"Locus coeruleus ablation exacerbates cognitive deficits, neuropathology, and lethality in P301S tau transgenic mice","volume":"38","author":"Chalermpalanupap","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1236335","article-title":"Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function","volume":"15","author":"Chen","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104998","article-title":"State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer\u2019s disease: challenges and opportunities","volume":"144","author":"Engels-Dom\u00ednguez","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tins.2024.09.004_bb0455","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.neubiorev.2013.05.008","article-title":"Ascending monoaminergic systems alterations in Alzheimer\u2019s disease. Translating basic science into clinical care","volume":"37","author":"Trillo","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tins.2024.09.004_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105358","article-title":"Declining locus coeruleus\u2013dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer\u2019s disease","volume":"153","author":"Dahl","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tins.2024.09.004_bb0465","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2024.09.004_bb0470","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neurobiolaging.2022.10.015","article-title":"A framework for concepts of reserve and resilience in aging","volume":"124","author":"Stern","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.834765","article-title":"Cognitive reserve and related constructs: a unified framework across cognitive and brain dimensions of aging","volume":"14","author":"Kremen","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0480","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13195-020-00609-2","article-title":"Improving the resistance and resilience framework for aging and dementia studies","volume":"12","author":"Arenaza-Urquijo","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.tins.2024.09.004_bb0485","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1017\/S1355617723011475","article-title":"Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer\u2019s disease","volume":"30","author":"Welhaf","year":"2024","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.tins.2024.09.004_bb0490","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/1754073915590623","article-title":"Micro-level affect dynamics in psychopathology viewed from complex dynamical system theory","volume":"7","author":"Wichers","year":"2015","journal-title":"Emot. Rev."},{"key":"10.1016\/j.tins.2024.09.004_bb0495","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jrp.2016.04.002","article-title":"Intra-individual variability and psychological flexibility: affect and health in a National US sample","volume":"69","author":"Hardy","year":"2017","journal-title":"J. Res. Pers."},{"key":"10.1016\/j.tins.2024.09.004_bb0500","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1037\/pag0000779","article-title":"Long-term aging trajectories of the accumulation of disease burden as predictors of daily affect dynamics and stressor reactivity","volume":"38","author":"Gerstorf","year":"2023","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0505","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1037\/a0024756","article-title":"Changing emotion dynamics: individual differences in the effect of anticipatory social stress on emotional inertia","volume":"12","author":"Koval","year":"2012","journal-title":"Emotion (Washington, D.C.)"},{"key":"10.1016\/j.tins.2024.09.004_bb0510","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1037\/a0033579","article-title":"Affect dynamics in relation to depressive symptoms: variable, unstable or inert?","volume":"13","author":"Koval","year":"2013","journal-title":"Emotion"},{"key":"10.1016\/j.tins.2024.09.004_bb0515","first-page":"985","article-title":"Activity diversity and its associations with psychological well-being across adulthood","volume":"73","author":"Lee","year":"2016","journal-title":"J. Gerontol. B"},{"key":"10.1016\/j.tins.2024.09.004_bb0520","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/geronb\/gbaa020","article-title":"Change is good for the brain: activity diversity and cognitive functioning across adulthood","volume":"76","author":"Lee","year":"2020","journal-title":"J. Gerontol. B"},{"key":"10.1016\/j.tins.2024.09.004_bb0525","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/geronb\/gbab144","article-title":"Rich and balanced experiences of daily emotions are associated with activity diversity across adulthood","volume":"77","author":"Lee","year":"2021","journal-title":"J. Gerontol. B"},{"key":"10.1016\/j.tins.2024.09.004_bb0530","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3758\/s13415-021-00942-5","article-title":"Diversity of daily activities is associated with greater hippocampal volume","volume":"22","author":"Urban-Wojcik","year":"2022","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0535","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41593-020-0636-4","article-title":"Association between real-world experiential diversity and positive affect relates to hippocampal\u2013striatal functional connectivity","volume":"23","author":"Heller","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2024.09.004_bb0540","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1177\/09567976221102070","article-title":"Real-world exploration increases across adolescence and relates to affect, risk taking, and social connectivity","volume":"33","author":"Saragosa-Harris","year":"2022","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.tins.2024.09.004_bb0545","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1037\/abn0000888","article-title":"The affective benefits of real-world exploration during the COVID-19 pandemic","volume":"133","author":"Reneau","year":"2023","journal-title":"J. Psychopathol. Clin. Sci."},{"key":"10.1016\/j.tins.2024.09.004_bb0550","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1037\/pag0000309","article-title":"Age differences in everyday stressor-related negative affect: a coordinated analysis","volume":"34","author":"Stawski","year":"2019","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0555","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1037\/a0034000","article-title":"Age differences in emotional responses to daily stress: the role of timing, severity, and global perceived stress","volume":"28","author":"Scott","year":"2013","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.tins.2024.09.004_bb0560","first-page":"38","article-title":"Waking up on the wrong side of the bed: the effects of stress anticipation on working memory in daily life","volume":"74","author":"Hyun","year":"2018","journal-title":"J. Gerontol. Ser. B Psychol. Sci. Soc. Sci."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223624001760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223624001760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T11:07:49Z","timestamp":1731409669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223624001760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":112,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0166223624001760"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2024.09.004","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Examining resilience to Alzheimer\u2019s disease through the lens of monoaminergic neuromodulator systems","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2024.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}