{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:48:12Z","timestamp":1793828892943,"version":"4.6.1"},"reference-count":159,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY032532"],"award-info":[{"award-number":["R01EY032532"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1193925N"],"award-info":[{"award-number":["1193925N"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009550","name":"Hasselt University","doi-asserted-by":"publisher","award":["BOF24DOC49"],"award-info":[{"award-number":["BOF24DOC49"]}],"id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G036320N"],"award-info":[{"award-number":["G036320N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["W001620N"],"award-info":[{"award-number":["W001620N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["016.196.367"],"award-info":[{"award-number":["016.196.367"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013846","name":"Francqui Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["BOF22KP17"],"award-info":[{"award-number":["BOF22KP17"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.tins.2025.02.004","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T09:23:22Z","timestamp":1741944202000},"page":"268-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["MicroRNA regulation of enteric nervous system development and disease"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-4477","authenticated-orcid":false,"given":"Amy Marie","family":"Holland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-4129","authenticated-orcid":false,"given":"Reindert","family":"Jehoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5587-0431","authenticated-orcid":false,"given":"Jorunn","family":"Vranken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-7678","authenticated-orcid":false,"given":"Stefanie Gabriele","family":"Wohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-0451","authenticated-orcid":false,"given":"Werend","family":"Boesmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2025.02.004_bb0005","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00018.2022","article-title":"The enteric nervous system","volume":"103","author":"Sharkey","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tins.2025.02.004_bb0010","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1007\/s00018-021-03812-y","article-title":"The enteric nervous system in gastrointestinal disease etiology","volume":"78","author":"Holland","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ceb.2020.08.015","article-title":"The multifaceted roles of microRNAs in differentiation","volume":"67","author":"Galagali","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0020","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/dna.2006.0545","article-title":"Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny","volume":"26","author":"Lee","year":"2007","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0025","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.cell.2005.11.023","article-title":"Animal microRNAs confer robustness to gene expression and have a significant impact on 3\u2032 UTR evolution","volume":"123","author":"Stark","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cell.2012.04.005","article-title":"Roles for microRNAs in conferring robustness to biological processes","volume":"149","author":"Ebert","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tins.2025.02.004_bb0040","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1242\/dev.144337","article-title":"MicroRNAs in neural development: from master regulators to fine-tuners","volume":"144","author":"Rajman","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.tins.2025.02.004_bb0045","article-title":"miR-146b-5p regulates the enteric nervous system development in Hirschsprung disease via targeting RET pathway","author":"Zhang","year":"2024","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0050","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12519-017-0064-z","article-title":"Preliminary identification of key miRNAs, signaling pathways, and genes associated with Hirschsprung\u2019s disease by analysis of tissue microRNA expression profiles","volume":"13","author":"Gao","year":"2017","journal-title":"World J. Pediatr."},{"key":"10.1016\/j.tins.2025.02.004_bb0055","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.3390\/ijms24076700","article-title":"Up-regulation of microRNA-424 causes an imbalance in AKT phosphorylation and impairs enteric neural crest cell migration in Hirschsprung disease","volume":"24","author":"Xu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0060","doi-asserted-by":"crossref","first-page":"336","DOI":"10.55782\/ane-2022-032","article-title":"miR-92a represses the viability and migration of nerve cells in Hirschsprung\u2019s disease by regulating the KLF4\/PI3K\/AKT pathway","volume":"82","author":"Ji","year":"2022","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"10.1016\/j.tins.2025.02.004_bb0065","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nsmb.1576","article-title":"A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination","volume":"16","author":"Zhao","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0070","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.devcel.2012.03.003","article-title":"miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors","volume":"22","author":"Coolen","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0075","article-title":"Interindividual variation in gut nitrergic neuron density is regulated by GDNF levels and ETV1","volume":"18","author":"Virtanen","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tins.2025.02.004_bb0080","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41390-021-01860-5","article-title":"Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p\/RET axis","volume":"92","author":"Xia","year":"2022","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0085","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/jcmm.12454","article-title":"SLIT 2\/ROBO 1-miR-218-1-RET\/PLAG 1: a new disease pathway involved in Hirschsprung\u2019s disease","volume":"19","author":"Tang","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0090","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2017.01.006","article-title":"Enteric nervous system development: a crest cell\u2019s journey from neural tube to colon","volume":"66","author":"Nagy","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41586-020-1975-8","article-title":"Neuronal programming by microbiota regulates intestinal physiology","volume":"578","author":"Obata","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.02.004_bb0100","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1053\/j.gastro.2017.10.005","article-title":"Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system","volume":"154","author":"Memic","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.02.004_bb0105","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0110","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.02.004_bb0120","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41576-020-00309-5","article-title":"The roles of microRNAs in mouse development","volume":"22","author":"DeVeale","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0125","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan microRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0130","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1093\/nar\/gkm641","article-title":"Tissue-dependent paired expression of miRNAs","volume":"35","author":"Ro","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0145","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ng1969","article-title":"DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal","volume":"39","author":"Wang","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0150","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development","volume":"35","author":"Bernstein","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0155","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ng1251","article-title":"The microRNA-producing enzyme Dicer1 is essential for zebrafish development","volume":"35","author":"Wienholds","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0160","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cub.2009.12.044","article-title":"MicroRNA function is globally suppressed in mouse oocytes and early embryos","volume":"20","author":"Suh","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0165","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ydbio.2010.01.039","article-title":"Dicer is required for survival of differentiating neural crest cells","volume":"340","author":"Zehir","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0170","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/jmcb\/mjq008","article-title":"Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice","volume":"2","author":"Huang","year":"2010","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0175","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1038\/s41467-023-41492-3","article-title":"A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia","volume":"14","author":"Laddach","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.02.004_bb0180","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1101\/gad.1248505","article-title":"Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing","volume":"19","author":"Kanellopoulou","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.tins.2025.02.004_bb0185","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","article-title":"Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression","volume":"135","author":"Nishino","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0190","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.3390\/cancers13215528","article-title":"A focus on regulatory networks linking microRNAs, transcription factors and target genes in neuroblastoma","volume":"13","author":"Perri","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.tins.2025.02.004_bb0195","first-page":"1","article-title":"Sequencing reveals miRNAs enriched in the developing mouse enteric nervous system","volume":"10","author":"Pai","year":"2023","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.tins.2025.02.004_bb0200","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/gb-2004-5-9-r68","article-title":"Microarray analysis of microRNA expression in the developing mammalian brain","volume":"5","author":"Miska","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0205","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2004-5-3-r13","article-title":"Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation","volume":"5","author":"Sempere","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0210","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nn.2294","article-title":"miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche","volume":"12","author":"Cheng","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2025.02.004_bb0215","doi-asserted-by":"crossref","first-page":"20788","DOI":"10.1074\/jbc.M113.525493","article-title":"MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression","volume":"289","author":"Neo","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2025.02.004_bb0220","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature10323","article-title":"MicroRNA-mediated conversion of human fibroblasts to neurons","volume":"476","author":"Yoo","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.02.004_bb0225","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrgastro.2017.149","article-title":"Hirschsprung disease \u2013 integrating basic science and clinical medicine to improve outcomes","volume":"15","author":"Heuckeroth","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tins.2025.02.004_bb0230","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ydbio.2016.07.008","article-title":"Genetics of enteric neuropathies","volume":"417","author":"Brosens","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0235","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/cge.13615","article-title":"What is new about the genetic background of Hirschsprung disease?","volume":"97","author":"Luz\u00f3n-Toro","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0240","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2217\/pme-2021-0001","article-title":"miR-938rs2505901 T>C polymorphism increases Hirschsprung disease risk: a case-control study of Chinese children","volume":"18","author":"Zhong","year":"2021","journal-title":"Per. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0245","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20193989","article-title":"miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children","volume":"40","author":"Zheng","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.tins.2025.02.004_bb0250","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520961680","article-title":"Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children","volume":"48","author":"Zheng","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0255","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.yexmp.2014.11.004","article-title":"A common polymorphism in pre-miR-146a underlies Hirschsprung disease risk in Han Chinese","volume":"97","author":"Zhu","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tins.2025.02.004_bb0260","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3301","article-title":"Associations between common genetic variants in microRNAs and Hirschsprung disease susceptibility in Southern Chinese children","volume":"23","author":"Wu","year":"2021","journal-title":"J. Gene Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0265","article-title":"miRNA profiling reveals dysregulation of RET and RET-regulating pathways in Hirschsprung\u2019s disease","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tins.2025.02.004_bb0270","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrc3680","article-title":"RET revisited: expanding the oncogenic portfolio","volume":"14","author":"Mulligan","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tins.2025.02.004_bb0275","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41583-018-0041-0","article-title":"Enteric nervous system development: what could possibly go wrong?","volume":"19","author":"Rao","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tins.2025.02.004_bb0280","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1007\/s11010-021-04055-y","article-title":"MiR-195-5p inhibits proliferation and invasion of nerve cells in Hirschsprung disease by targeting GFRA4","volume":"476","author":"Wang","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tins.2025.02.004_bb0285","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1089\/dna.2017.3821","article-title":"Downregulation of microRNA-483-5p promotes cell proliferation and invasion by targeting GFRA4 in Hirschsprung\u2019s disease","volume":"36","author":"Wang","year":"2017","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0290","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1080\/15384101.2018.1480210","article-title":"Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1","volume":"17","author":"Zhou","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.tins.2025.02.004_bb0295","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/jcmm.12799","article-title":"Suppressive action of miRNAs to ARP 2\/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease","volume":"20","author":"Tang","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0300","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1159\/000363021","article-title":"Decreased MiR-200a\/141 suppress cell migration and proliferation by targeting PTEN in Hirschsprung\u2019s disease","volume":"34","author":"Li","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tins.2025.02.004_bb0305","doi-asserted-by":"crossref","first-page":"808","DOI":"10.18632\/oncotarget.13656","article-title":"Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung\u2019s disease","volume":"8","author":"Peng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tins.2025.02.004_bb0310","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.7150\/ijms.18392","article-title":"LncRNA AFAP1-AS functions as a competing endogenous RNA to regulate RAP1B expression by sponging miR-181a in the HSCR","volume":"14","author":"Chen","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0315","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00383-022-05337-2","article-title":"Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung\u2019s disease by targeting mTOR","volume":"39","author":"Daiyue","year":"2022","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.tins.2025.02.004_bb0320","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12489","article-title":"Long non-coding RNA FAL 1 functions as a ceRNA to antagonize the effect of miR-637 on the down-regulation of AKT 1 in Hirschsprung\u2019s disease","volume":"51","author":"Li","year":"2018","journal-title":"Cell Prolif."},{"key":"10.1016\/j.tins.2025.02.004_bb0325","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1038\/onc.2014.419","article-title":"Decreased miRNA-637 is an unfavorable prognosis marker and promotes glioma cell growth, migration and invasion via direct targeting Akt1","volume":"34","author":"Que","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.tins.2025.02.004_bb0330","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41390-019-0324-9","article-title":"Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2","volume":"86","author":"Wu","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174273","article-title":"miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway","volume":"906","author":"Gheidari","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tins.2025.02.004_bb0340","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.143.5.1375","article-title":"Tumor suppressor PTEN inhibits integrin-and growth factor\u2013mediated mitogen-activated protein (MAP) kinase signaling pathways","volume":"143","author":"Gu","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006439","article-title":"A novel Zebrafish ret heterozygous model of Hirschsprung disease identifies a functional role for mapk10 as a modifier of enteric nervous system phenotype severity","volume":"12","author":"Heanue","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0350","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/jmedgenet-2019-106615","article-title":"MicroRNA-4516-mediated regulation of MAPK10 relies on 3\u2032 UTR cis-acting variants and contributes to the altered risk of Hirschsprung disease","volume":"57","author":"Wang","year":"2020","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0355","doi-asserted-by":"crossref","first-page":"W409","DOI":"10.1093\/nar\/gkab297","article-title":"miRTargetLink 2.0 \u2013 interactive miRNA target gene and target pathway networks","volume":"49","author":"Kern","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0360","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00383-020-04686-0","article-title":"Downregulation of miR-140-5p affects the pathogenesis of HSCR by targeting EGR2","volume":"36","author":"Du","year":"2020","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.tins.2025.02.004_bb0365","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1159\/000356601","article-title":"Aberrant reduction of MiR-141 increased CD47\/CUL3 in Hirschsprung\u2019s disease","volume":"32","author":"Tang","year":"2013","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.tins.2025.02.004_bb0370","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.3892\/mmr.2014.2022","article-title":"Study of the effect of miR-124 and the SOX9 target gene in Hirschsprung\u2019s disease","volume":"9","author":"Mi","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tins.2025.02.004_bb0375","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1111\/jcmm.13652","article-title":"Lipopolysaccharide enhances ADAR2 which drives Hirschsprung\u2019s disease by impairing miR-142-3p biogenesis","volume":"22","author":"Peng","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0380","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/jnc.13118","article-title":"Nidogen-1 is a common target of microRNAs MiR-192\/215 in the pathogenesis of Hirschsprung\u2019s disease","volume":"134","author":"Zhu","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tins.2025.02.004_bb0385","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41390-021-01872-1","article-title":"Hirschsprung\u2019s disease: key microRNAs and target genes","volume":"92","author":"Hong","year":"2022","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0390","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00383-023-05530-x","article-title":"Downregulation of miR-144 blocked the proliferation and invasion of nerve cells in Hirschsprung disease by regulating transcription factor AP 4 (TFAP4)","volume":"39","author":"Zheng","year":"2023","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.tins.2025.02.004_bb0395","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13023-018-0973-5","article-title":"Aberrant expressions of miRNA-206 target, FN1, in multifactorial Hirschsprung disease","volume":"14","author":"Gunadi","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.tins.2025.02.004_bb0400","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/jcmm.12348","article-title":"Specific serum micro RNA profile in the molecular diagnosis of Hirschsprung\u2019s disease","volume":"18","author":"Tang","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0405","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1111\/jcmm.13756","article-title":"IGF2-derived miR-483-3p associated with Hirschsprung\u2019s disease by targeting FHL1","volume":"22","author":"Zhi","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0410","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1159\/000453214","article-title":"Role of MiR-215 in Hirschsprung\u2019s disease pathogenesis by targeting SIGLEC-8","volume":"40","author":"Lei","year":"2016","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.tins.2025.02.004_bb0415","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1113\/EP088780","article-title":"Involvement of the lncRNA AFAP1-AS1\/microRNA-195\/E2F3 axis in proliferation and migration of enteric neural crest stem cells of Hirschsprung\u2019s disease","volume":"105","author":"Pan","year":"2020","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.tins.2025.02.004_bb0420","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-230X-14-123","article-title":"MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung\u2019s disease","volume":"14","author":"Lei","year":"2014","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.tins.2025.02.004_bb0425","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1002\/jcb.26830","article-title":"Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung\u2019s disease","volume":"119","author":"Cai","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tins.2025.02.004_bb0430","first-page":"126","article-title":"LncRNA DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p\/ITGA6 signal axis in Hirschsprung\u2019s disease","author":"Sun","year":"2021","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0435","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.chemosphere.2015.09.019","article-title":"The relationship between prenatal exposure to BP-3 and Hirschsprung\u2019s disease","volume":"144","author":"Huo","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.tins.2025.02.004_bb0440","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/dgd.12606","article-title":"Downregulation of microRNA-431-5p promotes enteric neural crest cell proliferation via targeting LRSAM1 in Hirschsprung\u2019s disease","volume":"61","author":"Hu","year":"2019","journal-title":"Develop. Growth Differ."},{"key":"10.1016\/j.tins.2025.02.004_bb0445","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.18632\/aging.101331","article-title":"MicroRNA-939 inhibits cell proliferation via targeting LRSAM1 in Hirschsprung\u2019s disease","volume":"9","author":"Chen","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.tins.2025.02.004_bb0450","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/jcmm.13108","article-title":"Persistent distention of colon damages interstitial cells of Cajal through Ca2+-ERK-AP-1-miR-34c-SCF deregulation","volume":"21","author":"Yang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0455","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2217\/epi-2019-0190","article-title":"Molecular function predictions and diagnostic value analysis of plasma exosomal miRNAs in Hirschsprung\u2019s disease","volume":"12","author":"Lv","year":"2020","journal-title":"Epigenomics"},{"key":"10.1016\/j.tins.2025.02.004_bb0460","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.3748\/wjg.v17.i45.4937","article-title":"Genetic interactions and modifier genes in Hirschsprung\u2019s disease","volume":"17","author":"Wallace","year":"2011","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.tins.2025.02.004_bb0465","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009106","article-title":"A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease","volume":"16","author":"Mederer","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0470","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00439-011-1035-4","article-title":"Mutations in the NRG1 gene are associated with Hirschsprung disease","volume":"131","author":"Tang","year":"2012","journal-title":"Hum. Genet."},{"key":"10.1016\/j.tins.2025.02.004_bb0475","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1073\/pnas.0809630105","article-title":"Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung\u2019s disease","volume":"106","author":"Garcia-Barcelo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.02.004_bb0480","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"miRDB: an online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0485","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1073\/pnas.0602152103","article-title":"Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes","volume":"103","author":"Heanue","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.02.004_bb0490","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3892\/mmr.2012.946","article-title":"microRNA-146a targets the L1 cell adhesion molecule and suppresses the metastatic potential of gastric cancer","volume":"6","author":"Hou","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tins.2025.02.004_bb0495","article-title":"Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung\u2019s disease","volume":"17","author":"Sreepada","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.tins.2025.02.004_bb0500","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/gut.2009.200444","article-title":"The London classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group","volume":"59","author":"Knowles","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.tins.2025.02.004_bb0505","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ajmg.a.20470","article-title":"Neuronal dysplasia: a controversial pathological correlate of intestinal pseudo-obstruction","volume":"122A","author":"Kapur","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.tins.2025.02.004_bb0510","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54245-4","article-title":"Identification of potential molecular pathogenesis mechanisms modulated by microRNAs in patients with Intestinal neuronal dysplasia type B","volume":"9","author":"Angelini","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2025.02.004_bb0515","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/1567202617666191223150510","article-title":"MicroRNA-451 aggravates kainic acid-induced seizure and neuronal apoptosis by targeting GDNF","volume":"17","author":"Weng","year":"2020","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0520","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2016.06.004","article-title":"miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy","volume":"433","author":"Sun","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tins.2025.02.004_bb0525","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.20101823","article-title":"miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice","volume":"208","author":"Boldin","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0530","doi-asserted-by":"crossref","first-page":"28556","DOI":"10.18632\/oncotarget.5597","article-title":"MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis","volume":"6","author":"Runtsch","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.tins.2025.02.004_bb0535","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150088","article-title":"Role of miRNA-146 in proliferation and differentiation of mouse neural stem cells","volume":"35","author":"Xiao","year":"2015","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.tins.2025.02.004_bb0540","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1038\/s41467-021-22641-y","article-title":"MicroRNA-146a limits tumorigenic inflammation in colorectal cancer","volume":"12","author":"Garo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.02.004_bb0545","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.651692","article-title":"MiRNA-146a\/AKT\/beta-catenin activation regulates cancer stem cell phenotype in oral squamous cell carcinoma by targeting CD24","volume":"11","author":"Ghuwalewala","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tins.2025.02.004_bb0550","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/biom12121849","article-title":"Enteric neuromyopathies: highlights on genetic mechanisms underlying chronic intestinal pseudo-obstruction","volume":"12","author":"Bianco","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.tins.2025.02.004_bb0555","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.283.5402.689","article-title":"Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder","volume":"283","author":"Nishino","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.tins.2025.02.004_bb0560","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.3390\/ijms22073681","article-title":"Circulating miRNAs as biomarkers for mitochondrial neuro-gastrointestinal encephalomyopathy","volume":"22","author":"Mencias","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0565","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1007\/s11064-019-02772-x","article-title":"Inhibition of microRNA-34a suppresses epileptiform discharges through regulating notch signaling and apoptosis in cultured hippocampal neurons","volume":"44","author":"Wang","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0570","doi-asserted-by":"crossref","first-page":"110209","DOI":"10.18632\/oncotarget.22597","article-title":"MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2","volume":"8","author":"Fan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tins.2025.02.004_bb0575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000356305","article-title":"Hedgehog and Notch signaling in enteric nervous system development","volume":"22","author":"Liu","year":"2014","journal-title":"Neurosignals"},{"key":"10.1016\/j.tins.2025.02.004_bb0580","doi-asserted-by":"crossref","first-page":"G668","DOI":"10.1152\/ajpgi.00222.2021","article-title":"Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types","volume":"321","author":"Shanahan","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tins.2025.02.004_bb0585","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1093\/ecco-jcc\/jjae108","article-title":"The microRNA expression in crypt-top and crypt-bottom colonic epithelial cell populations demonstrates cell-type specificity and correlates with endoscopic activity in ulcerative colitis","volume":"18","author":"Inciuraite","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.tins.2025.02.004_bb0590","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1053\/j.gastro.2008.07.068","article-title":"MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha","volume":"135","author":"Wu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.02.004_bb0595","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1179161","article-title":"Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action","volume":"14","author":"Wan","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tins.2025.02.004_bb0600","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149464","article-title":"LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction","volume":"132","author":"Ahmadzai","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tins.2025.02.004_bb0605","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3390\/cancers11091369","article-title":"MicroRNA regulation of the autotaxin-lysophosphatidic acid signaling axis","volume":"11","author":"Murph","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tins.2025.02.004_bb0610","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.02.004_bb0615","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14995","article-title":"Gut neuropathies and intestinal motility disorders","author":"Wattchow","year":"2025","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.tins.2025.02.004_bb0620","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41575-021-00561-y","article-title":"Gut feelings: mechanosensing in the gastrointestinal tract","volume":"19","author":"Mercado-Perez","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tins.2025.02.004_bb0625","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1053\/gast.2002.30346","article-title":"Sodium current in human jejunal circular smooth muscle cells","volume":"122","author":"Holm","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.02.004_bb0630","doi-asserted-by":"crossref","first-page":"C60","DOI":"10.1152\/ajpcell.00532.2001","article-title":"Cytoskeletal modulation of sodium current in human jejunal circular smooth muscle cells","volume":"284","author":"Strege","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tins.2025.02.004_bb0635","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/gutjnl-2019-318747","article-title":"microRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility","volume":"69","author":"Mazzone","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.tins.2025.02.004_bb0640","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.hrthm.2015.02.018","article-title":"Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice","volume":"12","author":"Daimi","year":"2015","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.tins.2025.02.004_bb0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123436","article-title":"Ion channel expression in the developing enteric nervous system","volume":"10","author":"Hirst","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tins.2025.02.004_bb0650","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1111\/jcmm.13269","article-title":"microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2025.02.004_bb0655","first-page":"7578","article-title":"miR-551b-5p increases intracellular Ca2+ concentration but does not alter c-Kit expression in rat interstitial cells of Cajal","volume":"10","author":"Ke","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.tins.2025.02.004_bb0660","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12664-020-01143-7","article-title":"miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of Cajal isolated from slow transit constipation rats by targeting c-kit","volume":"40","author":"Zheng","year":"2021","journal-title":"Indian J. Gastroenterol."},{"key":"10.1016\/j.tins.2025.02.004_bb0665","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1053\/j.gastro.2020.12.062","article-title":"miR-10b-5p rescues diabetes and gastrointestinal dysmotility","volume":"160","author":"Singh","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.02.004_bb0670","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.3390\/ijms25031942","article-title":"Role of microRNAs in immune regulation with translational and clinical applications","volume":"25","author":"Ga\u00e1l","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0675","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1007\/s10620-015-3612-1","article-title":"The relationship between colonic macrophages and microRNA-128 in the pathogenesis of slow transit constipation","volume":"60","author":"Liu","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0680","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","article-title":"CSF-1 regulation of the wandering macrophage: complexity in action","volume":"14","author":"Pixley","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0685","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108100","article-title":"Enteric glia modulate macrophage phenotype and visceral sensitivity following inflammation","volume":"32","author":"Grubisic","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2025.02.004_bb0695","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.07.048","article-title":"Self-maintaining gut macrophages are essential for intestinal homeostasis","volume":"175","author":"De Schepper","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.02.004_bb0700","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.2005.073197","article-title":"The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation","volume":"55","author":"Bassotti","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.tins.2025.02.004_bb0705","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s12035-023-03600-8","article-title":"MiR-26b-3p promotes intestinal motility disorder by targeting FZD10 to inhibit GSK3\u03b2\/\u03b2-catenin signaling and induce enteric glial cell apoptosis","volume":"61","author":"Zhan","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tins.2025.02.004_bb0710","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41572-022-00356-8","article-title":"Achalasia","volume":"8","author":"Savarino","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.tins.2025.02.004_bb0715","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13764","article-title":"microRNA-mRNA network model in patients with achalasia","volume":"32","author":"Palmieri","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.tins.2025.02.004_bb0720","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3390\/ijms24010668","article-title":"Downexpression of miR-200c-3p contributes to achalasia disease by targeting the PRKG1 gene","volume":"24","author":"Micale","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tins.2025.02.004_bb0725","first-page":"245","article-title":"Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype","volume":"34","author":"Boerth","year":"1997","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0730","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ydbio.2007.08.053","article-title":"Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration","volume":"311","author":"Langsdorf","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0735","doi-asserted-by":"crossref","first-page":"8721","DOI":"10.1073\/pnas.0602831103","article-title":"Myogenic factors that regulate expression of muscle-specific microRNAs","volume":"103","author":"Rao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.02.004_bb0740","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/ijc.25284","article-title":"miR-145, miR-133a and miR-133b: tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma","volume":"127","author":"Kano","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tins.2025.02.004_bb0745","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3390\/cancers13235874","article-title":"The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers","volume":"13","author":"Cavallari","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tins.2025.02.004_bb0750","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/gcc.21934","article-title":"The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett\u2019s esophageal carcinogenesis","volume":"51","author":"Leidner","year":"2012","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.tins.2025.02.004_bb0755","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/j.gastro.2013.10.053","article-title":"MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice","volume":"146","author":"Nezami","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.02.004_bb0760","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tins.2025.02.004_bb0765","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41580-020-0251-y","article-title":"RNA delivery by extracellular vesicles in mammalian cells and its applications","volume":"21","author":"O\u2019Brien","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tins.2025.02.004_bb0770","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/ecco-jcc\/jjaa179","article-title":"Extracellular vesicles in inflammatory bowel disease: small particles, big players","volume":"15","author":"Valter","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.tins.2025.02.004_bb0775","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41575-020-00377-2","article-title":"The enteric nervous system: the hub in a star network","volume":"17","author":"Bon-Frauches","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tins.2025.02.004_bb0780","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-0716-2823-2","article-title":"MicroRNA profiling methods and protocols","author":"Rani","year":"2023"},{"key":"10.1016\/j.tins.2025.02.004_bb0785","doi-asserted-by":"crossref","first-page":"D304","DOI":"10.1093\/nar\/gkad1071","article-title":"TarBase-v9.0 extends experimentally supported miRNA-gene interactions to cell-types and virally encoded miRNAs","volume":"52","author":"Skoufos","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tins.2025.02.004_bb0790","doi-asserted-by":"crossref","first-page":"19291","DOI":"10.1073\/pnas.0709971104","article-title":"A biochemical approach to identifying microRNA targets","volume":"104","author":"Karginov","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.02.004_bb0795","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019","volume":"438","author":"Krutzfeldt","year":"2005","journal-title":"Nature"}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223625000359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223625000359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:29:30Z","timestamp":1778725770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223625000359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":159,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0166223625000359"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2025.02.004","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA regulation of enteric nervous system development and disease","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2025.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}