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Chem."},{"key":"10.1016\/j.tins.2025.04.005_bb0550","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.658244","article-title":"Striatal dopamine transporter function is facilitated by converging biology of alpha-synuclein and cholesterol","volume":"15","author":"Threlfell","year":"2021","journal-title":"Front. Cell. 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A."},{"key":"10.1016\/j.tins.2025.04.005_bb0575","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00401-021-02329-9","article-title":"The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy","volume":"142","author":"Moors","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tins.2025.04.005_bb0580","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pneurobio.2005.02.001","article-title":"Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson's disease","volume":"75","author":"Fedorow","year":"2005","journal-title":"Prog. 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