{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:14:12Z","timestamp":1792199652130,"version":"4.4.0"},"reference-count":138,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R00NS129758"],"award-info":[{"award-number":["R00NS129758"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tins.2025.08.003","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T04:48:30Z","timestamp":1758170910000},"page":"780-791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sensory signals for nausea"],"prefix":"10.1016","volume":"48","author":[{"given":"Shiling","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-6073","authenticated-orcid":false,"given":"Chuchu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2025.08.003_bb0005","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/35007149","article-title":"Stomach rinsing in rays","volume":"404","author":"Sims","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04216","article-title":"Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans","volume":"438","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0015","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2017.0647","article-title":"Successful escape of bombardier beetles from predator digestive systems","volume":"14","author":"Sugiura","year":"2018","journal-title":"Biol. Lett."},{"key":"10.1016\/j.tins.2025.08.003_bb0020","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.appet.2007.09.015","article-title":"Why is the neurobiology of nausea and vomiting so important?","volume":"50","author":"Horn","year":"2008","journal-title":"Appetite"},{"key":"10.1016\/j.tins.2025.08.003_bb0025","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1007\/s00221-014-3981-2","article-title":"Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea","volume":"232","author":"Tarbell","year":"2014","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.tins.2025.08.003_bb0030","article-title":"Gastrointestinal side effects of cancer treatments","volume":"11","author":"O'Reilly","year":"2020","journal-title":"Ther Adv. Chronic Dis."},{"key":"10.1016\/j.tins.2025.08.003_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2024.100472","article-title":"Obesity medications: a narrative review of current and emerging agents","volume":"6","author":"Qi","year":"2024","journal-title":"Osteoarthr. Cartil. Open"},{"key":"10.1016\/j.tins.2025.08.003_bb0040","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1093\/bja\/69.supplement_1.2S","article-title":"Physiology of nausea and vomiting","volume":"69","author":"Andrews","year":"1992","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.tins.2025.08.003_bb0045","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.autneu.2006.01.008","article-title":"Signals for nausea and emesis: implications for models of upper gastrointestinal diseases","volume":"125","author":"Andrews","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.tins.2025.08.003_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/1c75cd5d-9dde-4ace-8524-a4980745e804","article-title":"Why can't rodents vomit? A comparative behavioral, anatomical, and physiological study","volume":"8","author":"Horn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tins.2025.08.003_bb0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3758\/BF03195979","article-title":"Taste avoidance and taste aversion: evidence for two different processes","volume":"31","author":"Parker","year":"2003","journal-title":"Learn. Behav."},{"key":"10.1016\/j.tins.2025.08.003_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304933120","article-title":"Vestibular CCK signaling drives motion sickness-like behavior in mice","volume":"120","author":"Machuca-Marquez","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.08.003_bb0065","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0014-4886(86)90312-2","article-title":"Motion sickness reflex arc bypasses the area postrema in cats","volume":"92","author":"Borison","year":"1986","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.tins.2025.08.003_bb0070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0301-0082(89)90028-2","article-title":"Area postrema: chemoreceptor circumventricular organ of the medulla oblongata","volume":"32","author":"Borison","year":"1989","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0075","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/1073858407311100","article-title":"The area postrema: a brain monitor and integrator of systemic autonomic state","volume":"14","author":"Price","year":"2008","journal-title":"Neuroscientist"},{"key":"10.1016\/j.tins.2025.08.003_bb0080","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2020.11.010","article-title":"Area postrema cell types that mediate nausea-associated behaviors","volume":"109","author":"Zhang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2025.08.003_bb0085","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s42255-021-00363-1","article-title":"A genetic map of the mouse dorsal vagal complex and its role in obesity","volume":"3","author":"Ludwig","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tins.2025.08.003_bb0090","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-024-07685-6","article-title":"Dissociable hindbrain GLP1R circuits for satiety and aversion","volume":"632","author":"Huang","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113960","article-title":"Activation of GFRAL(+) neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor","volume":"43","author":"Engstrom Ruud","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2025.08.003_bb0100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55164","article-title":"The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling","volume":"9","author":"Worth","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.tins.2025.08.003_bb0105","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/nmo.12821","article-title":"Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew","volume":"28","author":"Horn","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.tins.2025.08.003_bb0110","doi-asserted-by":"crossref","first-page":"R341","DOI":"10.1152\/ajpregu.00413.2013","article-title":"Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews","volume":"306","author":"Horn","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0115","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1111\/j.1462-5822.2007.00957.x","article-title":"Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is downregulated by cannabinoid receptor 1","volume":"9","author":"Hu","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1988.sp016905","article-title":"Vagally mediated gastric motor and emetic reflexes evoked by stimulation of the antral mucosa in anaesthetized ferrets","volume":"395","author":"Andrews","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","article-title":"Sensory neurons that detect stretch and nutrients in the digestive system","volume":"166","author":"Williams","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.08.003_bb0130","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cell.2020.03.004","article-title":"An airway protection program revealed by sweeping genetic control of vagal afferents","volume":"181","author":"Prescott","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.08.003_bb0135","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2019.10.031","article-title":"Genetic identification of vagal sensory neurons that control feeding","volume":"179","author":"Bai","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.08.003_bb0140","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s41586-022-05266-z","article-title":"Gut-brain circuits for fat preference","volume":"610","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0145","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41586-020-2199-7","article-title":"The gut-brain axis mediates sugar preference","volume":"580","author":"Tan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0150","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41586-022-05139-5","article-title":"A brainstem map for visceral sensations","volume":"609","author":"Ran","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0155","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41593-024-01828-8","article-title":"Parallel gut-to-brain pathways orchestrate feeding behaviors","volume":"28","author":"Wang","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2025.08.003_bb0160","article-title":"Brain circuits for retching-like behavior","volume":"11","author":"Huo","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.tins.2025.08.003_bb0165","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1016\/j.cell.2022.10.001","article-title":"The gut-to-brain axis for toxin-induced defensive responses","volume":"185","author":"Xie","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.08.003_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11905","article-title":"Genetically and functionally defined NTS to PBN brain circuits mediating anorexia","volume":"7","author":"Roman","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.08.003_bb0175","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tins.2018.03.007","article-title":"The parabrachial nucleus: CGRP neurons function as a general alarm","volume":"41","author":"Palmiter","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tins.2025.08.003_bb0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.autneu.2013.07.006","article-title":"Novel dynamic measures of emetic behavior in musk shrews","volume":"179","author":"Horn","year":"2013","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.tins.2025.08.003_bb0185","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1007\/s00221-014-3985-y","article-title":"Measuring the nausea-to-emesis continuum in non-human animals: refocusing on gastrointestinal vagal signaling","volume":"232","author":"Horn","year":"2014","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.tins.2025.08.003_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1077207","article-title":"Physiological changes associated with copper sulfate-induced nausea and retching in felines","volume":"14","author":"Murphey","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0195","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41593-024-01712-5","article-title":"A vagal-brainstem interoceptive circuit for cough-like defensive behaviors in mice","volume":"27","author":"Gannot","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2025.08.003_bb0200","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-weekly semaglutide in adults with overweight or obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tins.2025.08.003_bb0205","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1001\/jama.2021.1831","article-title":"Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 randomized clinical trial","volume":"325","author":"Wadden","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.tins.2025.08.003_bb0210","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.2337\/db17-1385","article-title":"Liraglutide modulates appetite and body weight through glucagon-like peptide 1 receptor-expressing glutamatergic neurons","volume":"67","author":"Adams","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.tins.2025.08.003_bb0215","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1172\/JCI72434","article-title":"Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect","volume":"124","author":"Sisley","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tins.2025.08.003_bb0220","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133429","article-title":"Semaglutide lowers body weight in rodents via distributed neural pathways","volume":"5","author":"Gabery","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.tins.2025.08.003_bb0225","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1038\/s42255-024-01168-8","article-title":"Molecular connectomics reveals a glucagon-like peptide 1 sensitive neural circuit for satiety","volume":"6","author":"Webster","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tins.2025.08.003_bb0230","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1210\/endo.132.4.8462472","article-title":"Cholecystokinin stimulates gonadotropin-releasing hormone release in the monkey (Macaca mulatta)","volume":"132","author":"Perera","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.tins.2025.08.003_bb0235","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1210\/jcem-68-4-837","article-title":"Neurohypophyseal secretion in response to cholecystokinin but not meal-induced gastric distention in humans","volume":"68","author":"Miaskiewicz","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tins.2025.08.003_bb0240","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1254\/jjp.89.324","article-title":"Vasopressin induces emesis in Suncus murinus","volume":"89","author":"Ikegaya","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.tins.2025.08.003_bb0245","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0196-9781(85)90028-2","article-title":"Emetic effects of centrally administered angiotensin II, arginine vasopressin and neurotensin in the dog","volume":"6","author":"Wu","year":"1985","journal-title":"Peptides"},{"key":"10.1016\/j.tins.2025.08.003_bb0250","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1111\/bph.15943","article-title":"Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea","volume":"179","author":"Makwana","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tins.2025.08.003_bb0255","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.2042-7158.1989.tb06402.x","article-title":"The antiemetic profile of zacopride","volume":"41","author":"Smith","year":"1989","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.tins.2025.08.003_bb0260","first-page":"1002","article-title":"Neuropeptide Y2 receptors as drug targets for the central regulation of body weight","volume":"6","author":"Feletou","year":"2005","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.tins.2025.08.003_bb0265","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0031-9384(92)90317-U","article-title":"Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions","volume":"51","author":"Sipols","year":"1992","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.tins.2025.08.003_bb0270","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0196-9781(88)90091-5","article-title":"Autoradiographic localization of peptide YY and neuropeptide Y binding sites in the medulla oblongata","volume":"9","author":"Leslie","year":"1988","journal-title":"Peptides"},{"key":"10.1016\/j.tins.2025.08.003_bb0275","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0196-9781(89)90069-7","article-title":"Identification and characterization of the emetic effects of peptide YY","volume":"10","author":"Harding","year":"1989","journal-title":"Peptides"},{"key":"10.1016\/j.tins.2025.08.003_bb0280","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00213-009-1726-x","article-title":"In vitro and in vivo characterization of JNJ-31020028 (N-(4-4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor","volume":"208","author":"Shoblock","year":"2010","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tins.2025.08.003_bb0285","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.2337\/db21-0848","article-title":"GIPR agonism inhibits PYY-induced nausea-like behavior","volume":"71","author":"Samms","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.tins.2025.08.003_bb0290","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0295","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tins.2025.08.003_bb0300","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cmet.2019.12.004","article-title":"GDF15 induces anorexia through nausea and emesis","volume":"31","author":"Borner","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.tins.2025.08.003_bb0305","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cmet.2022.12.011","article-title":"Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist","volume":"35","author":"Benichou","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.tins.2025.08.003_bb0310","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.tins.2025.08.003_bb0315","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-019-1911-y","article-title":"GDF15 mediates the effects of metformin on body weight and energy balance","volume":"578","author":"Coll","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0320","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41467-018-03258-0","article-title":"Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum","volume":"9","author":"Fejzo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.08.003_bb0325","article-title":"Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity","author":"Fejzo","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.tins.2025.08.003_bb0330","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/1471-0528.17129","article-title":"Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum","volume":"129","author":"Fejzo","year":"2022","journal-title":"BJOG"},{"key":"10.1016\/j.tins.2025.08.003_bb0335","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41572-019-0110-3","article-title":"Nausea and vomiting of pregnancy and hyperemesis gravidarum","volume":"5","author":"Fejzo","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tins.2025.08.003_bb0340","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41586-023-06921-9","article-title":"GDF15 linked to maternal risk of nausea and vomiting during pregnancy","volume":"625","author":"Fejzo","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0345","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1128\/IAI.71.1.567-570.2003","article-title":"Induction of emetic response to staphylococcal enterotoxins in the house musk shrew (Suncus murinus)","volume":"71","author":"Hu","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tins.2025.08.003_bb0350","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0031-6997(25)07328-4","article-title":"Physiology and pharmacology of vomiting","volume":"5","author":"Borison","year":"1953","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tins.2025.08.003_bb0355","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1113\/expphysiol.2009.052001","article-title":"Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia","volume":"95","author":"Percie du Sert","year":"2010","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0360","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74964","article-title":"Enteroendocrine cell types that drive food reward and aversion","volume":"11","author":"Bai","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.tins.2025.08.003_bb0365","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejphar.2013.10.014","article-title":"Looking beyond 5-HT(3) receptors: a review of the wider role of serotonin in the pharmacology of nausea and vomiting","volume":"722","author":"Johnston","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tins.2025.08.003_bb0370","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1073\/pnas.0805323106","article-title":"TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells","volume":"106","author":"Nozawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.08.003_bb0375","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-physiol-030212-183811","article-title":"TRPA1: a gatekeeper for inflammation","volume":"75","author":"Bautista","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0380","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41586-024-08581-9","article-title":"Topological segregation of stress sensors along the gut crypt-villus axis","volume":"640","author":"Touhara","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0385","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/bph.13428","article-title":"ROS in gastrointestinal inflammation: rescue or sabotage?","volume":"174","author":"Aviello","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tins.2025.08.003_bb0390","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2165\/00003088-200038040-00001","article-title":"Metabolism and pharmacokinetics of oxazaphosphorines","volume":"38","author":"Boddy","year":"2000","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.tins.2025.08.003_bb0395","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03567-22","article-title":"Viral gastroenteritis: sickness symptoms and behavioral responses","volume":"14","author":"Hellysaz","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.tins.2025.08.003_bb0400","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1073\/pnas.94.8.3960","article-title":"The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production","volume":"94","author":"Dong","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.08.003_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002115","article-title":"Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting","volume":"7","author":"Hagbom","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tins.2025.08.003_bb0410","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41467-020-16491-3","article-title":"Human norovirus targets enteroendocrine epithelial cells in the small intestine","volume":"11","author":"Green","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.08.003_bb0415","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/827965","article-title":"Staphylococcus aureus and staphylococcal food-borne disease: an ongoing challenge in public health","volume":"2014","author":"Kadariya","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.tins.2025.08.003_bb0420","first-page":"17","article-title":"A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus","volume":"129","author":"Agata","year":"1995","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.tins.2025.08.003_bb0425","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1574-695X.2011.00924.x","article-title":"Submucosal mast cells in the gastrointestinal tract are a target of staphylococcal enterotoxin type A","volume":"64","author":"Ono","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.tins.2025.08.003_bb0430","article-title":"Stratification of enterochromaffin cells by single-cell expression analysis","author":"Song","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2025.08.003_bb0435","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3390\/ijms24010809","article-title":"Molecular mechanisms of scombroid food poisoning","volume":"24","author":"Zhernov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tins.2025.08.003_bb0440","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2007.11.055","article-title":"Histamine depolarizes neurons in the dorsal vagal complex","volume":"432","author":"Poole","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2025.08.003_bb0445","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/gut.2004.061762","article-title":"Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract","volume":"55","author":"Sander","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.tins.2025.08.003_bb0450","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ecoenv.2018.06.005","article-title":"Anorectic responses to T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol correspond to plasma elevations of neurotransmitters 5-hydroxytryptamine and substance P","volume":"161","author":"Zhang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tins.2025.08.003_bb0455","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0306-4522(01)00452-3","article-title":"Neurokinin-1 and neurokinin-3 receptors are expressed in vagal efferent neurons that innervate different parts of the gastro-intestinal tract","volume":"110","author":"Blondeau","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.tins.2025.08.003_bb0460","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1254\/jphs.91.87","article-title":"Roles of substance P and NK(1) receptor in the brainstem in the development of emesis","volume":"91","author":"Saito","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tins.2025.08.003_bb0465","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1517\/17425255.4.7.923","article-title":"Intestinal efflux transporters and drug absorption","volume":"4","author":"Murakami","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.tins.2025.08.003_bb0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.109.002014","article-title":"Xenobiotic, bile acid, and cholesterol transporters: function and regulation","volume":"62","author":"Klaassen","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tins.2025.08.003_bb0475","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/toxins14010029","article-title":"Staphylococcal enterotoxin A induces intestinal barrier dysfunction and activates NLRP3 inflammasome via NF-kappaB\/MAPK signaling pathways in mice","volume":"14","author":"Liu","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.tins.2025.08.003_bb0480","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.anai.2022.10.021","article-title":"An allergist's approach to food poisoning","volume":"130","author":"Patel","year":"2023","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.tins.2025.08.003_bb0485","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrgastro.2016.187","article-title":"Food allergy and the gut","volume":"14","author":"Nowak-Wegrzyn","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tins.2025.08.003_bb0490","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12016-019-08732-1","article-title":"Eosinophilic gastrointestinal disorders","volume":"57","author":"Gonsalves","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.tins.2025.08.003_bb0495","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022087118","article-title":"The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch","volume":"118","author":"Voisin","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2025.08.003_bb0500","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1046\/j.1365-2222.1998.00399.x","article-title":"Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients","volume":"28","author":"Asero","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.tins.2025.08.003_bb0505","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3390\/cells10071586","article-title":"Pathophysiological roles of neuro-immune interactions between enteric neurons and mucosal mast cells in the gut of food allergy mice","volume":"10","author":"Yashiro","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tins.2025.08.003_bb0510","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.bbrc.2012.12.058","article-title":"Enhancement of CGRP sensory afferent innervation in the gut during the development of food allergy in an experimental murine model","volume":"430","author":"Lee","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tins.2025.08.003_bb0515","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41586-023-06188-0","article-title":"Mast cells link immune sensing to antigen-avoidance behaviour","volume":"620","author":"Plum","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0520","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41586-023-06362-4","article-title":"Immune sensing of food allergens promotes avoidance behaviour","volume":"620","author":"Florsheim","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0525","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-020-03118-2","article-title":"Local immune response to food antigens drives meal-induced abdominal pain","volume":"590","author":"Aguilera-Lizarraga","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0530","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jaci.2015.03.025","article-title":"Non-IgE-mediated gastrointestinal food allergy","volume":"135","author":"Nowak-Wegrzyn","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.tins.2025.08.003_bb0535","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12016-018-8710-3","article-title":"IgE-mediated food allergy","volume":"57","author":"Anvari","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.tins.2025.08.003_bb0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2021.0107","article-title":"Listeria monocytogenes infections: presentation, diagnosis and treatment","volume":"82","author":"Valenti","year":"2021","journal-title":"Br. J. Hosp. Med. (Lond.)"},{"key":"10.1016\/j.tins.2025.08.003_bb0545","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-05161-7","article-title":"Brainstem ADCYAP1(+) neurons control multiple aspects of sickness behaviour","volume":"609","author":"Ilanges","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0550","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0555","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20120571","article-title":"Neural reflexes in inflammation and immunity","volume":"209","author":"Andersson","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tins.2025.08.003_bb0560","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1038\/s41467-025-59248-6","article-title":"Neural representation of cytokines by vagal sensory neurons","volume":"16","author":"Huerta","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.08.003_bb0565","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-024-07469-y","article-title":"A body-brain circuit that regulates body inflammatory responses","volume":"630","author":"Jin","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tins.2025.08.003_bb0570","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tins.2025.08.003_bb0575","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.tins.2025.08.003_bb0580","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-024-48971-1","article-title":"Area postrema neurons mediate interleukin-6 function in cancer cachexia","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2025.08.003_bb0585","doi-asserted-by":"crossref","DOI":"10.1126\/science.adm8857","article-title":"A neuroimmune circuit mediates cancer cachexia-associated apathy","volume":"388","author":"Zhu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tins.2025.08.003_bb0590","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3389\/fphar.2018.00913","article-title":"A history of drug discovery for treatment of nausea and vomiting and the implications for future research","volume":"9","author":"Sanger","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tins.2025.08.003_bb0595","first-page":"293","article-title":"Practical selection of antiemetics in the ambulatory setting","volume":"91","author":"Flake","year":"2015","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.tins.2025.08.003_bb0600","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.autneu.2006.07.011","article-title":"Nausea and nutrition","volume":"129","author":"Bischoff","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.tins.2025.08.003_bb0605","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/1471-0528.17739","article-title":"The management of nausea and vomiting in pregnancy and hyperemesis gravidarum (green-top guideline no. 69)","volume":"131","author":"Nelson-Piercy","year":"2024","journal-title":"BJOG"},{"key":"10.1016\/j.tins.2025.08.003_bb0610","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s12884-022-04922-6","article-title":"Assessment of management approaches for hyperemesis gravidarum and nausea and vomiting of pregnancy: a retrospective questionnaire analysis","volume":"22","author":"Mares","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.tins.2025.08.003_bb0615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00431-017-3006-9","article-title":"Clinical practice: nausea and vomiting in acute gastroenteritis: physiopathology and management","volume":"177","author":"Canziani","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.tins.2025.08.003_bb0620","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1053\/j.gastro.2024.05.031","article-title":"AGA clinical practice update on diagnosis and management of cyclic vomiting syndrome: commentary","volume":"167","author":"Levinthal","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2025.08.003_bb0625","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11912-020-0871-6","article-title":"Nausea and vomiting: a palliative care imperative","volume":"22","author":"Wickham","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.tins.2025.08.003_bb0630","doi-asserted-by":"crossref","first-page":"e1191","DOI":"10.1136\/spcare-2022-003795","article-title":"Cyclizine pharmacovigilance in hospice\/palliative care: net effects for nausea or vomiting","volume":"13","author":"McNeill","year":"2024","journal-title":"BMJ Support. Palliat. Care"},{"key":"10.1016\/j.tins.2025.08.003_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2023.102512","article-title":"Efficacy and safety of antiemetic regimens for highly emetogenic chemotherapy-induced nausea and vomiting: a systematic review and network meta-analysis","volume":"115","author":"Filetti","year":"2023","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.tins.2025.08.003_bb0640","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13604","article-title":"Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association","volume":"31","author":"Venkatesan","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.tins.2025.08.003_bb0645","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11938-016-0113-z","article-title":"Chronic unexplained nausea and vomiting or gastric neuromuscular dysfunction (GND)? An update on nomenclature, pathophysiology and treatment, and relationship to gastroparesis","volume":"14","author":"Harer","year":"2016","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.tins.2025.08.003_bb0650","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-3260","article-title":"Antiemetics in children with acute gastroenteritis: a meta-analysis","volume":"145","author":"Nino-Serna","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.tins.2025.08.003_bb0655","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11938-018-0202-2","article-title":"Migraine, cyclic vomiting syndrome, and other gastrointestinal disorders","volume":"16","author":"Yu","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.tins.2025.08.003_bb0660","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-823357-3.00035-5","article-title":"Nonspecific analgesics, combination analgesics, and antiemetics","volume":"199","author":"Martinelli","year":"2024","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.tins.2025.08.003_bb0665","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1007\/s11695-020-04683-1","article-title":"Antiemetic prophylaxis and anesthetic approaches to reduce postoperative nausea and vomiting in bariatric surgery patients: a systematic review","volume":"30","author":"Naeem","year":"2020","journal-title":"Obes. Surg."},{"key":"10.1016\/j.tins.2025.08.003_bb0670","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.21832.1","article-title":"Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an updated review","volume":"9","author":"Elvir-Lazo","year":"2020","journal-title":"F1000Research"},{"key":"10.1016\/j.tins.2025.08.003_bb0675","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00540-017-2363-x","article-title":"An update on the management of postoperative nausea and vomiting","volume":"31","author":"Cao","year":"2017","journal-title":"J. Anesth."},{"key":"10.1016\/j.tins.2025.08.003_bb0680","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/jdi.12900","article-title":"Clinical factors associated with the occurrence of nausea and vomiting in type 2 diabetes patients treated with glucagon-like peptide-1 receptor agonists","volume":"10","author":"Shiomi","year":"2019","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.tins.2025.08.003_bb0685","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s42003-025-07479-0","article-title":"A deep learning-based system for automatic detection of emesis with high accuracy in Suncus murinus","volume":"8","author":"Lu","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tins.2025.08.003_bb0690","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/1756283X15618131","article-title":"Nausea: a review of pathophysiology and therapeutics","volume":"9","author":"Singh","year":"2016","journal-title":"Ther. Adv. Gastroenterol."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223625001705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223625001705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:09:13Z","timestamp":1760501353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223625001705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":138,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0166223625001705"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2025.08.003","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sensory signals for nausea","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2025.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}