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Med."},{"key":"10.1016\/j.tins.2026.03.004_bb0330","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1002\/alz.14098","article-title":"Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer\u2019s disease in the EMIF-AD study","volume":"20","author":"Smith","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2026.03.004_bb0335","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1002\/alz.14061","article-title":"Blood-based multivariate methylation risk score for cognitive impairment and dementia","volume":"20","author":"Koetsier","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tins.2026.03.004_bb0340","article-title":"The multiomics blueprint of the individual with the most extreme lifespan","volume":"6","author":"Santos-Pujol","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.tins.2026.03.004_bb0345","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41582-025-01105-7","article-title":"Epigenetic clocks and DNA methylation biomarkers of brain health and disease","volume":"21","author":"Conole","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.tins.2026.03.004_bb0350","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41576-024-00807-w","article-title":"Epigenetic ageing clocks: statistical methods and emerging computational challenges","volume":"26","author":"Teschendorff","year":"2025","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0355","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/acn3.51997","article-title":"Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia","volume":"11","author":"Giannini","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.tins.2026.03.004_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1272960","article-title":"Detection of neuron-derived cfDNA in blood plasma: a new diagnostic approach for neurodegenerative conditions","volume":"14","author":"Pollard","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.tins.2026.03.004_bb0365","article-title":"Circulating cell-free DNA methylation profiles enable disease-specific detection of Alzheimer\u2019s, Parkinson\u2019s, and ALS from blood","author":"Pollard","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.tins.2026.03.004_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-019-3307-2","article-title":"Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software","volume":"21","author":"Decamps","year":"2020","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.tins.2026.03.004_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-017-1511-5","article-title":"A comparison of reference-based algorithms for correcting cell-type heterogeneity in epigenome-wide association studies","volume":"18","author":"Teschendorff","year":"2017","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.tins.2026.03.004_bb0380","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-022-05580-6","article-title":"A DNA methylation atlas of normal human cell types","volume":"613","author":"Loyfer","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.03.004_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-35320-3","article-title":"Tumor fractions deciphered from circulating cell-free DNA methylation for cancer early diagnosis","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.03.004_bb0390","article-title":"Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring","volume":"120","author":"Li","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2026.03.004_bb0395","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202503417","article-title":"Epigenetic liquid biopsies reveal endothelial turnover and erythropoiesis in asymptomatic COVID-19","volume":"8","author":"Ben-Ami","year":"2025","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.tins.2026.03.004_bb0400","first-page":"1","article-title":"Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons","volume":"18","author":"Harvey","year":"2025","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0405","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/cr.2017.106","article-title":"5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages","volume":"27","author":"Song","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.tins.2026.03.004_bb0410","first-page":"569","article-title":"5-hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for late-onset Alzheimer\u2019s disease","volume":"85","author":"Chen","year":"2022","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.tins.2026.03.004_bb0415","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tig.2025.01.001","article-title":"Chromatin accessibility provides a window into the genetic etiology of human brain disease","volume":"41","author":"Bendl","year":"2025","journal-title":"Trends Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0420","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1126\/science.aba7612","article-title":"A human cell atlas of fetal chromatin accessibility","volume":"370","author":"Domcke","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.03.004_bb0425","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41392-024-02030-9","article-title":"Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tins.2026.03.004_bb0430","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s43587-024-00583-6","article-title":"A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson\u2019s disease\u2013associated glial changes","volume":"4","author":"Adams","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.tins.2026.03.004_bb0435","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s40478-024-01803-1","article-title":"Single-nucleus multi-omics of Parkinson\u2019s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks","volume":"12","author":"Shwab","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.tins.2026.03.004_bb0440","article-title":"The chromatin conformation landscape of Alzheimer\u2019s disease","author":"Nativio","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2026.03.004_bb0445","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ebiom.2018.06.015","article-title":"Initial identification of a blood-based chromosome conformation signature for aiding in the diagnosis of amyotrophic lateral sclerosis","volume":"33","author":"Salter","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tins.2026.03.004_bb0450","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41588-021-00894-z","article-title":"Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer\u2019s disease","volume":"53","author":"Morabito","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0455","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2014.06.034","article-title":"DNA damage and its links to neurodegeneration","volume":"83","author":"Madabhushi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.03.004_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2025.108066","article-title":"Epigenomic profile of GBA1 in Parkinson\u2019s disease","volume":"140","author":"Berson","year":"2025","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.tins.2026.03.004_bb0465","first-page":"1","article-title":"Establishing gene regulatory networks from Parkinson\u2019s disease risk loci","volume":"139","author":"Farrow","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.tins.2026.03.004_bb0470","article-title":"A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer\u2019s disease mutations","author":"Chandrashekar","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2026.03.004_bb0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41597-023-01948-z","article-title":"Three-dimensional chromatin architecture datasets for aging and Alzheimer\u2019s disease","volume":"10","author":"Meng","year":"2023","journal-title":"Sci. Data"},{"key":"10.1016\/j.tins.2026.03.004_bb0480","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/brain\/awaf066","article-title":"Mapping the peripheral immune landscape of Parkinson\u2019s disease patients with single-cell sequencing","volume":"148","author":"Moquin-Beaudry","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.tins.2026.03.004_bb0485","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s43587-025-00926-x","article-title":"A blood-based DNA damage signature in patients with Parkinson\u2019s disease is associated with disease progression","volume":"5","author":"Sproviero","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.tins.2026.03.004_bb0490","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2026.03.004_bb0495","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/MOG.0000000000001104","article-title":"Chromatin profiling to identify biomarkers in inflammatory bowel diseases","volume":"41","author":"Awad","year":"2025","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.tins.2026.03.004_bb0500","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.3390\/cancers15102696","article-title":"Development and validation of blood-based predictive biomarkers for response to PD-1\/PD-L1 checkpoint inhibitors: evidence of a universal systemic core of 3D immunogenetic profiling across multiple oncological indications","volume":"15","author":"Hunter","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tins.2026.03.004_bb0505","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-15668-8","article-title":"Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion","volume":"12","author":"Giroux","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2026.03.004_bb0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-023-39919-y","article-title":"Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes","volume":"14","author":"Garske","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.03.004_bb0515","article-title":"Research progress and applications of epigenetic biomarkers in cancer","volume":"15","author":"Gao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tins.2026.03.004_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-024-01803-z","article-title":"Cancer epigenetics: from laboratory studies and clinical trials to precision medicine","volume":"10","author":"Yu","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.tins.2026.03.004_bb0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-021-02710-y","article-title":"Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups","volume":"19","author":"Alshaker","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tins.2026.03.004_bb0530","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1126\/science.ads2169","article-title":"RNA polymerase II at histone genes predicts outcome in human cancer","volume":"387","author":"Henikoff","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.03.004_bb0535","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.14283\/jpad.2024.52","article-title":"Prediction of Alzheimer\u2019s disease based on 3D genome selected circRNA","volume":"11","author":"Chi","year":"2024","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.tins.2026.03.004_bb0540","first-page":"1","article-title":"Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies","volume":"7","author":"Challa","year":"2023","journal-title":"NPJ Precis. Oncol."},{"key":"10.1016\/j.tins.2026.03.004_bb0545","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/21678421.2024.2447919","article-title":"Amyotrophic lateral sclerosis estimated prevalence cases from 2022 to 2030, data from the national ALS Registry","volume":"26","author":"Mehta","year":"2025","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.tins.2026.03.004_bb0550","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-023-04769-w","article-title":"ALS is imprinted in the chromatin accessibility of blood cells","volume":"80","author":"K\u00fchlwein","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tins.2026.03.004_bb0555","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrm3949","article-title":"The selection and function of cell type-specific enhancers","volume":"16","author":"Heinz","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tins.2026.03.004_bb0560","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer\u2019s disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2026.03.004_bb0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-019-0636-y","article-title":"Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer\u2019s disease","volume":"11","author":"Smith","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.tins.2026.03.004_bb0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-23243-4","article-title":"A meta-analysis of epigenome-wide association studies in Alzheimer\u2019s disease highlights novel differentially methylated loci across cortex","volume":"12","author":"Smith","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.03.004_bb0575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.tins.2026.03.004_bb0580","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41573-025-01323-0","article-title":"Epigenetic editing: from concept to clinic","volume":"25","author":"Heller","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tins.2026.03.004_bb0585","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1126\/sciadv.abn2748","article-title":"Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure","volume":"8","author":"Bohnsack","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2026.03.004_bb0590","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA\u2013guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.03.004_bb0595","article-title":"(2014) The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.03.004_bb0600","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-021-00093-4","article-title":"High-content CRISPR screening","volume":"2","author":"Bock","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.tins.2026.03.004_bb0605","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41588-021-01008-5","article-title":"CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters","volume":"54","author":"Ortabozkoyun","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0610","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nmeth.4177","article-title":"Pooled CRISPR screening with single-cell transcriptome readout","volume":"14","author":"Datlinger","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.tins.2026.03.004_bb0615","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.cell.2016.11.038","article-title":"Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens","volume":"167","author":"Dixit","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.03.004_bb0620","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature17946","article-title":"Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage","volume":"533","author":"Komor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.03.004_bb0625","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature24644","article-title":"Programmable base editing of A\u2022T to G\u2022C in genomic DNA without DNA cleavage","volume":"551","author":"Gaudelli","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.03.004_bb0630","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","article-title":"Search-and-replace genome editing without double-strand breaks or donor DNA","volume":"576","author":"Anzalone","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.03.004_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010940","article-title":"Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants","volume":"19","author":"Sahu","year":"2023","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0640","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cell.2016.08.056","article-title":"Editing DNA methylation in the mammalian genome","volume":"167","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.03.004_bb0645","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2013.06.044","article-title":"CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes","volume":"154","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.03.004_bb0650","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.cell.2021.03.025","article-title":"Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing","volume":"184","author":"Nu\u00f1ez","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.03.004_bb0655","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nmeth.3312","article-title":"Highly-efficient Cas9-mediated transcriptional programming","volume":"12","author":"Chavez","year":"2015","journal-title":"Nat. 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Cancer"},{"key":"10.1016\/j.tins.2026.03.004_bb0675","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/hmg\/ddt451","article-title":"Altered CpG methylation in sporadic Alzheimer\u2019s disease is associated with APP and MAPT dysregulation","volume":"23","author":"Iwata","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tins.2026.03.004_bb0680","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/s41587-025-02901-8","article-title":"Artificial miRNA slows Huntington\u2019s","volume":"43","author":"Marshall","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tins.2026.03.004_bb0685","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.ymthe.2020.03.007","article-title":"AAV capsid-promoter interactions determine CNS cell-selective gene expression in vivo","volume":"28","author":"Powell","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tins.2026.03.004_bb0690","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-024-01780-w","article-title":"Adeno-associated virus as a delivery vector for gene therapy of human diseases","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. 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